Ownership Submission
FORM 5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Form 3 Holdings Reported
Form 4 Transactions Reported
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
BIONDI FRANK
 2. Issuer Name and Ticker or Trading Symbol
AMGEN INC [AMGN] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)

ONE AMGEN CENTER DRIVE		 3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year)
12/31/2010
(Street)


THOUSAND OAKS, CA 91320-1799		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Reporting
(check applicable line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Nqso (Right to Buy) $ 59.48 04/05/2010   J(1)   1,943.5 03/15/2005 03/15/2011 Common Stock
1,943.5
$ 59.48 1,897.96
I
The Frank Biondi, Jr. Annuity Trust No. 1
Nqso (Right to Buy) $ 59.48 04/05/2010   J(1) 1,943.5   03/15/2005 03/15/2011 Common Stock
1,943.5
$ 59.48 2,563.66
D
 
Nqso (Right to Buy) $ 59.48 04/06/2010   J(2)   1,897.96 03/15/2005 03/15/2011 Common Stock
1,897.96
$ 59.48 0
I
The Frank Biondi, Jr. Annuity Trust No. 1
Nqso (Right to Buy) $ 59.48 04/06/2010   J(2) 1,897.96   03/15/2005 03/15/2011 Common Stock
1,897.96
$ 59.48 4,461.62
D
 
Nqso (Right to Buy) $ 55.69 04/05/2010   J(1)   24,084.21 01/07/2003 01/07/2012 Common Stock
24,084.21
$ 55.69 20,611.65
I
The Frank Biondi, Jr. Annuity Trust No. 2
Nqso (Right to Buy) $ 55.69 04/05/2010   J(1) 24,084.21   01/07/2003 01/07/2012 Common Stock
24,084.21
$ 55.69 31,249.62
D
 
Nqso (Right to Buy) $ 55.69 04/06/2010   J(2)   20,611.65 01/07/2003 01/07/2012 Common Stock
20,611.65
$ 55.69 0
I
The Frank Biondi, Jr. Annuity Trust No. 2
Nqso (Right to Buy) $ 55.69 04/06/2010   J(2) 20,611.65   01/07/2003 01/07/2012 Common Stock
20,611.65
$ 55.69 51,861.27
D
 
Nqso (Right to Buy) $ 56.3 04/05/2010   J(1)   6,448.87 01/28/2003 01/28/2012 Common Stock
6,448.87
$ 56.3 5,503.32
I
The Frank Biondi, Jr. Annuity Trust No. 3
Nqso (Right to Buy) $ 56.3 04/05/2010   J(1) 6,448.87   01/28/2003 01/28/2012 Common Stock
6,448.87
$ 56.3 8,359.48
D
 
Nqso (Right to Buy) $ 56.3 04/06/2010   J(2)   5,503.32 01/28/2003 01/28/2012 Common Stock
5,503.32
$ 56.3 0
I
The Frank Biondi, Jr. Annuity Trust No. 3
Nqso (Right to Buy) $ 56.3 04/06/2010   J(2) 5,503.32   01/28/2003 01/28/2012 Common Stock
5,503.32
$ 56.3 13,862.8
D
 
Nqso (Right to Buy) $ 50.78 04/05/2010   J(1)   5,966.23 01/27/2004 01/27/2013 Common Stock
5,966.23
$ 50.78 5,459.84
I
The Frank Biondi, Jr. Annuity Trust No. 4
Nqso (Right to Buy) $ 50.78 04/05/2010   J(1) 5,966.23   01/27/2004 01/27/2013 Common Stock
5,966.23
$ 50.78 7,953.51
D
 
Nqso (Right to Buy) $ 50.78 04/06/2010   J(2)   5,459.84 01/27/2004 01/27/2013 Common Stock
5,459.84
$ 50.78 0
I
The Frank Biondi, Jr. Annuity Trust No. 4
Nqso (Right to Buy) $ 50.78 04/06/2010   J(2) 5,459.84   01/27/2004 01/27/2013 Common Stock
5,459.84
$ 50.78 13,413.35
D
 
Nqso (Right to Buy) $ 74.89 04/05/2010   J(1)   2,339.11 03/15/2006 03/15/2013 Common Stock
2,339.11
$ 74.89 1,652.33
I
The Frank Biondi, Jr. Annuity Trust No. 5
Nqso (Right to Buy) $ 74.89 04/05/2010   J(1) 2,339.11   03/15/2006 03/15/2013 Common Stock
2,339.11
$ 74.89 2,914.94
D
 
Nqso (Right to Buy) $ 74.89 04/06/2010   J(2)   1,652.33 03/15/2006 03/15/2013 Common Stock
1,652.33
$ 74.89 0
I
The Frank Biondi, Jr. Annuity Trust No. 5
Nqso (Right to Buy) $ 74.89 04/06/2010   J(2) 1,652.33   03/15/2006 03/15/2013 Common Stock
1,652.33
$ 74.89 4,567.27
D
 
Nqso (Right to Buy) $ 62.55 04/05/2010   J(1)   2,082.6 04/26/2007 04/26/2014 Common Stock
2,082.6
$ 62.55 1,636.69
I
The Frank Biondi, Jr. Annuity Trust No. 6
Nqso (Right to Buy) $ 62.55 04/05/2010   J(1) 2,082.6   04/26/2007 04/26/2014 Common Stock
2,082.6
$ 62.55 2,686.71
D
 
Nqso (Right to Buy) $ 62.55 04/06/2010   J(2)   1,636.69 04/26/2007 04/26/2014 Common Stock
1,636.69
$ 62.55 0
I
The Frank Biondi, Jr. Annuity Trust No. 6
Nqso (Right to Buy) $ 62.55 04/06/2010   J(2) 1,636.69   04/26/2007 04/26/2014 Common Stock
1,636.69
$ 62.55 4,323.4
D
 
Nqso (Right to Buy) $ 58.61 04/05/2010   J(1)   2,060.38 03/15/2005 03/15/2012 Common Stock
2,060.38
$ 58.61 1,718.55
I
The Frank Biondi, Jr. Annuity Trust No. 7
Nqso (Right to Buy) $ 58.61 04/05/2010   J(1) 2,060.38   03/15/2005 03/15/2012 Common Stock
2,060.38
$ 58.61 2,656.36
D
 
Nqso (Right to Buy) $ 58.61 04/06/2010   J(2)   1,718.55 03/15/2005 03/15/2012 Common Stock
1,718.55
$ 58.61 0
I
The Frank Biondi, Jr. Annuity Trust No. 7
Nqso (Right to Buy) $ 58.61 04/06/2010   J(2) 1,718.55   03/15/2005 03/15/2012 Common Stock
1,718.55
$ 58.61 4,374.91
D
 

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
BIONDI FRANK
ONE AMGEN CENTER DRIVE
THOUSAND OAKS, CA 91320-1799		   X      

Signatures

/s/ Frank J. Biondi, Jr. 02/02/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) On April 5, 2010, the Reporting Person exercised his power under the terms of the Annuity Trust, of which the Reporting Person is a trustee and a beneficiary, to substitute certain assets in exchange for receiving back Amgen stock options equal to the value of the assets assigned to the Annuity Trust.
(2) On April 6, 2010, the Annuity Trust distributed to the Reporting Person an annuity payment in the form of the assignment of a portion of the stock options held by the Annuity Trust (the "Annuity Payment") in satisfaction of the Annuity Trust's obligation to make annuity payments to the Reporting Person.

Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.