Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
MCINERNEY TIMOTHY
   2. Issuer Name and Ticker or Trading Symbol
ZIOPHARM ONCOLOGY INC [ZIOP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
ONE COVENTRY LANE		 3. Date of Earliest Transaction (Month/Day/Year)
04/14/2010
(Street)

HOPEWELL, NJ 08525		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $.001 par value               230,705 (1) D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Warrants to Purchase Common Stock $ 4.75             09/13/2005 05/31/2012 Common Stock, $.001 par value 20,767   20,767 D  
Director Stock Option (right to buy) $ 4.31             07/20/2007 07/20/2015 Common Stock, $.001 par value 15,029   15,029 D  
Director Stock Option (right to buy) $ 5.01             04/26/2006 04/26/2016 Common Stock 15,000   15,000 D  
Warrants to Purchase Common Stock $ 5.09             05/03/2006 05/03/2013 Common Stock, $.001 par value 80,737   80,737 D  
Director Stock Option (right to buy) $ 6.49             12/13/2009 12/13/2016 Common Stock 15,000   15,000 D  
Warrant $ 5.75             02/23/2007 02/23/2012 Common Stock 35,739   35,739 D  
Stock Option (right to buy) $ 4.85               (2) 06/18/2017 Common Stock 15,000   15,000 D  
Stock Option (right to buy) $ 2.73               (3) 12/12/2017 Common Stock 20,000   20,000 D  
Stock Option (right to buy) $ 0.7               (4) 05/13/2019 Common Stock 15,000   15,000 D  
Warrants to purchase common stock $ 2.04             09/15/2009 09/15/2014 Common Stock, $.001 par value 50,000   50,000 D  
Warrants to purchase common stock $ 2.04             09/15/2009 09/15/2014 Common Stock 40,298   40,298 D  
Warrants to Purchase Common Stock $ 4.02             12/09/2009 12/09/2014 Common Stock 25,000   25,000 D  
Stock Option (right to buy) $ 2.85               (5) 12/31/2019 Common Stock, $.001 par value 7,500   7,500 D  
Stock Option (right to buy) $ 5.09             03/31/2011 03/31/2020 Common Stock, $.001 par value 15,000   15,000 D  
Warrants to purchase Common Stock $ 4.02 04/14/2010   J(6)   29,898   04/14/2010 12/09/2014 Common Stock 29,898 (6) 29,898 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MCINERNEY TIMOTHY
ONE COVENTRY LANE
HOPEWELL, NJ 08525		   X      

Signatures

 /s/ Timothy McInerney   04/16/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Includes grants of restricted stock with restrictions that will lapse as to 3,750 shares on each of December 31, 2010 and December 31, 2011 and restrictions that lapse as to 15,000 shares on March 31, 2011.
(2) 5,000 shares vest on each of 6/18/08, 6/18/09 and 6/18/10.
(3) 6,667 shares vest on each of 12/12/08 and 12/12/09; 6,666 shares vest on 12/12/10.
(4) 5,000 shares vest on each of 12/31/09, 6/30/2010 and 12/31/2010.
(5) 3,750 shares vest on each of 12/31/2010 and 12/31/2011.
(6) Acquired upon distribution of a warrant previously held by the Reporting Person's employer.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.