FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person *   HA NGOC TUAN 2. Date of Event Requiring Statement (Month/Day/Year) 03/11/2010 3. Issuer Name and Ticker or Trading Symbol AVEO PHARMACEUTICALS INC [AVEO] (Last) (First) (Middle) C/O AVEO PHARMACEUTICALS, INC., 75 SIDNEY STREET 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chief Executive Officer 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) CAMBRIDGE, MA 02139 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 199,999 I Held by GRAT (8)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (right to buy)	  (1)	04/01/2019	Common Stock	57,499	$ 8.48	D	Â
Stock Option (right to buy)	  (2)	01/31/2018	Common Stock	62,499	$ 6.44	D	Â
Stock Option (right to buy)	  (3)	05/09/2017	Common Stock	238,749	$ 5.2	D	Â
Stock Option (right to buy)	  (4)	02/09/2016	Common Stock	87,500	$ 2	D	Â
Stock Option (right to buy)	  (5)	02/01/2015	Common Stock	250,000	$ 1.32	D	Â
Stock Option (right to buy)	  (6)	06/17/2012	Common Stock	50,000	$ 0.48	D	Â
Stock Option (right to buy)	  (7)	02/02/2020	Common Stock	39,999	$ 12.24	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
HA NGOC TUAN C/O AVEO PHARMACEUTICALS, INC. 75 SIDNEY STREET CAMBRIDGE, MA 02139	  X	Â	  Chief Executive Officer	Â

Signatures

/s/ Joseph D. Vittiglio, attorney-in-fact		03/11/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The option vests in equal monthly installments from January 1, 2009 through January 1, 2013.
(2)	This option vests in equal monthly installments from January 1, 2008 through January 1, 2012.
(3)	This option vests in equal monthly installments from January 1, 2007 through January 1, 2011.
(4)	This option is fully vested as of January 1, 2010.
(5)	This option is fully vested as of January 1, 2009.
(6)	This option is fully vested as of June 17, 2009.
(7)	This option vests in equal monthly installments from January 1, 2010 through January 1, 2014.
(8)	Shares are held by Gabriel Schmergel, Trustee, or his successors in trust, of the Tuan Ha-Ngoc 2009 GRAT. Mr. Schmergel is the trustee of the Tuan Ha-Ngoc 2009 GRAT and he exercises sole voting and investment power over the shares held of record by such trust. Mr. Ha-Ngoc disclaims beneficial ownership over all such shares, except to the extent of his pecuniary interest therein.

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