FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * PROSPECT VENTURE PARTNERS II LP   2. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [FOLD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O PROSPECT VENTURE PARTNERS, 435 TASSO STREET, SUITE 200 3. Date of Earliest Transaction (Month/Day/Year) 06/05/2007 (Street) PALO ALTO, CA 94301 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 06/05/2007   C   2,198,582 A (1) 2,198,582 I By Prospect Venture Partners II, L.P. (2) Common Stock 06/05/2007   X(4)   14,892 A $ 6.375 2,213,474 I By Prospect Venture Partners II, L.P. (2) Common Stock 06/05/2007   S(4)   6,330 D $ 15 2,207,144 I By Prospect Venture Partners II, L.P. (2) Common Stock 06/05/2007   C   33,478 A (1) 33,478 I By Prospect Associates II, L.P. (3) Common Stock 06/05/2007   X(5)   227 A $ 6.375 33,705 I By Prospect Associates II, L.P. (3) Common Stock 06/05/2007   S(5)   97 D $ 15 33,608 I By Prospect Associates II, L.P. (3)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series B Convertible Preferred Stock	(1)	06/05/2007		C			978,562 (1)	(1)	(1)	Common Stock	978,562 (1)	$ 0	$ 0	I	By Prospect Venture Partners II, L.P. (2)
Series B Convertible Preferred Stock	(1)	06/05/2007		C			14,902 (1)	(1)	(1)	Common Stock	14,902 (1)	$ 0	$ 0	I	By Prospect Associates II, L.P. (3)
Series C Convertible Preferred Stock	(1)	06/05/2007		C			1,000,978 (1)	(1)	(1)	Common Stock	1,000,978 (1)	$ 0	$ 0	I	By Prospect Venture Partners II, L.P. (2)
Series C Convertible Preferred Stock	(1)	06/05/2007		C			15,242 (1)	(1)	(1)	Common Stock	15,242 (1)	$ 0	$ 0	I	By Prospect Associates II, L.P. (3)
Series D Convertible Preferred Stock	(1)	06/05/2007		C			219,042 (1)	(1)	(1)	Common Stock	219,042 (1)	$ 0	$ 0	I	By Prospect Venture Partners II, L.P. (2)
Series D Convertible Preferred Stock	(1)	06/05/2007		C			3,334 (1)	(1)	(1)	Common Stock	3,334 (1)	$ 0	$ 0	I	By Prospect Associates II, L.P. (3)
Warrant to purchase Series B Preferred Stock	$ 6.375	06/05/2007		X			14,892	(6)	(6)	Common Stock	14,892	$ 0	$ 0	I	By Prospect Venture Partners II, L.P. (2)
Warrant to purchase Series B Preferred Stock	$ 6.375	06/05/2007		X			227	(7)	(7)	Common Stock	227	$ 0	$ 0	I	By Prospect Associates II, L.P. (3)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
PROSPECT VENTURE PARTNERS II LP C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X
PROSPECT ASSOCIATES II L P C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X
PROSPECT MANAGEMENT CO II LLC C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X
TANANBAUM JAMES B C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X
SCHNELL DAVID C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X
HIRSCH RUSSELL C C/O PROSPECT VENTURE PARTNERS 435 TASSO STREET, SUITE 200 PALO ALTO, CA 94301		X

Signatures

/s/ Dave Markland, Attorney in Fact for Prospect Venture Partners II, L.P.		06/06/2007
**Signature of Reporting Person		Date
/s/ Dave Markland, Attorney in Fact for Prospect Associates II, L.P.		06/06/2007
**Signature of Reporting Person		Date
/s/ Dave Markland, Attorney in Fact for Prospect Management Co. II, LLC		06/06/2007
**Signature of Reporting Person		Date
/s/ Dave Markland, Attorney in Fact for James B. Tananbaum, M.D.		06/06/2007
**Signature of Reporting Person		Date
/s/ Dave Markland, Attorney in Fact for David Schnell, M.D.		06/06/2007
**Signature of Reporting Person		Date
/s/ Dave Markland, Attorney in Fact for Russell C. Hirsch, M.D., Ph.D.		06/06/2007
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Each share of the Issuer's Preferred Stock converted automatically into shares of the Issuer's Common Stock on a 1-for-1 basis immediately prior to the closing of the Issuer's initial public offering and had no expiration date.
(2)	The shares are owned by Prospect Venture Partners II, L.P. ("PVP II"), which is under common control with Prospect Associates II, L.P. ("PA II"). Prospect Management Co. II, L.L.C. ("PMC II") serves as the sole general partner of PVP II. James B. Tananbaum, M.D., Alexander E. Barkas, Ph.D., David Schnell, M.D., and Russell C. Hirsch, M.D., Ph.D. are the Managing Directors of PMC II and shares voting and investment power over the shares held by PVP II. Each reporting person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein. Dr. Barkas is a director of the Issuer and, accordingly, files separate Section 16 reports.
(3)	The shares are owned by PA II. PMC II serves as the sole general partner of PA II. James B. Tananbaum, M.D., Alexander E. Barkas, Ph.D., David Schnell, M.D., and Russell C. Hirsch, M.D., Ph.D. are the Managing Directors of PMC II and shares voting and investment power over the shares held by PA II. Each reporting person disclaims beneficial ownership of the shares reported herein, except to the extent of his proportionate pecuniary interest therein. Dr. Barkas is a director of the Issuer and, accordingly, files separate Section 16 reports.
(4)	Net exercise of warrant held by PVP II for an aggregate acquisition of 8,562 shares of Common Stock.
(5)	Net exercise of warrant held by PA II for an aggregate acquisition of 130 shares of Common Stock.
(6)	The warrant is owned by PVP II and is immediately exercisable. The warrant was net exercised upon the closing of the Issuer's initial public offering.
(7)	The warrant is owned by PA II and is immediately exercisable. The warrant was net exercised upon the closing of the Issuer's initial public offering.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.