Registration No. 333-50340



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                         POST-EFFECTIVE AMENDMENT NO. 2
                                       TO
                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933



                           ORASURE TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                         36-4370966
  (State of incorporation)                     (IRS Employer Identification No.)

       150 Webster Street
       Bethlehem, Pennsylania                                18015
(Address of principal executive offices)                   (Zip Code)


                  ORASURE TECHNOLOGIES, INC. 2000 STOCK AWARD PLAN
                  ORASURE TECHNOLOGIES, INC. EMPLOYEE INCENTIVE
                     AND NON-QUALIFIED STOCK OPTION PLAN
                  EPITOPE, INC. 1991 STOCK AWARD PLAN
                  NONQUALIFIED STOCK OPTION AGREEMENT FOR
                     DISCOUNTED NON-PLAN OPTION GRANTED TO
                     ROBERT D. THOMPSON
                  AGRITOPE, INC. 1992 STOCK AWARD PLAN
                           (Full titles of the plans)


                                 Jack E. Jerrett
                       Vice President and General Counsel
                           OraSure Technologies, Inc.
                               150 Webster Street
                          Bethlehem, Pennsylvania 18015
                            Telephone (610) 882-1820
           (Name, address, and telephone number of agent for service)









     This post-effective  amendment No. 2 to registration  statement on Form S-8
(file no.  333-50340) is being filed to add plan titles to the cover page, which
were inadvertently  omitted from the original filing. The opinion of counsel and
power of attorney are also being revised to include  reference to the additional
plans.  No other changes are being made to the original filing and the number of
registered shares remains the same.

                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing on Form S-8 and has duly  caused  this  post-effective
amendment  No. 2 to  registration  statement  to be signed on its  behalf by the
undersigned,  thereunto  duly  authorized,  in the city of  Bethlehem,  state of
Pennsylvania, on the 12th of February, 2002.

                                    OraSure Technologies, Inc.
                                    (Registrant)

                                    By     /s/ Michael J. Gausling
                                           -------------------------------------
                                           Michael J. Gausling
                                           Chief Executive Officer and President

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities indicated as of the 12th day of February, 2002.

      Signature                               Title

      (1)  Principal Executive Officer

      /s/ Michael J. Gausling
      --------------------------------
      Michael J. Gausling                    Chief Executive Officer,  President
                                             and Director

      (2)  Principal Financial Officer

      /s/ Ronald H. Spair
      --------------------------------
      Ronald H. Spair                        Executive Vice President  and Chief
                                             Financial Officer

      (3)  Principal Accounting Officer

      /s/ Mark L. Kuna
      --------------------------------
      Mark L. Kuna                           Controller

      (4)  A majority of the Board of Directors


      * FRANK G. HAUSMANN                 Director
      * MICHAEL G. BOLTON                 Director
      * WILLIAM W. CROUSE                 Director
      * ROGER L. PRINGLE                  Director
      * CARTER H. ECKERT                  Director




* By  /s/ Michael J. Gausling
      --------------------------------
      Michael J. Gausling
      Attorney-in-fact





                                INDEX TO EXHIBITS


4.1   Certificate of Incorporation of the registrant.  Incorporated by reference
      to Exhibit  3.1 to the  registrant's  Registration  Statement  on Form S-4
      (File No. 333-39210) ("Form S-4").

4.1.1 Certificate  of Amendment to Certificate  of  Incorporation  dated May 23,
      2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4.

4.2   Amended and Restated Bylaws of the  registrant.  Incorporated by reference
      to  Exhibit  10 to  registrant's  Quarterly  Report  on Form  10-Q for the
      quarter ended September 30, 2001.

4.3   Rights  Agreement  dated as of May 6, 2000,  between  the  registrant  and
      ChaseMellon  Shareholder  Services,  L.L.C.  Incorporated  by reference to
      Exhibit 4.2 to Form S-4.

5     Opinion of Miller Nash LLP.

23.1  Consent of PricewaterhouseCoopers LLP.*

23.2  Consent of Arthur Andersen LLP.*

23.3  Consent of Miller Nash LLP.  Included in Exhibit 5.

24    Power of attorney of certain officers and directors.

*Previously filed


     Other exhibits listed in Item 601 to Regulation S-K are not applicable.