Registration No. 333-50340 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ORASURE TECHNOLOGIES, INC. (Exact name of registrant as specified in its charter) Delaware 36-4370966 (State of incorporation) (IRS Employer Identification No.) 150 Webster Street Bethlehem, Pennsylania 18015 (Address of principal executive offices) (Zip Code) ORASURE TECHNOLOGIES, INC. 2000 STOCK AWARD PLAN ORASURE TECHNOLOGIES, INC. EMPLOYEE INCENTIVE AND NON-QUALIFIED STOCK OPTION PLAN EPITOPE, INC. 1991 STOCK AWARD PLAN NONQUALIFIED STOCK OPTION AGREEMENT FOR DISCOUNTED NON-PLAN OPTION GRANTED TO ROBERT D. THOMPSON AGRITOPE, INC. 1992 STOCK AWARD PLAN (Full titles of the plans) Jack E. Jerrett Vice President and General Counsel OraSure Technologies, Inc. 150 Webster Street Bethlehem, Pennsylvania 18015 Telephone (610) 882-1820 (Name, address, and telephone number of agent for service) This post-effective amendment No. 2 to registration statement on Form S-8 (file no. 333-50340) is being filed to add plan titles to the cover page, which were inadvertently omitted from the original filing. The opinion of counsel and power of attorney are also being revised to include reference to the additional plans. No other changes are being made to the original filing and the number of registered shares remains the same. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this post-effective amendment No. 2 to registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Bethlehem, state of Pennsylvania, on the 12th of February, 2002. OraSure Technologies, Inc. (Registrant) By /s/ Michael J. Gausling ------------------------------------- Michael J. Gausling Chief Executive Officer and President Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated as of the 12th day of February, 2002. Signature Title (1) Principal Executive Officer /s/ Michael J. Gausling -------------------------------- Michael J. Gausling Chief Executive Officer, President and Director (2) Principal Financial Officer /s/ Ronald H. Spair -------------------------------- Ronald H. Spair Executive Vice President and Chief Financial Officer (3) Principal Accounting Officer /s/ Mark L. Kuna -------------------------------- Mark L. Kuna Controller (4) A majority of the Board of Directors * FRANK G. HAUSMANN Director * MICHAEL G. BOLTON Director * WILLIAM W. CROUSE Director * ROGER L. PRINGLE Director * CARTER H. ECKERT Director * By /s/ Michael J. Gausling -------------------------------- Michael J. Gausling Attorney-in-fact INDEX TO EXHIBITS 4.1 Certificate of Incorporation of the registrant. Incorporated by reference to Exhibit 3.1 to the registrant's Registration Statement on Form S-4 (File No. 333-39210) ("Form S-4"). 4.1.1 Certificate of Amendment to Certificate of Incorporation dated May 23, 2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4. 4.2 Amended and Restated Bylaws of the registrant. Incorporated by reference to Exhibit 10 to registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2001. 4.3 Rights Agreement dated as of May 6, 2000, between the registrant and ChaseMellon Shareholder Services, L.L.C. Incorporated by reference to Exhibit 4.2 to Form S-4. 5 Opinion of Miller Nash LLP. 23.1 Consent of PricewaterhouseCoopers LLP.* 23.2 Consent of Arthur Andersen LLP.* 23.3 Consent of Miller Nash LLP. Included in Exhibit 5. 24 Power of attorney of certain officers and directors. *Previously filed Other exhibits listed in Item 601 to Regulation S-K are not applicable.