1

     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 23, 2001
                                                     REGISTRATION NO. 333-
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
                                    FORM S-4
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                            ------------------------

                               JOHNSON & JOHNSON
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)


                                                                
            NEW JERSEY                            2834                            22-1024240
 (STATE OR OTHER JURISDICTION OF      (PRIMARY STANDARD INDUSTRIAL             (I.R.S. EMPLOYER
  INCORPORATION OR ORGANIZATION)      CLASSIFICATION CODE NUMBER)            IDENTIFICATION NO.)


                          ONE JOHNSON & JOHNSON PLAZA
                        NEW BRUNSWICK, NEW JERSEY 08933
                           TELEPHONE: (732) 524-0400
         (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING
            AREA CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------
                             JAMES R. HILTON, ESQ.
                            MICHAEL H. ULLMANN, ESQ.
                               JOHNSON & JOHNSON
                          ONE JOHNSON & JOHNSON PLAZA
                        NEW BRUNSWICK, NEW JERSEY 08933
                           TELEPHONE: (732) 524-0400
           (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
                   INCLUDING AREA CODE, OF AGENT FOR SERVICE)
                            ------------------------
                                   COPIES TO:


                                                 
           ROBERT I. TOWNSEND, III, ESQ.                             ALAN JACOBS, ESQ.
              CRAVATH, SWAINE & MOORE                       HELLER EHRMAN WHITE & MCAULIFFE LLP
                  WORLDWIDE PLAZA                                  275 MIDDLEFIELD ROAD
                 825 EIGHTH AVENUE                                 MENLO PARK, CA 94025
                NEW YORK, NY 10019                               TELEPHONE: (650) 324-7000
             TELEPHONE: (212) 474-1000


                            ------------------------
    APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE OF THE SECURITIES TO THE
PUBLIC: Upon consummation of the merger.
    If the securities being registered on this Form are being offered in
connection with the formation of a holding company and there is compliance with
General Instruction G, check the following box.  [ ]
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering.  [ ]
---------------
    If this Form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering.  [ ]
---------------

                        CALCULATION OF REGISTRATION FEE



--------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------
                                                                        PROPOSED             PROPOSED
                                                                         MAXIMUM              MAXIMUM
           TITLE OF EACH CLASS OF                  AMOUNT TO         OFFERING PRICE          AGGREGATE            AMOUNT OF
       SECURITIES TO BE REGISTERED(1)            BE REGISTERED          PER UNIT          OFFERING PRICE      REGISTRATION FEE
--------------------------------------------------------------------------------------------------------------------------------
                                                                                                 
Common Stock, par value $1.00 per share.....    144,956,602(2)             N/A          $12,874,512,809(3)       $3,218,628
--------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------


(1) This Registration Statement relates to securities of the registrant issuable
    to holders of common stock, par value $.005 per share ("ALZA common stock"),
    of ALZA Corporation, a Delaware corporation ("ALZA"), in the proposed merger
    of Express Merger Sub Inc., a Delaware corporation and a wholly owned
    subsidiary of the registrant ("Merger Sub"), with and into ALZA.
(2) Based on the maximum number of shares to be issued in connection with the
    merger, calculated as the product of (a) 295,829,798, the aggregate number
    of shares of ALZA common stock outstanding on April 19, 2001 (other than
    shares owned by ALZA, Merger Sub or the registrant) or issuable pursuant to
    the exercise of outstanding options or upon conversion of debentures prior
    to the date the merger is expected to be completed and (b) an exchange ratio
    of 0.49 shares of the registrant's common stock for each share of ALZA
    common stock.
(3) Estimated solely for the purpose of calculating the registration fee
    required by Section 6(b) of the Securities Act, and calculated pursuant to
    Rule 457(f) under the Securities Act. Pursuant to Rule 457(f)(1) under the
    Securities Act, the proposed maximum aggregate offering price of the
    registrant's common stock was calculated based upon the market value of
    shares of ALZA common stock (the securities to be cancelled in the merger)
    in accordance with Rule 457(c) under the Securities Act as follows: (a)
    $43.52, the average of the high and low prices per share of ALZA common
    stock on April 19, 2001, as reported on the New York Stock Exchange
    Composite Transactions Tape, multiplied by (b) 295,829,798, the aggregate
    number of shares of ALZA common stock outstanding as of April 19, 2001
    (other than shares owned by ALZA, Merger Sub or the registrant) or issuable
    pursuant to the exercise of outstanding options or upon conversion of
    debentures prior to the date the merger is expected to be completed.
                            ------------------------
    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(a),
MAY DETERMINE.
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
   2

                                ALZA CORPORATION

                              1900 CHARLESTON ROAD
                        MOUNTAIN VIEW, CALIFORNIA 94043

                                                                        --, 2001

Dear Stockholder:

     You are cordially invited to attend the special meeting of stockholders of
ALZA Corporation to be held on --, --, 2001, at -- a.m., local time, at --.

     At the special meeting, we will ask you to vote on the merger of ALZA with
a subsidiary of Johnson & Johnson. In the merger, you will receive 0.49 shares
of Johnson & Johnson common stock for each share of ALZA common stock that you
own. You will receive cash for any fractional shares of Johnson & Johnson common
stock that you would be entitled to receive in the merger.

     Johnson & Johnson common stock is listed on the New York Stock Exchange
under the trading symbol "JNJ" and on --, 2001, its closing price was $-- per
share.

     The ALZA board of directors has carefully reviewed and considered the terms
and conditions of the proposed merger. Based on its review, the ALZA board of
directors has determined that the terms of the merger agreement and the merger
are advisable to ALZA and its stockholders. THE ALZA BOARD OF DIRECTORS HAS
APPROVED THE MERGER AGREEMENT AND UNANIMOUSLY RECOMMENDS THAT YOU VOTE "FOR" THE
ADOPTION OF THE MERGER AGREEMENT.

     Your vote is important. We cannot complete the merger unless the merger
agreement is adopted by the affirmative vote of a majority of the shares of ALZA
common stock outstanding and entitled to vote at the special meeting. Failure to
submit a signed proxy or vote in person at the special meeting will have the
same effect as a vote against the adoption of the merger agreement. Only
stockholders who owned shares of ALZA common stock at the close of business on
--, 2001 will be entitled to vote at the special meeting.

     PLEASE COMPLETE, SIGN, DATE AND RETURN YOUR PROXY. If you hold your shares
in "street name", you should instruct your broker how to vote in accordance with
your voting instruction form.

     The accompanying proxy statement/prospectus explains the proposed merger
and merger agreement and provides specific information concerning the special
meeting. Please review this document carefully. YOU SHOULD CONSIDER THE MATTERS
DISCUSSED UNDER "RISK FACTORS RELATING TO THE MERGER" ON PAGE 10 OF THIS PROXY
STATEMENT/PROSPECTUS BEFORE VOTING.

                                          Sincerely,

                                          Ernest Mario
                                          Chairman and Chief Executive Officer

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
REGULATOR HAS APPROVED OR DISAPPROVED THE MERGER DESCRIBED IN THIS PROXY
STATEMENT/PROSPECTUS OR THE JOHNSON & JOHNSON COMMON STOCK TO BE ISSUED IN
CONNECTION WITH THE MERGER, OR DETERMINED IF THIS PROXY STATEMENT/PROSPECTUS IS
ACCURATE OR ADEQUATE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

               This proxy statement/prospectus is dated --, 2001,
        and is first being mailed to stockholders on or about --, 2001.
   3

                      REFERENCES TO ADDITIONAL INFORMATION

     This proxy statement/prospectus incorporates important business and
financial information about Johnson & Johnson and ALZA from documents that are
not included in or delivered with this proxy statement/prospectus. This
information is available to you without charge upon your written or oral
request. You can obtain the documents incorporated by reference in this proxy
statement/prospectus by requesting them in writing or by telephone from the
appropriate company at the following addresses and telephone numbers:


                                                
    JOHNSON & JOHNSON                              ALZA CORPORATION
    One Johnson & Johnson Plaza                    1900 Charleston Road
    New Brunswick, NJ 08933                        Mountain View, California 94043
    Attention: Office of Corporate Secretary       Attention: Investor Relations
    Telephone: (732) 524-2455                      Telephone: (650) 564-5222


     If you would like to request documents, please do so by --, 2001 in order
to receive them before the special meeting.

             See "Where You Can Find More Information" on page 68.
   4

                                ALZA CORPORATION

                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                             TO BE HELD ON --, 2001

To the Stockholders of ALZA Corporation:

     We will hold a special meeting of stockholders of ALZA Corporation on --,
--, 2001, at -- a.m., local time, at --, for the following purpose:

     To consider and vote upon a proposal to adopt the merger agreement among
     Johnson & Johnson, Express Merger Sub Inc., a wholly owned subsidiary of
     Johnson & Johnson, and ALZA. In the merger, ALZA will become a wholly owned
     subsidiary of Johnson & Johnson, and each outstanding share of ALZA common
     stock will be converted into the right to receive 0.49 shares of Johnson &
     Johnson common stock.

     We will transact no other business at the special meeting except such
business as may properly be brought before the special meeting or any
adjournment or postponement of it by the ALZA board of directors.

     Only stockholders who owned shares of ALZA common stock at the close of
business on --, 2001, the record date for the special meeting, are entitled to
notice of, and to vote at, the special meeting and any adjournment or
postponement of it.

     We cannot complete the merger unless the merger agreement is adopted by the
affirmative vote of a majority of the shares of ALZA common stock outstanding
and entitled to vote at the special meeting. Holders of ALZA common stock have
no appraisal rights under Delaware law in connection with the merger. This proxy
statement/prospectus describes the proposed merger and the actions to be taken
in connection with the merger and provides additional information about the
parties involved. Please give this information your careful attention.

     THE ALZA BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS VOTE
"FOR" THE ADOPTION OF THE MERGER AGREEMENT.

     Whether or not you plan to attend the special meeting, please complete,
sign and date the enclosed proxy and return it promptly in the enclosed
postage-paid return envelope. You may revoke the proxy at any time prior to its
exercise in the manner described in this proxy statement/prospectus. Any
stockholder present at the special meeting, including any adjournment or
postponement of it, may revoke such stockholder's proxy and vote personally on
the merger agreement to be considered at the special meeting. Executed proxies
with no instructions indicated thereon will be voted "FOR" the adoption of the
merger agreement.

     Please do not send any stock certificates at this time.

                                          By order of the board of directors,

                                          Julian N. Stern
                                          Secretary

Mountain View, California
--, 2001
   5

                               TABLE OF CONTENTS



                                                              PAGE
                                                              ----
                                                           
QUESTIONS AND ANSWERS ABOUT THE MERGER......................    1
SUMMARY.....................................................    2
  General...................................................    2
  The Special Meeting.......................................    3
  The Merger................................................    4
  The Companies.............................................    5
  Market Prices and Dividend Information....................    6
  Comparative Per Share Information.........................    7
  Selected Historical Consolidated Financial Data of Johnson
     & Johnson..............................................    8
  Selected Historical Consolidated Financial Data of ALZA
     Corporation............................................    9
RISK FACTORS RELATING TO THE MERGER.........................   10
THE SPECIAL MEETING.........................................   11
  Date, Time and Place......................................   11
  Purpose of the Special Meeting............................   11
  Record Date; Shares Entitled to Vote; Quorum..............   11
  Vote Required.............................................   11
  Shares Owned by ALZA Directors, Executive Officers and
     Affiliates.............................................   11
  Voting of Proxies.........................................   11
  Revocability of Proxies...................................   12
  Solicitation of Proxies...................................   12
THE COMPANIES...............................................   13
  ALZA......................................................   13
  Johnson & Johnson.........................................   13
  Material Contracts Between ALZA and Johnson & Johnson.....   13
THE MERGER..................................................   14
  Background to the Merger..................................   14
  Reasons for the Merger and Recommendation of the ALZA
     Board of Directors.....................................   15
  Opinions of JPMorgan and Merrill Lynch, Pierce, Fenner &
     Smith Incorporated.....................................   17
  Interests of ALZA Directors and Executive Officers in the
     Merger.................................................   30
  Accounting Treatment......................................   32
  Form of the Merger........................................   33
  Merger Consideration......................................   33
  Ownership of Johnson & Johnson Following the Merger.......   33
  Conversion of Shares; Procedures for Exchange of
     Certificates; Fractional Shares........................   33
  Effective Time of the Merger..............................   34
  Stock Exchange Listing of Johnson & Johnson Common
     Stock..................................................   34
  Delisting and Deregistration of ALZA Common Stock.........   34
  Material United States Federal Income Tax Consequences of
     the Merger.............................................   34
  Regulatory Matters........................................   36
  Appraisal Rights..........................................   36
  ALZA Employee Benefits Matters............................   36
  Effect on Awards Outstanding Under ALZA Stock Plans.......   38
  Resale of Johnson & Johnson Common Stock..................   38
THE MERGER AGREEMENT........................................   40
  Conditions to the Completion of the Merger................   40
  No Solicitation...........................................   42


                                        i
   6



                                                              PAGE
                                                              ----
                                                           
  Termination of the Merger Agreement.......................   44
  Fees and Expenses.........................................   45
  Conduct of Business Pending the Merger....................   45
  Representations and Warranties............................   49
  Certificate of Incorporation and By-laws of the Surviving
     Corporation............................................   50
  Amendment; Extension and Waiver...........................   50
THE STOCK OPTION AGREEMENT..................................   51
  General...................................................   51
  Exercise of the Option....................................   51
  Adjustments to Number and Type of Shares..................   51
  Cash Payments for the Option..............................   52
  Limitation on Total Profit................................   52
  Registration Rights and Listing...........................   52
  Assignability.............................................   52
  Effect of Stock Option Agreement..........................   53
COMPARATIVE STOCK PRICES AND DIVIDENDS......................   54
DESCRIPTION OF JOHNSON & JOHNSON CAPITAL STOCK..............   55
COMPARISON OF RIGHTS OF COMMON STOCKHOLDERS OF JOHNSON &
  JOHNSON AND ALZA..........................................   56
  Capitalization............................................   56
  Number, Election, Vacancy and Removal of Directors........   56
  Amendments to Charter Documents...........................   57
  Amendments to By-laws.....................................   58
  Action by Written Consent.................................   58
  Notice of Stockholder Actions.............................   59
  Special Stockholder Meetings..............................   60
  Stockholder Inspection Rights; Stockholder Lists..........   60
  Limitation of Personal Liability and Indemnification of
     Directors and Officers.................................   60
  Dividends.................................................   62
  Conversion................................................   62
  Rights Plan...............................................   62
  Voting Rights; Required Vote for Authorization of Certain
     Actions................................................   63
LEGAL MATTERS...............................................   67
EXPERTS.....................................................   68
OTHER MATTERS...............................................   68
FUTURE STOCKHOLDER PROPOSALS................................   68
WHERE YOU CAN FIND MORE INFORMATION.........................   68
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS...........   71
ANNEXES
  Annex 1 -- Agreement and Plan of Merger
  Annex 2 -- Stock Option Agreement
  Annex 3 -- Opinion of JPMorgan, a division of Chase
     Securities Inc.
  Annex 4 -- Opinion of Merrill Lynch, Pierce, Fenner &
     Smith Incorporated


                                        ii
   7

                     QUESTIONS AND ANSWERS ABOUT THE MERGER

Q:  WHAT WILL HAPPEN TO ALZA AS A RESULT OF THE MERGER?

A: If the merger is completed, ALZA will become a wholly owned subsidiary of
   Johnson & Johnson.

Q:  WHAT DO I NEED TO DO NOW?

A: After carefully reading and considering the information contained in this
   proxy statement/prospectus, please complete, sign and date your proxy and
   return it in the enclosed postage-paid return envelope as soon as possible,
   so that your shares may be represented at the special meeting. If you sign
   and send in your proxy and do not indicate how you want to vote, we will
   count your proxy as a vote in favor of the adoption of the merger agreement.
   Because the required vote of ALZA stockholders is based upon the number of
   outstanding shares of ALZA common stock, rather than upon the shares actually
   voted, the failure by the holder of any such shares to submit a proxy or to
   vote in person at the special meeting, including abstentions and broker
   non-votes, will have the same effect as a vote against the adoption of the
   merger agreement.

   The special meeting will take place on --, --, 2001, at -- a.m., local time,
   at --. You may attend the special meeting and vote your shares in person,
   rather than completing, signing, dating and returning your proxy.

Q:  CAN I CHANGE MY VOTE AFTER I HAVE MAILED MY SIGNED PROXY?

A: Yes. You can change your vote at any time before your proxy is voted at the
   special meeting. You can do this in one of three ways. First, you can send a
   written notice stating that you would like to revoke your proxy. Second, you
   can complete and submit a new proxy bearing a later date. If you choose
   either of these two methods, you must submit your notice of revocation or
   your new proxy to ALZA at 1900 Charleston Road, Mountain View, CA 94043,
   Attention: Secretary. Third, you can attend the special meeting and vote in
   person. Attendance at the special meeting will not in and of itself
   constitute revocation of a proxy.

Q:  IF MY ALZA SHARES ARE HELD IN "STREET NAME" BY MY BROKER, WILL MY BROKER
    VOTE MY SHARES FOR ME?

A: Your broker will vote your ALZA shares only if you provide instructions on
   how to vote. You should follow the directions provided by your broker
   regarding how to instruct your broker to vote your shares. Without
   instructions, your shares will not be voted, which will have the effect of a
   vote against the adoption of the merger agreement.

Q:  SHOULD I SEND IN MY STOCK CERTIFICATES NOW?

A: No. After the merger is completed, you will receive a transmittal form with
   instructions for the surrender of ALZA common stock certificates. Please do
   not send in your stock certificates with your proxy.

Q:  WHEN DO YOU EXPECT THE MERGER TO BE COMPLETED?

A: We are working to complete the merger as quickly as possible. If approved by
   ALZA stockholders and if we receive the necessary regulatory approvals, we
   expect to complete the merger during the third quarter of 2001.

Q:  WHO CAN HELP ANSWER MY QUESTIONS?

A: If you have any questions about the merger or if you need additional copies
   of this proxy statement/prospectus or the enclosed proxy, you should contact:

   ALZA Corporation
   1900 Charleston Road
   Mountain View, CA 94043
   Attention: Investor Relations
   Telephone: (650) 564-5222

                                        1
   8

                                    SUMMARY

     This summary highlights selected information from this proxy
statement/prospectus and may not contain all the information that is important
to you. To understand the merger fully and for a more complete description of
the legal terms of the merger, you should carefully read this entire proxy
statement/prospectus and the other documents to which we refer you, including in
particular the copies of the merger agreement, the stock option agreement and
the opinions of JPMorgan, a division of Chase Securities Inc., and Merrill
Lynch, Pierce, Fenner & Smith Incorporated that are attached to this proxy
statement/prospectus as Annexes 1, 2, 3 and 4, respectively. See also "Where You
Can Find More Information" on page 68. We have included page references
parenthetically to direct you to a more complete description of the topics
presented in this summary.

                                    GENERAL

WHAT ALZA STOCKHOLDERS WILL RECEIVE IN THE MERGER

     In the merger, holders of ALZA common stock will receive 0.49 shares of
Johnson & Johnson common stock for each share of ALZA common stock that they
own. ALZA stockholders will receive cash for any fractional shares of Johnson &
Johnson common stock they would otherwise receive in the merger. The amount of
cash for any fractional shares each ALZA stockholder will receive will be
calculated by multiplying the fractional share interest to which that
stockholder is entitled by the closing price of Johnson & Johnson common stock
on the date on which the merger is completed as reported on the New York Stock
Exchange Composite Transactions Tape.

OWNERSHIP OF JOHNSON & JOHNSON FOLLOWING THE MERGER (PAGE 33)

     Based on the number of outstanding shares of ALZA common stock on the
record date, we anticipate that ALZA stockholders will receive approximately --
shares of Johnson & Johnson common stock in the merger. Based on that number and
on the number of outstanding shares of Johnson & Johnson common stock on --,
2001, ALZA stockholders will own approximately --% of the outstanding shares of
Johnson & Johnson common stock following the merger.

APPRAISAL RIGHTS (PAGE 36)

     Under Delaware law, ALZA stockholders will not have appraisal rights in
connection with the merger.

MATERIAL UNITED STATES FEDERAL INCOME TAX CONSEQUENCES OF THE MERGER (PAGE 34)

     The merger is intended to qualify as a reorganization within the meaning of
the Internal Revenue Code of 1986. Assuming the merger qualifies as a
reorganization, holders of ALZA common stock will not recognize gain or loss for
United States Federal income tax purposes as a result of the exchange of their
ALZA common stock for Johnson & Johnson common stock in the merger, except for
cash received instead of fractional shares of Johnson & Johnson common stock.

     TAX MATTERS ARE VERY COMPLICATED AND THE TAX CONSEQUENCES OF THE MERGER TO
YOU WILL DEPEND ON THE FACTS OF YOUR OWN SITUATION. YOU SHOULD CONSULT YOUR OWN
TAX ADVISORS FOR A FULL UNDERSTANDING OF THE TAX CONSEQUENCES OF THE MERGER TO
YOU.

RECOMMENDATION OF THE ALZA BOARD OF DIRECTORS (PAGE 15)

     The ALZA board of directors believes that the merger and the other
transactions contemplated by the merger agreement are advisable to ALZA and its
stockholders and unanimously recommends that the stockholders vote "FOR" the
adoption of the merger agreement.

     To review the background of and reasons for the merger, as well as certain
risks related to the merger, see pages 10 and 14 through 17.

OPINIONS OF JPMORGAN AND MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED
(PAGE 17)

     In deciding to approve the merger, the ALZA board of directors considered
the opinions of JPMorgan, a division of Chase Securities Inc., and Merrill
Lynch, Pierce, Fenner & Smith

                                        2
   9

Incorporated, its financial advisors in connection with the merger, that, as of
March 26, 2001, the date of the merger agreement, and based upon and subject to
certain matters described in their respective opinions, the exchange ratio of
0.49 was fair, from a financial point of view, to ALZA stockholders. The
opinions address only the fairness of the exchange ratio to ALZA stockholders
from a financial point of view, do not address the merits of the underlying
decision by ALZA to engage in the merger and do not constitute a recommendation
to any ALZA stockholder as to how to vote on the proposal to adopt the merger
agreement. The full text of the written opinions of JPMorgan and Merrill Lynch,
which set forth the assumptions made, matters considered and limitations on the
review undertaken in connection with each of the opinions, are attached as
Annexes 3 and 4, respectively. You are urged to read each of the opinions
carefully and in its entirety.

INTERESTS OF ALZA DIRECTORS AND EXECUTIVE OFFICERS IN THE MERGER (PAGE 30)

     In considering the recommendation of the ALZA board of directors in favor
of the adoption of the merger agreement, ALZA stockholders should be aware that
the members of the ALZA board of directors and ALZA's executive officers have
personal interests in the merger that are different from, or in addition to, the
interests of other ALZA stockholders. These interests include the following:

     - under ALZA's stock plans, all outstanding options to purchase shares of
       ALZA common stock, including those held by executive officers and
       directors of ALZA, will fully vest at the effective time of the merger
       and will be converted into options to purchase shares of Johnson &
       Johnson common stock, subject to adjustment to reflect the exchange ratio

     - restrictions on all the shares of restricted stock held by executive
       officers of ALZA will lapse at the effective time of the merger and the
       shares will be converted into shares of Johnson & Johnson common stock,
       subject to adjustment to reflect the exchange ratio

     - the executive officers of ALZA will be entitled to severance payments and
       payments in connection with agreements not to compete with ALZA, as the
       surviving corporation in the merger, in the event of the termination of
       their employment following the merger

     - under the ALZA Executive Deferral Plan, some of ALZA's executive officers
       will benefit from accelerated vesting of their accounts at the effective
       time of the merger and will be entitled to retirement benefits under the
       plan if employment is terminated within two years of the closing of the
       merger and

     - all rights to indemnification and exculpation from liabilities for prior
       acts or omissions in favor of ALZA's directors and officers will be
       assumed by the surviving corporation in the merger, which will also
       provide directors' and officers' liability insurance coverage for six
       years on terms that are no less favorable than ALZA's current policies.

     The ALZA board of directors was aware of these interests and considered
them, among other matters, when approving the merger.

     For a more complete description, see "The Merger -- Interests of ALZA
Directors and Executive Officers in the Merger".

MATERIAL DIFFERENCES BETWEEN RIGHTS OF COMMON STOCKHOLDERS OF ALZA AND JOHNSON &
JOHNSON (PAGE 56)

     ALZA stockholders, whose rights are currently governed by the ALZA
certificate of incorporation, the ALZA by-laws and Delaware law, will, upon
completion of the merger, become stockholders of Johnson & Johnson and their
rights will be governed by the Johnson & Johnson certificate of incorporation,
the Johnson & Johnson by-laws and New Jersey law.

                         THE SPECIAL MEETING (PAGE 11)

     The special meeting of ALZA stockholders will be held at --, at -- a.m.,
local time, on --, --, 2001. At the special meeting, ALZA stockholders will be
asked to adopt the merger agreement.

RECORD DATE; VOTING POWER (PAGE 11)

     ALZA stockholders are entitled to vote at the special meeting if they owned
shares of ALZA

                                        3
   10

common stock as of the close of business on --, 2001, the record date.

     On the record date, there were -- shares of ALZA common stock entitled to
vote at the special meeting. Stockholders will have one vote at the special
meeting for each share of ALZA common stock that they owned on the record date.

VOTE REQUIRED (PAGE 11)

     The adoption of the merger agreement requires the affirmative vote of
stockholders holding a majority of the shares of ALZA common stock outstanding
on the record date.

SHARES OWNED BY ALZA DIRECTORS, EXECUTIVE OFFICERS AND AFFILIATES (PAGE 11)

     On the record date, directors and executive officers of ALZA and their
affiliates beneficially owned and were entitled to vote -- shares of ALZA common
stock, which represented approximately --% of the shares of ALZA common stock
outstanding on that date.

                              THE MERGER (PAGE 14)

     The merger agreement is attached as Annex 1 to this proxy
statement/prospectus. We encourage you to read the merger agreement because it
is the principal document governing the merger.

CONDITIONS TO THE COMPLETION OF THE MERGER (PAGE 40)

     Johnson & Johnson and ALZA will complete the merger only if they satisfy,
or in some cases, waive, several conditions, including the following:

     - the merger agreement has been adopted by the affirmative vote of
       stockholders of ALZA representing a majority of the shares of ALZA common
       stock outstanding on the record date

     - the shares of Johnson & Johnson common stock to be issued to ALZA
       stockholders upon completion of the merger have been approved for listing
       on the New York Stock Exchange

     - the waiting period applicable to the merger under the Hart-Scott-Rodino
       Antitrust Improvements Act of 1976 has expired or has been terminated

     - the European Commission has issued a decision, or has been deemed to have
       done so, under Council Regulation No. 4064/89 of the European Community
       declaring the merger compatible with the Common Market

     - no temporary restraining order, injunction or other court order or
       statute, law, rule, legal restraint or prohibition is in effect that
       prevents the completion of the merger

     - the registration statement on Form S-4, of which this proxy
       statement/prospectus forms a part, has been declared effective by the
       Securities and Exchange Commission and is not the subject of any stop
       order or proceedings seeking a stop order

     - Johnson & Johnson and ALZA have received letters from
       PricewaterhouseCoopers LLP and Ernst & Young LLP regarding those firms'
       concurrence with the Johnson & Johnson management's and the ALZA
       management's conclusions, respectively, that, as of the date the merger
       is completed, no conditions exist that would preclude accounting for the
       merger as a pooling of interests transaction under Accounting Principles
       Board Opinion No. 16 and applicable Securities and Exchange Commission
       rules and regulations if the merger is completed in accordance with the
       merger agreement

     - ALZA has received from its tax counsel an opinion stating that the merger
       will be treated for United States Federal income tax purposes as a
       reorganization within the meaning of Section 368(a) of the Internal
       Revenue Code and

     - other customary contractual conditions set forth in the merger agreement.

     In addition, Johnson & Johnson will complete the merger only if there is no
pending or threatened suit, action or proceeding by any governmental entity
seeking to restrain or prohibit the completion of the merger, to limit Johnson &
Johnson's or ALZA's ownership or operation of any material portion of either
company's business or assets, to compel Johnson & Johnson or ALZA to divest or
hold separate any material portion of

                                        4
   11

any business or assets as a result of the merger, to prevent Johnson & Johnson
from effectively controlling in any material respect the business or operations
of ALZA or otherwise having, or being reasonably expected to have, a material
adverse effect on ALZA.

     For a more complete description, see "The Merger Agreement -- Conditions to
the Completion of the Merger".

TERMINATION OF THE MERGER AGREEMENT; TERMINATION FEE (PAGES 44 AND 45)

     The merger agreement contains provisions addressing the circumstances under
which Johnson & Johnson or ALZA may terminate the merger agreement. In addition,
the merger agreement provides that, in several circumstances, ALZA may be
required to pay Johnson & Johnson a termination fee of $180 million. For a more
complete description, see "The Merger Agreement -- Termination of the Merger
Agreement" and "-- Fees and Expenses".

THE STOCK OPTION AGREEMENT (PAGE 51)

     ALZA has granted an option to Johnson & Johnson to purchase up to
47,466,356 shares of ALZA common stock if any of the events occur that entitle
Johnson & Johnson to receive the termination fee under the merger agreement. The
stock option agreement limits the total amount of profit that Johnson & Johnson
can receive under the agreement to $180 million.

REGULATORY MATTERS (PAGE 36)

     United States antitrust laws prohibit Johnson & Johnson and ALZA from
completing the merger until they have furnished certain information and
materials to the Antitrust Division of the Department of Justice and the Federal
Trade Commission and a required waiting period has ended. Johnson & Johnson and
ALZA each filed the required notification and report forms with the Antitrust
Division and the Federal Trade Commission on April 13, 2001 and have requested
an early termination of the required waiting period. If early termination of the
required waiting period is not granted and a request for additional information
by the relevant antitrust authorities is not made, the waiting period under the
Hart-Scott-Rodino Antitrust Improvements Act will expire at midnight on May 14,
2001.
     In addition, the merger is currently being reviewed by the European
Commission and may be subject to regulatory review in jurisdictions other than
the United States or Europe.

ACCOUNTING TREATMENT (PAGE 32)

     Johnson & Johnson and ALZA expect the merger to qualify as a pooling of
interests, which means that the merger of Johnson & Johnson and ALZA will be
accounted for as if Johnson & Johnson and ALZA had always been combined for
accounting and financial reporting purposes. As a result, the basis of ALZA's
assets and liabilities will be reflected in Johnson & Johnson's financial
statements at their historical book values and the shareholders' equity accounts
of Johnson & Johnson and ALZA will be combined on Johnson & Johnson's
consolidated balance sheet. On a pooling of interests accounting basis, Johnson
& Johnson will retroactively restate its financial statements issued after
completion of the merger to reflect the consolidated combined financial position
and results of operations of Johnson & Johnson and ALZA as if the merger had
taken place as of the earliest period covered by such financial statements.

FEES AND EXPENSES (PAGE 45)

     Each of Johnson & Johnson and ALZA will pay its own fees and expenses in
connection with the merger, except that they will share equally the expenses
incurred in connection with the filing, printing and mailing of the registration
statement of which this proxy statement/prospectus is a part and the filing fees
for the premerger notification and report forms under the Hart-Scott-Rodino
Antitrust Improvements Act and any similar foreign antitrust laws.

                            THE COMPANIES (PAGE 13)

ALZA Corporation
1900 Charleston Road
Mountain View, CA 94043
Telephone: (650) 564-5000

     ALZA is a research-based pharmaceutical company with leading drug delivery
technologies. ALZA applies its technologies to develop pharmaceutical products
with enhanced therapeutic value for its own portfolio and for many of the
world's leading pharmaceutical companies. ALZA's sales

                                        5
   12

and marketing efforts are focused on urology, oncology and central nervous
system products.

Johnson & Johnson
One Johnson & Johnson Plaza
New Brunswick, NJ 08933
Telephone: (732) 524-0400

     Johnson & Johnson, with approximately 99,200 employees, is the world's most
comprehensive and broadly-based manufacturer of health care products, as well as
a provider of related services, for the consumer, pharmaceutical and medical
devices and diagnostics markets. Johnson & Johnson has more than 190 operating
companies in 51 countries around the world, selling products in more than 175
countries.

                MARKET PRICES AND DIVIDEND INFORMATION (PAGE 54)

     Shares of Johnson & Johnson common stock and ALZA common stock are listed
on the New York Stock Exchange. The following table presents:

     - the last reported sale price of a share of Johnson & Johnson common
       stock, as reported by the Dow Jones & Company, Inc.

     - the last reported sale price of a share of ALZA common stock, as reported
       by the Dow Jones & Company, Inc. and

     - the market value of a share of ALZA common stock on an equivalent per
       share basis

in each case on March 26, 2001, the last full trading day prior to the public
announcement of the proposed merger, and on --, 2001, the last practicable
trading day prior to the date of this proxy statement/prospectus. The equivalent
price per share data for ALZA common stock has been determined by multiplying
the last reported sale price of a share of Johnson & Johnson common stock on
each of these dates by the exchange ratio of 0.49.



                                            EQUIVALENT
                                            PRICE PER
                       JOHNSON &             SHARE OF
                        JOHNSON     ALZA       ALZA
                        COMMON     COMMON     COMMON
DATE                     STOCK     STOCK      STOCK
----                   ---------   ------   ----------
                                   
March 26, 2001.......   $85.38     $38.75     $41.84
--, 2001.............       --        --          --


     Johnson & Johnson declares and pays regular quarterly dividends. ALZA does
not pay dividends. See "Comparative Stock Prices and Dividends".

                                        6
   13

                       COMPARATIVE PER SHARE INFORMATION

     The following table shows certain per share data of Johnson & Johnson and
ALZA and also shows similar information reflecting the combination of the two
companies, which is referred to as "pro forma" information. In presenting the
comparative pro forma information, it is assumed that the companies have been
combined for accounting and financial reporting purposes for all periods
presented, as required by the pooling of interests method of accounting.

     The comparative per share data is derived from, and should be read with,
the historical financial statements of Johnson & Johnson and the historical
financial statements of ALZA that are included in the documents described under
"Where You Can Find More Information" on page 68. The historical financial
statements of Johnson & Johnson reflect the restatement of Johnson & Johnson's
historical financial statements to reflect its merger in October 1999 with
Centocor, Inc., which was accounted for using the pooling of interests method of
accounting. The historical financial statements of ALZA reflect its merger in
March 1999 with SEQUUS Pharmaceuticals, Inc., which was accounted for using the
pooling of interests method of accounting.

     The ALZA "equivalent pro forma" data was calculated by multiplying the
corresponding pro forma combined data by an exchange ratio of 0.49. This data
shows how each share of ALZA common stock would have participated in net income
and book value of Johnson & Johnson if the companies had always been combined
for accounting and financial reporting purposes for all periods presented. These
amounts, however, are not intended to reflect future per share levels of net
income and book value of Johnson & Johnson. ALZA has not declared or paid any
cash dividends during any of the periods presented.



                                                                        FISCAL YEAR ENDED
                                                          ---------------------------------------------
                                                          JAN. 3, 1999    JAN. 2, 2000    DEC. 31, 2000
                                                          ------------    ------------    -------------
                                                                                 
JOHNSON & JOHNSON -- HISTORICAL
  Net income per diluted share..........................     $ 2.12          $ 2.94          $ 3.40
  Unaudited book value per share(1).....................      10.13           11.67           13.52
  Cash dividends per share..............................       0.97            1.09            1.24




                                                                 FISCAL YEAR ENDED DECEMBER 31,
                                                          ---------------------------------------------
                                                              1998            1999            2000
                                                          ------------    ------------    -------------
                                                                                 
ALZA -- HISTORICAL
  Net income per diluted share..........................     $ 0.53          $ 0.44          $  0.95
  Unaudited book value per share(1).....................       2.65            3.38             6.58
  Cash dividends per share..............................         --              --               --




                                                                        FISCAL YEAR ENDED
                                                          ---------------------------------------------
                                                          JAN. 3, 1999    JAN. 2, 2000    DEC. 31, 2000
                                                          ------------    ------------    -------------
                                                                                 
Unaudited pro forma combined net income per diluted
  share:
  Per Johnson & Johnson share...........................     $ 2.05          $ 2.80          $  3.22
  Equivalent per ALZA share.............................       1.01            1.37             1.58




                                                                        FISCAL YEAR ENDED
                                                          ---------------------------------------------
                                                          JAN. 3, 1999    JAN. 2, 2000    DEC. 31, 2000
                                                          ------------    ------------    -------------
                                                                                 
Unaudited pro forma combined book value per share:
  Per Johnson & Johnson share(1)........................     $ 9.82          $11.34          $13.47
  Equivalent per ALZA share(1)..........................       4.81            5.56            6.60




                                                                        FISCAL YEAR ENDED
                                                          ---------------------------------------------
                                                          JAN. 3, 1999    JAN. 2, 2000    DEC. 31, 2000
                                                          ------------    ------------    -------------
                                                                                 
Unaudited pro forma cash dividends per share(2).........     $ 0.48          $ 0.53          $ 0.61


---------------
(1) Historical book value per share is computed by dividing shareowners' equity
    or stockholders' equity by the number of shares of common stock outstanding
    at the end of each period. Johnson & Johnson unaudited pro forma combined
    book value per share is computed by dividing unaudited pro forma
    shareowners' equity by the unaudited pro forma number of shares of Johnson &
    Johnson common stock that would have been outstanding had the merger been
    completed as of each balance sheet date.

(2) Johnson & Johnson's current quarterly dividend is $0.32 per share ($1.28 per
    share annualized) and is subject to future approval and declaration by the
    Johnson & Johnson board of directors. ALZA does not currently pay a cash
    dividend. The dividend policy of the combined company after the merger will
    be determined by the Johnson & Johnson board of directors following the
    merger.

                                        7
   14

      SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA OF JOHNSON & JOHNSON

     The following selected consolidated financial information of Johnson &
Johnson as of and for the five fiscal years ended December 31, 2000 has been
derived from Johnson & Johnson's audited historical financial statements
incorporated by reference in this proxy statement/prospectus. The financial
statements for those periods were audited by PricewaterhouseCoopers LLP,
independent accountants. This information should be read in conjunction with
management's discussion and analysis of results of operations and financial
condition of Johnson & Johnson and the consolidated financial statements and
notes thereto of Johnson & Johnson incorporated by reference into this proxy
statement/prospectus.



                                                             FISCAL YEAR ENDED
                                           ------------------------------------------------------
                                           DEC. 29,    DEC. 28,    JAN. 3,    JAN. 2,    DEC. 31,
                                             1996        1997       1999       2000        2000
                                           --------    --------    -------    -------    --------
                                                    (IN MILLIONS, EXCEPT PER SHARE DATA)
                                                                          
EARNINGS DATA:
  Sales..................................  $21,755     $22,830     $23,995    $27,471    $29,139
  Costs and expenses.....................   17,735      18,243      19,813     21,718     22,517
  Earnings before taxes(1)...............    4,020       4,587       4,182      5,753      6,622
  Net earnings(1)........................  $ 2,882     $ 3,311     $ 3,003    $ 4,167    $ 4,800
  Net earnings per diluted share(1)......  $  2.05     $  2.34     $  2.12    $  2.94    $  3.40
  Cash dividends per share...............  $ 0.735     $  0.85     $  0.97    $  1.09    $  1.24
BALANCE SHEET DATA (AT PERIOD END):
  Total assets...........................  $20,603     $22,108     $27,292    $29,163    $31,321
  Long-term debt.........................    1,465       1,181       1,729      2,450      2,037
  Shareowners' equity....................  $11,324     $12,866     $14,077    $16,213    $18,808


---------------
(1) Results for the year ended January 3, 1999, excluding pre-tax restructuring
    and in-process research and development charges of $613 and $298,
    respectively, are:


                                                           
Earnings before taxes.......................................  $5,093
Net earnings................................................   3,700
Net earnings per diluted share..............................    2.61


                                        8
   15

      SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA OF ALZA CORPORATION

     The following selected consolidated financial information of ALZA at
December 31, 1997, 1998, 1999 and 2000, and for each of the five fiscal years
ended December 31, 2000, has been derived from ALZA's historical financial
statements which were audited by Ernst & Young LLP, independent auditors. The
consolidated balance sheet data at December 31, 1996 is unaudited and in the
opinion of the ALZA management includes all adjustments (consisting only of
normal recurring adjustments) necessary to present fairly ALZA's financial
position as of that date. The consolidated statement of operations data for the
fiscal years ended December 31, 1998, 1999 and 2000 and consolidated balance
sheet data at December 31, 1999 and 2000 have been derived from audited
consolidated financial statements incorporated by reference into this proxy
statement/prospectus. The consolidated statement of operations data for the
fiscal years ended December 31, 1996 and 1997 and consolidated balance sheet
data at December 31, 1996, 1997 and 1998 has been derived from consolidated
financial statements not incorporated by reference into this proxy
statement/prospectus. This information should be read in conjunction with
management's discussion and analysis of results of operations and financial
condition of ALZA and the consolidated financial statements and notes thereto
incorporated by reference into this proxy statement/prospectus.



                                                                 YEAR ENDED DECEMBER 31,
                                                  ------------------------------------------------------
                                                   1996     1997           1998     1999           2000
                                                  ------   ------         ------   ------         ------
                                                           (IN MILLIONS, EXCEPT PER SHARE DATA)
                                                                                   
CONSOLIDATED STATEMENT OF OPERATIONS DATA:
Total revenues..................................  $  446   $  504         $  647   $  796         $  988
Net income (loss)...............................      82     (275)(1)        108       91(2)         223(3)
Earnings (loss) per share(4):
  Basic.........................................    0.43    (1.41)          0.55     0.45           1.03
  Diluted.......................................    0.42    (1.41)          0.53     0.44           0.95
CONSOLIDATED BALANCE SHEET DATA (AT PERIOD END):
Cash and investments............................  $1,033   $  561         $  514   $  599         $1,461
Total assets....................................   1,699    1,451          1,667    1,852          2,922
Total long-term liabilities.....................     950      968          1,007    1,026          1,208
Total stockholders' equity......................     671      366            532      692          1,563


---------------
(1) Reflects a total of $369 (or $1.89 per share, diluted) of charges, including
    a $247 charge and $8 of interest expense related to ALZA's distribution of
    shares of Crescendo Pharmaceuticals Corporation, $108 for acquired
    in-process research and development, an asset write-down of $12 and costs of
    $2 related to a workforce reduction, less a tax benefit of $8.

(2) Reflects a total of $61 ($42 after tax, or $0.20 per share, diluted) of
    charges, including $32 relating to the acquisition of SEQUUS
    Pharmaceuticals, Inc., $13 resulting from a terminated merger agreement, $10
    relating to a change in sales return policy and an increase in the reserve
    for sales rebates and $5 primarily relating to a write-off of uncollectible
    accounts receivable.

(3) Reflects a total of $35 of net credit, net of tax, including $5 ($3 after
    tax) relating to the consolidation of research and development operations,
    $12 ($11 after tax) relating to the purchase of Crescendo Pharmaceuticals
    Corporation and payment to Chong Kun Dang Pharmaceutical Corporation, a
    charge of $7, net of tax, related to a cumulative effect of a change in
    accounting principle, offset by $56 credit related to a change in estimated
    amount of realizable deferred tax assets.

(4) Pro forma earnings per share amounts, assuming the accounting change in
    accordance with SAB 101 was applied retroactively to the beginning of the
    period presented, are as follows:



                                                       1996      1997       1998      1999      2000
                                                      ------    -------    ------    ------    ------
                                                      (IN MILLIONS, EXCEPT SHARE AND PER SHARE DATA)
                                                                                
Net income (loss)...................................  $ 77.8    $(275.5)   $104.8    $ 91.6    $230.7
Net earnings (loss) per share:
  Basic:............................................    0.41      (1.42)     0.53      0.45      1.06
  Diluted:..........................................    0.40      (1.42)     0.52      0.44      0.97
Weighted average shares outstanding (in millions):
  Basic:............................................   191.6      194.5     198.0     202.1     217.2
  Diluted:..........................................   194.8      194.5     203.0     206.9     269.9


                                        9
   16

                      RISK FACTORS RELATING TO THE MERGER

     In addition to the other information included and incorporated by reference
in this proxy statement/prospectus, ALZA stockholders should consider carefully
the matters described below in determining whether to adopt the merger
agreement.

     THE EXCHANGE RATIO FOR SHARES OF JOHNSON & JOHNSON COMMON STOCK TO BE
RECEIVED IN THE MERGER IS FIXED AND WILL NOT BE ADJUSTED IN THE EVENT OF ANY
CHANGE IN STOCK PRICE.  Under the merger agreement, each share of ALZA common
stock will be converted into the right to receive 0.49 shares of Johnson &
Johnson common stock. This exchange ratio is a fixed number and will not be
adjusted in the event of any increase or decrease in the price of Johnson &
Johnson common stock or ALZA common stock. The prices of Johnson & Johnson
common stock and ALZA common stock at the closing of the merger may vary from
their respective prices on the date of this proxy statement/prospectus and on
the date of the special meeting. These prices may vary as a result of changes in
the business, operations or prospects of Johnson & Johnson or ALZA, market
assessments of the likelihood that the merger will be completed, the timing of
the completion of the merger, the prospects of post-merger operations,
regulatory considerations, general market and economic conditions and other
factors. Because the date that the merger is completed may be later than the
date of the special meeting, the prices of Johnson & Johnson common stock and
ALZA common stock on the date of the special meeting may not be indicative of
their respective prices on the date the merger is completed. We urge ALZA
stockholders to obtain current market quotations for Johnson & Johnson common
stock and ALZA common stock.

     THE INTEGRATION OF JOHNSON & JOHNSON AND ALZA FOLLOWING THE MERGER WILL
PRESENT SIGNIFICANT CHALLENGES.  Johnson & Johnson and ALZA will face
significant challenges in combining their operations and product lines in a
timely and efficient manner and retaining key ALZA personnel. The integration of
Johnson & Johnson and ALZA will be complex and time-consuming. The failure to
integrate successfully Johnson & Johnson and ALZA and to manage successfully the
challenges presented by the integration process may result in Johnson & Johnson
and ALZA not achieving the anticipated potential benefits of the merger.

     THE PRICE OF JOHNSON & JOHNSON COMMON STOCK MAY BE AFFECTED BY FACTORS
DIFFERENT FROM THOSE AFFECTING THE PRICE OF ALZA COMMON STOCK.  Upon completion
of the merger, holders of ALZA common stock will become holders of Johnson &
Johnson common stock. Johnson & Johnson's business is different from that of
ALZA, and Johnson & Johnson's result of operations, as well as the price of
Johnson & Johnson common stock, may be affected by factors different than those
affecting ALZA's results of operations and price of ALZA common stock. For a
discussion of Johnson & Johnson's and ALZA's businesses and certain factors to
consider in connection with such businesses, see Johnson & Johnson's Annual
Report on Form 10-K for the fiscal year ended December 31, 2000 and ALZA's
Annual Report on Form 10-K for the fiscal year ended December 31, 2000, as
amended, each of which is incorporated by reference in this proxy
statement/prospectus.

                                        10
   17

                              THE SPECIAL MEETING

     We are furnishing this proxy statement/prospectus to stockholders of ALZA
as of the record date as part of the solicitation of proxies by the ALZA board
of directors for use at the special meeting.

DATE, TIME AND PLACE

     We will hold the special meeting at --, at -- a.m., local time, on --, --,
2001.

PURPOSE OF THE SPECIAL MEETING

     At the special meeting, we will ask holders of ALZA common stock to adopt
the merger agreement. The ALZA board of directors has determined that the merger
and the other transactions contemplated by the merger agreement are advisable to
ALZA and its stockholders, has approved the merger agreement and the merger and
unanimously recommends that ALZA stockholders vote "FOR" the adoption of the
merger agreement.

RECORD DATE; SHARES ENTITLED TO VOTE; QUORUM

     Only holders of record of ALZA common stock at the close of business on --,
2001, the record date, are entitled to notice of and to vote at the special
meeting. On the record date, -- shares of ALZA common stock were issued and
outstanding and held by approximately -- holders of record. A quorum is present
at the special meeting if a majority of all the shares of ALZA common stock
issued and outstanding on the record date and entitled to vote at the special
meeting are represented at the special meeting in person or by a properly
executed proxy. In the event that a quorum is not present at the special
meeting, it is expected that the meeting will be adjourned or postponed to
solicit additional proxies. Holders of record of ALZA common stock on the record
date are entitled to one vote per share on each matter submitted to a vote at
the special meeting.

VOTE REQUIRED

     The adoption of the merger agreement requires the affirmative vote of
stockholders holding a majority of the shares of ALZA common stock outstanding
on the record date. Because the required vote of ALZA stockholders is based upon
the number of outstanding shares of ALZA common stock, rather than upon the
shares actually voted, the failure by the holder of any such shares to submit a
proxy or to vote in person at the special meeting, including abstentions and
broker non-votes, will have the same effect as a vote against the adoption of
the merger agreement.

SHARES OWNED BY ALZA DIRECTORS, EXECUTIVE OFFICERS AND AFFILIATES

     At the close of business on the record date, directors and executive
officers of ALZA and their affiliates beneficially owned and were entitled to
vote -- shares of ALZA common stock, which represented approximately --% of the
shares of ALZA common stock outstanding on that date.

VOTING OF PROXIES

     All shares represented by properly executed proxies received in time for
the special meeting will be voted at the special meeting in the manner specified
by the holders. Properly executed proxies that do not contain voting
instructions will be voted "FOR" the adoption of the merger agreement.

     Shares of ALZA common stock represented at the special meeting but not
voting, including shares of ALZA common stock for which proxies have been
received but for which holders of shares have abstained, will be treated as
present at the special meeting for purposes of determining the presence or
absence of a quorum for the transaction of all business.

     Brokers who hold shares of ALZA common stock in "street name" for customers
who are the beneficial owners of such shares may not give a proxy to vote those
customers' shares in the absence of

                                        11
   18

specific instructions from those customers. These non-voted shares are referred
to as broker non-votes and count as votes against the adoption of the merger
agreement.

     The persons named as proxies by a stockholder may propose and vote for one
or more adjournments of the special meeting, including adjournments to permit
further solicitations of proxies. No proxy voted against the proposal to adopt
the merger agreement will be voted in favor of any such adjournment or
postponement.

     ALZA does not expect that any matter other than the proposal to adopt the
merger agreement will be brought before the special meeting. If, however, the
ALZA board of directors properly presents other matters, the persons named as
proxies will vote in accordance with their judgment.

REVOCABILITY OF PROXIES

     The grant of a proxy on the enclosed form of proxy does not preclude a
stockholder from voting in person at the special meeting. A stockholder may
revoke a proxy at any time prior to its exercise by filing with the Secretary of
ALZA a properly executed revocation of proxy, by submitting a properly executed
proxy to the Secretary of ALZA bearing a later date or by appearing at the
special meeting and voting in person. Attendance at the special meeting will not
in and of itself constitute revocation of a proxy.

SOLICITATION OF PROXIES

     ALZA will bear the cost of the solicitation of proxies from its
stockholders. In addition to solicitation by mail, the directors, officers and
employees of ALZA may solicit proxies from stockholders by telephone or other
electronic means or in person. ALZA will cause brokerage houses and other
custodians, nominees and fiduciaries to forward solicitation materials to the
beneficial owners of stock held of record by such persons. ALZA will reimburse
such custodians, nominees and fiduciaries for their reasonable out-of-pocket
expenses in doing so.

     Corporate Investor Communications, Inc. will assist in the solicitation of
proxies by ALZA. ALZA will pay Corporate Investor Communications, Inc. a fee of
$10,000, plus reimbursement of certain out-of-pocket expenses, and will
indemnify Corporate Investor Communications, Inc. against any losses arising out
of its proxy solicitation services on behalf of ALZA.

     STOCKHOLDERS SHOULD NOT SEND STOCK CERTIFICATES WITH THEIR PROXIES.  A
transmittal form with instructions for the surrender of ALZA common stock
certificates will be mailed to ALZA stockholders shortly after completion of the
merger.

                                        12
   19

                                 THE COMPANIES

ALZA

     ALZA is a research-based pharmaceutical company with leading drug delivery
technologies. ALZA applies its technologies to develop pharmaceutical products
with enhanced therapeutic value for its own portfolio and for many of the
world's leading pharmaceutical companies. ALZA's sales and marketing efforts are
focused on urology, oncology and central nervous system products.

     ALZA was incorporated in the State of California on June 11, 1968, and
changed its legal domicile from California to Delaware in 1987. The address of
its principal executive offices is 1900 Charleston Road, Mountain View,
California, and the telephone number at that address is (650) 564-5000.

JOHNSON & JOHNSON

     Johnson & Johnson, with approximately 99,200 employees, is the world's most
comprehensive and broadly-based manufacturer of health care products, as well as
a provider of related services, for the consumer, pharmaceutical and medical
devices and diagnostics markets. Johnson & Johnson has more than 190 operating
companies in 51 countries around the world, selling products in more than 175
countries.

     Johnson & Johnson's worldwide business is divided into three segments:
consumer, pharmaceutical and medical devices and diagnostics. The consumer
segment's principal products are personal care and hygienic products, including
oral and baby care products, first aid products, nonprescription drugs, sanitary
protection products and adult skin and hair care products. These products are
marketed principally to the general public and distributed both to wholesalers
and directly to independent and chain retail outlets.

     The pharmaceutical segment's principal worldwide franchises are in the
anti-infective, anti-fungal, anti-anemia, central nervous system, contraceptive,
dermatology, gastrointestinal and pain management fields. These products are
distributed both directly and through wholesalers for use by health care
professionals and the general public.

     The medical devices and diagnostics segment includes suture and mechanical
wound closure products, minimally invasive surgical instruments, diagnostic
products, cardiology products, disposable contact lenses, surgical instruments,
orthopaedic joint replacements and products for wound management and infection
prevention and other medical equipment and devices. These products are used
principally in the professional fields by physicians, nurses, therapists,
hospitals, diagnostic laboratories and clinics. Distribution to these markets is
done both directly and through surgical supply and other dealers.

     Johnson & Johnson was organized in the State of New Jersey in 1887. The
address of its principal executive offices is One Johnson & Johnson Plaza, New
Brunswick, New Jersey, and the telephone number at that address is (732)
524-0400.

MATERIAL CONTRACTS BETWEEN ALZA AND JOHNSON & JOHNSON

     ALZA and Janssen Pharmaceutica Inc., a subsidiary of Johnson & Johnson, are
parties to a product development and commercialization agreement dated as of May
24, 1988, as well as related supply agreement and product development
agreements. Under the agreements, Janssen markets the Duragesic product, which
was developed by ALZA, worldwide and manufactures Duragesic in Europe. ALZA
received royalty, manufacturing, product development, co-promotion and other
revenues of approximately $133.5 million and $144.8 million under its agreements
with Janssen in 1999 and 2000, respectively.

     ALZA and McNeil Consumer Products Company, a subsidiary of Johnson &
Johnson, are parties to a co-promotion agreement dated as of April 18, 2000,
relating to ALZA's Concerta product. Under the agreement, ALZA and McNeil
Consumer Products Company co-promote Concerta in the United States. McNeil
receives payments based on sales calls made and based on sales of Concerta above
certain levels.

                                        13
   20

                                   THE MERGER

BACKGROUND TO THE MERGER

     During the spring of 2000, representatives of ALZA and Johnson & Johnson
discussed from time to time ways in which the companies could cooperate,
including by means of a potential business combination. A confidentiality
agreement was executed on May 18, 2000 in connection with these discussions. The
companies terminated the discussions before reaching any agreement as to the
price or structure of a potential business combination. Following the
termination of discussions in June 2000, Johnson & Johnson destroyed all
information it had received from ALZA under the confidentiality agreement.

     On December 11, 2000, Mr. William Weldon, Johnson & Johnson's Vice Chairman
(who at the time of the meeting was Johnson & Johnson's Worldwide Chairman,
Pharmaceuticals Group), met with Dr. Ernest Mario, ALZA's Chairman and Chief
Executive Officer, and discussed various matters concerning the ongoing
product-related relationships between the companies. The meeting included a
general discussion regarding exploration of a possible broader relationship
between the companies, including the possibility of a potential business
combination.

     On January 16, 2001, business development executives of ALZA and Johnson &
Johnson met to review current information regarding ALZA's business and
financial status.

     On February 20, 2001, Mr. Weldon met Dr. Mario. They discussed the
possibility of a business combination between ALZA and Johnson & Johnson and the
potential strategic, commercial and financial benefits of such a transaction.

     Following the February 20, 2001 meeting, Dr. Mario conferred with members
of the ALZA board of directors and several members of the ALZA management
regarding the potential benefits of a business combination.

     On February 23, 2001, ALZA provided to Johnson & Johnson a mutual
confidentiality and standstill agreement, which the two companies signed on
February 27, 2001.

     Thereafter, the ALZA senior management retained JPMorgan, a division of
Chase Securities Inc., and Merrill Lynch, Pierce, Fenner & Smith Incorporated to
provide financial advisory services to ALZA regarding the proposed business
combination with Johnson & Johnson. The ALZA senior management also engaged
Heller Ehrman White & McAuliffe LLP, as counsel, to represent ALZA in the
proposed business combination.

     On March 1, 2001, members of the ALZA senior management and Johnson &
Johnson each began their due diligence reviews of the other's business.

     At a meeting of the ALZA board of directors held on March 5, 2001, JPMorgan
and Merrill Lynch reviewed with the ALZA board of directors selected publicly
available business and financial information concerning Johnson & Johnson, its
products and stock performance, and a potential business combination between
Johnson & Johnson and ALZA.

     On March 6, 2001, a draft merger agreement and stock option agreement were
circulated to senior management and the advisors of each company. Thereafter,
the management and advisors of each company reviewed and negotiated the legal
and economic terms of the merger agreement and the stock option agreement.

     On March 14, 2001, Mr. Weldon and Dr. Mario met to review business and
organizational issues relating to the potential business combination.

     At a meeting of the ALZA board of directors held on March 15, 2001, the
ALZA senior management made presentations regarding the proposed business
combination and the status of the negotiations and discussions about the merger
agreement. ALZAs' financial, legal and accounting advisors also participated in
the meeting. After discussion, the ALZA board of directors directed the ALZA
                                        14
   21

management and advisors to continue negotiations with Johnson & Johnson. Further
negotiations occurred on March 15 and 16, 2001.

     On March 16, 2001, Johnson & Johnson and ALZA failed to reach an agreement
on an exchange ratio, and merger discussions were suspended.

     On March 20, 2001, Mr. Weldon and Dr. Mario reinitiated discussions
regarding the proposed business combination, including the proposed exchange
ratio and other terms of a business combination of Johnson & Johnson and ALZA.
From March 23, 2001 through March 26, 2001, representatives of ALZA and Johnson
& Johnson held discussions and negotiations regarding the terms of the proposed
business combination, the merger agreement and the stock option agreement.

     At a meeting of the ALZA board of directors held on March 25, 2001, the
ALZA senior management made further presentations regarding the status of the
discussions and negotiations about the merger agreement. At the same meeting,
JPMorgan and Merrill Lynch reviewed with the ALZA board of directors various
financial analyses of the proposed business combination, including implied
exchange ratios under various valuation methodologies. Heller Ehrman White &
McAuliffe LLP updated the ALZA board of directors regarding changes to the draft
merger agreement and the status of negotiations. Ernst & Young LLP also
participated in the meeting. After discussion, the ALZA board of directors
directed the ALZA management and advisors to continue negotiations with Johnson
& Johnson.

     At a meeting of the ALZA board of directors held on March 26, 2001, the
ALZA senior management made further presentations regarding the status of the
discussions and negotiations about the merger agreement, including the proposed
exchange ratio. At that meeting, JPMorgan and Merrill Lynch delivered their
respective opinions to the ALZA board of directors to the effect that the
proposed exchange ratio was fair, from a financial point of view, to ALZA
stockholders. After further review and discussion, the ALZA board of directors
approved, with one director absent, the merger agreement and declared its
advisability, approved the stock option agreement and authorized management to
execute and deliver to Johnson & Johnson the merger agreement and the stock
option agreement. Concurrently, the Johnson & Johnson board of directors held a
meeting at which the Johnson & Johnson board of directors considered the merger
and authorized the execution and delivery of the merger agreement and the stock
option agreement.

     The definitive merger agreement and stock option agreement were executed on
behalf of ALZA, Johnson & Johnson and Express Merger Sub on March 26, 2001, and
on March 27, 2001 the parties issued a joint press release announcing the
signing of the merger agreement.

REASONS FOR THE MERGER AND RECOMMENDATION OF THE ALZA BOARD OF DIRECTORS

     REASONS FOR THE MERGER.  In the course of reaching its decision to approve
the merger agreement, the ALZA board of directors considered and reviewed with
the ALZA senior management and outside advisors a number of factors relevant to
the merger, including ALZA's strategic business plans, its commercial
operations, its financial position and potential for growth in revenues and
earnings, its products and research and development portfolio and its commercial
operations.

     The ALZA board of directors also considered, among other matters:

     - the ALZA board of directors' view that the combination of the businesses
       of ALZA and Johnson & Johnson will result in a combined organization with
       greater financial, technical and other resources than ALZA could provide
       as a stand-alone entity, and will allow for a significant acceleration in
       the commercial success of ALZA products and technologies

     - the ALZA board of directors' view that Johnson & Johnson will provide
       greater resources and opportunities for ALZA technology and product
       development programs, including the potential application of ALZA drug
       delivery technologies to a large portfolio of existing products and
       pharmaceutical compounds resulting from Johnson & Johnson's research
       efforts

                                        15
   22

     - the ALZA board of directors' view that the products marketed by ALZA are
       complementary with Johnson & Johnson's therapeutic areas of focus,
       including women's health, urology, central nervous system conditions,
       pain management and oncology, and that the combined organization will be
       able to increase sales of ALZA products in those areas more rapidly than
       ALZA as a stand-alone entity

     - the ALZA board of directors' view that Johnson & Johnson's strong
       international commercial presence and strengths in worldwide product
       registration, marketing and distribution will complement the capabilities
       of ALZA and will accelerate the introduction and growth of ALZA products
       in international markets

     - the ALZA board of directors' assessment of the existing relationships
       between ALZA and Johnson & Johnson, its assessment of the complementary
       strengths of each of the companies, the compatibility of corporate
       cultures and the historical success of Johnson & Johnson in incorporating
       acquired companies into a decentralized corporate organization

     - the ALZA board of directors' view that as a result of the merger, the
       ALZA stockholders will hold interests in a more diversified entity, with
       business and revenues not only from a large, diverse pharmaceutical
       products business, but also from medical devices and consumer products
       businesses

     - the ALZA board of directors' assessment of ALZA's strategic alternatives
       and its view that the merger presented more attractive opportunities than
       remaining as an independent company or attempting to increase ALZA's
       business by acquiring other companies

     - information regarding historical market prices and other information with
       respect to ALZA common stock, and the financial performance and
       condition, assets, liabilities, business operations and prospects of each
       of Johnson & Johnson and ALZA and their projected future values and
       prospects as separate entities and on a combined basis

     - the presentations delivered by JPMorgan and Merrill Lynch, and the
       written opinions of JPMorgan and Merrill Lynch, to the ALZA board of
       directors to the effect that as of the date of the opinions and based on
       and subject to the matters set forth in their respective opinions, the
       exchange ratio was fair, from a financial point of view, to ALZA
       stockholders

     - the ALZA board of directors' assessment of the value of shares of Johnson
       & Johnson common stock to be received by ALZA stockholders in the merger
       and the premium represented thereby over various historical prices for
       ALZA common stock

     - a comparison of selected recent acquisition and merger transactions in
       the industry as well as the trading performance for comparable companies
       in the industry

     - the ALZA board of directors' belief that the terms of the merger
       agreement, including the parties' mutual representations, warranties and
       covenants, are reasonable

     - the expected tax and accounting treatment of the merger and

     - reports from the ALZA management and advisors as to the results of their
       review of Johnson & Johnson's business.

     The ALZA board of directors also considered a number of potentially
negative factors in its deliberations concerning the merger, including, but not
limited to:

     - the risk that the benefits sought to be achieved in the merger will not
       be achieved

     - the fixed nature of the exchange ratio and the resulting risk that,
       should there be a decrease in the market value of Johnson & Johnson
       common stock, the value of the consideration to be received by the ALZA
       stockholders in the merger would be reduced

     - the risks inherent in Johnson & Johnson's broad-based health care
       products business, including risks associated with potential changes in
       the health care industry generally and

                                        16
   23

     - the risks to ALZA's business that might result from constraints imposed
       by interim operating covenants contained in the merger agreement.

     This summary is not meant to be an exhaustive description of the
information and factors considered by the ALZA board of directors but includes
all material factors considered. In view of the wide variety of factors
considered by the ALZA board of directors, it was not possible to quantify or to
give relative weights to the various factors. After taking into consideration
all the factors set forth above, as well as other factors not specifically
described above, the ALZA board of directors approved the merger and the merger
agreement because of the ALZA board of directors' belief that the merger is
advisable to ALZA and its stockholders.

     RECOMMENDATION OF THE ALZA BOARD OF DIRECTORS.  After careful
consideration, the ALZA board of directors has approved the merger agreement and
determined that the merger and the other transactions contemplated by the merger
agreement are advisable to ALZA and its stockholders. The ALZA board of
directors unanimously recommends that the stockholders of ALZA vote "FOR" the
adoption of the merger agreement.

OPINIONS OF JPMORGAN AND MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED

     OPINION OF JPMORGAN

     JPMorgan acted as ALZA's financial advisor in connection with the merger.
ALZA requested JPMorgan, in its role as a financial advisor, to evaluate the
fairness, from a financial point of view, of the exchange ratio in the merger to
the holders of ALZA common stock. On March 26, 2001, JPMorgan delivered its
written opinion to the ALZA board of directors to the effect that, as of such
date and based upon and subject to certain matters stated therein, the exchange
ratio in the merger was fair, from a financial point of view, to the holders of
ALZA common stock.

     THE FULL TEXT OF THE JPMORGAN FAIRNESS OPINION, WHICH SETS FORTH THE
ASSUMPTIONS MADE, FACTORS CONSIDERED AND LIMITATIONS UPON THE REVIEW UNDERTAKEN
BY JPMORGAN IN RENDERING ITS OPINION, IS INCLUDED IN THIS PROXY
STATEMENT/PROSPECTUS AS ANNEX 3. JPMORGAN'S WRITTEN OPINION WAS ADDRESSED TO THE
ALZA BOARD OF DIRECTORS, WAS DIRECTED ONLY TO THE FAIRNESS, FROM A FINANCIAL
POINT OF VIEW, OF THE EXCHANGE RATIO IN THE MERGER TO THE HOLDERS OF ALZA COMMON
STOCK AND DOES NOT CONSTITUTE A RECOMMENDATION TO ANY ALZA STOCKHOLDER AS TO HOW
SUCH STOCKHOLDER SHOULD VOTE ON THE MERGER OR ANY OTHER MATTER. THE FOLLOWING
SUMMARY OF THE MATERIAL PROVISIONS OF THE JPMORGAN FAIRNESS OPINION IS QUALIFIED
BY REFERENCE TO SUCH OPINION. ALZA STOCKHOLDERS ARE URGED TO READ THIS OPINION
IN ITS ENTIRETY.

     In arriving at its opinion, JPMorgan, among other things:

     - reviewed a draft of the merger agreement dated March 26, 2001

     - reviewed certain publicly available business and financial information
       concerning ALZA and Johnson & Johnson and the industries in which they
       operate

     - compared the proposed financial terms of the merger with the publicly
       available financial terms of certain transactions involving companies
       JPMorgan deemed relevant and the consideration received for such
       companies

     - compared the financial and operating performance of ALZA and Johnson &
       Johnson with publicly available information concerning certain other
       companies JPMorgan deemed relevant

     - reviewed the current and historical market prices of ALZA common stock
       and Johnson & Johnson common stock and certain publicly traded securities
       of such other companies

     - reviewed certain internal financial analyses and forecasts prepared by
       ALZA and its management relating to ALZA's business and

     - performed such other financial studies and analyses and considered such
       other information as JPMorgan deemed appropriate for the purposes of its
       opinion.

                                        17
   24

     JPMorgan also held discussions with certain members of the management of
ALZA and Johnson & Johnson with respect to certain aspects of the merger, and
the past and current business operations of ALZA and Johnson & Johnson, the
financial condition and future prospects and operations of ALZA and Johnson &
Johnson and certain other matters believed necessary or appropriate to
JPMorgan's inquiry. In addition, JPMorgan reviewed such other financial studies
and analyses and considered such other information as it deemed appropriate for
the purposes of its opinion. JPMorgan did not receive any forecast from Johnson
& Johnson as to its projected financial performance other than guidance that
JPMorgan could rely on consensus research analyst earnings estimates for the
year 2001.

     In rendering its opinion, JPMorgan relied upon and assumed, without
independent verification, the accuracy and completeness of all information that
was publicly available or that was furnished to it by ALZA and Johnson & Johnson
or otherwise reviewed by it, and JPMorgan did not assume any responsibility or
liability therefor. JPMorgan did not conduct any valuation or appraisal of any
assets or liabilities, nor were any valuations or appraisals provided to it. In
relying on financial analyses and forecasts provided to it, JPMorgan assumed
that they were reasonably prepared based on assumptions reflecting the best
currently available estimates and judgments by management as to the expected
future results of operations and financial condition of ALZA and Johnson &
Johnson to which such analyses or forecasts relate. In addition, JPMorgan
assumed that the merger will qualify as a tax-free reorganization for United
States Federal income tax purposes and be accounted for as a pooling of
interests under United States generally accepted accounting principles and that
the merger and the other transactions contemplated by the merger agreement will
be completed as described in the merger agreement. JPMorgan further assumed that
the definitive merger agreement will not differ in any material respects from
the draft merger agreement dated March 26, 2001 furnished to it. JPMorgan
further assumed that all material governmental, regulatory or other consents and
approvals necessary for the completion of the merger will be obtained without
any adverse effect on ALZA or Johnson & Johnson or on the contemplated benefits
of the merger.

     The projections furnished to JPMorgan for ALZA were prepared by the
management of ALZA. ALZA does not publicly disclose internal management
projections of the type provided to JPMorgan in connection with JPMorgan's
analysis of the exchange ratio in the merger, and such projections were not
prepared with a view toward public disclosure. These projections were based on
numerous variables and assumptions that are inherently uncertain and may be
beyond the control of management, including, without limitation, factors related
to general economic and competitive conditions and prevailing interest rates.
Accordingly, actual results could vary significantly from those set forth in
such projections.

     JPMorgan's opinion was necessarily based on economic, market and other
conditions as in effect on, and the information made available to JPMorgan as
of, the date of its opinion. Subsequent developments may affect the opinion, and
JPMorgan does not have any obligation to update, revise or reaffirm such
opinion. JPMorgan's opinion was limited to the fairness, from a financial point
of view, of the exchange ratio in the merger to the holders of ALZA common stock
and JPMorgan expressed no opinion as to the underlying decision of ALZA to
engage in the merger. JPMorgan expressed no opinion as to the price at which
ALZA common stock or Johnson & Johnson common stock will trade at any future
time.

     JPMorgan's opinion noted that JPMorgan was not authorized to and did not
solicit any expressions of interest from any other parties with respect to the
sale of all or any part of ALZA or any other alternative transaction.

     In accordance with customary investment banking practice, JPMorgan employed
generally accepted valuation methods in reaching its opinion. The following is a
summary of the material financial analyses utilized by JPMorgan in connection
with delivering its opinion. Some of the analyses include information presented
in a tabular format. To understand fully the financial analyses used by
JPMorgan, the tables must be read together with the text of each summary. The
tables alone do not constitute a complete description of the financial analyses.

                                        18
   25

     Public Companies Analysis.  Using publicly available information, JPMorgan
compared certain financial and operating information and ratios for ALZA with
corresponding financial and operating information and ratios for the following
specialty pharmaceutical companies:

     - Allergan, Inc.

     - Elan Corporation, plc

     - Forest Laboratories, Inc.

     - ICN Pharmaceuticals, Inc.

     - King Pharmaceuticals, Inc.

     - Medicis Pharmaceutical Corporation

     - Shire Pharmaceutical Group plc

     - Watson Pharmaceuticals, Inc.

The analysis indicated that:

     - the ratio of the per share market price of those companies to projected
       earnings per share ranged from 14.9x to 36.5x for calendar year 2001,
       with a mean of 27.4x, compared to 30.2x for ALZA, and ranged from 11.4x
       to 29.8x for calendar year 2002, with a mean of 22.0x, compared to 24.6x
       for ALZA and

     - the ratio of the per share market price of those companies to projected
       2001 earnings per share compared to projected five-year total return
       ranged from approximately 0.58x to 1.73x, with a mean of 1.15x, compared
       to approximately 1.41x for ALZA.

     JPMorgan also compared certain financial and operating information and
ratios for Johnson & Johnson with corresponding financial and operating
information and ratios for the following companies in the pharmaceutical
industry:

     - Abbott Laboratories

     - American Home Products Corporation

     - Aventis Group

     - Bristol-Myers Squibb Co.

     - Eli Lilly & Co.

     - GlaxoSmithKline plc

     - Merck & Co. Inc.

     - Novartis AG

     - Pharmacia Corporation

     - Pfizer Inc.

     - Roche Holdings AG

     - Schering-Plough Corporation

This analysis indicated that:

     - the ratio of the per share market price of those companies to projected
       earnings per share ranged from 18.6x to 41.3x for calendar year 2001,
       with a mean of 25.5x, compared to 23.0x for Johnson & Johnson, and ranged
       from 16.6x to 31.8x for calendar year 2002, with a mean of 21.9x,
       compared to 20.3x for Johnson & Johnson and

                                        19
   26

     - the ratio of the per share market price of those companies to projected
       2001 earnings per share compared to projected five-year total return
       ranged from approximately 1.26x to 2.64x, with a mean of 1.65x, compared
       to approximately 1.61x for Johnson & Johnson.

     Based upon the range of multiples derived from the analysis conducted for
the two sets of companies listed above, JPMorgan also calculated the implied
exchange ratios by comparing the implied per share equity values of ALZA common
stock and Johnson & Johnson common stock. The analysis yielded the following
implied exchange ratios (rounded to the nearest hundredth), in each case
compared to the proposed exchange ratio of 0.49:



COMPARISON                                                    IMPLIED EXCHANGE RATIO
----------                                                    ----------------------
                                                           
Highest estimated valuation of ALZA common stock to lowest
  estimated valuation of Johnson & Johnson common stock.....          0.41x
Lowest estimated valuation of ALZA common stock to highest
  estimated valuation of Johnson & Johnson common stock.....          0.25x


     Precedent Transactions Analysis.  JPMorgan reviewed certain publicly
available information regarding selected business combinations in the specialty
pharmaceutical and biotechnology industries announced since April 1998. These
transactions and the month in which each transaction was announced were as
follows:

     - Shire Pharmaceuticals Group plc/BioChem Pharma Inc. (December 2000)

     - Corixa Corporation/Coulter Pharmaceutical, Inc. (October 2000)

     - Genzyme Corp./Geltex Pharmaceuticals Inc. (September 2000)

     - Elan Corporation, plc/Dura Pharmaceuticals, Inc. (September 2000)

     - Chiron Corporation/PathoGenesis Corporation (August 2000)

     - Cephalon, Inc./Anesta Corp. (July 2000)

     - King Pharmaceutical, Inc./Jones Pharma Incorporated (July 2000)

     - Elan Corporation, plc/The Liposome Company, Inc. (March 2000)

     - King Pharmaceutical, Inc./Medco Research, Inc. (December 1999)

     - Celltech plc/Medeva plc (November 1999)

     - MedImmune, Inc./U.S. Bioscience, Inc. (September 1999)

     - Shire Pharmaceuticals Group plc/Roberts Pharmaceutical Corp. (July 1999)

     - Celltech plc/Chiroscience Group plc (June 1999)

     - Gilead Sciences, Inc./NeXstar Pharmaceuticals, Inc. (March 1999)

     - Warner-Lambert Company/Agouron Pharmaceuticals, Inc. (January 1999)

     - Johnson & Johnson/Centocor, Inc. (July 1999)

     - ALZA/SEQUUS Pharmaceuticals, Inc. (October 1998)

     - Elan Corporation, plc/Neurex Corporation (April 1998)

     Based upon a price per share of Johnson & Johnson common stock of $88.21,
which was the closing price per share on March 23, 2001, this analysis indicated
that:

     - the transaction value as a percentage premium to the closing prices of
       the target company's stock the day prior to the announcement of the
       transaction ranged from approximately 6% to 61%, with a mean of
       approximately 28%, compared to an approximately 44% premium to the
       closing price per share of ALZA common stock on March 23, 2001

                                        20
   27

     - the percentage premium to the average closing prices of the target
       company's stock the week prior to the announcement of the transaction
       ranged from approximately 4% to 81%, with a mean of approximately 31%,
       compared to an approximately 29% premium to the average closing price per
       share of ALZA common stock for the week ending on March 23, 2001

     - the percentage premium to the average closing prices of the target
       company's stock the month prior to the announcement of the transaction
       ranged from approximately 9% to 186%, with a mean of approximately 49%,
       compared to an approximately 10% premium to the average closing price per
       share of ALZA common stock for the month ending on March 23, 2001

     - the percentage premium to the average closing prices of the target
       company's stock the three months prior to the announcement of the
       transaction ranged from approximately 22% to 156%, with a mean of
       approximately 74%, compared to an approximately 2% discount to the
       average closing price per share of ALZA common stock for the three-month
       period ending on March 23, 2001 and

     - the transaction value as a multiple of forward-twelve-months earnings per
       share ranged from approximately 4.3x to 82.7x, with a mean of
       approximately 42.9x, compared to a multiple of approximately 43.1x
       implied by the merger.

     Relative Discounted Cash Flow Analysis.  JPMorgan performed a discounted
cash flow analysis for each of ALZA and Johnson & Johnson using financial
forecasts for ALZA provided by ALZA for years 2001 and 2002 and based on
publicly available research analyst estimates for years 2003-2005, and financial
forecasts for Johnson & Johnson based on publicly available research analyst
estimates. JPMorgan calculated a discounted cash flow analysis for ALZA assuming
discount rates ranging from 11% to 13%, and terminal multiples of tax-effected
earnings before interest and taxes, which is referred to as tax-effected EBIT,
in the year 2005 ranging from 30.0x to 38.0x, and for Johnson & Johnson assuming
discount rates ranging from 9.5% to 11.5%, and terminal multiples of
tax-effected EBIT in the year 2005 ranging from 24.0x to 28.0x. Based upon the
estimated valuation ranges of ALZA and Johnson & Johnson set forth above,
JPMorgan calculated an implied exchange ratio of a share of Johnson & Johnson
common stock to a share of ALZA common stock. The analysis yielded the following
implied exchange ratios (rounded to the nearest hundredth), in each case
compared to the proposed exchange ratio of 0.49:



COMPARISON                                                    IMPLIED EXCHANGE RATIO
----------                                                    ----------------------
                                                           
Highest estimated valuation of ALZA common stock to lowest
  estimated valuation of Johnson & Johnson common stock.....          0.50x
Lowest estimated valuation of ALZA common stock to highest
  estimated valuation of Johnson & Johnson common stock.....          0.31x


     Historical Exchange Ratio Analysis.  JPMorgan reviewed the per share daily
closing market price movements of ALZA common stock and Johnson & Johnson common
stock for the three-year period ending March 23, 2001, and calculated the
historical exchange ratios during this period implied by dividing the daily
closing prices per share of ALZA common stock by those of Johnson & Johnson
common stock and the average of those historical trading ratios for the 30-day,
90-day, 180-day, 1-year, 2-year and 3-year periods ending March 23, 2001. The
analysis resulted in the following average historical trading ratios for the
periods indicated (rounded to the nearest hundredth), compared to the proposed
exchange ratio of 0.49:



PERIOD                                                        MEAN
------                                                        -----
                                                           
March 23, 2001..............................................  0.34x
30-day......................................................  0.40x
90-day......................................................  0.41x
180-day.....................................................  0.40x
1-year......................................................  0.37x
2-year......................................................  0.30x
3-year......................................................  0.29x


                                        21
   28

The highest historical exchange ratio on any single day during the 1-year period
was approximately 0.49x, and the lowest historical exchange ratio on any single
day during this period was approximately 0.25x, compared to the proposed
exchange ratio of 0.49x.

     JPMorgan also calculated a range of implied exchange ratios by comparing
the high and low intra-day trading prices per share of ALZA common stock and
Johnson & Johnson common stock during the 52-week period ended March 23, 2001.
The analysis yielded the following implied exchange ratios (rounded to the
nearest hundredth), in each case compared to the proposed exchange ratio of
0.49:



                                                              IMPLIED EXCHANGE
COMPARISON                                                         RATIO
----------                                                    ----------------
                                                           
52-week high intra-day trading price of ALZA common stock to
  52-week low intra-day trading price of Johnson & Johnson
  common stock..............................................       0.68x
52-week low intra-day trading price of ALZA common stock to
  52-week high intra-day trading price of Johnson & Johnson
  common stock..............................................       0.16x


     Contribution Analysis.  JPMorgan estimated the contribution of each of ALZA
and Johnson & Johnson to the pro forma combined company with respect to revenue,
EBIT and net income for fiscal years 2001 and 2002 using financial forecasts for
ALZA provided by ALZA and for Johnson & Johnson based on publicly available
research analyst estimates. The analysis showed that ALZA would contribute
approximately:

     - 3.8% of 2001 estimated revenues

     - 4.3% of 2001 estimated EBIT

     - 5.0% of 2001 estimated net income

     - 4.0% of 2002 estimated revenues

     - 4.9% of 2002 estimated EBIT and

     - 5.3% of 2002 estimated net income,

compared to the approximately 8.9% pro forma ownership of the combined company
by ALZA stockholders.

     Pro Forma Analysis.  JPMorgan also analyzed certain pro forma effects
resulting from the merger, including the potential impact of the merger on
projected earnings per share of Johnson & Johnson following the merger, using
earnings per share forecasts for ALZA provided by ALZA for fiscal years 2001 and
2002 and publicly available research analyst estimates for fiscal year 2003 and
financial forecasts for Johnson & Johnson based on publicly available research
analyst estimates. Assuming no synergies, this analysis indicated that the
merger would be dilutive to Johnson & Johnson stockholders in years 2001, 2002
and 2003 by -4.2%, -4.0% and -3.5% per share, respectively.

     The summary set forth above does not purport to be a complete description
of the analyses or data presented by JPMorgan. The preparation of a fairness
opinion is a complex process and is not necessarily susceptible to partial
analysis or summary description. JPMorgan believes that the summary set forth
above and its analyses must be considered as a whole and that selecting portions
thereof, without considering all of its analyses, could create an incomplete
view of the processes underlying its analyses and opinion. JPMorgan based its
analyses on assumptions that it deemed reasonable, including assumptions
concerning general business and economic conditions and industry-specific
factors. The other principal assumptions upon which JPMorgan based its analyses
are set forth above under the description of each such analysis. JPMorgan's
analyses are not necessarily indicative of actual values or actual future
results that might be achieved, which values may be higher or lower than those
indicated. Moreover, JPMorgan's analyses are not and do not purport to be
appraisals or otherwise reflective of the prices at which businesses actually
could be bought or sold.

                                        22
   29

     None of the public companies used in the public companies analysis
described above is identical to ALZA or Johnson & Johnson, and none of the
precedent transactions used in the precedent transactions analysis described
above is identical to the merger. Accordingly, an analysis of publicly traded
comparable companies and transactions is not mathematical; rather it involves
complex considerations and judgments concerning differences in financial and
operating characteristics of the comparable companies and other factors that
could affect the public trading value of the comparable companies or company to
which they are being compared.

     As a part of its investment banking business, JPMorgan and its affiliates
are continually engaged in the valuation of businesses and their securities in
connection with mergers and acquisitions, investments for passive and control
purposes, negotiated underwritings, secondary distributions of listed and
unlisted securities, private placements and valuations for estate, corporate and
other purposes. JPMorgan was selected to advise ALZA with respect to the merger
and deliver an opinion to the ALZA board of directors with respect to the
exchange ratio in the merger on the basis of such experience and its familiarity
with ALZA.

     For services rendered in connection with the merger and the delivery of its
opinion, ALZA has agreed to pay JPMorgan an announcement fee of $5 million,
payable upon the execution of the merger agreement, and a fee of $20 million,
payable upon the closing of the merger, against which the announcement fee will
be credited. In addition, ALZA has agreed to reimburse JPMorgan for its expenses
incurred in connection with its services, including the fees and disbursements
of counsel, and will indemnify JPMorgan against certain liabilities, including
liabilities arising under the Federal securities laws.

     In the past, JPMorgan has acted as financial advisor to ALZA and JPMorgan
and its affiliates have also provided financial advisory and financing services
to Johnson & Johnson, and may continue to do so and have received, and may
receive, fees for such services.

     In addition, in the ordinary course of their businesses, JPMorgan and its
affiliates may actively trade the debt and equity securities of ALZA or Johnson
& Johnson for their own accounts or for the accounts of customers and,
accordingly, they may at any time hold long or short positions in such
securities. As of March 23, 2001, JPMorgan and its affiliates held approximately
5.8% of the outstanding shares of ALZA common stock primarily for the account of
customers.

     OPINION OF MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED

     Merrill Lynch has acted as financial advisor to ALZA in connection with the
merger. On March 26, 2001, Merrill Lynch delivered to the ALZA board of
directors a written opinion to the effect that, as of such date, and based upon
and subject to the factors and assumptions set forth in the opinion, the
exchange ratio was fair from a financial point of view to the holders of ALZA
common stock other than Johnson & Johnson and its affiliates.

     THE FULL TEXT OF THE MERRILL LYNCH FAIRNESS OPINION, WHICH SETS FORTH THE
ASSUMPTIONS MADE, MATTERS CONSIDERED AND QUALIFICATIONS AND LIMITATIONS ON THE
REVIEW UNDERTAKEN BY MERRILL LYNCH, IS INCLUDED IN THIS PROXY
STATEMENT/PROSPECTUS AS ANNEX 4. THE SUMMARY OF THE MERRILL LYNCH FAIRNESS
OPINION SET FORTH IN THIS PROXY STATEMENT/PROSPECTUS IS QUALIFIED IN ITS
ENTIRETY BY REFERENCE TO THE FULL TEXT OF THE MERRILL LYNCH FAIRNESS OPINION.
ALZA STOCKHOLDERS ARE URGED TO READ SUCH OPINION CAREFULLY AND IN ITS ENTIRETY.

     The Merrill Lynch fairness opinion was provided to the ALZA board of
directors for its information and is directed only to the fairness from a
financial point of view of the exchange ratio. The Merrill Lynch fairness
opinion does not address any other aspect of the merger, including the merits of
the underlying decision by ALZA to engage in the merger, and does not constitute
a recommendation to any ALZA stockholder as to how such stockholder should vote
on the proposed merger agreement or any related matter. The exchange ratio was
determined through negotiations between Johnson & Johnson and ALZA and was
approved by the ALZA board of directors.

                                        23
   30

     In arriving at its opinion, Merrill Lynch, among other things:

     - reviewed publicly available business and financial information relating
       to ALZA and Johnson & Johnson that Merrill Lynch deemed to be relevant

     - reviewed certain information, including financial forecasts relating to
       the business, earnings, cash flow, assets, liabilities and prospects of
       ALZA

     - conducted discussions with members of senior management of ALZA and
       Johnson & Johnson concerning the matters described above, as well as the
       business and prospects of ALZA and Johnson & Johnson before giving effect
       to the merger (and, in the case of the prospects of Johnson & Johnson,
       Johnson & Johnson instructed Merrill Lynch to rely upon public analysts'
       estimates as the most reasonable estimates for the future operating
       performance of Johnson & Johnson)

     - reviewed the market prices and valuation multiples for ALZA common stock
       and Johnson & Johnson common stock and compared them with those of
       certain publicly traded companies that Merrill Lynch deemed to be
       relevant

     - compared the proposed financial terms of the merger with the financial
       terms of other transactions that Merrill Lynch deemed to be relevant

     - participated in discussions and negotiations among representatives of
       ALZA and Johnson & Johnson and their financial and legal advisors

     - reviewed the potential pro forma impact of the merger

     - reviewed a draft dated March 26, 2001 of the merger agreement and

     - reviewed such other financial studies and analyses and took into account
       such other matters as Merrill Lynch deemed necessary, including Merrill
       Lynch's assessment of general economic, market and monetary conditions.

     In preparing its opinion, Merrill Lynch assumed and relied on the accuracy
and completeness of all information supplied or otherwise made available to
Merrill Lynch, discussed with or reviewed by or for Merrill Lynch, or publicly
available, and Merrill Lynch did not assume any responsibility for independently
verifying such information. Merrill Lynch has not undertaken an independent
evaluation or appraisal of any of the assets or liabilities of ALZA or Johnson &
Johnson or been furnished with any such evaluation or appraisal. In addition,
Merrill Lynch did not assume any obligation to conduct any physical inspection
of the properties or facilities of ALZA or Johnson & Johnson. With respect to
the financial forecast information furnished to or discussed with Merrill Lynch
by ALZA and the financial forecast guidance provided to Merrill by Johnson &
Johnson, Merrill Lynch assumed that they had been reasonably prepared and
reflected the best available estimates and judgment of the ALZA or the Johnson &
Johnson management as to the expected future financial performance of ALZA or
Johnson & Johnson, as the case may be. Merrill Lynch further assumed that the
merger will be accounted for as a pooling of interests under generally accepted
accounting principles and that it will qualify as a tax-free reorganization for
U.S. Federal income tax purposes. Merrill Lynch also assumed that the final form
of the merger agreement would be substantially similar to the draft dated March
26, 2001 reviewed by it.

     The Merrill Lynch fairness opinion is necessarily based on market, economic
and other conditions as they existed and could be evaluated on, and on the
information made available to Merrill Lynch as of, the date of the opinion.
Merrill Lynch assumed that in the course of obtaining the necessary regulatory
or other consents or approvals (contractual or otherwise) for the merger, no
restrictions, including any divestiture requirements or amendments or
modifications, will be imposed that will have a material adverse effect on the
contemplated benefits of the merger. Merrill Lynch did not express any opinion
as to the prices at which ALZA common stock or Johnson & Johnson common stock
will trade following the announcement or completion of the merger. In connection
with the preparation of its opinion, Merrill Lynch was not authorized by ALZA or
the ALZA board of directors to solicit, nor did Merrill Lynch

                                        24
   31

solicit, third-party indications of interest for the acquisition of all or any
part of ALZA. Although Merrill Lynch evaluated the exchange ratio from a
financial point of view, Merrill Lynch was not requested to, and did not,
address the merits of the underlying decision of ALZA to engage in the merger
and did not recommend to any stockholder how such stockholder should vote on the
proposed merger or any related matter.

     In preparing its opinion to the ALZA board of directors, Merrill Lynch
performed financial and comparative analyses, including those described below.
The summary of analyses set forth in this proxy statement/prospectus does not
purport to be a complete description of the analyses underlying the Merrill
Lynch fairness opinion or the presentation made by Merrill Lynch to the ALZA
board of directors. The preparation of a fairness opinion is a complex analytic
process involving various determinations as to the most appropriate and relevant
methods of financial analysis and the application of those methods to the
particular circumstances and, therefore, such an opinion is not readily
susceptible to partial analysis or summary description. No company, business or
transaction used in such analyses as a comparison is identical to ALZA, Johnson
& Johnson or the merger, nor is an evaluation of the results of such analyses
entirely mathematical. Rather, it involves complex considerations and judgments
concerning financial and operating characteristics and other factors that could
affect the acquisition, public trading or other values of the companies,
business segments or transactions being analyzed.

     In arriving at its opinion, Merrill Lynch did not attribute any particular
weight to any analysis or factor considered by it, but rather made qualitative
judgments as to the significance and relevance of each analysis and factor.
Accordingly, Merrill Lynch believes that its analyses must be considered as a
whole and that selecting portions of its analyses, without considering all
analyses, would create an incomplete view of the process underlying its opinion.

     In performing its analyses, numerous assumptions were made with respect to
industry performance, general business, economic, market and financial
conditions and other matters, many of which are beyond the control of Merrill
Lynch, ALZA or Johnson & Johnson. The estimates contained in the analyses
performed by Merrill Lynch and the ranges of valuations resulting from any
particular analysis are not necessarily indicative of actual values or
predictive of future results or values, which may be significantly more or less
favorable than those suggested by such analyses. Additionally, estimates of the
value of businesses or securities do not purport to be appraisals or to reflect
the prices at which such businesses or securities might actually be sold.
Accordingly, such analyses and estimates are inherently subject to substantial
uncertainty. In addition, as described above, the Merrill Lynch fairness opinion
was among several factors taken into consideration by the ALZA board of
directors in making its determination to approve the merger agreement and the
merger. Consequently, the Merrill Lynch analyses described below should not be
viewed as determinative of the decision of the ALZA board of directors or the
ALZA management with respect to the fairness of the exchange ratio.

     The following is a summary of the material financial and comparative
analyses performed by Merrill Lynch in arriving at its March 26, 2001 opinion
and presented to the ALZA board of directors. The Merrill Lynch opinion is based
upon Merrill Lynch's consideration of the collective results of all such
analyses, together with the other factors referred to in its opinion letter.

     Exchange Ratio Analysis.  In the merger, each outstanding share of ALZA
common stock will be converted into the right to receive 0.49 shares of Johnson
& Johnson common stock. Merrill Lynch compared this exchange ratio to each range
of implied exchange ratios set forth below, which were derived from analyses
performed by Merrill Lynch, and noted that this exchange ratio was higher than
or in the range of such implied exchange ratios.

                                        25
   32



                                                              IMPLIED EXCHANGE
                                                                   RATIO
                                                              ----------------
METHODOLOGY                                                    LOW       HIGH
-----------                                                   -----      -----
                                                                   
Historical share price analysis.............................  0.344      0.409
Comparable company trading analysis.........................  0.243      0.449
Contribution analysis.......................................  0.280      0.337
Discounted cash flow analysis...............................  0.336      0.522


     Historical Share Price Analysis.  Merrill Lynch analyzed the ratio of the
daily closing share prices of ALZA common stock to corresponding prices of
Johnson & Johnson common stock for various periods ended March 23, 2001 and
calculated the average of the daily implied exchange ratios for the periods
listed below.



                                                              AVERAGE IMPLIED
PERIOD                                                        EXCHANGE RATIO
------                                                        ---------------
                                                           
1 week......................................................       0.344
2 weeks.....................................................       0.353
1 month.....................................................       0.377
2 months....................................................       0.409
3 months....................................................       0.406


     Based on this historical share price analysis, Merrill Lynch calculated an
implied exchange ratio range of 0.344 to 0.409.

     Comparable Company Trading Analysis.  Using publicly available information,
Merrill Lynch compared selected historical and estimated stock price and
financial ratios for groups of selected publicly traded companies in the
pharmaceutical industry considered by Merrill Lynch to be reasonably comparable
to ALZA and Johnson & Johnson, respectively, for the purposes of this analysis.
The companies comparable to ALZA included:

     - Allergan, Inc.

     - Elan Corporation, plc

     - Forest Laboratories, Inc.

     - King Pharmaceuticals, Inc.

     - Shire Pharmaceuticals Group plc

     - Teva Pharmaceutical Industries Limited

     - Watson Pharmaceuticals, Inc.

The companies comparable to Johnson & Johnson included:

     - Abbott Laboratories

     - American Home Products Corporation

     - Bristol-Myers Squibb Company

     - Eli Lilly & Company

     - Merck & Co., Inc.

     - Pfizer Inc.

     - Pharmacia Corporation

     - Schering-Plough Corporation

                                        26
   33

     Merrill Lynch calculated the price of each of the comparable companies'
common stock as a multiple of estimated 2001 earnings per share. Merrill Lynch
also calculated the 2001 price-to-earnings ratio of each of the comparable
companies as a multiple of estimated total return (defined to be the estimated
five-year earnings per share growth rate plus the current dividend yield, which
is equal to (a) four times the most recent quarterly dividend per share, divided
by (b) the stock price). This analysis indicated that:

     - the 2001 price-to-earnings ratio for the companies comparable to ALZA
       ranged from 21.9x to 35.6x

     - the 2001 price-to-earnings to total return ratio for the companies
       comparable to ALZA ranged from 1.01x to 1.74x

     - the 2001 price-to-earnings ratio for the companies comparable to Johnson
       & Johnson ranged from 21.5x to 28.9x and

     - the 2001 price-to-earnings to total return ratio for the companies
       comparable to Johnson & Johnson ranged from 1.20x to 1.78x.

     Based upon a comparison of the companies comparable to ALZA and the
companies comparable to Johnson & Johnson, the implied exchange ratio ranged
from 0.243x to 0.449x.

     Because of the inherent differences among the operations of ALZA, Johnson &
Johnson and the selected comparable companies, Merrill Lynch believes that a
purely quantitative comparable company analysis would not be dispositive in the
context of the merger. Merrill Lynch further believes that an appropriate use of
a comparable company analysis in this instance involves qualitative judgments
concerning differences among the financial and operating characteristics of
ALZA, Johnson & Johnson and the selected comparable companies, which judgments
are reflected in the Merrill Lynch opinion.

     Contribution Analysis.  In order to determine an implied exchange ratio
range based upon a contribution analysis, Merrill Lynch calculated the
contribution on a percentage basis of each of ALZA and Johnson & Johnson to the
estimated net income, earnings before interest and taxes and earnings before
interest, taxes, depreciation and amortization to common stockholders of the pro
forma combined company for the twelve month periods ending December 31, 2000,
2001 and 2002 (excluding the effect of any cost savings and related expenses and
synergies expected to result from the merger) using projections provided by the
management of ALZA and information in selected equity research reports on
Johnson & Johnson.

     The results of these calculations indicated that ALZA's contribution
percentages for the relevant measure would be as set forth below:



                                                              YEAR ENDED DECEMBER 31,
                                                              ------------------------
MEASURE                                                       2000      2001      2002
-------                                                       ----      ----      ----
                                                                         
Earnings before interest, taxes, depreciation and
  amortization..............................................  4.0%      4.2%      4.8%
Earnings before interest and taxes..........................  4.0%      4.3%      4.9%
Net income..................................................  4.4%      5.0%      5.3%


     Merrill Lynch noted that if former stockholders of ALZA were to own like
percentages of the equity of the combined company as the ALZA contribution
percentages for the relevant measures for the twelve month periods ending
December 31, 2000, 2001 and 2002, the implied exchange ratios would be as set
forth below:



                                                            YEAR ENDED DECEMBER 31,
                                                           --------------------------
MEASURE                                                     2000      2001      2002
-------                                                    ------    ------    ------
                                                                      
Earnings before interest, taxes, depreciation and
  amortization...........................................  0.274x    0.290x    0.330x
Earnings before interest and taxes.......................  0.274x    0.290x    0.337x
Net income...............................................  0.243x    0.280x    0.298x


                                        27
   34

     The implied exchange ratios with respect to earnings before interest,
taxes, depreciation and amortization and earnings before interest and taxes set
forth above were estimated based upon ALZA's earnings before interest, taxes,
depreciation and amortization and earnings before interest and taxes,
respectively, for the periods indicated proportionately adjusted to reflect the
lower net debt-to-capitalization ratio of ALZA as compared to Johnson & Johnson.

     Discounted Cash Flow Analysis.  In order to determine an implied exchange
ratio range based upon discounted cash flow analysis, Merrill Lynch performed
discounted cash flow analyses for each of ALZA and Johnson & Johnson using
projections provided to Merrill Lynch by the management of ALZA and information
in selected equity research reports on Johnson & Johnson and calculated ranges
of values per share for ALZA common stock and Johnson & Johnson common stock.

     Discount rates ranging from 11.5% to 13.5% were applied to ALZA's projected
free cash flows for the years 2001 through 2005 and implied enterprise values in
2005 were based on a range of multiples of estimated tax-effected 2005 earnings
before interest and taxes of 29.0x to 37.0x. Discount rates ranging from 10.0%
to 12.0% were applied to Johnson & Johnson's projected free cash flows for the
years 2001 through 2005 and implied enterprise values in 2005 were based on a
range of multiples of estimated tax-effected 2005 earnings before interest and
taxes of 24.0x to 28.0x.

     Based upon a comparison of high-to-low estimated equity values per share
for each of ALZA and Johnson & Johnson resulting from the discounted cash flow
analyses, the implied exchange ratios ranged from 0.336x to 0.522x.

     Comparable Transaction Analysis.  Merrill Lynch also reviewed publicly
available information relating to sixteen comparable acquisition transactions
involving pharmaceutical companies completed in the last three years. With
respect to ALZA, Merrill Lynch examined the following:

     - premiums paid for the targets' equity over pre-announcement stock prices
       one week prior to announcement and one month prior to announcement

     - multiples of offered price per share to projected one-year forward and
       two-year forward earnings per share and

     - multiples of the consideration paid for the common equity and the value
       of the indebtedness, less cash and cash equivalents, assumed in each of
       the transactions to such acquired companies' projected one-year forward
       and two-year forward sales and earnings before interest, taxes,
       depreciation and amortization.

     This analysis indicated that the average premiums paid for the targets'
equity over pre-announcement stock prices one week prior to announcement and one
month prior to announcement were 32.1% and 41.6%, respectively. The multiples of
offered price per share to projected one-year forward and two-year forward
earnings per share ranged from 28.3x to 63.8x and 22.6x to 47.2x, respectively.
The ranges for the multiples of the consideration paid for the common equity and
the value of the indebtedness, less cash and cash equivalents, assumed in each
of the transactions to such acquired companies' projected one-year forward and
two-year forward sales and earnings before interest, taxes, depreciation and
amortization would be as set forth below:



MEASURE                                               ONE-YEAR FORWARD    TWO-YEAR FORWARD
-------                                               ----------------    ----------------
                                                                    
Sales...............................................    3.4x to 19.8x       2.9x to 17.6x
Earnings before interest, taxes, depreciation and
  amortization......................................   15.5x to 45.6x      11.8x to 31.0x


     Applying these multiples for the sixteen comparable acquisitions in the
pharmaceutical industry and to corresponding financial data of ALZA indicated an
implied equity reference range for its common stock of $37.75 to $48.50 per
share.

     Because the reasons for, and circumstances surrounding, each of the
comparable transactions analyzed were so diverse and due to the inherent
differences between the operations and financial conditions of

                                        28
   35

ALZA and the selected companies, Merrill Lynch believes that a purely
quantitative comparable transaction analysis would not be dispositive in the
context of the merger. Merrill Lynch further believes that an appropriate use of
a comparable transaction analysis in this instance involves qualitative
judgments concerning the differences between the characteristics of these
transactions and the merger that would affect the value of the acquired
companies and businesses and ALZA, which judgments are reflected in the Merrill
Lynch opinion.

     Pro Forma Merger Analysis.  Merrill Lynch analyzed certain pro forma
effects which could result from the merger, based on financial forecasts for
ALZA provided by the ALZA management for each year through 2003 and information
in selected equity research reports on Johnson & Johnson for the same period.
The ALZA management advised Merrill Lynch that the merger will be accounted for
as a pooling of interests under generally accepted accounting principles. This
pro forma analysis indicated that:

     - for fiscal 2001, the merger would be dilutive to the forecasted earnings
       per share of Johnson & Johnson if cost savings and/or revenue synergies
       were as much as $600 million or less per year

     - for fiscal 2002, the merger would be dilutive to such forecasted earnings
       if cost savings and/or revenue synergies were $400 million or less per
       year and accretive to such forecasted earnings if cost savings and/or
       revenue synergies were $600 million or more per year, and

     - for fiscal 2003, the merger would be dilutive to such forecasted earnings
       if cost savings and/or revenue synergies were $200 million per year or
       less and accretive to such forecasted earnings if cost savings and/or
       revenue synergies were $400 million or more per year.

     Other Factors and Analyses.  In the course of preparing its opinion,
Merrill Lynch performed other analyses and reviewed other matters, including,
among other things:

     - historical and expected trading characteristics of ALZA common stock and
       Johnson & Johnson common shares and

     - pro forma operating results and capitalization of the combined company.

     Pursuant to the terms of a letter agreement between ALZA and Merrill Lynch,
referred to as the Merrill Lynch letter agreement, ALZA has agreed to pay the
following fees to Merrill Lynch for its financial advisory services in
connection with the merger:

     - a fee of $3 million, contingent upon and payable in cash upon the
       execution of a definitive agreement to effect a business combination as
       defined in the Merrill Lynch letter agreement and

     - if, during the period Merrill Lynch is retained by ALZA or within 18
       months thereafter, a business combination is completed with an acquiror
       as defined in the Merrill Lynch letter agreement, or ALZA enters into an
       agreement with an acquiror that subsequently results in a business
       combination, a fee in an amount equal to $12 million, payable in cash
       upon the closing of such business combination; provided, however, that
       any fee previously paid to Merrill Lynch pursuant to the previous bullet
       point will be deducted from any fee to which Merrill Lynch is entitled
       pursuant to this bullet point.

     ALZA has also agreed to pay Merrill Lynch the lesser of the aggregate fees
described above payable to Merrill Lynch if the merger were completed and 10% of
any fee or payment paid to ALZA pursuant to or in connection with, the
termination, abandonment or failure to occur, of the merger, within 18 months of
the termination of the Merrill Lynch letter agreement. ALZA also has agreed to
reimburse Merrill Lynch for all reasonable out-of-pocket expenses incurred by
Merrill Lynch in performing its services, including the fees and expenses for
legal counsel, provided that Merrill Lynch is not entitled to reimbursement of
out of-pocket expenses in excess of $100,000 without the prior approval of ALZA.
ALZA has also agreed to indemnify Merrill Lynch and related persons and entities
against liabilities under Federal or state law arising out of a business
combination contemplated by the Merrill Lynch letter agreement or the engagement
of Merrill Lynch pursuant to such agreement.

                                        29
   36

     ALZA retained Merrill Lynch based upon Merrill Lynch's experience and
expertise. Merrill Lynch is an internationally recognized investment banking
business, is regularly engaged in the valuation of businesses and securities in
connection with mergers and acquisitions, negotiated underwritings, competitive
biddings, secondary distributions of listed and unlisted securities, private
placements and valuations for corporate and other purposes.

     In the ordinary course of business, Merrill Lynch and its affiliates may
actively trade in securities of ALZA and Johnson & Johnson for their own
accounts and for the accounts of customers and, accordingly, may at any time
hold a long or short position in such securities.

INTERESTS OF ALZA DIRECTORS AND EXECUTIVE OFFICERS IN THE MERGER

     In considering the recommendation of the ALZA board of directors with
respect to the merger, ALZA stockholders should be aware that the members of the
ALZA board of directors and ALZA's executive officers have personal interests in
the merger that are or may be different from, or in addition to, the interests
of other ALZA stockholders.

     ACCELERATION OF BENEFITS.  The members of the ALZA board of directors and
ALZA's executive officers are beneficiaries of certain ALZA compensation
programs under which vesting is accelerated upon the occurrence of certain
events, of which the merger is one.

     - Under the ALZA stock plan adopted by vote of ALZA stockholders in 1992
       and amended in 1995, all outstanding options to purchase ALZA common
       stock issued under the ALZA stock plan, including those held by executive
       officers and directors of ALZA, vest automatically at the closing of a
       merger such as the proposed merger with Johnson & Johnson, subject to
       adjustment to reflect the exchange ratio. Based upon options outstanding
       as of March 26, 2001, options held by ALZA's executive officers and
       directors relating to 5,508,726 shares of ALZA common stock will be
       subject to accelerated vesting at the effective time of the merger.
       Please see the table below for further details relating to the options
       held by ALZA's directors that are subject to accelerated vesting.

     - Restrictions on 390,796 shares of restricted stock held by executive
       officers of ALZA as of March 26, 2001, including 96,166 held by Dr.
       Mario, will lapse at the effective time of the merger and the shares will
       be converted into the right to receive unrestricted shares of Johnson &
       Johnson common stock, subject to adjustment to reflect the exchange
       ratio.

     - Under the ALZA Executive Deferral Plan initially approved by the ALZA
       board of directors in 1986, some of ALZA's directors and executive
       officers will benefit from accelerated vesting of their accounts at the
       effective time of the merger, and will be entitled to retirement benefits
       under the plan if their board membership or employment is terminated
       within two years of the closing of the merger. The aggregate unvested
       amount in the accounts of ALZA's directors and executive officers as of
       March 31, 2001 was $87,977.

     The following table sets forth, as of March 26, 2001, the number of shares
subject to unvested options held by ALZA's directors and the average exercise
prices of those options:



                           NUMBER OF SHARES SUBJECT TO UNVESTED OPTIONS HELD BY
NAME                          DIRECTORS/AVERAGE EXERCISE PRICE PER SHARE($)
----                       ----------------------------------------------------
                        
Dr. Ernest Mario.........                    600,000 / 21.73
Dr. William R. Brody.....                     20,000 / 23.04
Dr. Robert J. Glaser.....                     16,000 / 23.06
Dr. I. Craig Henderson...                    149,900 / 20.40
Jerry T. Jackson.........                     12,000 / 41.81
Dean O. Morton...........                     16,000 / 23.06
Denise M. O'Leary........                     20,000 / 23.04
Julian N. Stern..........                     24,000 / 23.10


                                        30
   37

     All of these options, other than options held by Dr. Mario and Dr.
Henderson, were granted under the automatic grant provisions of the ALZA stock
plan. The exercise price of all outstanding options issued under the ALZA stock
plan is equal to the fair market value of ALZA common stock on the date of the
option grant.

     Although all unvested options will vest and all restrictions on restricted
stock held by executive officers will lapse upon the closing of the merger,
under a separate agreement with Johnson & Johnson, the ALZA directors' and
executive officers' ability to sell their shares of Johnson & Johnson common
stock received in exchange for shares of ALZA common stock, restricted stock or
shares issuable on exercise of stock options is restricted until after Johnson &
Johnson publicly releases earnings that include at least 30 days of post-merger
combined operations of the two companies.

     EXECUTIVE AGREEMENTS.  ALZA and each of the executives listed below are
parties to executive agreements that provide for severance benefits in the event
of termination of the executive's employment by ALZA or its successor, other
than for "cause", or by the executive for "good reason", in either case at or
within 24 months following a "change in control" of ALZA, each as defined in the
executive agreements. The merger would constitute a change in control for
purposes of the executive agreements. The executive agreements were initially
entered into in November 1995 or upon the date the executive became an executive
officer, whichever was later, and were most recently amended in June 1999. Each
executive agreement, other than Dr. Mario's, provides:

     - for severance benefits equal to 2.5 times the executive's annual cash
       compensation

     - that for the 24 month period following the executive's termination, but
       not later than the third anniversary of the completion of the merger, the
       executive will receive life, disability and accident and health insurance
       benefits substantially similar to those the executive received prior to
       the executive's termination

     - for a partial gross-up for any excise tax that may be payable by the
       executive under Section 4999 of the Internal Revenue Code, and any income
       and employment withholding taxes on the gross-up payment, with respect to
       severance payments that are not attributable to the acceleration of
       equity-based awards to the executive and

     - that the executive will enter into a noncompetition agreement for a
       period of one year following the executive's termination, for which the
       executive is entitled to receive four quarterly payments of $25,000.

     Dr. Mario is a party to an executive agreement that is substantially the
same as the executive agreements described above, except that Dr. Mario's
executive agreement provides for a severance payment equal to three times the
sum of his annual cash compensation and a 2001 bonus payment of $775,000, but
not less than $4.5 million in the aggregate, and a four-year post-termination
noncompetition agreement, for which he is entitled to receive quarterly payments
of $31,250.

                                        31
   38

     The following executive officers of ALZA are parties to executive
agreements:



NAME                                             TITLE
----                      ---------------------------------------------------
                       
Dr. Ernest Mario........  Chairman and Chief Executive Officer
Bruce C. Cozadd.........  Executive Vice President, Chief Operating Officer
Harold E. Fethe.........  Senior Vice President, Human Resources
Matthew K. Fust.........  Senior Vice President and Chief Financial Officer
Dr. Ronald P. Haak......  Senior Vice President, Technology Development and
                          Principal Scientist
Robert M. Myers.........  Senior Vice President, Commercial Development
Dr. Samuel R. Saks......  Group Vice President -- ALZA Pharmaceuticals
Peter D. Staple.........  Executive Vice President, Chief Administrative
                          Officer and General Counsel
Daniel N. Swisher,
  Jr. ..................  Senior Vice President, Sales and Marketing
Janne L. Wissel.........  Senior Vice President, Operations


     INDEMNIFICATION AND INSURANCE.  The merger agreement provides that all
rights to indemnification and exculpation from liabilities for acts or omissions
occurring at or prior to the effective time of the merger existing in favor of
current or former directors or officers of ALZA under the ALZA certificate of
incorporation, bylaws or indemnification agreements will be assumed by the
surviving corporation in the merger and will continue in full force and effect
in accordance with their terms following completion of the merger.

     The merger agreement also provides that for six years after the effective
time of the merger, Johnson & Johnson will maintain directors' and officers'
liability insurance for acts or omissions occurring at or prior to the effective
time of the merger, covering each person who was, as of the date of the merger
agreement, covered by ALZA's directors' and officers' liability insurance, on
terms no less favorable than those in effect as of the date of the merger
agreement. Johnson & Johnson's obligation to provide this insurance coverage is
subject to a cap of 200% of the amount of premiums paid by ALZA in its last full
fiscal year for its existing insurance coverage. If Johnson & Johnson cannot
maintain the existing or equivalent insurance coverage without exceeding the
200% cap, Johnson & Johnson is required to maintain only that amount of
insurance coverage that can be obtained by paying an annual premium equal to the
200% cap.

     ALZA EXECUTIVE ESTATE PROTECTION PLAN AND THE ALZA GRANTOR TRUST
AGREEMENT.  The merger agreement provides that Johnson & Johnson will, from and
after the effective time of the merger, guarantee all obligations of the
surviving corporation in the merger for the performance of its obligations under
the ALZA Executive Estate Protection Plan and the related ALZA Grantor Trust
Agreement.

     The ALZA board of directors was aware of the interests described above and
considered them, among other matters, when approving the merger.

ACCOUNTING TREATMENT

     Completion of the merger is conditioned upon its being accounted for on a
pooling of interests accounting basis and the receipt by Johnson & Johnson and
ALZA of letters from PricewaterhouseCoopers LLP and Ernst & Young LLP regarding
those firms' concurrence with the Johnson & Johnson management's and the ALZA
management's conclusions, respectively, that, as of the date the merger is
completed, no conditions exist that would preclude accounting for the merger as
a pooling of interests transaction under Accounting Principles Board Opinion No.
16 and applicable Securities and Exchange Commission rules and regulations, if
the merger is completed in accordance with the merger agreement. Under this
accounting treatment, upon completion of the merger, the assets and liabilities
of ALZA would be added to those of Johnson & Johnson at their recorded book
values and the shareholders' equity accounts of Johnson & Johnson and ALZA would
be combined on Johnson & Johnson's consolidated balance sheet. On a pooling of
interests accounting basis, Johnson & Johnson will retroactively restate its
financial statements issued after completion of the merger to reflect the

                                        32
   39

consolidated combined financial position and results of operations of Johnson &
Johnson and ALZA as if the merger had taken place as of the earliest period
covered by such financial statements.

FORM OF THE MERGER

     Subject to the terms and conditions of the merger agreement and in
accordance with Delaware law, at the effective time of the merger, Express
Merger Sub Inc., a wholly owned subsidiary of Johnson & Johnson and a party to
the merger agreement, will merge with and into ALZA. ALZA will survive the
merger as a wholly owned Delaware subsidiary of Johnson & Johnson.

MERGER CONSIDERATION

     At the effective time of the merger, each outstanding share of ALZA common
stock will be converted into the right to receive 0.49 shares of Johnson &
Johnson common stock, except that treasury stock and stock held by Johnson &
Johnson and Express Merger Sub Inc. will be canceled. ALZA stockholders will
receive cash for any fractional shares which they would otherwise receive in the
merger. The amount of cash for fractional shares each ALZA stockholder will
receive will be calculated by multiplying the fractional share interest to which
that stockholder is entitled by the closing price of Johnson & Johnson common
stock on the closing date of the merger as reported on the New York Stock
Exchange Composite Transactions Tape. The exchange ratio of 0.49 was determined
through arm's-length negotiations between Johnson & Johnson and ALZA.

OWNERSHIP OF JOHNSON & JOHNSON FOLLOWING THE MERGER

     Based on the number of outstanding shares of ALZA common stock on the
record date, we anticipate that ALZA stockholders will receive approximately --
shares of Johnson & Johnson common stock in the merger. Based on that number and
on the number of outstanding shares of Johnson & Johnson common stock on --,
2001, ALZA stockholders will own approximately --% of the outstanding shares of
Johnson & Johnson common stock following the merger.

CONVERSION OF SHARES; PROCEDURES FOR EXCHANGE OF CERTIFICATES; FRACTIONAL SHARES

     The conversion of ALZA common stock into the right to receive Johnson &
Johnson common stock will occur automatically at the effective time of the
merger. As soon as reasonably practicable after the completion of the merger,
EquiServe Trust Company, the exchange agent, will send a letter of transmittal
to each former ALZA stockholder. The transmittal letter will contain
instructions for obtaining shares of Johnson & Johnson common stock and cash for
any fractional shares of Johnson & Johnson common stock in exchange for shares
of ALZA common stock.

     ALZA STOCKHOLDERS SHOULD NOT RETURN STOCK CERTIFICATES WITH THE ENCLOSED
PROXY.

     After the effective time of the merger, each certificate that previously
represented shares of ALZA common stock will no longer be outstanding, will be
automatically canceled and retired, will cease to exist and will represent only
the right to receive the Johnson & Johnson common stock into which such shares
are converted in the merger and the right to receive cash for any fractional
shares of Johnson & Johnson common stock as described below.

     Until holders of certificates previously representing ALZA common stock
have surrendered those certificates to the exchange agent for exchange, those
holders will not receive dividends or distributions on the Johnson & Johnson
common stock into which such shares have been converted with a record date after
the effective time of the merger and will not receive cash for any fractional
shares of Johnson & Johnson common stock. When holders surrender such
certificates, they will receive any dividends with a record date after the
effective time of the merger and a payment date on or prior to the date of
surrender and any cash for fractional shares of Johnson & Johnson common stock,
in each case without interest.

     In the event of a transfer of ownership of ALZA common stock that is not
registered in the transfer records of ALZA, a certificate representing the
proper number of shares of Johnson & Johnson common
                                        33
   40

stock may be issued to a person other than the person in whose name the
certificate so surrendered is registered if:

     - such certificate is properly endorsed or otherwise is in proper form for
       transfer and

     - the person requesting such exchange pays any transfer or other taxes
       resulting from the issuance of shares of Johnson & Johnson common stock
       to a person other than the registered holder of such certificate.

     All shares of Johnson & Johnson common stock issued in exchange for shares
of ALZA common stock, including any cash paid instead of any fractional shares
of Johnson & Johnson common stock, will be issued in full satisfaction of all
rights relating to such shares of ALZA common stock.

     No fractional shares of Johnson & Johnson common stock will be issued to
any ALZA stockholder upon surrender of certificates previously representing ALZA
common stock. Each ALZA stockholder who would otherwise have been entitled to
receive a fraction of a share of Johnson & Johnson common stock will receive
cash in an amount equal to the product obtained by multiplying (1) the
fractional share interest to which such holder would otherwise be entitled by
(2) the closing price for a share of Johnson & Johnson common stock on the
closing date of the merger as reported on the New York Stock Exchange Composite
Transactions Tape.

EFFECTIVE TIME OF THE MERGER

     The merger will become effective upon the filing of the certificate of
merger with the Secretary of State of the State of Delaware or such later time
as is agreed upon by Johnson & Johnson and ALZA and specified in the certificate
of merger. The filing of the certificate of merger will occur as soon as
practicable after satisfaction or waiver of the conditions to the completion of
the merger described in the merger agreement.

STOCK EXCHANGE LISTING OF JOHNSON & JOHNSON COMMON STOCK

     It is a condition to the completion of the merger that the Johnson &
Johnson common stock issuable to:

     - ALZA stockholders in the merger

     - holders of options to acquire shares of ALZA common stock, which will be
       converted into options to acquire shares of Johnson & Johnson common
       stock, subject to adjustment to reflect the exchange ratio, upon exercise
       of such options and

     - holders of certain convertible securities of ALZA to be assumed by the
       surviving corporation in the merger upon conversion of such securities

have been approved for listing on the New York Stock Exchange, subject to
official notice of issuance.

DELISTING AND DEREGISTRATION OF ALZA COMMON STOCK

     If the merger is completed, ALZA common stock will be delisted from the New
York Stock Exchange and will be deregistered under the Securities Exchange Act
of 1934.

MATERIAL UNITED STATES FEDERAL INCOME TAX CONSEQUENCES OF THE MERGER

     The following general discussion summarizes the anticipated material United
States Federal income tax consequences of the merger to holders of ALZA common
stock. This discussion addresses only such stockholders who hold their ALZA
common stock as a capital asset, and does not address all of the United States
Federal income tax consequences that may be relevant to particular stockholders
in light of their individual circumstances or to stockholders who are subject to
special rules, such as holders who are subject to alternative minimum tax
provisions of the Internal Revenue Code, financial institutions, tax-exempt
organizations, insurance companies, mutual funds, dealers in securities or
foreign currencies,
                                        34
   41

foreign holders, persons who hold such shares as a hedge against currency risk,
or as part of a constructive sale or conversion transaction, holders whose
shares are qualified small business stock for purposes of Sections 1202 and 1045
of the Internal Revenue Code or holders who acquired their shares upon the
exercise of employee stock options or otherwise as compensation. Tax
consequences under state, local and foreign laws are not addressed, nor are the
tax consequences of transactions effectuated prior or subsequent to, or
concurrently with, the merger (whether or not any such transactions are
undertaken in connection with the merger), including without limitation any
transaction in which shares of ALZA common stock are acquired or shares of
Johnson & Johnson common stock are disposed of.

     The following discussion is not binding on the Internal Revenue Service. It
is based upon the Internal Revenue Code, and other laws, regulations, rulings
and decisions in effect as of the date of this proxy statement/prospectus, all
of which are subject to change, possibly with retroactive effect. The parties
are not requesting a ruling from the Internal Revenue Service as to the United
States Federal income tax consequences of the merger and there can be no
assurance that the Internal Revenue Service will agree with the conclusions
expressed below. The obligation of ALZA to complete the merger is conditioned on
the receipt by ALZA of the opinion of Heller Ehrman White & McAuliffe LLP, tax
counsel to ALZA, that on the basis of the facts, representations and assumptions
set forth or referred to therein, the merger will qualify as a reorganization
within the meaning of Section 368(a) of the Internal Revenue Code, and each of
ALZA, Johnson & Johnson and Express Merger Sub will be a party to the
reorganization within the meaning of Section 368(b) of the Internal Revenue
Code. This tax opinion is based on the continued accuracy and completeness of
the facts, assumptions and representations referred to above. The discussion
below assumes that the merger qualifies as a reorganization under the Internal
Revenue Code.

     HOLDERS OF ALZA COMMON STOCK ARE URGED TO CONSULT THEIR TAX ADVISORS AS TO
THE SPECIFIC TAX CONSEQUENCES TO THEM OF THE MERGER, INCLUDING THE APPLICABILITY
AND EFFECT OF FEDERAL, STATE, LOCAL AND FOREIGN INCOME AND OTHER TAX LAWS TO
THEIR PARTICULAR CIRCUMSTANCES.

     EFFECT OF QUALIFICATION AS A REORGANIZATION; EXCHANGE OF ALZA COMMON STOCK
FOR JOHNSON & JOHNSON COMMON STOCK.  If the merger qualifies as a
reorganization, the following tax consequences will apply to holders of ALZA
common stock who exchange their ALZA common stock for Johnson & Johnson common
stock in the merger:

     - each such stockholder will not recognize gain or loss for United States
       Federal income tax purposes as a result of the merger, except with
       respect to cash, if any, that such stockholder receives instead of a
       fractional share of Johnson & Johnson common stock

     - each such stockholder's aggregate tax basis in the Johnson & Johnson
       common stock received in the merger will be the same as such
       stockholder's aggregate tax basis in the ALZA common stock surrendered in
       the merger, decreased by the amount of any tax basis allocable to any
       fractional share interest for which cash is received

     - the holding period of the Johnson & Johnson common stock received in the
       merger by each such stockholder will include the holding period of the
       ALZA common stock that such stockholder surrendered in the merger and

     - each such stockholder who receives cash instead of a fractional share of
       Johnson & Johnson common stock will recognize gain or loss equal to the
       difference between the amount of cash received and such stockholder's tax
       basis in the ALZA common stock surrendered for the fractional share.

     BACKUP WITHHOLDING.  Certain noncorporate holders of ALZA common stock may
be subject to backup withholding at a 31% rate on amounts received in exchange
for their ALZA common stock. Backup withholding will not apply, however, to a
stockholder who (1) furnishes a correct taxpayer identification number and
certifies that he or she is not subject to backup withholding on the substitute
Form W-9 or successor form included in the letter of transmittal that will be
mailed to ALZA stockholders by the exchange agent shortly after completion of
the merger, (2) provides a certification of foreign status on Form W-8BEN or
successor form or (3) is otherwise exempt from backup withholding.
                                        35
   42

REGULATORY MATTERS

     UNITED STATES ANTITRUST.  Under the Hart-Scott-Rodino Antitrust
Improvements Act and related rules, certain transactions, including the merger,
may not be completed unless certain waiting period requirements have been
satisfied. On April 13, 2001, Johnson & Johnson and ALZA each filed a
Notification and Report Form with the Antitrust Division of the Department of
Justice and the Federal Trade Commission and requested an early termination of
the required waiting period. If early termination is not granted and a request
for additional information by the relevant antitrust authorities is not made,
the waiting period will expire at midnight on May 14, 2001. At any time before
or after the effective time of the merger, the Antitrust Division, the Federal
Trade Commission or others could take action under the antitrust laws, including
seeking to prevent the merger, to rescind the merger or to conditionally approve
the merger upon the divestiture of substantial assets of Johnson & Johnson or
ALZA. There can be no assurance that a challenge to the merger on antitrust
grounds will not be made or, if such a challenge is made, that it would not be
successful.

     EUROPE.  In addition, both Johnson & Johnson and ALZA conduct business in
member states of the European Union. Council Regulation 4064/89 requires
notification to and approval by the European Commission of mergers or
acquisitions involving parties with aggregate worldwide sales and individual
European Union sales exceeding specified thresholds. Such approval by the
European Commission is a condition to the completion of the merger. Johnson &
Johnson and ALZA each filed a merger notification with the European Commission
on --, 2001.

     GENERAL.  It is possible that any of the governmental entities with which
filings are made may seek, as conditions for granting approval of the merger,
various regulatory concessions. There can be no assurance that:

     - Johnson & Johnson or ALZA will be able to satisfy or comply with such
       conditions

     - compliance or non-compliance will not have adverse consequences on
       Johnson & Johnson after completion of the merger or

     - the required regulatory approvals will be obtained within the time frame
       contemplated by Johnson & Johnson and referred to in this proxy
       statement/prospectus or on terms that will be satisfactory to Johnson &
       Johnson and ALZA.

See "The Merger Agreement -- Conditions to the Completion of the Merger".

APPRAISAL RIGHTS

     Under Delaware law, holders of ALZA common stock are not entitled to
appraisal rights in connection with the merger because, on the record date, ALZA
common stock was listed on the New York Stock Exchange and will be converted
into shares of Johnson & Johnson common stock, which at the effective time of
the merger will be listed on the New York Stock Exchange.

ALZA EMPLOYEE BENEFITS MATTERS

     Johnson & Johnson and ALZA have agreed that:

     - for a period ending not earlier than December 31, 2001, employees of ALZA
       and its subsidiaries will receive employee benefits under the material
       ALZA benefit plans (other than stock-based plans) according to their
       terms as in effect immediately before the completion of the merger and

     - from January 1, 2002 through December 31, 2002, employees of ALZA and its
       subsidiaries will be provided employee benefits that are no less
       favorable in the aggregate than the benefits provided under ALZA's
       material benefit plans (other than stock-based plans and ALZA's bonus
       leave program) as in effect immediately before the completion of the
       merger.

                                        36
   43

With respect to ALZA's bonus leave program, Johnson & Johnson and ALZA have
agreed that:

     - the bonus leave program is not required to be continued for participants
       other than employees of ALZA and its subsidiaries immediately before the
       completion of the merger

     - in the event Johnson & Johnson discontinues the bonus leave program after
       December 31, 2001, it will provide to each participant who as of December
       31, 2001 has earned partial service credit toward a paid bonus leave
       under the bonus leave program either:

        - a paid leave for the number of days equal to the product (rounded down
          to the nearest whole day) of the number of days of paid bonus leave
          that would have been provided under the bonus leave program if the
          participant had accrued the full bonus leave as of December 31, 2001,
          multiplied by a fraction, the numerator of which is the number of
          completed calendar months (with 15 or more calendar days of accrued
          service credit in any month being treated as a full completed calendar
          month) of service credit towards the paid bonus leave accrued through
          December 31, 2001, and the denominator of which is 96 or

        - a payment in cash in an amount equal to the participant's annual base
          salary multiplied by a fraction, the numerator of which is the number
          of days determined under the preceding bullet point and the
          denominator of which is 365 and

     - upon the termination of employment after the completion of the merger but
       prior to December 31, 2001 of any participant in the bonus leave program,
       Johnson & Johnson will cause the terminating participant to be paid the
       value of all service credit earned toward bonus leave under the bonus
       leave program, such value to be calculated in the same manner as set
       forth above.

     Johnson & Johnson has also agreed that:

     - with respect to any benefit plan for which Johnson & Johnson or its
       subsidiaries file a Form 5500 and with respect to Johnson & Johnson's
       vacation program, Johnson & Johnson will recognize or cause to be
       recognized, continuing ALZA employees' service with ALZA and its
       subsidiaries prior to the completion of the merger, provided that:

        - Johnson & Johnson will not be required to recognize such service under
          its short-term disability, retiree medical and retiree life insurance
          benefit plans

        - under Johnson & Johnson's defined benefit pension plan, service will
          be recognized for purposes of eligibility and vesting but not for
          benefit accrual purposes

        - the annual accrual under ALZA's personal time off (or PTO) program
          that such employees would be eligible to receive on or after the
          completion of the merger will not be reduced and

        - Johnson & Johnson and its subsidiaries are not required to provide any
          such benefit on or after the completion of the merger

     - with respect to any welfare plan in which employees of ALZA and its
       subsidiaries are eligible to participate after the completion of the
       merger, Johnson & Johnson will, and will cause the surviving corporation
       to:

        - waive all limitations as to preexisting conditions, exclusions and
          waiting periods with respect to participation and coverage
          requirements applicable to such employees to the extent such
          conditions were satisfied under the welfare plans of ALZA and its
          subsidiaries prior to the completion of the merger and

        - provide each such employee with credit for any co-payments and
          deductibles paid prior to the completion of the merger in satisfying
          any analogous deductible or out-of-pocket requirements to the extent
          applicable under such plan.

                                        37
   44

The ALZA board of directors has adopted resolutions providing as follows with
respect to the ALZA Employee Stock Purchase Plan and Supplemental Employee Stock
Purchase Plan, which we refer to together as the stock purchase plans:

     - no further contributions will be permitted to be made to the stock
       purchase plans following the completion of the merger by any participant
       with respect to any outstanding enrollments in respect of the
       then-current offering periods under the stock purchase plans

     - at the completion of the merger, each outstanding right to purchase
       shares of ALZA common stock under the stock purchase plans will be
       converted into a right to purchase, on the same terms and conditions as
       were applicable under such right, the number of shares of Johnson &
       Johnson common stock (rounded down to the nearest whole share) determined
       by multiplying the number of shares of ALZA common stock for which such
       purchase right would otherwise have been exercisable determined as of the
       relevant grant date by the exchange ratio, at a purchase price per share
       equal to 85% of the lesser of (1) the fair market value of a share of
       ALZA common stock on the applicable enrollment date under the stock
       purchase plans, divided by the exchange ratio and (2) the fair market
       value of a share of Johnson & Johnson common stock on the applicable
       purchase date under the stock purchase plans and

     - immediately following the first purchase date under the stock purchase
       plans that occurs following the completion of the merger, the stock
       purchase plans and all then outstanding enrollments in respect of the
       then current offering periods will be terminated.

ALZA has also agreed that:

     - neither ALZA nor any of its subsidiaries will take any action on or prior
       to the completion of the merger to alter, change, modify or impair the
       terms and conditions of employment of any European-based employee without
       the consent of Johnson & Johnson

     - ALZA and its subsidiaries will comply with all obligations to notify and
       consult with recognized employee representatives in connection with the
       transactions contemplated by the merger agreement and

     - prior to the completion of the merger, ALZA will take all steps as may be
       required to cause the disposition of equity securities and derivative
       equity securities of ALZA (including ALZA stock options) in connection
       with the merger agreement or the transactions contemplated by the merger
       agreement by each individual who is a director or officer of ALZA, to be
       exempt under Rule 16b-3 promulgated under the Securities Exchange Act.

EFFECT ON AWARDS OUTSTANDING UNDER ALZA STOCK PLANS

     Under the merger agreement, when the merger is completed, Johnson & Johnson
will assume each stock plan of ALZA. Each option to acquire shares of ALZA
common stock under such plans will be converted into an option to acquire
Johnson & Johnson common stock on the same terms and conditions, except that (1)
the number of shares of Johnson & Johnson common stock subject to the option
will equal the number of shares of ALZA common stock subject to the option
multiplied by the exchange ratio and rounded down to the nearest whole share and
(2) the exercise price per share of Johnson & Johnson common stock will equal
the aggregate exercise price for the shares of ALZA common stock subject to the
option divided by the total number of shares of Johnson & Johnson common stock
to be subject to such option and rounded up to the nearest whole cent; provided,
that the stock purchase rights granted under the stock purchase plans will have
a purchase price determined as provided above under "-- ALZA Employee Benefits
Matters".

RESALE OF JOHNSON & JOHNSON COMMON STOCK

     Johnson & Johnson common stock issued in the merger will not be subject to
any restrictions on transfer arising under the Securities Act of 1933, except
for shares issued to any ALZA stockholder who

                                        38
   45

may be deemed to be an "affiliate" of ALZA or Johnson & Johnson for purposes of
Rule 145 under the Securities Act or for purposes of qualifying the merger for
pooling of interests accounting treatment. It is expected that each affiliate
will agree not to transfer any Johnson & Johnson common stock received in the
merger except in compliance with the resale provisions of Rule 144 or 145 under
the Securities Act or as otherwise permitted under the Securities Act. In
addition, it is expected that each such affiliate will agree not to make any
such disposition within 30 days prior to completion of the merger, and until
after such time as financial results covering at least 30 days of combined
operations of Johnson & Johnson and ALZA after the merger have been published.
The merger agreement requires ALZA to use commercially reasonable efforts to
cause its affiliates to enter into such agreements, and Johnson & Johnson has
agreed to use commercially reasonable efforts to cause its affiliates to comply
with the transfer restrictions referred to in the preceding sentence. In
addition, it is a condition to the completion of the merger that certain
specified persons enter into such agreements. This proxy statement/prospectus
does not cover resales of Johnson & Johnson common stock received by any person
upon completion of the merger, and no person is authorized to make any use of
this proxy statement/prospectus in connection with any such resale.

                                        39
   46

                              THE MERGER AGREEMENT

     This is a summary of the material provisions of the merger agreement. The
merger agreement, which is attached as Annex 1 to this proxy
statement/prospectus and is incorporated herein by reference, contains the
complete terms of that agreement. You should read the entire merger agreement
carefully.

CONDITIONS TO THE COMPLETION OF THE MERGER

     CONDITIONS TO JOHNSON & JOHNSON'S AND ALZA'S OBLIGATIONS TO COMPLETE THE
MERGER.  Each party's obligation to effect the merger is subject to the
satisfaction or waiver of various conditions that include, in addition to other
customary closing conditions, the following:

     - the merger agreement has been adopted by the affirmative vote of
       stockholders of ALZA representing a majority of the shares of ALZA common
       stock outstanding and entitled to vote at the special meeting

     - the shares of Johnson & Johnson common stock to be issued to:

        - ALZA stockholders upon completion of the merger

        - holders of options to acquire shares of ALZA common stock, which will
          be converted into options to acquire shares of Johnson & Johnson
          common stock, subject to adjustment to reflect the exchange ratio,
          upon exercise of such options and

        - holders of certain convertible securities of ALZA to be assumed by the
          surviving corporation in the merger upon conversion of such securities

       have been approved for listing on the New York Stock Exchange, subject to
       official notice of issuance.

     - the waiting period applicable to the merger under the Hart-Scott-Rodino
       Antitrust Improvements Act has expired or has been terminated

     - the European Commission has issued, or has been deemed to have issued, a
       decision under Council Regulation No. 4064/89 of the European Community
       declaring the merger compatible with the Common Market

     - no temporary restraining order, injunction or other court order or
       statute, law, rule, legal restraint or prohibition is in effect that
       prevents the completion of the merger

     - the registration statement on Form S-4, of which this proxy
       statement/prospectus forms a part, has been declared effective by the
       Securities and Exchange Commission and is not the subject of any stop
       order or proceedings seeking a stop order and

     - Johnson & Johnson and ALZA each having received letters dated as of the
       date on which the merger is to be completed from PricewaterhouseCoopers
       LLP and Ernst & Young LLP regarding such firms' concurrence with the
       Johnson & Johnson management's and the ALZA management's conclusions,
       respectively, that, as of the date the merger is completed, no conditions
       exist that would preclude accounting for the merger as a pooling of
       interests transaction under Accounting Principles Board Opinion No. 16
       and applicable Securities and Exchange Commission rules and regulations
       if the merger is completed in accordance with the merger agreement.

       CONDITIONS TO JOHNSON & JOHNSON'S OBLIGATION TO COMPLETE THE
       MERGER.  Johnson & Johnson's obligation to effect the merger is further
subject to satisfaction or waiver of the following additional conditions:

     - the representations and warranties of ALZA relating to (1) the
       capitalization of ALZA and (2) various state takeover statutes and
       provisions of the ALZA certificate of incorporation and the ALZA by-laws
       are true and correct in all material respects as of the date of the
       merger agreement

                                        40
   47

       and as of the closing date of the merger as though made on the closing
       date, or if such representations and warranties expressly relate to an
       earlier date, then as of such date

     - the representations and warranties of ALZA relating to (1) the granting
       of various employee benefits or the entering into various employee
       contracts by ALZA, (2) agreements that may restrict the ability of
       affiliates of ALZA to develop, market or distribute products or services
       and (3) various other agreements that relate to the marketing,
       development, promotion or supply of selected products of ALZA are true
       and correct as of the date of the merger agreement and as of the closing
       date of the merger as though made on the closing date, or if such
       representations and warranties expressly relate to an earlier date, then
       as of such date, except to the extent that the facts or matters as to
       which such representations and warranties are not so true and correct as
       of such dates, individually or in the aggregate, could not reasonably be
       expected to have a material adverse effect on the reasonably expected
       benefits of the merger to Johnson & Johnson

     - all the other representations and warranties of ALZA set forth in the
       merger agreement are true and correct as of the date of the merger
       agreement and as of the closing date of the merger as though made on the
       closing date, or if such representations and warranties expressly relate
       to an earlier date, then as of such date, except to the extent that the
       facts or matters as to which such representations and warranties are not
       so true and correct as of such dates, without giving effect to any
       qualifications or limitations as to materiality or material adverse
       effect set forth in such representations and warranties, individually or
       in the aggregate, have not had and could not reasonably be expected to
       have a material adverse effect on ALZA

     - ALZA has performed in all material respects all obligations required to
       be performed by it under the merger agreement on or prior to the date on
       which the merger is to be completed

     - Johnson & Johnson has received from various identified affiliates of ALZA
       an executed agreement under which those persons agree to restrictions on
       their ability to sell the shares of Johnson & Johnson common stock they
       will receive in the merger and

     - there is no pending or threatened suit, action or proceeding by any
       governmental entity (1) challenging the acquisition by Johnson & Johnson
       of any shares of ALZA common stock, seeking to restrain or prohibit the
       completion of the merger, or seeking to place limitations on the
       ownership of shares of ALZA common stock (or shares of common stock of
       the surviving corporation in the merger) by Johnson & Johnson or seeking
       to obtain from ALZA or Johnson & Johnson any damages that are material in
       relation to ALZA, (2) seeking to prohibit or materially limit the
       ownership or operation by ALZA, Johnson & Johnson or any of their
       respective subsidiaries of any material portion of any business or of any
       assets of ALZA and its subsidiaries, taken as a whole, and Johnson &
       Johnson and its subsidiaries, taken as a whole, or to compel ALZA,
       Johnson & Johnson or any of their respective subsidiaries to divest or
       hold separate any material portion of business or of any assets of ALZA
       and its subsidiaries, taken as a whole, and Johnson & Johnson and its
       subsidiaries, taken as a whole, as a result of the merger, (3) seeking to
       prohibit Johnson & Johnson or any of its subsidiaries from effectively
       controlling in any material respect the business or operations of ALZA or
       any of its subsidiaries or (4) otherwise having, or being reasonably
       expected to have, a material adverse effect on ALZA.

     CONDITIONS TO ALZA'S OBLIGATION TO COMPLETE THE MERGER.  ALZA's obligation
to effect the merger is further subject to satisfaction or waiver of the
following additional conditions:

     - the representations and warranties of Johnson & Johnson and Express
       Merger Sub set forth in the merger agreement that are qualified as to
       materiality are true and correct, and the representations and warranties
       set forth in the merger agreement that are not so qualified are true and
       correct in all material respects, in each case as of the date of the
       merger agreement and as of the closing date of the merger as though made
       on the closing date, or if such representations and warranties expressly
       relate to an earlier date, then as of such date, except to the extent
       that the facts or matters as to which such representations and warranties
       are not so true and correct as of such dates, without

                                        41
   48

       giving effect to any qualifications or limitations as to materiality or
       material adverse effect set forth in such representations and warranties,
       individually or in the aggregate, have not had and could not reasonably
       be expected to have a material adverse effect on Johnson & Johnson

     - Johnson & Johnson and Express Merger Sub have performed in all material
       respects all obligations required to be performed by them under the
       merger agreement on or prior to the date on which the merger is to be
       completed and

     - ALZA has received from Heller Ehrman White & McAuliffe LLP, tax counsel
       to ALZA, on the closing date of the merger an opinion dated as of the
       closing date and stating that the merger will be treated for United
       States Federal income tax purposes as a reorganization within the meaning
       of Section 368(a) of the Internal Revenue Code. The issuance of this
       opinion is conditioned upon the receipt by such tax counsel of
       representation letters from each of ALZA and Johnson & Johnson.

     The merger agreement provides that a "material adverse effect" or "material
adverse change" means, when used in connection with ALZA or Johnson & Johnson,
any change, effect, event, occurrence or state of facts (or any development or
developments which individually or in the aggregate could reasonably be expected
to result in any change or effect) that is materially adverse to the business,
properties, assets, liabilities (contingent or otherwise), financial condition
or results of operations of ALZA and its subsidiaries, taken as a whole, or
Johnson & Johnson and its subsidiaries, taken as a whole, as the case may be,
other than any change, effect, event, occurrence, state of facts or development:

     - relating to the economy in general or

     - relating to the industry in which ALZA operates or the industries in
       which Johnson & Johnson operates, as the case may be, in general and not
       specifically relating to ALZA or Johnson & Johnson.

     ALZA can provide no assurance that all of the conditions precedent to the
merger will be satisfied or waived by the party permitted to do so. ALZA cannot
at this point determine whether it would resolicit proxies in the event that it
decides to waive any of the items listed above. This decision would depend upon
the facts and circumstances leading to ALZA's decision to complete the merger
and whether ALZA believes there has been a material change in the terms of the
merger and its effect on ALZA and its stockholders. In making this
determination, ALZA would consider, among other factors, the reasons for the
waiver, the effect of the waiver on the terms of the merger, whether the
requirement being waived was necessary in order to make the transaction fair to
the stockholders from a financial point of view, the availability of alternative
transactions and the prospects of ALZA as an independent entity. If ALZA
determines that a waiver of a condition would materially change the terms of the
merger, including the expected qualification of the merger as a reorganization
within the meaning of Section 368(a) of the Internal Revenue Code, it will
resolicit proxies.

NO SOLICITATION

     The merger agreement provides that ALZA will not, nor will it authorize or
permit any of its subsidiaries, any of their respective directors, officers or
employees or any investment banker, financial advisor, attorney, accountant or
other advisor, agent or representative retained by it or any of its subsidiaries
to, directly or indirectly through another person:

     - solicit, initiate or encourage, or take any other action to facilitate,
       any inquiries or the making of any proposal that constitutes, or could
       reasonably be expected to lead to, a takeover proposal, as described
       below, or

     - participate in any discussions or negotiations regarding, or furnish to
       any person any information, or otherwise cooperate in any way with, any
       takeover proposal.

                                        42
   49

     The merger agreement provides that the term "takeover proposal" means:

     - any proposal or offer for a merger, consolidation, dissolution,
       recapitalization or other business combination involving ALZA

     - any proposal for the issuance of 15% or more of the equity securities of
       ALZA as consideration for the assets or securities of another person or

     - any proposal or offer to acquire in any manner, directly or indirectly,
       15% or more of the equity securities of ALZA or assets (including equity
       securities of any subsidiary of ALZA) that represent 15% or more of the
       total consolidated assets of ALZA,

in each case, other than the transactions contemplated by the merger agreement
or the stock option agreement entered into with Johnson & Johnson.

     The merger agreement provides further that, notwithstanding the
restrictions described above, if, at any time prior to the time ALZA
stockholders have adopted the merger agreement with Johnson & Johnson:

     - ALZA receives a bona fide written takeover proposal that the ALZA board
       of directors determines in good faith, after consultation with outside
       counsel and a financial advisor of nationally recognized reputation,
       constitutes or is reasonably likely to lead to a superior proposal, as
       described below, and

     - such takeover proposal was unsolicited and made after the date of the
       merger agreement and did not otherwise result from a breach by ALZA of
       the no solicitation provisions described above,

ALZA may, if the ALZA board of directors determines in good faith, after
consultation with outside counsel, that it is required to do so in order to
comply with its fiduciary duties to the ALZA stockholders under applicable law,
subject to providing prior notice to Johnson & Johnson:

     - furnish information about ALZA and its subsidiaries to the person making
       such takeover proposal under a confidentiality agreement not less
       restrictive than the confidentiality agreement between ALZA and Johnson &
       Johnson, provided that all such information is also provided to Johnson &
       Johnson and

     - participate in discussions or negotiations regarding such takeover
       proposal.

     The merger agreement provides that the term "superior proposal" means any
bona fide offer made by a third party that if completed would result in such
person (or its shareholders) owning, directly or indirectly, all or
substantially all of the shares of ALZA common stock then outstanding (or of the
surviving entity in a merger or the direct or indirect parent of the surviving
entity in a merger) or all or substantially all the assets of ALZA, which the
ALZA board of directors determines in good faith, after consultation with a
financial advisor of nationally recognized reputation, to be:

     - more favorable to the ALZA stockholders from a financial point of view
       than the merger, taking into account all the terms and conditions of such
       proposal and the merger agreement with Johnson & Johnson, including any
       changes to the financial terms of the merger proposed by Johnson &
       Johnson in response to such proposal or otherwise and

     - reasonably capable of being completed, taking into account all financial,
       legal, regulatory and other aspects of such proposal.

     The merger agreement provides further that neither the ALZA board of
directors nor any committee of the ALZA board of directors may:

     - withdraw, or modify in a manner adverse to Johnson & Johnson, or propose
       to withdraw, or modify in a manner adverse to Johnson & Johnson, the
       approval, recommendation or declaration of advisability by the ALZA board
       of directors or such committee of the ALZA board of directors of the
       merger agreement, the stock option agreement or the merger

                                        43
   50

     - recommend, adopt or approve, or propose publicly to recommend, adopt or
       approve, any takeover proposal or

     - approve or recommend, or propose to approve or recommend, or allow ALZA
       or any of its subsidiaries to execute or enter into, any letter of
       intent, memorandum of understanding, agreement in principle, merger
       agreement, acquisition agreement, option agreement, joint venture
       agreement, partnership agreement or other similar agreement related to
       any takeover proposal.

     Notwithstanding the above, at any time prior to the time ALZA stockholders
have adopted the merger agreement with Johnson & Johnson, the ALZA board of
directors may withdraw its recommendation of the merger agreement, the stock
option agreement and the merger or recommend the approval of a takeover proposal
if the ALZA board of directors determines in good faith, after consultation with
outside counsel, that it is required to do so in order to comply with its
fiduciary duties to the ALZA stockholders under applicable law. No such
withdrawal of the ALZA board of directors' recommendation of the merger
agreement, the stock option agreement and the merger or recommendation of a
takeover proposal in response to a takeover proposal that constitutes a superior
proposal may be made until after the third business day following Johnson &
Johnson's receipt of written notice from ALZA advising Johnson & Johnson that
the ALZA board of directors intends to take such action and specifying the terms
and conditions of such superior proposal. In determining whether to take such
action, the ALZA board of directors must take into account any changes to the
financial terms of the merger proposed by Johnson & Johnson in response to its
receipt of such notice from ALZA or otherwise.

     In addition to the no solicitation provisions described above, the merger
agreement provides that ALZA must promptly advise Johnson & Johnson orally and
in writing of any bona fide takeover proposal, the material terms and conditions
of any such takeover proposal and the identity of the person making any such
takeover proposal. ALZA must keep Johnson & Johnson fully informed of the status
and details, including any changes, of any such takeover proposal or inquiry and
must provide to Johnson & Johnson copies of all correspondence and other written
material sent or provided by any person to ALZA or any of its subsidiaries that
describes any of the terms or conditions of any takeover proposal as soon as
practicable after receipt or delivery of such correspondence or other written
material.

     Nothing in the merger agreement prohibits the ALZA board of directors from
taking and disclosing to the ALZA stockholders a position contemplated by Rule
14e-2(a) or Item 1012(a) of Regulation M-A promulgated under the Securities
Exchange Act or from making any required disclosure to ALZA stockholders if, in
the good faith judgment of the ALZA board of directors, after consultation with
outside counsel, failure to make such disclosure would constitute a violation of
applicable law, except that in no event may ALZA or its board of directors or
any committee of the ALZA board of directors withdraw its recommendation of the
merger agreement, the stock option agreement or the merger, recommend a takeover
proposal or enter into an agreement regarding a takeover proposal in a manner
prohibited by the no solicitation provisions described above.

TERMINATION OF THE MERGER AGREEMENT

     The merger agreement may be terminated at any time prior to the effective
time of the merger, even if the merger agreement has been adopted by the ALZA
stockholders:

     - by mutual written consent of Johnson & Johnson and ALZA

     - by either Johnson & Johnson or ALZA, if the merger has not been completed
       by December 31, 2001, except that this right to terminate the merger
       agreement will not be available to any party whose action or failure to
       act has been a principal cause of or resulted in the failure of the
       merger to be completed on or before that date

     - by either Johnson & Johnson or ALZA, if there exists a restraining order,
       injunction or other court order or statute, law, rule, legal restraint or
       prohibition, in each case that has become final and cannot be appealed
       and which prevents the completion of the merger

                                        44
   51

     - by either Johnson & Johnson or ALZA, if the ALZA stockholders do not
       adopt the merger agreement at the special meeting

     - by either Johnson & Johnson or ALZA, if the other party has breached or
       failed to perform any of its representations, warranties, covenants or
       agreements set forth in the merger agreement, which breach or failure to
       perform would give rise to the failure of a condition to the merger and
       has not been or cannot be cured within 30 calendar days following
       receiving written notice from the other party of such breach or failure
       to perform and

     - by Johnson & Johnson, if the ALZA board of directors or any committee of
       the ALZA board of directors withdraws, or modifies in a manner adverse to
       Johnson & Johnson, or proposes to withdraw, or modify in a manner adverse
       to Johnson & Johnson, its approval, recommendation or declaration of
       advisability of the merger agreement, the stock option agreement or the
       merger or recommends, adopts or approves, or proposes publicly to
       recommend, adopt or approve, any takeover proposal.

FEES AND EXPENSES

     GENERAL.  The merger agreement provides that each party will pay its own
fees and expenses in connection with the merger agreement and the transactions
contemplated by the merger agreement, whether or not the merger is completed,
except that Johnson & Johnson and ALZA will each pay one-half of (1) the
expenses incurred in connection with filing, printing and mailing of the
registration statement of which this proxy statement/prospectus is a part and
(2) the filing fees for the premerger notification and report forms under the
Hart-Scott-Rodino Antitrust Improvements Act and any similar foreign antitrust
laws.

     TERMINATION FEE.  ALZA must pay to Johnson & Johnson a termination fee of
$180 million in each of the following circumstances:

     - the merger agreement is terminated by Johnson & Johnson pursuant to its
       right described in the last bullet point under "-- Termination of the
       Merger Agreement", if the ALZA board of directors action which gave rise
       to such termination right was made in response to a superior proposal,
       and within 12 months after such termination, ALZA enters into a
       definitive agreement for, or completes, the transactions contemplated by
       any takeover proposal (for purposes of this provision, the term "takeover
       proposal" has the same meaning as described under "-- No Solicitation",
       except that references to 15% are deemed references to 30%) or

     - a takeover proposal is made to ALZA or directly to the ALZA stockholders
       generally or otherwise becomes publicly known or any person publicly
       announces an intention, whether or not conditional, to make a takeover
       proposal, the merger agreement is terminated by either Johnson & Johnson
       or ALZA pursuant to their respective rights described in the second or
       fourth bullet points under "--Termination of the Merger Agreement" and
       within 12 months after such termination, ALZA enters into a definitive
       agreement for, or completes, the transactions contemplated by any
       takeover proposal (for purposes of this provision, the term "takeover
       proposal" has the same meaning as described under "-- No Solicitation",
       except that references to 15% are deemed references to 30%).

CONDUCT OF BUSINESS PENDING THE MERGER

     Under the merger agreement, ALZA has agreed that, during the period from
the date of the merger agreement to the effective time of the merger, it will,
and will cause each of its subsidiaries to, carry on its business in the
ordinary course consistent with past practice and in compliance with applicable
laws and regulations and, to the extent consistent with such laws and
regulations, will use all commercially reasonable efforts to preserve intact its
current business organizations, keep available the services of its current
officers, employees and consultants and preserve its relationships with
customers, suppliers, licensors, licensees, distributors and others having
business dealings with it with the intention that its

                                        45
   52

goodwill and ongoing business will be unimpaired at the effective time of the
merger. In addition, without limiting the generality of the foregoing, during
the period from the date of the merger agreement to the effective time of the
merger, ALZA has agreed that it will not, and will not permit any of its
subsidiaries to, without Johnson & Johnson's prior written consent:

     - declare, set aside or pay any dividends on, or make any other
       distributions (whether in cash, stock or property) in respect of, any of
       its capital stock, other than dividends or distributions by a direct or
       indirect wholly owned subsidiary of ALZA to its parent

     - split, combine or reclassify any of its capital stock or issue or
       authorize the issuance of any other securities in respect of, in lieu of
       or in substitution for shares of its capital stock

     - purchase, redeem or otherwise acquire any shares of its capital stock or
       any other securities of ALZA or any rights, warrants or options to
       acquire any such shares or other securities

     - issue, deliver, sell, grant, pledge or otherwise encumber or subject to
       any lien any shares of its capital stock, any other voting securities or
       any securities convertible into, or any rights, warrants or options to
       acquire, any such shares, voting securities or convertible securities, or
       any "phantom" stock, "phantom" stock rights, stock appreciation rights or
       stock based performance units, other than:

        - the issuance of shares of ALZA common stock upon the exercise of
          options to acquire ALZA common stock outstanding on the date of the
          merger agreement or granted after the date of the merger agreement in
          accordance with the last sub-bullet below in accordance with their
          terms on the date of the merger agreement or on the date of grant, if
          later

        - the issuance of shares of ALZA common stock upon the conversion of the
          convertible notes outstanding on the date of the merger agreement in
          accordance with their terms on the date of the merger agreement

        - the issuance of shares of ALZA common stock pursuant to an exercise of
          the option granted under the stock option agreement or

        - the grant to newly hired or promoted employees of options to acquire
          shares of ALZA common stock and, after consultation with Johnson &
          Johnson, the grant to existing employees of options to acquire shares
          of ALZA common stock consisting of ALZA's annual option grants, in
          either case in accordance with ALZA's ordinary course of business
          consistent with ALZA's guidelines in respect of option grants

     - amend the ALZA certificate of incorporation or the ALZA by-laws or other
       comparable charter or organizational documents

     - directly or indirectly acquire (1) by merging or consolidating with, or
       by purchasing assets of, or by any other manner, any person or division,
       business or equity interest of any corporation, partnership or other
       business organization or (2) any assets that, individually, have a
       purchase price in excess of $3,000,000 or, in the aggregate, have a
       purchase price in excess of $15,000,000, except for purchases of raw
       materials or supplies in the ordinary course of business consistent with
       past practice

     - sell, lease, license, mortgage, sell and leaseback or otherwise encumber
       or subject to any lien or otherwise dispose of any of its properties or
       other assets or any interests therein (including securitizations), except
       for sales of inventory in the ordinary course of business consistent with
       past practice

     - incur any indebtedness for borrowed money or guarantee any such
       indebtedness of another person, issue or sell any debt securities or
       warrants or other rights to acquire any debt securities of ALZA or any of
       its subsidiaries, guarantee any debt securities of another person, enter
       into any "keep well" or other agreement to maintain any financial
       statement condition of another person or enter

                                        46
   53

       into any arrangement having the economic effect of any of the foregoing,
       except for short-term borrowings incurred in the ordinary course of
       business consistent with past practice

     - make any loans, advances or capital contributions to, or investments in,
       any other person, other than in the ordinary course of business
       consistent with past practice or to or in any direct or indirect wholly
       owned subsidiary of ALZA

     - except for projects contemplated in ALZA's 2001 capital assets budget,
       make any new capital expenditure or expenditures which, individually, is
       in excess of $2,000,000 or, in the aggregate, are in excess of
       $10,000,000

     - pay, discharge, settle or satisfy any claims, liabilities, obligations or
       litigation (absolute, accrued, asserted or unasserted, contingent or
       otherwise), other than the payment, discharge, settlement or satisfaction
       in the ordinary course of business consistent with past practice or in
       accordance with their terms, of liabilities disclosed, reflected or
       reserved against in the most recent financial statements of ALZA (or the
       notes thereto) filed with the Securities and Exchange Commission or
       incurred since the date of such financial statements in the ordinary
       course of business consistent with past practice, cancel any material
       indebtedness, waive or assign any claims or rights of substantial value,
       waive any benefits of, or agree to modify in any respect, any standstill
       or similar agreement to which ALZA or any of its subsidiaries is a party
       or, other than in the ordinary course of business consistent with past
       practice, waive any material benefit of, or agree to modify in any
       material respect, any confidentiality or similar agreement to which ALZA
       or any of its subsidiaries is a party

     - except in the ordinary course of business consistent with past practice,
       modify, amend or terminate any material contract or agreement to which
       ALZA or any of its subsidiaries is a party or waive, release or assign
       any material rights or claims thereunder

     - enter into any contracts, agreements, binding arrangements or
       understandings relating to the research, development, distribution,
       supply, license, co-promotion or manufacturing by third parties of
       products of ALZA or any subsidiary of ALZA or products licensed by ALZA
       or any subsidiary of ALZA, other than:

        - under any such contracts, agreements, arrangements or understandings
          currently in place in accordance with their terms as of the date of
          the merger agreement

        - contracts, agreements, binding arrangements or understandings relating
          to research or development or under which ALZA or any of its
          subsidiaries obtains the supply of ingredients or components of
          products, in each case entered into in the ordinary course of business
          consistent with past practice and that do not provide for the grant of
          any licenses or marketing rights under any intellectual property
          rights of ALZA or any of its subsidiaries and

        - contracts, agreements, binding arrangements or understandings relating
          to research or development entered into in the ordinary course of
          business consistent with past practice and any license agreements or
          arrangements entered into in the ordinary course of business
          consistent with past practice in connection therewith, provided that
          ALZA or the applicable subsidiary of ALZA consults with Johnson &
          Johnson a reasonable period of time prior to entering into any such
          contract, agreement, binding arrangement or understanding and such
          associated license agreement or arrangement is limited to the use of
          ALZA's intellectual property rights in the field of drug delivery in
          conjunction with any substance, material, chemical, formulation or
          composition which contains as an active ingredient a compound, protein
          or other biological material that is proprietary to the licensee
          thereunder

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, adopt, enter into, terminate or amend in
       any material respect any collective bargaining agreement or benefit plan
       or any benefit agreement or other agreement, plan or policy involving

                                        47
   54

       ALZA or any of its subsidiaries and one or more of their respective
       current or former directors, officers, employees or consultants

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, increase in any manner the compensation,
       bonus or fringe or other benefits of, or pay any bonus to, any current or
       former director, officer, employee or consultant, except for normal
       increases of cash compensation, cash bonuses or fringe benefits or
       perquisites in the ordinary course of business consistent with past
       practice that, in the aggregate, do not materially increase the benefits
       or compensation expenses of ALZA and its subsidiaries, taken as a whole

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, pay any benefit or amount not required
       under any benefit plan or benefit agreement or any other benefit
       arrangement of ALZA or any of its subsidiaries as in effect on the date
       of the merger agreement

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, increase in any material manner the
       severance or termination pay of any current or former director, officer
       or key employee of ALZA or any of its subsidiaries or increase the
       severance or termination pay of any other employees of ALZA or any of its
       subsidiaries in a manner that results in the aggregate in any material
       increase in the severance or termination pay expenses of ALZA and its
       subsidiaries

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, grant any awards under any bonus,
       incentive, performance or other compensation plan or arrangement or
       benefit plan

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, amend or modify any stock option

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, take any action to fund or in any other
       way secure the payment of compensation or benefits under any employee
       plan, agreement, contract or arrangement or benefit plan

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, take any action to accelerate the vesting
       or payment of any compensation or benefit under any benefit plan, other
       than non-discretionary actions required by the terms of any existing
       plans, agreements, contracts, arrangements or benefit plans

     - except as otherwise contemplated by the merger agreement or as required
       to comply with applicable law, materially change any actuarial or other
       assumption used to calculate funding obligations with respect to any
       pension plan or change the manner in which contributions to any pension
       plan are made or the basis on which such contributions are determined

     - except as otherwise contemplated by the merger agreement, enter into any
       agreement of a nature that would be required to be filed as an exhibit to
       Form 10-K under the Securities Exchange Act

     - revalue any material assets of ALZA or any of its subsidiaries or, except
       as required by generally accepted accounting principles, make any change
       in accounting methods, principles or practices

     - other than license agreements or arrangements permitted under the merger
       agreement, sell, transfer or license to any person or otherwise extend,
       amend or modify any rights relating to the intellectual property rights
       of ALZA or any of its subsidiaries or

     - authorize any of, or commit, propose or agree to take any of, the
       foregoing actions.

                                        48
   55

REPRESENTATIONS AND WARRANTIES

     The merger agreement contains customary representations and warranties
relating to, among other things:

     - corporate organization and similar corporate matters of Johnson &
       Johnson, Express Merger Sub and ALZA

     - capital structure of Johnson & Johnson, Express Merger Sub and ALZA

     - obligations with respect to capital stock of Johnson & Johnson and ALZA

     - authorization, execution, delivery, performance and enforceability of,
       and required consents, approvals, orders and authorizations of
       governmental authorities relating to, the merger agreement and related
       matters of Johnson & Johnson, Express Merger Sub and ALZA

     - approval by the ALZA board of directors of the merger agreement, the
       stock option agreement and related transactions

     - documents filed by each of Johnson & Johnson and ALZA with the Securities
       and Exchange Commission and the accuracy of information contained in such
       documents

     - absence of undisclosed liabilities of ALZA

     - accuracy of information supplied by each of Johnson & Johnson and ALZA in
       connection with this proxy statement/prospectus and the registration
       statement of which it is a part

     - absence of material changes or events concerning Johnson & Johnson and
       ALZA

     - pending or threatened material litigation of Johnson & Johnson and ALZA

     - certain contracts and agreements of ALZA, including agreements that
       relate to the marketing, development, promotion or supply of selected
       products of ALZA

     - compliance with applicable laws, including environmental laws, by ALZA

     - absence of changes in benefit plans and labor relations matters of ALZA

     - matters relating to the Employee Retirement Income Security Act for ALZA

     - absence of excess parachute payments to any director, officer, employee
       or consultant of ALZA or its affiliates

     - filing of tax returns and payment of taxes by ALZA

     - title to ALZA's properties and ALZA's compliance with the terms of its
       material leases

     - intellectual property rights of Johnson & Johnson and ALZA

     - required stockholder vote of ALZA and no required stockholder vote of
       Johnson & Johnson

     - satisfaction of the requirements of certain state takeover statutes and
       provisions of the ALZA certificate of incorporation and the ALZA by-laws
       by ALZA

     - engagement and payment of fees of brokers, investment bankers, finders
       and financial advisors of Johnson & Johnson and ALZA

     - receipt of fairness opinions by ALZA from its financial advisors

     - the absence of actions by Johnson & Johnson and ALZA that would prevent
       using the pooling of interests method to account for the merger

     - absence of actions by ALZA, Johnson & Johnson and Express Merger Sub that
       would prevent the merger from qualifying as a tax-free reorganization for
       Federal income tax purposes

                                        49
   56

     - applicability of the rights agreement between ALZA and Fleet National
       Bank (formerly BankBoston, N.A.)

     - compliance by Johnson & Johnson and ALZA with applicable regulatory and
       governmental requirements

     - amendment of the grantor trust agreement between ALZA and Wachovia Bank,
       N.A.

     - organization and operations of Express Merger Sub and

     - Johnson & Johnson common stock to be issued in the merger.

CERTIFICATE OF INCORPORATION AND BY-LAWS OF THE SURVIVING CORPORATION

     The merger agreement provides that the certificate of incorporation of the
surviving corporation will be amended to read in its entirety as set forth in
Exhibit A to the merger agreement and, as so amended, will be the certificate of
incorporation of the surviving corporation until changed or amended. The merger
agreement further provides that the by-laws of Express Merger Sub, as in effect
immediately prior to the completion of the merger, will be the by-laws of the
surviving corporation until changed or amended. For a summary of certain
provisions of the current ALZA certificate of incorporation, by-laws and the
associated rights of ALZA stockholders, see "Comparison of Rights of Common
Stockholders of Johnson & Johnson and ALZA".

AMENDMENT; EXTENSION AND WAIVER

     Subject to applicable law:

     - the merger agreement may be amended by mutual consent of the parties in
       writing at any time, except that after the merger agreement has been
       adopted by the stockholders of ALZA, no amendment may be entered into
       which requires further approval by ALZA stockholders or requires the
       approval of stockholders of Johnson & Johnson unless such approval is
       obtained and

     - at any time prior to the effective time of the merger, a party may, by
       written instrument signed on behalf of such party;

        - extend the time for performance of any of the obligations or other
          acts of any other party to the merger agreement

        - waive inaccuracies in representations and warranties of any other
          party contained in the merger agreement or in any related document or

        - waive compliance by any other party with any agreements or conditions
          in the merger agreement, except that no such waiver may be made after
          the merger agreement has been adopted by the stockholders of ALZA
          which requires further approval by ALZA stockholders or requires the
          approval of stockholders of Johnson & Johnson unless such approval is
          obtained.

                                        50
   57

                           THE STOCK OPTION AGREEMENT

     This is a summary of the material provisions of the stock option agreement.
The stock option agreement, which is attached as Annex 2 to this proxy
statement/prospectus and is incorporated herein by reference, contains the
complete terms of that agreement. You should read the entire stock option
agreement carefully.

GENERAL

     Concurrently with the execution and delivery of the merger agreement,
Johnson & Johnson and ALZA entered into a stock option agreement under which
ALZA granted Johnson & Johnson an option to purchase up to 47,466,356 shares of
ALZA common stock, at a price per share of $41.84, under certain conditions that
are described below.

EXERCISE OF THE OPTION

     Except as described below, the option is exercisable by Johnson & Johnson
at any time after the occurrence of any event as a result of which Johnson &
Johnson is entitled to receive the termination fee under the merger agreement.
The right to purchase shares under the ALZA stock option agreement will expire
upon the first to occur of:

     - the effective time of the merger

     - 12 months after the first occurrence of any event as a result of which
       Johnson & Johnson is entitled to receive the termination fee under the
       merger agreement and

     - termination of the merger agreement prior to the occurrence of any event
       as a result of which Johnson & Johnson is entitled to receive the
       termination fee, unless Johnson & Johnson has the right to receive such
       termination fee upon the occurrence of certain events, in which case the
       option will not terminate until the later of (1) ten business days
       following the time such termination fee becomes payable and (2) the
       expiration of the period during which Johnson & Johnson has the right to
       receive a termination fee.

     Any purchase of shares upon the exercise of the option is subject to
compliance with the Hart-Scott-Rodino Antitrust Improvements Act and the
obtaining or making of any governmental or regulatory consents, approvals,
orders, notifications, filings or authorizations, the failure of which to have
obtained or made would make the issuance of shares subject to the option
illegal. If the option has been exercised before its termination, Johnson &
Johnson will be entitled to purchase the option shares and the termination of
the option will not affect any rights under the stock option agreement. If
Johnson & Johnson receives notice that a regulatory approval required for the
purchase of any option shares under the option will not be issued or granted or
such regulatory approval has not been issued or granted within six months of the
date of the exercise notice, Johnson & Johnson will have the right to exercise
its cash-out right with respect to the option shares for which such regulatory
approval will not be issued or granted or has not been issued or granted.

ADJUSTMENTS TO NUMBER AND TYPE OF SHARES

     The number and type of securities subject to the option and the purchase
price will be adjusted for any change in the common stock subject to the option
by reason of a stock dividend, split-up, merger, recapitalization, combination,
exchange of shares or similar transaction, such that Johnson & Johnson will
receive, upon exercise of the option, the number and type of securities that it
would have received if the option had been exercised immediately before the
occurrence of such event, or the record date of such event. If any additional
shares of ALZA common stock are issued after the date of the stock option
agreement, or if the number of outstanding shares of ALZA common stock is
reduced, the number of shares of ALZA common stock subject to the option will be
adjusted so that, after such issuance or reduction, it equals the same
percentage of the aggregate number of issued and outstanding shares of ALZA
common stock as it did prior to such issuance or reduction. The agreement
provides further that in
                                        51
   58

no event may the number of shares of ALZA common stock subject to the option
exceed 19.9% of the issued and outstanding shares of ALZA common stock at the
time of exercise of the option not including the shares issued pursuant to such
exercise.

     If ALZA agrees to (1) consolidate with or merge into any person other than
Johnson & Johnson or one of its subsidiaries, (2) permit any person other than
Johnson & Johnson or one of its subsidiaries to merge into it or (3) sell or
otherwise transfer all or substantially all of its assets to any person other
than Johnson & Johnson or one of its subsidiaries, then the agreement governing
that transaction must provide that the option will, upon the completion of such
transaction, be converted into or exchanged for an option to acquire the number
and class of shares or other securities or property Johnson & Johnson would have
received in respect of ALZA common stock if the option had been exercised
immediately prior to such consolidation, merger, sale or transfer, or the record
date of such event.

CASH PAYMENTS FOR THE OPTION

     Instead of purchasing shares of common stock under the option, Johnson &
Johnson may exercise its right to have ALZA pay to Johnson & Johnson an amount
per share of ALZA common stock equal to the number of shares of ALZA's common
stock subject to the option multiplied by the difference between:

     - the average closing price on the New York Stock Exchange of shares of
       ALZA's common stock for the 10 trading days commencing on the 12th
       trading day immediately preceding the date on which Johnson & Johnson
       notifies ALZA of its exercise of the option and

     - the per share exercise price of the option.

LIMITATION ON TOTAL PROFIT

     In addition, the stock option agreement provides that in no event will
Johnson & Johnson's total profit from the option exceed $180 million in the
aggregate and, if Johnson & Johnson's total profit from the option would
otherwise exceed such amount, Johnson & Johnson is required to:

     - reduce the number of shares of common stock subject to the option

     - deliver to ALZA for cancelation shares of ALZA common stock previously
       purchased by Johnson & Johnson

     - pay cash to ALZA or

     - do any combination of the foregoing, so that Johnson & Johnson's total
       profit from the option does not exceed $180 million after taking into
       account the foregoing actions.

REGISTRATION RIGHTS AND LISTING

     Johnson & Johnson has certain rights to require registration by ALZA of any
shares purchased under the option under the securities laws if necessary for
Johnson & Johnson to be able to sell such shares and to require the listing of
such shares on the New York Stock Exchange or other national securities exchange
or national securities quotation system.

ASSIGNABILITY

     The stock option agreement may not be assigned or delegated by Johnson &
Johnson or ALZA without the prior written consent of the other. Shares of ALZA
common stock received by Johnson & Johnson pursuant to an exercise of the option
may not be sold, assigned, transferred or otherwise disposed of except in an
underwritten public offering or to a purchaser or transferee who would not,
immediately after such sale, assignment, transfer or disposal, beneficially own
more than 5.0% of the outstanding voting power of ALZA stockholders; provided,
however, that Johnson & Johnson is permitted to sell any shares if the sale is
made in connection with a tender or exchange offer that has been approved or
recommended by a majority of the ALZA board of directors.

                                        52
   59

EFFECT OF STOCK OPTION AGREEMENT

     The stock option agreement is intended to increase the likelihood that the
merger will be completed on the terms set forth in the merger agreement.
Consequently, certain aspects of the stock option agreement may discourage
persons who might now or prior to the effective time of the merger be interested
in acquiring all or a significant interest in ALZA from considering or proposing
such an acquisition, even if such persons were prepared to offer higher
consideration per share for ALZA common stock than that implicit in the 0.49
exchange ratio or a higher price per share for ALZA common stock than the market
price.

                                        53
   60

                     COMPARATIVE STOCK PRICES AND DIVIDENDS

     Johnson & Johnson common stock is listed for trading on the New York Stock
Exchange under the trading symbol "JNJ" and ALZA common stock is listed for
trading on the New York Stock Exchange under the trading symbol "AZA". The
following table sets forth, for the periods indicated, dividends declared and
the high and low sales prices per share of Johnson & Johnson common stock and of
ALZA common stock as reported by the Dow Jones & Company, Inc. The prices of
ALZA common stock have been adjusted to reflect a two-for-one stock split
effected in November 2000. For current price information, ALZA stockholders are
urged to consult publicly available sources.



                                         JOHNSON & JOHNSON
                                            COMMON STOCK                   ALZA COMMON STOCK
                                   ------------------------------    -----------------------------
                                                        DIVIDENDS                        DIVIDENDS
CALENDAR PERIOD                     HIGH       LOW      DECLARED      HIGH      LOW      DECLARED
---------------                    -------    ------    ---------    ------    ------    ---------
                                                                       
1997
  First Quarter..................  $ 62.75    $48.63      $0.19      $15.69    $12.38         --
  Second Quarter.................    66.88     51.13       0.22       15.69     12.75         --
  Third Quarter..................    65.88     55.13       0.22       16.25     14.03         --
  Fourth Quarter.................    67.31     52.63       0.22       15.91     12.44         --
1998
  First Quarter..................    76.44     63.38       0.22       22.79     15.44         --
  Second Quarter.................    77.88     67.06       0.25       26.44     20.25         --
  Third Quarter..................    80.81     68.13       0.25       22.75     16.88         --
  Fourth Quarter.................    89.75     72.63       0.25       27.00     19.28         --
1999
  First Quarter..................    94.00     77.00       0.25       27.88     18.91         --
  Second Quarter.................   103.00     87.81       0.28       25.53     15.50         --
  Third Quarter..................   105.88     90.00       0.28       26.78     20.84         --
  Fourth Quarter.................   106.88     90.13       0.28       24.81     14.81         --
2000
  First Quarter..................    96.94     66.13       0.28       19.75     15.94         --
  Second Quarter.................   101.88     70.00       0.32       30.81     18.50         --
  Third Quarter..................   101.44     90.25       0.32       44.28     27.97         --
  Fourth Quarter.................   105.94     89.19       0.32       47.00     35.50         --
2001
  First Quarter..................   104.69     80.50       0.32       44.75     26.20         --
  Second Quarter (through
     --, 2001)...................       --        --         --          --        --         --


     The following table sets forth the high, low and last reported sales prices
per share of Johnson & Johnson common stock and of ALZA common stock as reported
by the Dow Jones & Company, Inc. and the market value of a share of ALZA common
stock on an equivalent per share basis, in each case on March 26, 2001, the last
full trading day prior to the public announcement of the proposed merger, and on
--, 2001, the last practicable trading day before the date of this proxy
statement/prospectus. The equivalent price per share data for ALZA common stock
has been determined by multiplying the last reported sale price of a share of
Johnson & Johnson common stock on each of these dates by the exchange ratio of
0.49.



                                    JOHNSON & JOHNSON                    ALZA               EQUIVALENT PRICE
                                       COMMON STOCK                  COMMON STOCK             PER SHARE OF
                                --------------------------    --------------------------          ALZA
                                 HIGH      LOW      CLOSE      HIGH      LOW      CLOSE       COMMON STOCK
                                ------    ------    ------    ------    ------    ------    ----------------
                                                                       
March 26, 2001................  $87.50    $85.02    $85.38    $38.85    $36.85    $38.75         $41.84
--, 2001......................      --        --        --        --        --        --             --


                                        54
   61

                 DESCRIPTION OF JOHNSON & JOHNSON CAPITAL STOCK

     The following summary of the capital stock of Johnson & Johnson is subject
in all respects to applicable New Jersey law, the Johnson & Johnson restated
certificate of incorporation, as amended, and the Johnson & Johnson by-laws. See
"Comparison of Rights of Common Stockholders of Johnson & Johnson and ALZA" on
page 56 and "Where You Can Find More Information" on page 68.

     The total authorized shares of capital stock of Johnson & Johnson consist
of (1) 2,160,000,000 shares of common stock, par value $1.00 per share, and (2)
2,000,000 shares of preferred stock, without par value. At the close of business
on --, 2001, approximately -- shares of Johnson & Johnson common stock were
issued and outstanding and no shares of Johnson & Johnson preferred stock were
issued and outstanding.

     The Johnson & Johnson board of directors is authorized to provide for the
issuance from time to time of Johnson & Johnson preferred stock in series and,
as to each series, to fix the designation, the dividend rate and the
preferences, if any, which dividends on that series will have compared to any
other class or series of capital stock of Johnson & Johnson, the voting rights,
if any, the voluntary and involuntary liquidation prices, the conversion or
exchange privileges, if any, applicable to that series and the redemption price
or prices and the other terms of redemption, if any, applicable to that series.
Cumulative dividends, dividend preferences and conversion, exchange and
redemption provisions, to the extent that some or all of these features may be
present when shares of Johnson & Johnson preferred stock are issued, could have
an adverse effect on the availability of earnings for distribution to the
holders of Johnson & Johnson common stock or for other corporate purposes.

                                        55
   62

                  COMPARISON OF RIGHTS OF COMMON STOCKHOLDERS
                         OF JOHNSON & JOHNSON AND ALZA

     Johnson & Johnson is a New Jersey corporation subject to the provisions of
the New Jersey Business Corporation Act, which we refer to as New Jersey law.
ALZA is a Delaware corporation subject to the provisions of the General
Corporation Law of the State of Delaware, which we refer to as Delaware law.
ALZA stockholders, whose rights are currently governed by the ALZA certificate
of incorporation, the ALZA by-laws and Delaware law, will, upon completion of
the merger, become stockholders of Johnson & Johnson and their rights will be
governed by the Johnson & Johnson certificate of incorporation, the Johnson &
Johnson by-laws and New Jersey law.

     The following description summarizes the material differences that may
affect the rights of stockholders of Johnson & Johnson and ALZA but does not
purport to be a complete statement of all those differences, or a complete
description of the specific provisions referred to in this summary. The
identification of specific differences is not intended to indicate that other
equally or more significant differences do not exist. Stockholders should read
carefully the relevant provisions of New Jersey law, Delaware law, the Johnson &
Johnson certificate of incorporation, the Johnson & Johnson by-laws, the ALZA
certificate of incorporation and the ALZA by-laws.

CAPITALIZATION

     JOHNSON & JOHNSON

     Johnson & Johnson's authorized capital stock is described under
"Description of Johnson & Johnson Capital Stock".

     ALZA

     The total authorized shares of capital stock of ALZA consist of (1)
1,000,000,000 shares of common stock, par value $0.005 per share, and (2)
100,000 shares of preferred stock, par value $0.01 per share. On the close of
business on --, 2001, approximately -- shares of ALZA common stock were issued
and outstanding and no shares of ALZA preferred stock were issued and
outstanding.

     The ALZA certificate of incorporation provides that shares of ALZA
preferred stock may be issued as a class, without series or, if so determined
from time to time by the ALZA board of directors, in one or more series. The
ALZA certificate of incorporation further provides that shares of ALZA preferred
stock, and each series thereof, will have the voting powers and other rights,
privileges, preferences and restrictions as set forth in the resolution of the
ALZA board of directors providing for the issuance of the shares of ALZA
preferred stock. The ALZA board of directors is expressly authorized to fix or
alter any and all the rights, preferences, privileges and restrictions and other
terms of the ALZA preferred stock and any series thereof, and the number of
shares constituting any such series and the designation thereof and to increase
or decrease the number of shares of any series subsequent to the issuance of
shares of such series, but not below the number of shares of such series then
outstanding.

NUMBER, ELECTION, VACANCY AND REMOVAL OF DIRECTORS

     JOHNSON & JOHNSON

     The Johnson & Johnson certificate of incorporation and the Johnson &
Johnson by-laws provide that the total number of Johnson & Johnson directors
will be not less than nine nor more than 18, as determined by the Johnson &
Johnson board of directors from time to time. Johnson & Johnson currently has 15
directors. All directors are elected at each annual meeting of stockholders to
serve until the next annual meeting. The Johnson & Johnson by-laws do not
provide for cumulative voting in the election of directors. The Johnson &
Johnson by-laws provide that vacancies on the Johnson & Johnson board of
directors will be filled by appointment made by a majority vote of the remaining
directors. The Johnson & Johnson certificate of incorporation and the Johnson &
Johnson by-laws provide that directors may be removed, with cause, by a majority
vote of the stockholders.

                                        56
   63

     ALZA

     The ALZA by-laws provide that the number of directors of ALZA is eight, but
may be increased or decreased from time to time either by a resolution or by-law
duly adopted by the ALZA board of directors. The ALZA certificate of
incorporation and by-laws provide that the ALZA board of directors will be
divided into three classes, which shall be as nearly equal in number as
possible. Each director serves for a term ending on the date of the third annual
meeting of stockholders following the annual meeting at which the director was
elected. The ALZA by-laws provide that any director may be removed from office,
only with cause, by the holders of a majority of the shares entitled to vote in
an election of directors. The ALZA certificate of incorporation and by-laws
provide that in the event of any increase or decrease in the authorized number
of directors, any newly-created or eliminated directorships resulting from such
increase or decrease shall be apportioned by the ALZA board of directors among
the three classes of directors so as to maintain such classes as nearly equal in
number as possible. No decrease in the number of directors constituting the ALZA
board of directors will shorten the term of any incumbent director.
Newly-created directorships resulting from any increase in the number of
directors and any vacancies on the ALZA board of directors resulting from death,
resignation, disqualification, removal or other cause shall be filled by the
affirmative vote of a majority of the remaining directors then in office (and
not by stockholders), even though less than a quorum of the ALZA board of
directors. Any director elected in accordance with the immediately preceding
sentence shall hold office for the remainder of the full term of the class of
directors in which the new directorship was created or the vacancy occurred and
until such director's successor shall have been elected and qualified.

AMENDMENTS TO CHARTER DOCUMENTS

     JOHNSON & JOHNSON

     Under New Jersey law, a proposed amendment to a corporation's certificate
of incorporation requires approval by its board of directors and an affirmative
vote of a majority of the votes cast by the holders of shares entitled to vote
on the amendment, unless a specific provision of New Jersey law or the
corporation's certificate of incorporation provides otherwise. The Johnson &
Johnson certificate of incorporation provides that if any class or series of
shares is entitled to vote thereon as a class, the affirmative vote of a
majority of the votes cast in each class is required. The Johnson & Johnson
certificate of incorporation also provides that the affirmative vote of the
holders of not less than 80% of the votes entitled to be cast by the holders of
all then outstanding shares of voting stock, voting together as a single class,
and the affirmative vote of a majority of the combined votes entitled to be cast
by "disinterested stockholders" voting together as a single class is required to
amend, repeal or adopt provisions inconsistent with Article Eight of the Johnson
& Johnson certificate of incorporation which relates to business combinations
with interested parties, unless the amendment, repeal or adoption is unanimously
recommended by the Johnson & Johnson board of directors if none of its directors
are affiliates or associates of any interested stockholder.

     ALZA

     Under Delaware law, an amendment to the certificate of incorporation of a
corporation requires the approval of the board of directors and the approval of
the holders of a majority of the outstanding stock entitled to vote upon the
proposed amendment. The holders of the outstanding shares of a class are
entitled to vote as a separate class on a proposed amendment that would:

     - increase or decrease the aggregate number of authorized shares of the
       class

     - increase or decrease the par value of the shares of the class or

     - alter or change the powers, preferences or special rights of the shares
       of the class, so as to affect them adversely.

                                        57
   64

     If any proposed amendment would alter or change the powers, preferences or
special rights of one or more series of any class so as to affect them
adversely, but would not so affect the entire class, then only the shares of the
series so affected by the amendment will be considered a separate class.

     The ALZA certificate of incorporation provides that ALZA reserves the right
to amend and repeal any provision contained in the ALZA certificate of
incorporation, and to take other corporate action to the extent and in the
manner permitted or prescribed by Delaware law, subject to the provisions of
Article 5(g) of the ALZA certificate of incorporation, which contains provisions
requiring the affirmative vote of not less than 75% of the ALZA board of
directors or the affirmative vote of not less than 80% of the outstanding shares
of capital stock of ALZA entitled to vote in an election of directors to amend
Article 5 of the ALZA certificate of incorporation, which contains provisions
relating to the ALZA board of directors, and Article 10 of the ALZA certificate
of incorporation, which contains provisions regarding certain transactions.

AMENDMENTS TO BY-LAWS

     JOHNSON & JOHNSON

     Under New Jersey law, the Johnson & Johnson certificate of incorporation
and the Johnson & Johnson by-laws, the Johnson & Johnson by-laws generally may
be amended or repealed in whole or in part by the stockholders at a regular or
special meeting of the stockholders or by the Johnson & Johnson board of
directors at a regular or special meeting of the board of directors, if notice
of the proposed amendment is contained in the notice of such meeting, except
that a by-law adopted or amended by the Johnson & Johnson board of directors may
be superseded by stockholder action and that stockholder action may preempt any
further action by the Johnson & Johnson board of directors with respect to that
by-law provision.

     ALZA

     Under Delaware law, unless a corporation's certificate of incorporation
provides otherwise, the stockholders entitled to vote have the power to adopt,
amend or repeal the corporation's by-laws. The ALZA certificate of incorporation
provides that in furtherance and not in limitation of the powers conferred by
Delaware law, the ALZA board of directors and ALZA stockholders are each
expressly authorized to adopt, amend or repeal the ALZA by-laws subject to any
particular provisions concerning amendments set forth in the ALZA certificate of
incorporation or by-laws. The ALZA by-laws provide that by-laws may be amended
or repealed or new by-laws may be adopted by ALZA stockholders or the ALZA board
or directors, except that no provision of Section 10 of the ALZA by-laws, which
contains provisions regarding certain transactions, may be amended except in
accordance with such Section 10 and no provision of Sections 16 of the ALZA
by-laws, which contains provisions regarding the number, classification and term
of directors, and no provision of Section 19 of the ALZA by-laws, which contains
provisions regarding newly-created directorships and vacancies of the ALZA board
of directors, may be amended or repealed except by resolution adopted by the
affirmative vote of not less than 75% of the ALZA board of directors or the
affirmative vote of the holders of not less than 80% of the outstanding shares
of capital stock of ALZA entitled to vote in an election of directors.

ACTION BY WRITTEN CONSENT

     JOHNSON & JOHNSON

     Under New Jersey law, any action required or permitted to be taken at a
meeting of stockholders may be taken without a meeting, without prior notice and
without a vote, upon the written consent of stockholders who would have been
entitled to cast the minimum number of votes which would be necessary to
authorize the action at a meeting at which all stockholders entitled to vote
thereon were present and voting; provided, however, that in case of an annual
meeting of stockholders for the election of directors, any consent in writing
must be unanimous.

                                        58
   65

     ALZA

     Under the ALZA certificate of incorporation, action required to be taken by
stockholders must be effected at a duly called annual or special meeting of
stockholders and may not be effected by any consent in writing of such
stockholders.

NOTICE OF STOCKHOLDER ACTIONS

     JOHNSON & JOHNSON

     New Jersey law and the Johnson & Johnson by-laws provide that written
notice of the time, place and purpose or purposes of every meeting of
stockholders must be given not less than 10 nor more than 60 days before the
date of the meeting, either personally or by mail, telegram or telex, to each
stockholder of record entitled to vote at the meeting. The Johnson & Johnson
by-laws further provide that the only matters that may be considered and acted
upon at an annual meeting of stockholders are those matters brought before the
meeting:

     - through the notice of meeting

     - by the Johnson & Johnson board of directors or

     - by a stockholder of record entitled to vote at the meeting.

Generally, the Johnson & Johnson by-laws require a stockholder who intends to
bring matters before an annual meeting to provide advance notice of such
intended action not less than 120 days prior to the date of the proxy statement
relating to the prior year's annual meeting. The notice must contain a brief
description of the business desired to be brought before the meeting and must
identify any personal or other material interest of the stockholder in such
proposed business. The person presiding at the meeting will have the discretion
to determine whether any item of business was brought before such meeting in
compliance with the above procedures.

     ALZA

     The ALZA by-laws provide that a written notice of the place, date and time
of all meetings of stockholders shall be given not less than 10 days nor more
than 60 days before the date of any such meeting to each stockholder entitled to
vote at such meeting, except in the case of a stockholder meeting where
stockholders will vote on a merger of ALZA, in which case Delaware law requires
notice to be provided to each stockholder not less than 20 days prior to the
meeting. The ALZA by-laws further provide that the only matters that may be
considered and acted upon at an annual meeting of stockholders are those matters
brought before the meeting:

     - through the notice of meeting

     - by the ALZA board of directors or

     - by a stockholder of ALZA upon proper written notice.

Such notice shall set forth the name and address of the person advancing the
proposal, any material interest of such person in the proposal and such other
information concerning the person making such proposal and the proposal itself
as would be required by the appropriate rules and regulations of the Securities
and Exchange Commission to be included in a proxy statement soliciting proxies
for the proposal. In order to be timely, a notice by an ALZA stockholder of
proposals shall be delivered to the Secretary of ALZA not later than 75 days
prior to the first anniversary of the date on which ALZA first mailed its proxy
materials for the preceding year's annual meeting of stockholders, except that
if the date of the annual meeting is advanced by more than 30 days prior to, or
delayed by more than 30 days after, the anniversary of the preceding year's
annual meeting, notice by the stockholder to be timely must be so delivered not
later than the close of business on the later of the 90th day prior to such
annual meeting or the 10th day following the day on which public announcement of
the date of such meeting is first made.

                                        59
   66

SPECIAL STOCKHOLDER MEETINGS

     JOHNSON & JOHNSON

     Under the Johnson & Johnson by-laws, a special meeting of the stockholders
may be called at any time by the chairman of the Johnson & Johnson board of
directors, a vice-chairman of the Johnson & Johnson board of directors, the
chairman of the executive committee, a vice-chairman of the executive committee,
the president or by a majority of the Johnson & Johnson board of directors, and
may be held on the business day and place stated in the notice of the meeting.

     In addition, New Jersey law provides that holders of not less than 10% of
all shares entitled to vote at a meeting may apply to the New Jersey Superior
Court to request that a special meeting of the stockholders be called for good
cause shown. At such a meeting, the stockholders present in person or by proxy
will constitute a quorum for the transaction of business described in such
order.

     ALZA

     Under Delaware law, a special meeting of stockholders may be called by the
board of directors or by other persons authorized by the certificate of
incorporation or the by-laws. The ALZA by-laws provide that special meetings of
the stockholders may only be called by the ALZA board of directors, the chairman
of the ALZA board of directors or the president of ALZA.

STOCKHOLDER INSPECTION RIGHTS; STOCKHOLDER LISTS

     JOHNSON & JOHNSON

     Under New Jersey law, a stockholder who has been a stockholder for at least
six months or who holds, or is authorized in writing by holders of, at least 5%
of the outstanding shares of any class or series of stock of a corporation has
the right, for any proper purpose and upon at least five days' written notice,
to inspect in person or by agent or attorney the minutes of the proceedings of
the corporation's stockholders and its record of stockholders. Irrespective of
the period such stockholder has held his, her or its stock or the amount of
stock such stockholder holds, a court may, upon proof of proper purpose, compel
production for examination by the stockholder of the books and records of
account, minutes and record of stockholders of Johnson & Johnson.

     ALZA

     Under Delaware law, any stockholder, in person or by attorney or other
agent, may, upon written demand given under oath and stating the purpose
thereof, inspect for any proper purpose ALZA's stock ledger, a list of its
stockholders and its other books and records. A proper purpose is a purpose
reasonably related to such person's interest as a stockholder. A complete list
of stockholders entitled to vote at any meeting of stockholders must be open to
the examination of any stockholder, for any purpose germane to the meeting, for
a period of at least 10 days prior to such meeting. The list must also be kept
at the place of the meeting during the whole time thereof and may be inspected
by any stockholder who is present.

LIMITATION OF PERSONAL LIABILITY AND INDEMNIFICATION OF DIRECTORS AND OFFICERS

     JOHNSON & JOHNSON

     Under New Jersey law, a corporation may indemnify a director or officer
against his or her expenses and liabilities in connection with any proceeding
involving the director or officer by reason of his or her being or having been a
director or officer, other than a proceeding by or in the right of the
corporation, if:

     - the director or officer acted in good faith and in a manner he or she
       reasonably believed to be in or not opposed to the best interests of the
       corporation and

     - with respect to any criminal proceeding, the director or officer had no
       reasonable cause to believe his or her conduct was unlawful.

                                        60
   67

     The Johnson & Johnson certificate of incorporation provides that, to the
full extent permitted under New Jersey law, no director or officer of Johnson &
Johnson will be personally liable to Johnson & Johnson or its stockholders for
damages for breach of any duty owed to Johnson & Johnson or its stockholders.

     The Johnson & Johnson by-laws provide that to the full extent permitted
under New Jersey law, Johnson & Johnson will indemnify any person who was or is
involved in any manner in any threatened, pending or completed investigation,
claim, action, suit or proceeding, whether civil, criminal, administrative,
arbitrative, legislative or investigative, or who is threatened with being so
involved, by reason of the fact that he or she is or was a director or officer
of Johnson & Johnson or, while serving as a director or officer of Johnson &
Johnson, is or was at the request of Johnson & Johnson also serving as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against all expenses (including attorneys'
fees), judgments, fines, penalties, excise taxes and amounts paid in settlement
actually and reasonably incurred in connection with such proceeding.

     Johnson & Johnson enters into indemnification agreements with its directors
and officers and enters into insurance agreements on its own behalf.

     ALZA

     The ALZA certificate of incorporation provides that no director shall be
held personally liable to the Company or its stockholders for monetary damages
of any kind for breach of fiduciary duty as a director, except for liability:

     - for any breach of a director's duty of loyalty to the corporation or its
       stockholders

     - for acts or omissions not in good faith or which involve intentional
       misconduct or a knowing violation of law

     - statutory liability for unlawful payment of dividends or unlawful stock
       purchase or redemption or

     - for any transaction from which the director derived an improper personal
       benefit.

     The ALZA certificate of incorporation provides that each person who was or
is made a party or is threatened to be made a party to or is involved in any
action, suit or proceeding whether civil, criminal, administrative or
investigative, because he or she, or a person of whom he or she is the legal
representative, is or was a director or officer of ALZA or is or was serving at
the request of ALZA as a director, officer, employee or agent of another
corporation or of a partnership, joint venture, trust or other enterprise
(including service with respect to employee benefit plans), whether the basis of
the proceeding is alleged action in an official capacity as a director, officer,
employee or agent or in any other capacity while serving as a director, officer,
employee or agent, shall be indemnified and held harmless by ALZA to the fullest
extent authorized by Delaware law, as the same exists or may be amended, but, in
the case of any such amendment, only to the extent that such amendment permits
ALZA to provide broader indemnification rights than Delaware law permitted ALZA
to provide before such amendment, against all expense, liability and loss
reasonably incurred or suffered by such person in connection therewith, except
that ALZA will indemnify any such person seeking indemnification in connection
with a proceeding initiated by such person only if the proceeding was authorized
by the ALZA board of directors. Such indemnification shall continue as to a
person who has ceased to be a director, officer, employee or agent and will
inure to the benefit of his or her heirs, executors and administrators.

     The right to indemnification conferred by the ALZA certificate of
incorporation is a contract right which may not be retroactively amended and
shall include the right to be paid by ALZA the expenses incurred in defending
any such proceeding in advance of its final disposition, except that, if
Delaware law requires, the payment of such expenses incurred by a director or
officer in his or her capacity as a director or officer, and not in any other
capacity in which service was or is rendered by such person while a director or
officer, including, without limitation, service with respect to an employee
benefit plan, in advance of the final disposition of the proceeding shall be
made only upon delivery to ALZA of an

                                        61
   68

undertaking, by or on behalf of such director or officer, to repay all amounts
so advanced if ultimately it shall be determined that such director or officer
is not entitled to be indemnified under the ALZA certificate of incorporation or
otherwise. ALZA may, by action of the ALZA board of directors, provide
indemnification to employees and agents of ALZA with the same scope and effect
as the indemnification of directors and officers.

     The ALZA certificate of incorporation further provides that the right to
indemnification and the payment of expenses incurred in defending a proceeding
in advance of its final disposition conferred in the ALZA certificate of
incorporation is not exclusive of any other right which any person may have or
acquire under any statute, provision of the ALZA certificate of incorporation or
by-laws, agreement, vote of stockholders or disinterested directors or
otherwise.

     The ALZA certificate of incorporation also provides that ALZA may maintain
insurance, at its expense, to protect itself and any director, officer, employee
or agent of ALZA or another corporation, partnership, joint venture, trust or
other enterprise against any such expense, liability or loss, whether or not
ALZA would have the power to indemnify such person against such expense,
liability or loss under Delaware law.

DIVIDENDS

     JOHNSON & JOHNSON

     The Johnson & Johnson certificate of incorporation provides that the
Johnson & Johnson board of directors may from time to time declare dividends on
its outstanding shares in accordance with New Jersey law.

     ALZA

     Delaware law provides that a corporation may pay dividends out of its
surplus or, if there is no surplus, out of its net profits for the fiscal year
in which the dividend is declared and for the preceding fiscal year. Delaware
law also provides that dividends may not be paid out of the net profits if,
after the payment of the dividend, the corporation's capital would be less than
the capital represented by the issued and outstanding stock of all classes
having a preference upon the distribution of assets.

CONVERSION

     JOHNSON & JOHNSON

     Holders of Johnson & Johnson common stock have no rights to convert their
shares into any other securities.

     ALZA

     Holders of ALZA common stock have no rights to convert their shares into
any other securities.

RIGHTS PLAN

     JOHNSON & JOHNSON

     Johnson & Johnson does not have a rights plan. New Jersey law, however,
endorses share rights or options issued by New Jersey corporations that, among
other things, include conditions precluding holders of a specified percentage of
outstanding shares of a corporation from exercising such share rights or options
or which invalidate the share rights or options beneficially owned by such
holders and their transferees.

     ALZA

     In December 1999, the ALZA board of directors adopted the ALZA rights
agreement and issued, as a dividend, one preferred stock purchase right for each
outstanding share of ALZA common stock. One

                                        62
   69

ALZA purchase right has also been issued with respect to each share of ALZA
common stock issued since the date of that dividend.

     Each ALZA purchase right entitles the holder to buy one unit (or 1/10,000
of a share) of ALZA's Series RP Preferred Stock at a price of $200 per unit,
subject to adjustment, or, under certain circumstances described below, shares
of ALZA common stock or common stock of a third party. The ALZA purchase rights
will be exercisable after the earlier of:

     - the first date after a public announcement that a person or group of
       affiliated or associated persons has acquired, obtained the right to
       acquire, or otherwise obtained beneficial ownership of 15% or more of the
       outstanding shares of ALZA common stock or

     - the close of business on the tenth date (or such later date as may be
       determined by the ALZA board of directors) after the commencement of, or
       the first public announcement of the intention to commence, a tender or
       exchange offer which would result in a person or group beneficially
       owning 15% or more of the outstanding shares of ALZA common stock.

     If a person or group beneficially owns 15% or more of the outstanding
shares of ALZA common stock, each holder of a ALZA purchase right may receive,
in lieu of shares of Series RP Preferred Stock, upon exercise of each purchase
right then held, shares of ALZA common stock with a market value equal to two
times the exercise price of a ALZA purchase right, except that purchase rights
owned by such acquiring person or group will be void. If, following the date
that a person or group becomes the beneficial owner of 15% or more of the
outstanding shares of ALZA common stock, ALZA is acquired in a merger or other
business combination, each ALZA purchase right will be exercisable, in lieu of
shares of Series RP Preferred Stock, for the number of the acquiring company's
shares of common stock having a market value equal to two times the exercise
price of the ALZA purchase right.

     ALZA may redeem the purchase rights at a price of $0.001 per purchase right
at any time prior to such time as any person or group becomes a beneficial owner
of 15% or more of the outstanding shares of ALZA common stock. Furthermore, at
any time prior to such time as any person or group becomes a beneficial owner of
15% or more of the outstanding shares of ALZA common stock, ALZA may amend or
supplement any provision of the rights agreement without the approval of any
holders of purchase rights.

     ALZA and Fleet National Bank (formerly BankBoston, N.A.), the rights agent
under the ALZA rights agreement entered into an amendment dated as of March 26,
2001 to the ALZA rights agreement to render the ALZA rights agreement
inapplicable to the execution and delivery of the merger agreement or the stock
option agreement or the completion of the transactions contemplated thereby.

VOTING RIGHTS; REQUIRED VOTE FOR AUTHORIZATION OF CERTAIN ACTIONS

     JOHNSON & JOHNSON

     Each holder of Johnson & Johnson common stock is entitled to one vote for
each share held of record and may not cumulate votes for the election of
directors.

     Merger or Consolidation.  Under New Jersey law, the consummation of a
merger or consolidation of a New Jersey corporation organized prior to January
1, 1969, such as Johnson & Johnson, requires the approval of such corporation's
board of directors and the affirmative vote of two-thirds of the votes cast by
the holders of shares of the corporation entitled to vote thereon; however, no
such approval and vote are required if such corporation is the surviving
corporation and

     - such corporation's certificate of incorporation is not amended

     - the stockholders of the surviving corporation whose shares were
       outstanding immediately before the effective date of the merger will hold
       the same number of shares, with identical designations, preferences,
       limitations, and rights, immediately after and

                                        63
   70

     - the number of voting shares and participation shares outstanding after
       the merger will not exceed by 40% the total number of voting or
       participating shares of the surviving corporation before the merger.

Similarly, a sale of all or substantially all of such corporation's assets other
than in the ordinary course of business, or a voluntary dissolution of such
corporation, requires the approval of such corporation's board of directors and
the affirmative vote of two-thirds of the votes cast by the holders of shares of
such corporation entitled to vote thereon.

     Business Combinations.  Under New Jersey law, no New Jersey corporation may
engage in any "business combination" with any interested stockholder (generally,
a 10% or greater stockholder) for a period of five years following such
interested stockholder's stock acquisition, unless such business combination is
approved by the board of directors of such corporation prior to the stock
acquisition.

     Under New Jersey law, "business combination" includes:

     - any merger or consolidation of a resident domestic corporation or one of
       its subsidiaries:

        - with an interested stockholder or

        - with any corporation which is, or would be after such merger or
          consolidation, an affiliate or associate of an interested stockholder

     - any transfer or other disposition to or with an interested stockholder or
       any affiliate or associate of an interested stockholder of at least 10%
       of (1) the assets, (2) the outstanding shares or (3) the earning power or
       income, on a consolidated basis, of such resident domestic corporation
       and

     - other specified self-dealing transactions between such resident domestic
       corporation and an interested stockholder or any affiliate or associate
       thereof.

     In addition, no resident domestic corporation may engage, at any time, in
any business combination with any interested stockholder of such corporation
other than:

     - a business combination approved by the board of directors of such
       corporation prior to the stock acquisition

     - a business combination approved by the affirmative vote of the holders of
       two-thirds of the voting stock not beneficially owned by such interested
       stockholder at a meeting called for such purpose or

     - a business combination in which the interested stockholder meets certain
       fair price criteria.

     In addition to the requirement under New Jersey law regarding business
combinations with an interested stockholder, the Johnson & Johnson certificate
of incorporation prohibits Johnson & Johnson from engaging in any "business
combination" with any interested stockholder (generally, a 10% or greater
stockholder) without (1) the affirmative vote of at least 80% of the votes
entitled to be cast by the holders of all then outstanding shares of Johnson &
Johnson voting stock, voting together as a single class, and (2) the affirmative
vote of a majority of the combined votes entitled to be cast by "disinterested
stockholders" (as defined in the all then outstanding shares of Johnson &
Johnson restated certificate of incorporation), voting together as a single
class; provided that any business combination will require only the approval
required under New Jersey law if, among other things, such business combination
has been approved at any time by a majority of the "continuing directors" (as
defined in the Johnson & Johnson restated certificate of incorporation) and
certain fair price requirements are met.

     The Johnson & Johnson certificate of incorporation defines "business
combination" to include:

     - any merger or consolidation of Johnson & Johnson

        - with an interested stockholder or

        - with any other corporation which is, or after such merger or
          consolidation would be, an affiliate or associate of an interested
          stockholder

                                        64
   71

     - any transfer or other disposition to or with any interested stockholder
       or any affiliate or associate of an interested stockholder of any assets
       or securities of Johnson & Johnson or any of its subsidiaries having an
       aggregate fair market value of 5% of the total assets of Johnson &
       Johnson and its subsidiaries

     - the adoption of a plan of liquidation of Johnson & Johnson proposed by an
       interested stockholder or any affiliate or associate of an interested
       stockholder and

     - any transaction which increases the capital stock beneficially owned by
       an interested stockholder or any affiliate or associate of an interested
       stockholder.

     ALZA

     Each holder of ALZA common stock is entitled to one vote for each share
held of record.

     Merger or Consolidation.  Under Delaware law, mergers or consolidations or
sales or exchanges of all or substantially all of a corporation's assets or a
dissolution of the corporation require the affirmative vote of the board of
directors (except in certain limited circumstances). In addition, the
affirmative vote of a majority of the outstanding stock of the corporation
entitled to vote on the matter is required, except in certain cases where
stockholder approval is not required by a corporation's certificate of
incorporation.

     Under Delaware law, stockholder consent is not required under the following
circumstances:

     - for a corporation that survives a merger and does not issue in the merger
       more than 20% of its outstanding shares immediately prior to the merger

     - if the merger agreement does not amend in any respect the survivor's
       certificate of incorporation

     - if each share of the surviving corporation outstanding immediately prior
       to the merger remains an identical outstanding share of the surviving
       corporation after the merger and

     - for either corporation where one corporation owns 90% of each class of
       outstanding stock of the other corporation.

     Business Combinations.  ALZA is subject to the anti-takeover provisions in
Delaware law. The anti-takeover provisions prohibit business combinations
between a Delaware corporation and an interested stockholder, as described
below, within three years of the time the interested stockholder became an
interested stockholder unless:

     - before that time, the board of directors approved either the business
       combination or the transaction in which the interested stockholder became
       an interested stockholder

     - upon completion of the transaction that resulted in the stockholder
       becoming an interested stockholder, the stockholder owned at least 85% of
       the voting stock of the corporation, excluding shares held by directors
       who are also officers of the corporation and by employee stock ownership
       plans that do not permit employees to determine confidentially whether
       shares held by the plan will be tendered in a tender or exchange offer or

     - on or following that time, the business combination is approved by the
       board of directors and the business combination transaction is approved
       by the holders of at least 66 2/3% of the outstanding voting stock of the
       corporation not owned by the interested stockholder.

     The business combination restrictions described above do not apply if:

     - the corporation's original certificate of incorporation contains a
       provision expressly electing not to be governed by the anti-takeover
       provisions in Delaware law

     - the holders of a majority of the voting stock of the corporation approve
       an amendment to its certificate of incorporation or by-laws expressly
       electing not to be governed by the anti-takeover provisions, which
       election will be effective 12 months after the amendment's adoption and
       would

                                        65
   72

       not apply to any business combination with a person who was an interested
       stockholder at or prior to the time the amendment was approved or

     - the corporation does not have a class of voting stock that is (1) listed
       on a national securities exchange, (2) authorized for quotation on The
       Nasdaq Stock Market or (3) owned by more than 2,000 stockholders of
       record.

     The anti-takeover provisions do not apply to a business combination that:

     - is proposed after the public announcement of, and before the consummation
       or abandonment of

        - a merger or consolidation of the corporation,

        - a sale of 50% or more of the aggregate market value of the assets of
          the corporation and its subsidiaries determined on a consolidated
          basis or the aggregate market value of all outstanding shares of the
          corporation or

        - a tender or exchange offer for 50% or more of the outstanding shares
          of voting stock of the corporation

     - is with a person who either was not an interested stockholder during the
       previous three years or who became an interested stockholder with the
       approval of the board of directors and

     - is approved by a majority of the current directors who were also
       directors before any person became an interested stockholder during the
       previous three years.

     An "interested stockholder" generally is defined as a person that owns 15%
or more of the corporation's outstanding voting stock and the affiliates and
associates of that person.

     The term "business combination" includes the following transactions with an
interested stockholder:

     - a merger or consolidation of the corporation with an interested
       stockholder

     - any sale, lease, exchange, mortgage, pledge, transfer or other
       disposition, except proportionately as a stockholder of the corporation,
       of assets of the corporation or its subsidiaries having an aggregate
       market value equal to 10% or more of either the aggregate market value of
       all assets of the corporation and its subsidiaries determined on a
       consolidated basis or the aggregate market value of all the outstanding
       stock of the corporation

     - any transaction which results in the issuance or transfer by the
       corporation or its subsidiaries of stock of the corporation or the
       subsidiary to the interested stockholder, except for transactions
       involving the exercise, conversion or exchange of securities outstanding
       before the interested stockholder became an interested stockholder and
       certain other transactions which do not increase the interested
       stockholder's proportionate share of any class or series of the
       corporation's stock

     - any transaction involving the corporation or any of its subsidiaries
       which increases the proportionate share of any class or series of stock,
       or securities convertible into the stock of any class or series, of the
       corporation or any subsidiary which is owned by the interested
       stockholder, except as a result of immaterial changes due to fractional
       share adjustments or as a result of any purchase or redemption of any
       shares of stock not caused by the interested stockholder or

     - any receipt by the interested stockholder of the benefit, except
       proportionately as a stockholder of the corporation, of any loans,
       advances, guarantees, pledges or other financial benefits provided by the
       corporation or its subsidiaries.

     In addition to the requirement under Delaware law regarding business
combinations with an interested stockholder, the ALZA certificate of
incorporation also provides that any business combination with a related person
requires the affirmative vote of the holders of at least 80% of the voting power
of all of the then outstanding shares of all classes of stock of ALZA entitled
to vote for the election of directors, voting together as a single class. Such
affirmative vote is required notwithstanding the fact that no vote may be
required, or that a lesser percentage may be specified, by Delaware law or in
any agreement.
                                        66
   73

     The provisions in the immediately preceding paragraph do not apply to any
business combination if:

     - a majority of the continuing directors of ALZA has approved the business
       combination either in advance of or subsequent to such related person's
       having become a related person;

     - the business combination is solely between ALZA and another company, one
       hundred percent of the voting stock of which is owned directly or
       indirectly by ALZA or

     - the business combination is a merger or consolidation and the cash or
       fair market value, as determined by a majority of the continuing
       directors, of the property, securities or other consideration to be
       received per share by holders of stock of ALZA in the business
       combination is not less than the highest per share price or the highest
       equivalent price paid by the related person in acquiring any of ALZA's
       stock.

     The ALZA certificate of incorporation defines "business combination" to
mean:

     - any merger or consolidation of ALZA with or into a related person

     - any sale, lease, exchange, transfer or other disposition, including,
       without limitation, a mortgage or any other security device, of all or
       any substantial part of the assets of ALZA or any subsidiary of ALZA, to
       a related person

     - any merger or consolidation of a related person with or into ALZA or a
       subsidiary of ALZA

     - the issuance of any securities of ALZA or a subsidiary of ALZA to a
       related person

     - any recapitalization that would have the effect of increasing the voting
       power in ALZA of a related person and

     - any agreement, contract or other arrangement providing for any of the
       transactions described in this definition of business combination.

     The ALZA certificate of incorporation defines a "related person" to mean:

     - any person, corporation or other entity which, alone or together with its
       affiliates and associates or

     - members of a group of which such person, company or other entity is a
       member, beneficially owns shares of the outstanding capital stock of ALZA
       which, in the aggregate, have 20% or more of the total combined power to
       elect directors of ALZA.

     The ALZA certificate of incorporation defines a "continuing director" to
mean a director who is unaffiliated with the related person and who was member
of the ALZA board of directors immediately prior to the time that the related
person involved in a business combination became a related person.

                                 LEGAL MATTERS

     The legality of Johnson & Johnson common stock offered by this proxy
statement/prospectus will be passed upon for Johnson & Johnson by Joseph S.
Orban, Esq., Associate General Counsel of Johnson & Johnson. Joseph S. Orban is
paid a salary by Johnson & Johnson, is a participant in various employee benefit
plans offered to employees of Johnson & Johnson generally and owns and has
options to purchase shares of Johnson & Johnson common stock.

     Certain United States Federal income tax consequences of the merger will be
passed upon for ALZA by its tax counsel, Heller Ehrman White & McAuliffe LLP,
Menlo Park, California. Heller Ehrman White & McAuliffe LLP from time to time
acts as counsel for ALZA and its subsidiaries. Julian N. Stern, who is the sole
employee of a professional corporation that is a member of Heller Ehrman White &
McAuliffe LLP, is Secretary of ALZA and a member of its board of directors. Mr.
Stern owns 153,150 shares of ALZA common stock and holds options to acquire an
additional 52,000 shares of ALZA common stock.

                                        67
   74

                                    EXPERTS

     The consolidated financial statements of Johnson & Johnson and subsidiaries
incorporated in this proxy statement/prospectus by reference to the Johnson &
Johnson Annual Report on Form 10-K for the fiscal year ended December 31, 2000,
have been so incorporated in reliance on the report of PricewaterhouseCoopers
LLP, independent accountants, given on the authority of said firm as experts in
auditing and accounting.

     The consolidated financial statements of ALZA and its subsidiaries
appearing in ALZA's Annual Report on Form 10-K for the fiscal year ended
December 31, 2000, have been audited by Ernst & Young LLP, independent auditors,
as set forth in their report thereon included therein and incorporated in this
proxy statement/prospectus by reference. Such consolidated financial statements
are incorporated by reference in this proxy statement/prospectus in reliance
upon such report given on the authority of such firm as experts in accounting
and auditing.

                                 OTHER MATTERS

     As of the date of this proxy statement/prospectus, the ALZA board of
directors knows of no matters that will be presented for consideration at the
special meeting other than as described in this proxy statement/prospectus.

                          FUTURE STOCKHOLDER PROPOSALS

     ALZA's 2001 annual meeting of stockholders is scheduled to take place on
May 3, 2001. ALZA will hold a 2002 annual meeting of ALZA stockholders only if
the merger is not completed before the time of such meeting. The deadline for
submission of stockholder proposals for inclusion in ALZA's proxy materials for
the 2001 ALZA annual meeting was December 15, 2000. The deadline for submission
of stockholder proposals for inclusion in ALZA's proxy materials for the 2002
annual meeting is November 30, 2001. If the merger is not completed, ALZA
stockholders may present proper proposals for consideration at the 2002 annual
meeting of ALZA stockholders by submitting their proposal in writing to the
Secretary of ALZA.

     Separate from the requirements described above concerning the notice
required for a proposal to be included in the proxy statement distributed by
ALZA, the ALZA by-laws also provide for certain advance notice of nominations by
stockholders for election of stockholder nominees as directors at an annual
meeting, and proposals for the inclusion of other business at an annual meeting
of stockholders, even if such nominations or proposals are not to be included in
the ALZA proxy statement. In addition to meeting other requirements specified in
the ALZA by-laws, the required notice by the stockholder for the 2002 annual
meeting must be received in writing by the Secretary of ALZA no later than
January 14, 2002; provided, however, that if the date of the 2002 annual meeting
is advanced more than 30 days prior to, or delayed by more than 30 days after,
the anniversary of the 2001 annual meeting, the stockholders notice must be
received no later than the close of business on the later of (1) the 90th day
prior to such annual meeting or (2) the 10th day following the day on which
public announcement of the meeting is first made.

                      WHERE YOU CAN FIND MORE INFORMATION

     Johnson & Johnson and ALZA file annual, quarterly and special reports,
proxy statements and other information with the Securities and Exchange
Commission. You may read and copy any reports, statements or other information
that Johnson & Johnson and ALZA file with the Securities and Exchange

                                        68
   75

Commission at the Securities and Exchange Commission's public reference rooms at
the following locations:


                                                          
   Public Reference Room          New York Regional Office        Chicago Regional Office
   450 Fifth Street, N.W.           7 World Trade Center              Citicorp Center
         Room 1024                       Suite 1300               500 West Madison Street
   Washington, D.C. 20549            New York, NY 10048                  Suite 1400
                                                                   Chicago, IL 60661-2511


     Please call the Securities and Exchange Commission at 1-800-SEC-0330 for
further information on the public reference rooms. These Securities and Exchange
Commission filings are also available to the public from commercial document
retrieval services and at the website maintained by the Securities and Exchange
Commission at "http://www.sec.gov". Reports, proxy statements and other
information concerning Johnson & Johnson and ALZA may also be inspected at the
offices of the New York Stock Exchange at 20 Broad Street, New York, New York
10005.

     Johnson & Johnson filed a registration statement on Form S-4 on April 23,
2001 to register with the Securities and Exchange Commission the Johnson &
Johnson common stock to be issued to ALZA stockholders in the merger. This proxy
statement/prospectus is a part of that registration statement and constitutes a
prospectus of Johnson & Johnson in addition to being a proxy statement of ALZA.
As allowed by Securities and Exchange Commission rules, this proxy
statement/prospectus does not contain all the information you can find in
Johnson & Johnson's registration statement or the exhibits to the registration
statement.

     The Securities and Exchange Commission allows Johnson & Johnson and ALZA to
"incorporate by reference" information into this proxy statement/prospectus,
which means that the companies can disclose important information to you by
referring you to other documents filed separately with the Securities and
Exchange Commission. The information incorporated by reference is considered
part of this proxy statement/prospectus, except for any information superseded
by information contained directly in this proxy statement/prospectus or in later
filed documents incorporated by reference in this proxy statement/prospectus.

     This proxy statement/prospectus incorporates by reference the documents set
forth below that Johnson & Johnson and ALZA have previously filed with the
Securities and Exchange Commission. These documents contain important business
and financial information about Johnson & Johnson and ALZA that is not included
in or delivered with this proxy statement/prospectus.




                                             
JOHNSON & JOHNSON FILINGS                       PERIOD
(FILE NO. 001-03215)
Annual Report on Form 10-K..................    Fiscal Year ended December 31, 2000

ALZA FILINGS                                    PERIOD
(FILE NO. 001-6247)
Annual Report on Form 10-K..................    Fiscal Year ended December 31, 2000, as
                                                amended by Amendment No. 1 thereto filed on
                                                Form 10-K/A on April 17, 2001
Current Report on Form 8-K..................    Filed March 28, 2001
The description of ALZA's capital stock set
forth in ALZA's registration statement on
Form 8-A, including any amendment or report
filed with the Securities and Exchange
Commission for purposes of updating such
description.................................    Filed May 14, 1992


     Johnson & Johnson and ALZA also incorporate by reference additional
documents that may be filed with the Securities and Exchange Commission under
Section 13(a), 13(c), 14 or 15(d) of the Exchange Act between the date of this
proxy statement/prospectus and, in the case of Johnson & Johnson, the date

                                        69
   76

of the completion of the merger, and, in the case of ALZA, the date of the
special meeting of ALZA's stockholders. These include periodic reports, such as
Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports
on Form 8-K, as well as proxy statements.

     Johnson & Johnson has supplied all information contained or incorporated by
reference in this proxy statement/prospectus relating to Johnson & Johnson and
ALZA has supplied all such information relating to ALZA.

     ALZA stockholders should not send in their ALZA certificates until they
receive the transmittal materials from the exchange agent. ALZA stockholders of
record who have further questions about their share certificates or the exchange
of their ALZA common stock for Johnson & Johnson common stock should contact the
exchange agent at the address or telephone number that will be included in the
transmittal materials.

     If you are a stockholder, we may have sent you some of the documents
incorporated by reference, but you can obtain any of them through the companies,
the Securities and Exchange Commission or the Securities and Exchange
Commission's website as described above. Documents incorporated by reference are
available from the companies without charge, excluding all exhibits, except that
if the companies have specifically incorporated by reference an exhibit in this
proxy statement/prospectus, the exhibit will also be provided without charge.
Stockholders may obtain documents incorporated by reference in this proxy
statement/prospectus by requesting them in writing or by telephone from the
appropriate company at the following addresses:


                                     
         Johnson & Johnson                        ALZA Corporation
    One Johnson & Johnson Plaza                 1900 Charleston Road
      New Brunswick, NJ 08933                 Mountain View, CA 94043
   Attention: Office of Corporate          Attention: Investor Relations
             Secretary                       Telephone: (650) 564-5222
     Telephone: (732) 524-2455


     You should rely only on the information contained or incorporated by
reference in this proxy statement/prospectus. We have not authorized anyone to
provide you with information that is different from what is contained in this
proxy statement/prospectus. This proxy statement/prospectus is dated --, 2001.
You should not assume that the information contained in this proxy
statement/prospectus is accurate as of any date other than that date. Neither
the mailing of this proxy statement/prospectus to stockholders nor the issuance
of Johnson & Johnson common stock in the merger creates any implication to the
contrary.

                                        70
   77

               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

     This proxy statement/prospectus contains certain forward-looking statements
within the meaning of the Private Securities Litigation Reform Act of 1995 with
respect to the financial condition, results of operations, business strategies,
operating efficiencies or synergies, competitive positions, growth opportunities
for existing products, plans and objectives of management, markets for stock of
Johnson & Johnson and ALZA and other matters. Statements in this proxy
statement/prospectus that are not historical facts are hereby identified as
"forward-looking statements" for the purpose of the safe harbor provided by
Section 21E of the Exchange Act and Section 27A of the Securities Act. Such
forward-looking statements, including, without limitation, those relating to the
future business prospects, revenues and income, in each case relating to Johnson
& Johnson and ALZA, wherever they occur in this proxy statement/prospectus, are
necessarily estimates reflecting the best judgment of the senior management of
Johnson & Johnson (with regard to matters relating to Johnson & Johnson) and
ALZA (with regard to matters relating to ALZA) and involve a number of risks and
uncertainties that could cause actual results to differ materially from those
suggested by the forward-looking statements. Such forward-looking statements
should, therefore, be considered in light of various important factors,
including those set forth in this proxy statement/prospectus. Important factors
that could cause actual results to differ materially from estimates or
projections contained in the forward-looking statements include without
limitation:

     - competitive factors, including technological advances achieved and
       patents attained by competitors and generic competition as patents on
       Johnson & Johnson's and ALZA's products expire and

     - government laws and regulations affecting domestic and foreign
       operations, including those relating to trade, monetary and fiscal
       policies, taxes, price controls, regulatory approval of new products and
       licensing.

     Words such as "estimate," "project," "plan," "intend," "expect," "believe"
and similar expressions are intended to identify forward-looking statements.
These forward-looking statements are found at various places throughout this
proxy statement/prospectus and the other documents incorporated by reference,
including, but not limited to, the Annual Report on Form 10-K for the year ended
December 31, 2000 of Johnson & Johnson, including any amendments, and the Annual
Report on Form 10-K for the year ended December 31, 2000 of ALZA, including any
amendments. Readers are cautioned not to place undue reliance on these
forward-looking statements, which speak only as of the date of this proxy
statement/prospectus. Neither Johnson & Johnson nor ALZA undertakes any
obligation to publicly update or release any revisions to these forward-looking
statements to reflect events or circumstances after the date of this proxy
statement/prospectus or to reflect the occurrence of unanticipated events.

     The foregoing list sets forth some, but not all, of the factors that could
impact upon Johnson & Johnson's and ALZA's ability to achieve results described
in any forward-looking statements. A further list and description of these and
other factors can be found in Exhibit 99(b) of Johnson & Johnson's Annual Report
on Form 10-K for the fiscal year ended December 31, 2000. Investors are
cautioned not to place undue reliance on such statements that speak only as of
the date made. Investors also should understand that it is not possible to
predict or identify all such factors and that this list should not be considered
a complete statement of all potential risks and uncertainties. Investors should
also realize that if underlying assumptions prove inaccurate or unknown risks or
uncertainties materialize, actual results could vary materially from Johnson &
Johnson's and ALZA's projections. Johnson & Johnson and ALZA undertake no
obligation to update any forward-looking statements as a result of future events
or developments.

                                        71
   78

                                                                         ANNEX 1
--------------------------------------------------------------------------------

                          AGREEMENT AND PLAN OF MERGER

                           DATED AS OF MARCH 26, 2001

                                     AMONG

                               JOHNSON & JOHNSON,

                            EXPRESS MERGER SUB INC.

                                      AND

                                ALZA CORPORATION

--------------------------------------------------------------------------------
   79

                               TABLE OF CONTENTS



                                                                                                           PAGE
                                                                                                           ----
                                                                                                     
                                                   ARTICLE I
                                                  THE MERGER
SECTION 1.01.  The Merger................................................................................   1-1
SECTION 1.02.  Closing...................................................................................   1-1
SECTION 1.03.  Effective Time............................................................................   1-1
SECTION 1.04.  Effects of the Merger.....................................................................   1-2
SECTION 1.05.  Certificate of Incorporation and By-laws..................................................   1-2
SECTION 1.06.  Directors.................................................................................   1-2
SECTION 1.07.  Officers..................................................................................   1-2

                                                  ARTICLE II
                         EFFECT OF THE MERGER ON THE CAPITAL STOCK OF THE CONSTITUENT
                                    CORPORATIONS; EXCHANGE OF CERTIFICATES
SECTION 2.01.  Effect on Capital Stock...................................................................   1-2
SECTION 2.02.  Exchange of Certificates..................................................................   1-3

                                                  ARTICLE III
                                        REPRESENTATIONS AND WARRANTIES
SECTION 3.01.  Representations and Warranties of the Company.............................................   1-5
SECTION 3.02.  Representations and Warranties of Parent and Merger Sub...................................  1-19

                                                  ARTICLE IV
                                   COVENANTS RELATING TO CONDUCT OF BUSINESS
SECTION 4.01.  Conduct of Business.......................................................................  1-22
SECTION 4.02.  No Solicitation...........................................................................  1-25

                                                   ARTICLE V
                                             ADDITIONAL AGREEMENTS
SECTION 5.01.  Preparation of the Form S-4 and the Proxy Statement; Stockholders' Meeting................  1-27
SECTION 5.02.  Letter of the Company's Accountants.......................................................  1-28
SECTION 5.03.  Letter of Parent's Accountants............................................................  1-28
SECTION 5.04.  Access to Information; Confidentiality....................................................  1-28
SECTION 5.05.  Commercially Reasonable Efforts...........................................................  1-29
SECTION 5.06.  Stock Options.............................................................................  1-29
SECTION 5.07.  Indemnification, Exculpation and Insurance; Company Grantor Trust.........................  1-30
SECTION 5.08.  Fees and Expenses.........................................................................  1-31
SECTION 5.09.  Public Announcements......................................................................  1-32
SECTION 5.10.  Affiliates................................................................................  1-32
SECTION 5.11.  Stock Exchange Listing....................................................................  1-32
SECTION 5.12.  Pooling of Interests......................................................................  1-32
SECTION 5.13.  Tax Treatment.............................................................................  1-32
SECTION 5.14.  Stockholder Litigation....................................................................  1-32
SECTION 5.15.  Rights Agreement..........................................................................  1-33
SECTION 5.16.  Employee Matters..........................................................................  1-33
SECTION 5.17.  Convertible Notes.........................................................................  1-35


                                       1-i
   80



                                                                                                           PAGE
                                                                                                           ----
                                                                                                     
                                                  ARTICLE VI
                                             CONDITIONS PRECEDENT
SECTION 6.01.  Conditions to Each Party's Obligation to Effect the Merger................................  1-35
SECTION 6.02.  Conditions to Obligations of Parent and Merger Sub........................................  1-36
SECTION 6.03.  Conditions to Obligation of the Company...................................................  1-37
SECTION 6.04.  Frustration of Closing Conditions.........................................................  1-37

                                                  ARTICLE VII
                                       TERMINATION, AMENDMENT AND WAIVER
SECTION 7.01.  Termination...............................................................................  1-37
SECTION 7.02.  Effect of Termination.....................................................................  1-38
SECTION 7.03.  Amendment.................................................................................  1-38
SECTION 7.04.  Extension; Waiver.........................................................................  1-38
SECTION 7.05.  Procedure for Termination or Amendment....................................................  1-38

                                                 ARTICLE VIII
                                              GENERAL PROVISIONS
SECTION 8.01.  Nonsurvival of Representations and Warranties.............................................  1-38
SECTION 8.02.  Notices...................................................................................  1-39
SECTION 8.03.  Definitions...............................................................................  1-39
SECTION 8.04.  Interpretation............................................................................  1-40
SECTION 8.05.  Counterparts..............................................................................  1-40
SECTION 8.06.  Entire Agreement; No Third-Party Beneficiaries............................................  1-40
SECTION 8.07.  Governing Law.............................................................................  1-41
SECTION 8.08.  Assignment................................................................................  1-41
SECTION 8.09.  Specific Enforcement; Consent to Jurisdiction.............................................  1-41
SECTION 8.10.  Severability..............................................................................  1-41

Annex I   Index of Defined Terms.........................................................................  1-43
Exhibit A  Form of Certificate of Incorporation of the Surviving Corporation.............................  1-45
Exhibit B  Form of Affiliate Letter......................................................................  1-46


                                       1-ii
   81

                              AGREEMENT AND PLAN OF MERGER (this "Agreement")
                         dated as of March 26, 2001, among JOHNSON & JOHNSON, a
                         New Jersey corporation ("Parent"), EXPRESS MERGER SUB
                         INC., a Delaware corporation and a wholly owned
                         Subsidiary of Parent ("Merger Sub"), and ALZA
                         CORPORATION, a Delaware corporation (the "Company").

     WHEREAS the respective Boards of Directors of Parent, Merger Sub and the
Company have approved and declared advisable this Agreement and the merger of
Merger Sub with and into the Company (the "Merger"), upon the terms and subject
to the conditions set forth in this Agreement, whereby each issued and
outstanding share of common stock, par value $.005 per share, of the Company
("Company Common Stock"), other than shares of Company Common Stock owned by
Parent, Merger Sub or the Company, will be converted into the right to receive
common stock, par value $1.00 per share, of Parent ("Parent Common Stock");

     WHEREAS, simultaneously with the execution and delivery of this Agreement,
Parent and the Company are entering into a stock option agreement (the "Option
Agreement"), pursuant to which the Company will grant to Parent an option (the
"Option") to purchase shares of Company Common Stock, upon the terms and subject
to the conditions set forth therein;

     WHEREAS, for Federal income tax purposes, it is intended that the Merger
shall qualify as a reorganization within the meaning of Section 368(a) of the
Internal Revenue Code of 1986, as amended (the "Code"), and that this Agreement
constitutes a plan of reorganization;

     WHEREAS, for financial accounting purposes, it is intended that the Merger
will be accounted for as a pooling of interests transaction; and

     WHEREAS Parent, Merger Sub and the Company desire to make certain
representations, warranties, covenants and agreements in connection with the
Merger and also to prescribe various conditions to the Merger.

     NOW, THEREFORE, in consideration of the representations, warranties,
covenants and agreements contained in this Agreement, the parties hereto agree
as follows:

                                   ARTICLE I

                                   THE MERGER

     SECTION 1.01.  The Merger.  Upon the terms and subject to the conditions
set forth in this Agreement, and in accordance with the General Corporation Law
of the State of Delaware (the "DGCL"), Merger Sub shall be merged with and into
the Company at the Effective Time. Following the Effective Time, the separate
corporate existence of Merger Sub shall cease and the Company shall continue as
the surviving corporation in the Merger (the "Surviving Corporation") and shall
succeed to and assume all the rights and obligations of Merger Sub in accordance
with the DGCL.

     SECTION 1.02.  Closing.  The closing of the Merger (the "Closing") will
take place at 10:00 a.m. on a date to be specified by the parties (the "Closing
Date"), which shall be no later than the second business day after satisfaction
or waiver of the conditions set forth in Article VI (other than those conditions
that by their terms are to be satisfied at the Closing, but subject to the
satisfaction or waiver of those conditions), at the offices of Cravath, Swaine &
Moore, Worldwide Plaza, 825 Eighth Avenue, New York, New York 10019, unless
another date or place is agreed to in writing by the parties hereto.

     SECTION 1.03.  Effective Time.  Subject to the provisions of this
Agreement, as soon as practicable on the Closing Date, the parties shall file a
certificate of merger (the "Certificate of Merger") executed in accordance with
the relevant provisions of the DGCL and, as soon as practicable on or after the
Closing Date, shall make all other filings or recordings required under the
DGCL. The Merger shall become effective at such time as the Certificate of
Merger is duly filed with the Secretary of State of the

                                       1-1
   82

State of Delaware, or at such other time as Parent and the Company shall agree
and shall specify in the Certificate of Merger (the time the Merger becomes
effective being the "Effective Time").

     SECTION 1.04.  Effects of the Merger.  The Merger shall have the effects
set forth in Section 259 of the DGCL.

     SECTION 1.05.  Certificate of Incorporation and By-laws.  (a) The
Certificate of Incorporation of the Surviving Corporation shall be amended at
the Effective Time to be in the form of Exhibit A and, as so amended, such
Certificate of Incorporation shall be the Certificate of Incorporation of the
Surviving Corporation until thereafter changed or amended as provided therein or
by applicable law.

     (b) The By-laws of Merger Sub, as in effect immediately prior to the
Effective Time, shall be the By-laws of the Surviving Corporation until
thereafter changed or amended as provided therein or by applicable law.

     SECTION 1.06.  Directors.  The directors of Merger Sub immediately prior to
the Effective Time shall be the directors of the Surviving Corporation until the
earlier of their resignation or removal or until their respective successors are
duly elected and qualified, as the case may be.

     SECTION 1.07.  Officers.  The officers of the Company immediately prior to
the Effective Time shall be the officers of the Surviving Corporation, until the
earlier of their resignation or removal or until their respective successors are
duly elected and qualified, as the case may be.

                                   ARTICLE II

                EFFECT OF THE MERGER ON THE CAPITAL STOCK OF THE
               CONSTITUENT CORPORATIONS; EXCHANGE OF CERTIFICATES

     SECTION 2.01.  Effect on Capital Stock.  As of the Effective Time, by
virtue of the Merger and without any action on the part of the holder of any
shares of Company Common Stock or any shares of capital stock of Merger Sub:

          (a) Capital Stock of Merger Sub.  Each issued and outstanding share of
     capital stock of Merger Sub shall be converted into and become one validly
     issued, fully paid and nonassessable share of common stock, par value $0.01
     per share, of the Surviving Corporation.

          (b) Cancelation of Treasury Stock and Parent-Owned Stock.  Each share
     of Company Common Stock that is owned by the Company, Parent or Merger Sub
     shall automatically be canceled and retired and shall cease to exist, and
     no shares of Parent Common Stock or other consideration shall be delivered
     in exchange therefor.

          (c) Conversion of Company Common Stock.  Subject to Section 2.02(e),
     each issued and outstanding share of Company Common Stock (other than
     shares to be canceled in accordance with Section 2.01(b)) shall be
     converted into the right to receive 0.49 (the "Exchange Ratio") validly
     issued, fully paid and nonassessable shares of Parent Common Stock (the
     "Merger Consideration"). As of the Effective Time, all such shares of
     Company Common Stock shall no longer be outstanding and shall automatically
     be canceled and retired and shall cease to exist, and each holder of a
     certificate which immediately prior to the Effective Time represented any
     such shares of Company Common Stock (each, a "Certificate") shall cease to
     have any rights with respect thereto, except the right to receive the
     Merger Consideration, any dividends or other distributions to which such
     holder is entitled pursuant to Section 2.02(c) and cash in lieu of
     fractional shares of Parent Common Stock to which such holder is entitled
     pursuant to Section 2.02(e), in each case to be issued or paid in
     consideration therefor upon surrender of such Certificate in accordance
     with Section 2.02(b), without interest. Notwithstanding the foregoing, if
     between the date of this Agreement and the Effective Time, the outstanding
     shares of Parent Common Stock shall have been changed into a different
     number of shares or a different class, by reason of the occurrence or
     record date of any stock dividend, subdivision, reclassification,
     recapitalization, split, combination, exchange of shares or similar

                                       1-2
   83

     transaction, the Exchange Ratio shall be appropriately adjusted to reflect
     such stock dividend, subdivision, reclassification, recapitalization,
     split, combination, exchange of shares or similar transaction.

     SECTION 2.02.  Exchange of Certificates.  (a) Exchange Agent.  As of the
Effective Time, Parent shall deposit with EquiServe Trust Company or such other
bank or trust company of similar size as may be designated by Parent (the
"Exchange Agent"), for the benefit of the holders of shares of Company Common
Stock, for exchange in accordance with this Article II, through the Exchange
Agent, certificates representing the shares of Parent Common Stock issuable
pursuant to Section 2.01 in exchange for outstanding shares of Company Common
Stock (such shares of Parent Common Stock, together with any dividends or other
distributions with respect thereto with a record date after the Effective Time
and any cash payments in lieu of any fractional shares of Parent Common Stock,
being hereinafter referred to as the "Exchange Fund").

     (b) Exchange Procedures.  As soon as reasonably practicable after the
Effective Time, Parent shall cause the Exchange Agent to mail to each holder of
record of a Certificate whose shares of Company Common Stock were converted into
the right to receive the Merger Consideration pursuant to Section 2.01(c), (i) a
letter of transmittal (which shall specify that delivery shall be effected, and
risk of loss and title to the Certificates shall pass, only upon delivery of the
Certificates to the Exchange Agent and shall be in such form and have such other
provisions as Parent may reasonably specify) and (ii) instructions for use in
surrendering the Certificates in exchange for certificates representing the
Merger Consideration, any dividends or other distributions to which holders of
Certificates are entitled pursuant to Section 2.02(c) and cash in lieu of any
fractional shares of Parent Common Stock to which such holders are entitled
pursuant to Section 2.02(e). Upon surrender of a Certificate for cancelation to
the Exchange Agent, together with such letter of transmittal, duly executed, and
such other documents as may reasonably be required by the Exchange Agent, the
holder of such Certificate shall be entitled to receive in exchange therefor (i)
a certificate representing that number of whole shares of Parent Common Stock
which such holder has the right to receive pursuant to the provisions of this
Article II after taking into account all the shares of Company Common Stock then
held by such holder under all such Certificates so surrendered, (ii) any
dividends or other distributions to which such holder is entitled pursuant to
Section 2.02(c) and (iii) cash in lieu of fractional shares of Parent Common
Stock to which such holder is entitled pursuant to Section 2.02(e), and the
Certificate so surrendered shall forthwith be canceled. In the event of a
transfer of ownership of shares of Company Common Stock that is not registered
in the transfer records of the Company, a certificate representing the proper
number of shares of Parent Common Stock may be issued to a person other than the
person in whose name the Certificate so surrendered is registered, if, upon
presentation to the Exchange Agent, such Certificate shall be properly endorsed
or otherwise be in proper form for transfer and the person requesting such
issuance shall pay any transfer or other taxes required by reason of the
issuance of shares of Parent Common Stock to a person other than the registered
holder of such Certificate or establish to the reasonable satisfaction of Parent
that such tax has been paid or is not applicable. Until surrendered as
contemplated by this Section 2.02(b), each Certificate shall be deemed at any
time after the Effective Time to represent only the right to receive upon such
surrender the Merger Consideration, any dividends or other distributions to
which the holder of such Certificate is entitled pursuant to Section 2.02(c) and
cash in lieu of fractional shares of Parent Common Stock to which such holder is
entitled pursuant to Section 2.02(e). No interest will be paid or will accrue on
any cash payable to holders of Certificates pursuant to Section 2.02(c) or
2.02(e).

     (c) Distributions with Respect to Unexchanged Shares.  No dividends or
other distributions with respect to Parent Common Stock with a record date after
the Effective Time shall be paid to the holder of any unsurrendered Certificate
with respect to the shares of Parent Common Stock that the holder thereof has
the right to receive upon the surrender thereof, and no cash payment in lieu of
fractional shares of Parent Common Stock shall be paid to any such holder
pursuant to Section 2.02(e), in each case until the holder of such Certificate
shall surrender such Certificate in accordance with this Article II. Following
surrender of any Certificate, there shall be paid to the record holder of the
certificate representing whole shares of Parent Common Stock issued in exchange
therefor, without interest, (i) at the time of such

                                       1-3
   84

surrender, the amount of any cash payable in lieu of a fractional share of
Parent Common Stock to which such holder is entitled pursuant to Section 2.02(e)
and the amount of dividends or other distributions with a record date after the
Effective Time theretofore paid with respect to such whole shares of Parent
Common Stock and (ii) at the appropriate payment date, the amount of dividends
or other distributions with a record date after the Effective Time but prior to
such surrender and a payment date subsequent to such surrender payable with
respect to such whole shares of Parent Common Stock.

     (d) No Further Ownership Rights in Company Common Stock.  All shares of
Parent Common Stock issued upon the surrender for exchange of Certificates in
accordance with the terms of this Article II (including any dividends or other
distributions paid pursuant to Section 2.02(c) and cash paid in lieu of
fractional shares pursuant to Section 2.02(e)) shall be deemed to have been
issued (and paid) in full satisfaction of all rights pertaining to the shares of
Company Common Stock previously represented by such Certificates, and after the
Effective Time there shall be no further registration of transfers on the stock
transfer books of the Surviving Corporation of the shares of Company Common
Stock that were outstanding immediately prior to the Effective Time. Subject to
the last sentence of Section 2.02(f), if, at any time after the Effective Time,
Certificates are presented to the Surviving Corporation or the Exchange Agent
for any reason, they shall be canceled and exchanged as provided in this Article
II.

     (e) No Fractional Shares.  (i) No certificates or scrip representing
fractional shares of Parent Common Stock shall be issued upon the surrender for
exchange of Certificates, no dividends or other distributions of Parent shall
relate to such fractional share interests and such fractional share interests
will not entitle the owner thereof to vote or to any rights of a shareholder of
Parent.

     (ii) In lieu of such fractional share interests, Parent shall pay to each
former holder of shares of Company Common Stock an amount in cash equal to the
product obtained by multiplying (A) the fractional share interest to which such
former holder (after taking into account all shares of Company Common Stock held
at the Effective Time by such holder) would otherwise be entitled by (B) the per
share closing price of Parent Common Stock on the Closing Date, as such price is
reported on the New York Stock Exchange, Inc. (the "NYSE") Composite
Transactions Tape (as reported by The Wall Street Journal (Northeast edition),
or, if not reported thereby, as reported by any other authoritative source).

     (f) Termination of Exchange Fund.  Any portion of the Exchange Fund that
remains undistributed to the holders of the Certificates for six months after
the Effective Time shall be delivered to Parent, upon demand, and any holders of
Certificates who have not theretofore complied with this Article II shall
thereafter look only to Parent for, and Parent shall remain liable for, payment
of their claim for the Merger Consideration, any dividends or other
distributions with respect to shares of Parent Common Stock and cash in lieu of
fractional shares of Parent Common Stock in accordance with this Article II. If
any Certificates shall not have been surrendered prior to five years after the
Effective Time (or immediately prior to such earlier date on which any Merger
Consideration (and all dividends or other distributions payable pursuant to
Section 2.02(c) and all cash payable in lieu of fractional shares pursuant to
Section 2.02(e)) would otherwise escheat to or become the property of any
Governmental Entity), any such Merger Consideration in respect thereof shall, to
the extent permitted by applicable law, become the property of the Parent, free
and clear of all claims or interest of any person previously entitled thereto.

     (g) No Liability.  None of Parent, Merger Sub, the Company or the Exchange
Agent shall be liable to any person in respect of any shares of Parent Common
Stock (or dividends or other distributions with respect thereto) or cash in lieu
of fractional shares of Parent Common Stock or cash from the Exchange Fund, in
each case delivered to a public official pursuant to any applicable abandoned
property, escheat or similar law.

     (h) Investment of Exchange Fund.  The Exchange Agent shall invest any cash
included in the Exchange Fund, as directed by Parent, on a daily basis. Any
interest and other income resulting from such investments shall be the property
of, and shall be paid to, Parent.

     (i) Lost Certificates.  If any Certificate shall have been lost, stolen or
destroyed, upon the making of an affidavit of that fact by the person claiming
such Certificate to be lost, stolen or destroyed and, if

                                       1-4
   85

required by Parent, the posting by such person of a bond in such reasonable
amount as Parent may direct as indemnity against any claim that may be made
against it with respect to such Certificate, the Exchange Agent will issue in
exchange for such lost, stolen or destroyed Certificate the Merger
Consideration, any dividends or other distributions to which the holder of such
Certificate would be entitled pursuant to Section 2.02(c) and cash in lieu of
fractional shares of Parent Common Stock to which such holder would be entitled
pursuant to Section 2.02(e), in each case pursuant to this Agreement.

     (j) Withholding Rights.  The Exchange Agent shall be entitled to deduct and
withhold from the consideration otherwise payable to any holder of shares of
Company Common Stock pursuant to this Agreement such amounts as may be required
to be deducted and withheld with respect to the making of such payment under the
Code, or under any provision of foreign tax law. If any withholding obligation
may be avoided by the holder providing information to the Exchange Agent, the
Exchange Agent shall request such information before withholding. To the extent
that amounts are so withheld and paid over to the appropriate taxing authority,
the Exchange Agent will be treated as though it withheld from the type of
consideration from which withholding is required, an appropriate amount
otherwise payable pursuant to this Agreement to any holder of shares of Company
Common Stock in order to provide for such withholding obligation. If withholding
is required from Parent Common Stock, the Exchange Agent shall be treated as
having sold such consideration for an amount of cash equal to the fair market
value of such consideration at the time of such deemed sale and paid such cash
proceeds to the appropriate taxing authority.

                                  ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

     SECTION 3.01.  Representations and Warranties of the Company.  Except as
disclosed in the Filed Company SEC Documents or as set forth in the disclosure
schedule delivered by the Company to Parent prior to the execution of this
Agreement (the "Company Disclosure Schedule"), the Company represents and
warrants to Parent and Merger Sub as follows:

          (a) Organization, Standing and Corporate Power.  Each of the Company
     and its Subsidiaries is a corporation duly organized, validly existing and
     in good standing under the laws of the jurisdiction in which it is
     incorporated and has all requisite corporate power and authority to carry
     on its business as now being conducted. Each of the Company and its
     Subsidiaries is duly qualified or licensed to do business and is in good
     standing in each jurisdiction in which the nature of its business or the
     ownership, leasing or operation of its properties makes such qualification
     or licensing necessary, other than in such jurisdictions where the failure
     to be so qualified or licensed individually or in the aggregate has not had
     and could not reasonably be expected to have a Material Adverse Effect. The
     Company has made available to Parent prior to the execution of this
     Agreement complete and correct copies of its Restated Certificate of
     Incorporation (the "Company Certificate") and its By-laws (the "Company
     By-laws"), in each case as amended to the date hereof.

          (b) Subsidiaries.  Schedule 3.01(b) of the Company Disclosure Schedule
     lists all the Subsidiaries of the Company and, for each such Subsidiary,
     the state of incorporation and, to the Knowledge of the Company, each
     jurisdiction in which such Subsidiary is qualified or licensed to do
     business. All the outstanding shares of capital stock of, or other equity
     interests in, each such Subsidiary have been validly issued and are fully
     paid and nonassessable and are owned directly or indirectly by the Company
     free and clear of all pledges, claims, liens, charges, encumbrances or
     security interests of any kind or nature whatsoever (collectively, "Liens",
     which term shall not include any licenses relating to Intellectual Property
     Rights), and free of any restriction on the right to vote, sell or
     otherwise dispose of such capital stock or other equity interests. No
     Subsidiary of the Company is a "significant subsidiary" as such term is
     defined in Rule 1-02 of Regulation S-X (17 C.F.R. Part 210).

                                       1-5
   86

          (c) Capital Structure.  The authorized capital stock of the Company
     consists of 1,000,000,000 shares of Company Common Stock and 100,000 shares
     of preferred stock, par value $0.01 per share ("Company Preferred Stock").
     At the close of business on March 23, 2001, (i) 238,524,403 shares of
     Company Common Stock were issued and outstanding, (ii) no shares of Company
     Common Stock were held by the Company in its treasury, (iii) 28,999,035
     shares of Company Common Stock were reserved for issuance pursuant to the
     Company Stock Plans (of which 17,273,535 shares of Company Common Stock
     were subject to outstanding options to purchase shares of Company Common
     Stock granted under the Company Stock Plans ("Stock Options")), (iv)
     24,307,949 shares of Company Common Stock were reserved for issuance upon
     conversion of the Company's 5 1/4% Liquid Yield Option Notes due 2014 (the
     "Notes"), (v) 15,289,430 shares of Company Common Stock were reserved for
     issuance upon conversion of the Company's 3% Zero Coupon Convertible
     Subordinated Debentures due 2020 (the "Debentures" and, together with the
     Notes, the "Convertible Notes"), (vi) no shares of Company Preferred Stock
     were issued or outstanding and (vii) 30,000 shares of Company Preferred
     Stock designated as Series RP Preferred Stock were reserved for issuance in
     connection with the Rights issued pursuant to the Rights Agreement. Except
     as set forth above in this Section 3.01(c), at the close of business on
     March 23, 2001, no shares of capital stock or other voting securities of
     the Company were issued, reserved for issuance or outstanding. Except as
     set forth above in this Section 3.01(c) and pursuant to the Option
     Agreement, there are no outstanding stock appreciation rights, rights to
     receive shares of Company Common Stock on a deferred basis or other rights
     that are linked to the value of Company Common Stock, granted under the
     Company Stock Plans or otherwise. The Company has provided to Parent on or
     prior to the date of this Agreement a complete and accurate summary, as of
     March 1, 2001, of all outstanding Stock Options or other rights to purchase
     or receive Company Common Stock granted under the Company Stock Plans or
     otherwise (other than pursuant to the Option Agreement), the number of
     shares of Company Common Stock subject thereto and the grant dates,
     expiration dates and exercise prices thereof. All outstanding shares of
     capital stock of the Company are, and all shares which may be issued
     pursuant to the Company Stock Plans will be, when issued in accordance with
     the terms thereof, duly authorized, validly issued, fully paid and
     nonassessable and not subject to preemptive rights. Except as set forth
     above in this Section 3.01(c), there are no bonds, debentures, notes or
     other indebtedness of the Company having the right to vote (or convertible
     into, or exchangeable for, securities having the right to vote) on any
     matters on which stockholders of the Company may vote. Except as set forth
     above in this Section 3.01(c) and for shares of Company Common Stock
     reserved for issuance and issuable pursuant to the Option Agreement, (x)
     there are not issued, reserved for issuance or outstanding (A) any shares
     of capital stock or other voting securities of the Company, (B) any
     securities of the Company convertible into or exchangeable or exercisable
     for shares of capital stock or voting securities of the Company or (C) any
     warrants, calls, options or other rights to acquire from the Company or any
     of its Subsidiaries, or any obligation of the Company or any of its
     Subsidiaries to issue, any capital stock, voting securities or securities
     convertible into or exchangeable or exercisable for capital stock or voting
     securities of the Company and (y) there are not any outstanding obligations
     of the Company or any of its Subsidiaries to repurchase, redeem or
     otherwise acquire any such securities or to issue, deliver or sell, or
     cause to be issued, delivered or sold, any such securities. Neither the
     Company nor any of its Subsidiaries is a party to any voting agreement with
     respect to the voting of any such securities. Except as set forth above in
     this Section 3.01(c), there are no outstanding (1) securities of the
     Company or any of its Subsidiaries convertible into or exchangeable or
     exercisable for shares of capital stock or voting securities or ownership
     interests in any Subsidiary of the Company, (2) warrants, calls, options or
     other rights to acquire from the Company or any of its Subsidiaries, and no
     obligation of the Company or any of its Subsidiaries to issue, any capital
     stock, voting securities or other ownership interests in, or any securities
     convertible into or exchangeable or exercisable for any capital stock,
     voting securities or ownership interests in, any Subsidiary of the Company
     or (3) obligations of the Company or any of its Subsidiaries to repurchase,
     redeem or otherwise acquire any such outstanding securities of any
     Subsidiary of the Company or to issue, deliver or sell, or cause to be
     issued, delivered or sold, any such securities.

                                       1-6
   87

          (d) Authority; Noncontravention.  The Company has all requisite
     corporate power and authority to enter into this Agreement and, subject to
     receipt of the Stockholder Approval, to consummate the transactions
     contemplated by this Agreement. The Company has all requisite corporate
     power and authority to enter into the Option Agreement and to consummate
     the transactions contemplated thereby. The execution and delivery of this
     Agreement and the Option Agreement by the Company and the consummation by
     the Company of the transactions contemplated by this Agreement and the
     Option Agreement have been duly authorized by all necessary corporate
     action on the part of the Company and no other corporate proceedings on the
     part of the Company are necessary to authorize this Agreement or the Option
     Agreement or to consummate the transactions contemplated hereby and
     thereby, subject, in the case of the Merger, to receipt of the Stockholder
     Approval. This Agreement and the Option Agreement have been duly executed
     and delivered by the Company and, assuming the due authorization, execution
     and delivery by each of the other parties hereto and thereto, constitute
     legal, valid and binding obligations of the Company, enforceable against
     the Company in accordance with their respective terms. The Board of
     Directors of the Company, at a meeting duly called and held, duly adopted
     resolutions (i) approving and declaring advisable this Agreement and the
     Option Agreement, the Merger and the other transactions contemplated by
     this Agreement and the Option Agreement, (ii) directing that the adoption
     of this Agreement be submitted to a vote at a meeting of the stockholders
     of the Company and (iii) recommending that the stockholders of the Company
     adopt this Agreement. The execution and delivery of this Agreement and the
     Option Agreement do not, and the consummation of the Merger and the other
     transactions contemplated by this Agreement and the Option Agreement and
     compliance with the provisions of this Agreement and the Option Agreement
     will not, conflict with, or result in any violation or breach of, or
     default (with or without notice or lapse of time, or both) under, or give
     rise to a right of termination, cancelation or acceleration of any
     obligation or to the loss of a benefit under, or result in the creation of
     any Lien in or upon any of the properties or other assets of the Company or
     any of its Subsidiaries under, (x) the Company Certificate or the Company
     By-laws or the comparable organizational documents of any of its
     Subsidiaries, (y) any loan or credit agreement, bond, debenture, note,
     mortgage, indenture, lease or other contract, agreement, obligation,
     commitment, arrangement, understanding, instrument, permit or license,
     whether oral or written, to which the Company or any of its Subsidiaries is
     a party or any of their respective properties or other assets is subject or
     (z) subject to the governmental filings and other matters referred to in
     the following sentence, any (A) statute, law, ordinance, rule or regulation
     or (B) order, writ, injunction, decree, judgment or stipulation, in each
     case applicable to the Company or any of its Subsidiaries or their
     respective properties or other assets, other than, in the case of clauses
     (y) and (z), any such conflicts, violations, breaches, defaults, rights,
     losses or Liens that individually or in the aggregate have not had and
     could not reasonably be expected to have a Material Adverse Effect. No
     consent, approval, order or authorization of, action by or in respect of,
     or registration, declaration or filing with, any Federal, state, local or
     foreign government, any court, administrative, regulatory or other
     governmental agency, commission or authority or any non-governmental
     self-regulatory agency, commission or authority (each, a "Governmental
     Entity") is required by or with respect to the Company or any of its
     Subsidiaries in connection with the execution and delivery of this
     Agreement or the Option Agreement by the Company or the consummation by the
     Company of the Merger or the other transactions contemplated by this
     Agreement or the Option Agreement, except for (1)(A) the filing of a
     premerger notification and report form by the Company under the
     Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the "HSR
     Act"), (B) the receipt of a decision under Article 6(1)(b) or 8(2) of
     Council Regulation No. 4064/89 of the European Community, as amended (the
     "EC Merger Regulation"), declaring the Merger compatible with the EC Common
     Market and (C) and any other applicable filings and approvals under similar
     foreign antitrust laws and regulations, (2) the filing with the Securities
     and Exchange Commission (the "SEC") of (A) a proxy statement relating to
     the adoption by the stockholders of the Company of this Agreement (as
     amended or supplemented from time to time, the "Proxy Statement") and (B)
     such reports under Section 13(a), 13(d), 15(d) or 16(a) of the Securities
     Exchange Act of 1934, as amended (the "Exchange Act"), as may be required
     in connection with this Agreement, the Option Agreement and the
     transactions contemplated by this

                                       1-7
   88

     Agreement or the Option Agreement, (3) the filing of the Certificate of
     Merger with the Secretary of State of the State of Delaware and appropriate
     documents with the relevant authorities of other states in which the
     Company is qualified to do business, (4) such filings with and approvals of
     the NYSE to permit the shares of Company Common Stock that are issuable
     pursuant to the Option Agreement to be listed on the NYSE and (5) such
     other consents, approvals, orders, authorizations, registrations,
     declarations and filings the failure of which to be obtained or made
     individually or in the aggregate has not had and could not reasonably be
     expected to have a Material Adverse Effect.

          (e) Company SEC Documents.  The Company has filed all reports,
     schedules, forms, statements and other documents (including exhibits and
     other information incorporated therein) with the SEC required to be filed
     by the Company since January 1, 1999 (such documents, together with any
     documents filed during such period by the Company with the SEC on a
     voluntary basis on Current Reports on Form 8-K, the "Company SEC
     Documents"). As of their respective dates, the Company SEC Documents
     complied in all material respects with the requirements of the Securities
     Act of 1933, as amended (the "Securities Act"), or the Exchange Act, as the
     case may be, and the rules and regulations of the SEC promulgated
     thereunder applicable to such Company SEC Documents, and none of the
     Company SEC Documents contained any untrue statement of a material fact or
     omitted to state a material fact required to be stated therein or necessary
     in order to make the statements therein, in light of the circumstances
     under which they were made, not misleading. Except to the extent that
     information contained in any Company SEC Document has been revised or
     superseded by a later-filed Company SEC Document, none of the Company SEC
     Documents contains any untrue statement of a material fact or omits to
     state any material fact required to be stated therein or necessary in order
     to make the statements therein, in light of the circumstances under which
     they were made, not misleading. The financial statements of the Company
     included in the Company SEC Documents comply as to form in all material
     respects with applicable accounting requirements and the published rules
     and regulations of the SEC with respect thereto, have been prepared in
     accordance with generally accepted accounting principles ("GAAP") (except,
     in the case of unaudited statements, as permitted by Form 10-Q of the SEC)
     applied on a consistent basis during the periods involved (except as may be
     indicated in the notes thereto) and fairly present the financial position
     of the Company and its consolidated Subsidiaries as of the dates thereof
     and the consolidated results of their operations and cash flows for the
     periods then ended (subject, in the case of unaudited statements, to normal
     year-end audit adjustments). Except as set forth in the most recent
     financial statements included in the Company SEC Documents filed by the
     Company and publicly available prior to the date of this Agreement (the
     "Filed Company SEC Documents") or for liabilities incurred in connection
     with this Agreement, neither the Company nor any of its Subsidiaries has
     any liabilities or obligations of any nature (whether accrued, absolute,
     contingent or otherwise) which, individually or in the aggregate, have had
     or could reasonably be expected to have a Material Adverse Effect.

          (f) Information Supplied.  None of the information supplied or to be
     supplied by the Company specifically for inclusion or incorporation by
     reference in (i) the registration statement on Form S-4 to be filed with
     the SEC by Parent in connection with the issuance of shares of Parent
     Common Stock in the Merger (as amended or supplemented from time to time,
     the "Form S-4") will, at the time the Form S-4 is filed with the SEC, at
     any time it is amended or supplemented and at the time it becomes effective
     under the Securities Act, contain any untrue statement of a material fact
     or omit to state any material fact required to be stated therein or
     necessary to make the statements therein, in light of the circumstances
     under which they are made, not misleading or (ii) the Proxy Statement will,
     at the date it is first mailed to the stockholders of the Company and at
     the time of the Stockholders' Meeting, contain any untrue statement of a
     material fact or omit to state any material fact required to be stated
     therein or necessary in order to make the statements therein, in light of
     the circumstances under which they are made, not misleading. The Proxy
     Statement will comply as to form in all material respects with the
     requirements of the Exchange Act and the rules and regulations thereunder,
     except that no representation or warranty is made by the Company with
     respect to statements made or incorporated by reference therein based on
     information supplied by Parent or Merger Sub specifically for inclusion or
     incorporation by reference in the Proxy Statement.

                                       1-8
   89

          (g) Absence of Certain Changes or Events.  Except for liabilities
     incurred in connection with this Agreement or the Option Agreement, since
     the date of the most recent audited financial statements included in the
     Filed Company SEC Documents, the Company and its Subsidiaries have
     conducted their respective businesses only in the ordinary course
     consistent with past practice, and there has not been (i) any Material
     Adverse Change, (ii) any declaration, setting aside or payment of any
     dividend or other distribution (whether in cash, stock or property) with
     respect to any of the Company's capital stock, (iii) any split, combination
     or reclassification of any of the Company's capital stock or any issuance
     or the authorization of any issuance of any other securities in respect of,
     in lieu of or in substitution for shares of its capital stock, (iv) (A) any
     granting by the Company or any of its Subsidiaries to any current or former
     director, executive officer or other employee listed in Section 3.01(g)(iv)
     of the Company Disclosure Schedule (each such other employee, a "Key
     Employee") of the Company or any of its Subsidiaries of any increase in
     compensation, bonus or other benefits, except for normal increases in cash
     compensation in the ordinary course of business consistent with past
     practice or as was required under employment agreements in effect as of the
     date of the most recent Filed Company SEC Document, (B) any granting by the
     Company or any of its Subsidiaries to any current or former director,
     executive officer or Key Employee of the Company of any of its Subsidiaries
     of any increase in severance or termination pay, except as was required
     under any employment, severance or termination agreement in effect as of
     the date of the most recent Filed Company SEC Document, (C) any entry by
     the Company or any of its Subsidiaries into, or any amendment of, (1) any
     employment, deferred compensation, consulting, severance, termination or
     indemnification agreement, arrangement or understanding with any current or
     former director, executive officer or Key Employee of the Company or any of
     its Subsidiaries or (2) any agreement with any current or former director,
     executive officer or Key Employee of the Company or any of its Subsidiaries
     the benefits of which are contingent, or the terms of which are materially
     altered, upon the occurrence of a transaction involving the Company of a
     nature contemplated by this Agreement (all such agreements under this
     clause (C), collectively, "Benefit Agreements"), (D) any amendment to, or
     modification of, any Stock Option or (E) any adoption of, or amendment to,
     a Benefit Plan; provided, that any such increases or amendments or new
     agreements not required to be disclosed by clauses (A) (other than normal
     increases in cash compensation in the ordinary course of business as
     provided therein), (B) and (C) of this subsection (iv) do not result in the
     aggregate in any material increase in compensation, benefits or other such
     expenses of the Company and its Subsidiaries, (v) any damage, destruction
     or loss, whether or not covered by insurance, that individually or in the
     aggregate has had or could reasonably be expected to have a Material
     Adverse Effect, (vi) any change in accounting methods, principles or
     practices by the Company materially affecting its assets, liabilities or
     businesses, except insofar as may have been required by a change in GAAP or
     (vii) any tax election material to the Company or any settlement or
     compromise of any material income tax liability.

          (h) Litigation.  There is no suit, action or proceeding pending or, to
     the Knowledge of the Company, threatened against or affecting the Company
     or any of its Subsidiaries that individually or in the aggregate has had or
     could reasonably be expected to have a Material Adverse Effect, nor is
     there any judgment, decree, injunction, rule or order of any Governmental
     Entity or arbitrator outstanding against, or, to the Knowledge of the
     Company, investigation by any Governmental Entity involving, the Company or
     any of its Subsidiaries that individually or in the aggregate has had or
     could reasonably be expected to have a Material Adverse Effect.

          (i) Contracts.  Neither the Company nor any of its Subsidiaries is a
     party to, and none of their respective properties or other assets is
     subject to, any contract or agreement that is of a nature required to be
     filed as an exhibit to a report or filing under the Securities Act or the
     Exchange Act and the rules and regulations promulgated thereunder other
     than agreements that are filed as an exhibit to the Filed Company SEC
     Documents. Neither the Company nor any of its Subsidiaries is in violation
     of or in default under (nor does there exist any condition which upon the
     passage of time or the giving of notice or both would cause such a
     violation of or default under) any loan or credit agreement, bond,
     debenture, note, mortgage, indenture, lease or other contract, agreement,
     obligation,

                                       1-9
   90

     commitment, arrangement, understanding, instrument, permit or license,
     whether oral or written, to which it is a party or by which it or any of
     its properties or other assets is bound, except for violations or defaults
     that individually or in the aggregate have not had and could not reasonably
     be expected to have a Material Adverse Effect. Neither the Company nor any
     of its Subsidiaries has entered into any material contract, agreement,
     obligation, commitment, arrangement or understanding with any Affiliate of
     the Company that is currently in effect other than agreements that are
     disclosed in the Filed Company SEC Documents. Neither the Company nor any
     of its Subsidiaries is a party to or otherwise bound by (i) any agreement
     or covenant not to compete or (ii) any agreement or covenant restricting in
     any respect the development, marketing or distribution of products or
     services, in each case that (x) would materially interfere with the conduct
     of the business of the Company or any Subsidiary of the Company as
     presently conducted or (y) binds or restricts by its terms any current
     Affiliate of the Company (other than the Company and the Subsidiaries of
     the Company) or, after giving effect to the consummation of the Merger,
     Parent or any of its operating Subsidiaries in a manner that is materially
     adverse to Parent or any of its operating Subsidiaries.

          (j) Compliance with Laws.  (i) Each of the Company and its
     Subsidiaries is in compliance with all statutes, laws, ordinances, rules,
     regulations, judgments, orders and decrees of any Governmental Entity
     (collectively, "Legal Provisions") applicable to it, its properties or
     other assets or its business or operations, except for instances of
     noncompliance or possible noncompliance that individually or in the
     aggregate have not had and could not reasonably be expected to have a
     Material Adverse Effect. Each of the Company and its Subsidiaries has in
     effect all approvals, authorizations, certificates, filings, franchises,
     licenses and permits from, and has submitted notices to, all Governmental
     Entities, including all authorizations under the Federal Food, Drug and
     Cosmetic Act of 1938, as amended (the "FDCA"), and the regulations of the
     Federal Food and Drug Administration (the "FDA") promulgated thereunder,
     and under Environmental Laws (collectively, "Permits"), necessary for it to
     own, lease or operate its properties and other assets and to carry on its
     business and operations as presently conducted, except for the failure to
     have such Permits or provide such notices that individually or in the
     aggregate has not had and could not reasonably be expected to have a
     Material Adverse Effect. There has occurred no default under, or violation
     of, any such Permit, except individually or in the aggregate as has not had
     and could not reasonably be expected to have a Material Adverse Effect. The
     consummation of the Merger, in and of itself, would not cause the
     revocation or cancelation of any such Permit that individually or in the
     aggregate could reasonably be expected to have a Material Adverse Effect.
     No action, demand, requirement or investigation by any Governmental Entity
     and no suit, action or proceeding by any other person, in each case with
     respect to the Company or any of its Subsidiaries or any of their
     respective properties or other assets under any Legal Provision, is pending
     or, to the Knowledge of the Company, threatened, other than, in each case,
     those the outcome of which individually or in the aggregate have not had
     and could not reasonably be expected to have a Material Adverse Effect.

          (ii) Except for those matters that individually or in the aggregate
     have not had and could not reasonably be expected to have a Material
     Adverse Effect: (A) each of the Company and its Subsidiaries is, and has
     been, in compliance with all applicable Environmental Laws; (B) during the
     period of ownership or operation by the Company or any of its Subsidiaries
     of any of their respective currently or previously owned, leased or
     operated properties, there have been no Releases or threatened Releases of
     Hazardous Materials in, on, under or affecting such properties or any
     surrounding sites; (C) prior to the period of ownership or operation by the
     Company or any of its Subsidiaries of any of their respective currently or
     previously owned, leased or operated properties, to the Knowledge of the
     Company, no Hazardous Materials were generated, treated, stored, disposed
     of, used, handled or manufactured at, or transported or disposed of at or
     from, such properties, and there were no Releases of Hazardous Materials
     in, on, under or affecting any such property or any surrounding site; (D)
     there is no investigation, suit, claim, action or proceeding pending, or to
     the Knowledge of the Company, threatened against or affecting the Company
     or any of its Subsidiaries relating to or arising under Environmental Laws,
     and neither the Company nor any of its Subsidiaries has received any notice
     of or entered into or assumed by contract or operation of law or otherwise,

                                       1-10
   91

     any obligation, liability, order, settlement, judgment, injunction or
     decree relating to or arising under Environmental Laws; and (E) to the
     Knowledge of the Company, there are no facts, circumstances or conditions
     that could reasonably be expected to form the basis for any suit, claim,
     action or proceeding against or affecting the Company or any of its
     Subsidiaries relating to or arising under Environmental Laws. The term
     "Environmental Laws" means all statutes, laws (including the common law),
     rules, regulations, codes, ordinances, orders, decrees, judgments,
     injunctions, notices, Permits or binding agreements issued, promulgated or
     entered into by any Governmental Entity, relating in any way to the
     environment, preservation or reclamation of natural resources, the
     presence, management, Release or threat of Release of, or exposure to,
     Hazardous Materials, or to human health and safety. The term "Hazardous
     Materials" means (A) petroleum products and by-products, asbestos and
     asbestos-containing materials, urea formaldehyde foam insulation, medical
     or infectious wastes, polychlorinated biphenyls, radon gas,
     chlorofluorocarbons and all other ozone-depleting substances or (B) any
     chemical, material, substance, waste, pollutant or contaminant that is
     prohibited, limited or regulated by or pursuant to any Environmental Law.
     The term "Release" means any spilling, leaking, pumping, pouring, emitting,
     emptying, discharging, injecting, escaping, leaching, dumping, disposing or
     migrating into or through the environment or any natural or man-made
     structure.

          (k) Absence of Changes in Benefit Plans; Labor Relations.  Since the
     date of the most recent audited financial statements included in the Filed
     Company SEC Documents, there has not been any adoption or amendment in any
     material respect by the Company or any of its Subsidiaries of any
     collective bargaining agreement or any employment, bonus, pension, profit
     sharing, deferred compensation, incentive compensation, stock ownership,
     stock purchase, stock appreciation, restricted stock, stock option, phantom
     stock, performance, retirement, thrift, savings, stock bonus, paid time
     off, perquisite, fringe benefit, vacation, severance, disability, death
     benefit, hospitalization, medical, welfare benefit or other plan, program,
     policy, arrangement or understanding (whether or not legally binding)
     maintained, contributed to or required to be maintained or contributed to
     by the Company or any of its Subsidiaries or any other person or entity
     that, together with the Company, is treated as a single employer under
     Section 414(b), (c), (m) or (o) of the Code (each, a "Commonly Controlled
     Entity"), in each case providing benefits to any current or former
     director, officer, employee or individual consultant of the Company or any
     of its Subsidiaries (collectively, the "Benefit Plans"), or any material
     change in any actuarial or other assumption used to calculate funding
     obligations with respect to any Pension Plans, or any change in the manner
     in which contributions to any Pension Plans are made or the basis on which
     such contributions are determined. There exist no currently binding Benefit
     Agreements other than those that are filed as exhibits to the Filed Company
     SEC Documents. There are no collective bargaining or other labor union
     agreements to which the Company or any of its Subsidiaries is a party or by
     which the Company or any of its Subsidiaries is bound. Since January 1,
     1999, neither the Company nor any of its Subsidiaries has encountered any
     labor union organizing activity or had any actual or threatened employee
     strikes, work stoppages, slowdowns or lockouts.

          (l) ERISA Compliance.  (i) Section 3.01(l)(i) of the Company
     Disclosure Schedule contains a complete and accurate list of each Benefit
     Plan that is an "employee pension benefit plan" (as defined in Section 3(2)
     of the Employee Retirement Income Security Act of 1974, as amended
     ("ERISA")) (sometimes referred to herein as a "Pension Plan"), each Benefit
     Plan that provides severance benefits, vacation, paid time off or bonus
     leave, each Benefit Plan that provides for the purchase or issuance of
     shares of capital stock, warrants, options, stock appreciation rights or
     other rights in respect of any shares of capital stock of any entity or any
     securities convertible or exchangeable into such shares, each "employee
     welfare benefit plan" (as defined in Section 3(1) of ERISA) that provides
     for medical, dental, life and disability insurance benefits, and each other
     material Benefit Plan. The Company has provided to Parent true, complete
     and correct copies of (A) each Benefit Plan required to be listed on
     Section 3.01(l)(i) of the Company Disclosure Schedule (or, in the case of
     any such Benefit Plan that is unwritten, descriptions thereof), (B) the two
     most recent annual reports on Form 5500 required to be filed with the
     Internal Revenue Service (the "IRS") with

                                       1-11
   92

     respect to each Benefit Plan (if any such report was required), (C) the
     most recent summary plan description for each Benefit Plan for which such
     summary plan description is required and (D) each trust agreement and
     insurance or group annuity contract relating to any Benefit Plan. Each
     Benefit Plan maintained, contributed to or required to be contributed to by
     the Company or any of its Subsidiaries has been administered in all
     material respects in accordance with its terms. The Company, its
     Subsidiaries and all the Benefit Plans are all in compliance in all
     material respects with the applicable provisions of ERISA, the Code and all
     other applicable laws, including laws of foreign jurisdictions.

          (ii) All Pension Plans maintained, contributed to or required to be
     contributed to by the Company or any of its Subsidiaries intended to be
     tax-qualified have been the subject of determination letters from the IRS
     to the effect that such Pension Plans are qualified and exempt from Federal
     income taxes under Sections 401(a) and 501(a), respectively, of the Code,
     no such determination letter has been revoked (or, to the Knowledge of the
     Company, has revocation been threatened) and, to the Knowledge of the
     Company, no event has occurred since the date of the most recent
     determination letter or application therefor relating to any such Pension
     Plan that would adversely affect the qualification of such Pension Plan or
     materially increase the costs relating thereto or require security under
     Section 307 of ERISA. All Pension Plans maintained, contributed to or
     required to be contributed to by the Company or any of its Subsidiaries
     required to have been approved by any foreign Governmental Entity have been
     so approved, no such approval has been revoked (or, to the Knowledge of the
     Company, has revocation been threatened) and, to the Knowledge of the
     Company, no event has occurred since the date of the most recent approval
     or application therefor relating to any such Pension Plan that would
     materially affect any such approval relating thereto or materially increase
     the costs relating thereto. The Company has delivered to Parent a true and
     complete copy of the most recent determination letter received with respect
     to each Pension Plan maintained, contributed to or required to be
     contributed to by the Company or any of its Subsidiaries, as well as a true
     and complete copy of each pending application for a determination letter,
     if any. The Company has also provided to Parent a true and complete list of
     all amendments to any Pension Plan maintained, contributed to or required
     to be contributed to by the Company or any of its Subsidiaries as to which
     a favorable determination letter has not yet been received.

          (iii) Neither the Company nor any Commonly Controlled Entity has (A)
     maintained, contributed to or been required to contribute to any Benefit
     Plan that is subject to Title IV of ERISA or (B) any unsatisfied liability
     under Title IV of ERISA.

          (iv) All material reports, returns and similar documents with respect
     to all Benefit Plans required to be filed with any Governmental Entity or
     distributed to any Benefit Plan participant have been duly and timely filed
     or distributed. The Company has received no notice of, and to the Knowledge
     of the Company, there are no investigations by any Governmental Entity with
     respect to, termination proceedings or other claims (except claims for
     benefits payable in the normal operation of the Benefit Plans), suits or
     proceedings against or involving any Benefit Plan or asserting any rights
     or claims to benefits under any Benefit Plan that could give rise to any
     material liability, and, to the Knowledge of the Company, there are not any
     facts that could give rise to any material liability in the event of any
     such investigation, claim, suit or proceeding.

          (v) All contributions, premiums and benefit payments under or in
     connection with the Benefit Plans that are required to have been made as of
     the date hereof in accordance with the terms of the Benefit Plans have been
     timely made or have been reflected on the most recent consolidated balance
     sheet filed or incorporated by reference into the Filed Company SEC
     Documents. No Pension Plan has an "accumulated funding deficiency" (as such
     term is defined in Section 302 of ERISA or Section 412 of the Code),
     whether or not waived.

          (vi) With respect to each Benefit Plan, (A) there has not occurred any
     prohibited transaction in which the Company or any of its Subsidiaries or
     any of their respective employees has engaged that could subject the
     Company or any of its Subsidiaries or any of their respective employees,
     or, to the

                                       1-12
   93

     Knowledge of the Company, a trustee, administrator or other fiduciary of
     any trust created under any Benefit Plan, to the tax or penalty on
     prohibited transactions imposed by Section 4975 of ERISA or the sanctions
     imposed under Title I of ERISA and (B) neither the Company nor any of its
     Subsidiaries nor, to the Knowledge of the Company, any trustee,
     administrator or other fiduciary of any Benefit Plan nor any agent of any
     of the foregoing, has engaged in any transaction or acted in a manner that
     could, or failed to act so as to, subject the Company or any of its
     Subsidiaries or, to the Knowledge of the Company, any trustee,
     administrator or other fiduciary, to any liability for breach of fiduciary
     duty under ERISA or any other applicable law. No Benefit Plan or related
     trust has been terminated, nor has there been any "reportable event" (as
     that term is defined in Section 4043 of ERISA) for which the 30-day
     reporting requirement has not been waived with respect to any Benefit Plan
     during the last five years, and no notice of a reportable event will be
     required to be filed in connection with the transactions contemplated by
     this Agreement.

          (vii) Section 3.01(l)(vii) of the Company Disclosure Schedule
     discloses whether each Benefit Plan that is an employee welfare benefit
     plan and which is required to be listed in Section 3.01(l)(i) of the
     Company Disclosure Schedule is (A) unfunded, (B) funded through a "welfare
     benefit fund", as such term is defined in Section 419(e) of the Code, or
     other funding mechanism or (C) insured. Each such employee welfare benefit
     plan may be amended or terminated (including with respect to benefits
     provided to retirees and other former employees) without material liability
     to the Company or any of its Subsidiaries at any time after the Effective
     Time. Each of the Company and its Subsidiaries complies in all material
     respects with the applicable requirements of Section 4980B(f) of the Code
     or any similar state statute with respect to each Benefit Plan that is a
     group health plan, as such term is defined in Section 5000(b)(1) of the
     Code or such state statute. Neither the Company nor any of its Subsidiaries
     has any material obligations for retiree health or life insurance benefits
     under any Benefit Plan that is required to be listed in Section 3.01(l)(i)
     of the Company Disclosure Schedule.

          (viii) None of the execution and delivery of this Agreement, the
     obtaining of the Stockholder Approval or the consummation of the Merger or
     any other transaction contemplated by this Agreement (including as a result
     of any termination of employment during a fixed period following the
     Effective Time) will (A) entitle any current or former director, officer,
     employee or consultant of the Company or any of its Subsidiaries to
     severance or termination pay, (B) accelerate the time of payment or vesting
     or trigger any payment or funding (through a grantor trust or otherwise) of
     compensation or benefits under, increase the amount payable or trigger any
     other material obligation pursuant to, any Benefit Plan or (C) result in
     any breach or violation of, or a default under, any Benefit Plan.

          (ix) Neither the Company nor any of its Subsidiaries has any material
     liability or obligations, including under or on account of a Benefit Plan,
     arising out of the hiring of persons to provide services to the Company or
     any of its Subsidiaries and treating such persons as consultants or
     independent contractors and not as employees of the Company or any of its
     Subsidiaries.

          (m) No Excess Parachute Payments.  Other than payments or benefits
     that may be made pursuant to the agreements and plans listed in Section
     3.01(m) of the Company Disclosure Schedule, no amount or other entitlement
     or economic benefit that could be received (whether in cash or property or
     the vesting of property) by or for the benefit of any director, officer,
     employee or consultant of the Company or any of its Affiliates who is a
     "disqualified individual" (as such term is defined in proposed Treasury
     Regulation Section 1.280G-1) under any Benefit Plan, Benefit Agreement or
     otherwise would be characterized as an "excess parachute payment" (as such
     term is defined in Section 280G(b)(1) of the Code). No person is entitled
     to receive any additional payment from the Company or any of its
     Subsidiaries, the Surviving Corporation or any other person in the event
     that the excise tax required by Section 4999(a) of the Code is imposed on
     such person (a "Parachute Gross Up Payment"). The Board of Directors of the
     Company has not granted to any director, officer, employee or consultant of
     the Company or any of its Subsidiaries any right to receive any Parachute
     Gross Up Payment.

                                       1-13
   94

          (n) Taxes.  The Company and each of its Subsidiaries has timely filed
     all material Federal, state and foreign tax returns and reports required to
     be filed by it, and all taxes required to be paid by it have either been
     paid by it or are reflected in accordance with GAAP as a reserve for taxes
     on the most recent financial statements included in the Filed Company SEC
     Documents, and all such returns and reports are true, complete and correct
     in all material respects, or requests for extensions to file such returns
     or reports have been timely filed, granted and have not expired, except to
     the extent that such failures to file, to pay or to have extensions granted
     that remain in effect individually or in the aggregate have not had and
     could not reasonably be expected to have a Material Adverse Effect, and the
     most recent financial statements included in the Filed Company SEC
     Documents reflect an adequate reserve for all taxes payable by the Company
     and its Subsidiaries for all taxable periods and portions thereof through
     the date of such financial statements. All material taxes required to be
     withheld by the Company or any of its Subsidiaries have been withheld and
     have been (or will be) duly and timely paid to the proper taxing authority.
     No deficiencies for any taxes have been proposed, asserted or assessed
     against the Company or any of its Subsidiaries that are still pending. No
     requests for waivers of the time to assess any such taxes have been made
     that are still pending. The Federal income tax returns of the Company and
     its Subsidiaries consolidated in such returns have not been examined for
     any year after 1996. The statute of limitations for Federal income tax
     purposes with respect to the Company and its Subsidiaries is closed for all
     years before 1997. No income tax return of the Company or its Subsidiaries
     is under current examination by the IRS or by any state or foreign tax
     authority. All assessments for taxes due with respect to any concluded
     litigation have been fully paid or have been adequately reserved on the
     most recent financial statements included in the Filed Company SEC
     Documents in accordance with GAAP. Neither the Company nor any of its
     Affiliates has taken or agreed to take any action or knows of any fact or
     circumstance that is reasonably likely to prevent the Merger from
     qualifying as a reorganization within the meaning of Section 368(a) of the
     Code. The Benefit Plans and other employee compensation arrangements of the
     Company or any of its Subsidiaries in effect as of the date of this
     Agreement have been designed so that the disallowance of a deduction under
     Section 162(m) of the Code for employee remuneration will not apply to any
     material amounts paid or payable by the Company or any of its Subsidiaries
     under any such plan or arrangement and, to the Knowledge of the Company, no
     fact or circumstance exists that is reasonably likely to cause such
     disallowance to apply to any such amounts. Neither the Company nor any of
     its Subsidiaries has constituted either a "distributing corporation" or a
     "controlled corporation" (within the meaning of Section 355(a)(1)(A) of the
     Code) in a distribution of stock qualifying for tax-free treatment under
     Section 355 of the Code (x) in the past two years or (y) in a distribution
     which could otherwise constitute part of a "plan" or "series of related
     transactions" (within the meaning of Section 355(e) of the Code) in
     conjunction with the Merger. The Company has not distributed property to
     its stockholders as a dividend or made a distribution in return of capital
     within the past two years. Neither the Company nor any of its Subsidiaries
     is liable for the taxes of any other person as a result of any
     indemnification provision or other contractual obligation. As used in this
     Agreement, the term "taxes" includes all Federal, state and local, domestic
     and foreign, income, property, sales, excise and other taxes, tariffs or
     governmental charges of any nature whatsoever, including any interest,
     penalties or additions with respect thereto, imposed by any Governmental
     Entity or any obligation to pay taxes imposed on any entity for which the
     Company or any of its Subsidiaries is liable by operation of law.

          (o) Title to Properties.  (i) Each of the Company and its Subsidiaries
     has good and marketable title to, or valid leasehold interests in, all its
     material properties and other assets except for such as are no longer used
     or useful in the conduct of its business or as have been disposed of in the
     ordinary course of business and except for defects in title, easements,
     restrictive covenants and similar encumbrances that individually or in the
     aggregate have not materially interfered with, and could not reasonably be
     expected to materially interfere with, its ability to conduct its business
     as presently conducted. All such material assets and properties, other than
     assets and properties in which the Company or any of its Subsidiaries has a
     leasehold interest, are free and clear of all Liens, except for Liens that
     individually or in the aggregate have not materially interfered with, and
     could not

                                       1-14
   95

     reasonably be expected to materially interfere with, the ability of the
     Company or any of its Subsidiaries to conduct its business as presently
     conducted.

          (ii) Each of the Company and its Subsidiaries has complied with the
     terms of all material leases to which it is a party and under which it is
     in occupancy, and all such leases are in full force and effect, except for
     such noncompliance or failure to be in full force and effect that
     individually or in the aggregate has not had and could not reasonably be
     expected to have a Material Adverse Effect. Each of the Company and its
     Subsidiaries enjoys peaceful and undisturbed possession under all such
     leases, except for failures to do so that individually or in the aggregate
     have not had and could not reasonably be expected to have a Material
     Adverse Effect.

          (p) Intellectual Property.  (i) Each of the Company and its
     Subsidiaries owns, or is validly licensed or otherwise has the right to use
     all patents, patent applications, trademarks, trademark rights, trade
     names, trade name rights, domain names, service marks, service mark rights,
     copyrights, technical know-how and other proprietary intellectual property
     rights and computer programs (collectively, "Intellectual Property Rights")
     which are material to the conduct of the business of the Company and its
     Subsidiaries, taken as a whole, in each case free and clear of all Liens.
     Section 3.01(p)(i) of the Company Disclosure Schedule sets forth, as of the
     date hereof, all agreements under which the Company or any Subsidiary of
     the Company is obligated to make payments to third parties for use of any
     Intellectual Property Rights with respect to the commercialization of any
     products that are, as of the date hereof, being sold, manufactured by or
     under development by the Company or any of its Subsidiaries and for which
     such payments are in excess of $500,000 per year for any single product.
     The aggregate amount of all such payments that the Company and its
     Subsidiaries are obligated to make under agreements of the type described
     in the immediately preceding sentence that are not required to be disclosed
     pursuant to such sentence does not exceed $3,000,000 per year.

          (ii) No claims are pending or, to the Knowledge of the Company,
     threatened that the Company or any of its Subsidiaries is infringing
     (including with respect to the manufacture, use or sale by the Company or
     any of its Subsidiaries of their respective commercial products) the rights
     of any person with regard to any Intellectual Property Right which,
     individually or in the aggregate, have had or could reasonably be expected
     to have a Material Adverse Effect. As of the date of this Agreement, to the
     Knowledge of the Company, no person or persons are infringing the rights of
     the Company or any of its Subsidiaries with respect to any Intellectual
     Property Right in a manner which, individually or in the aggregate, has had
     or could reasonably be expected to have a Material Adverse Effect.

          (iii) No claims are pending or, to the Knowledge of the Company,
     threatened with regard to the ownership by the Company or any of its
     Subsidiaries of any of their respective Intellectual Property Rights which,
     individually or in the aggregate, have had or could reasonably be expected
     to have a Material Adverse Effect.

          (iv) Under cover of a letter dated March 16, 2001, the Company has
     provided to Parent lists identifying all patents, trademarks and
     applications therefor that are owned by the Company or any of its
     Subsidiaries, which lists are complete and accurate, as of the respective
     dates indicated in such lists, except to the extent that any omissions
     therefrom or inaccuracies therein, individually or in the aggregate, could
     not reasonably be expected to be material to the business of the Company.
     All patents, trademarks and applications therefor owned by the Company or
     any of its Subsidiaries have been duly registered, filed with or issued by
     each appropriate Governmental Entity in the jurisdiction indicated on such
     lists, all necessary affidavits of continuing use have been filed and all
     necessary maintenance fees have been timely paid to continue all such
     rights in effect, except for failures to register, file or pay that
     individually or in the aggregate have not had and could not reasonably be
     expected to have a Material Adverse Effect. None of the material patents
     listed on such lists has been declared invalid or unenforceable, in whole
     or in part, by any Governmental Entity. Each inventor named on the patents
     and patent applications identified as being owned by the Company or any of
     its Subsidiaries on such lists has executed an agreement assigning his, her
     or its entire right, title and

                                       1-15
   96

     interest in and to such patent or patent application, and the inventions
     embodied and claimed therein, to the Company or a Subsidiary of the
     Company, except to the extent that any failures to assign, individually or
     in the aggregate, have not been and could not reasonably be expected to be
     material to the business of the Company.

          (v) Except as disclosed in Section 3.01(p)(v) of the Company
     Disclosure Schedule, the Company has not granted material licenses or
     options for licenses to Intellectual Property Rights of the Company other
     than licenses or options that are limited to the use of such Intellectual
     Property Rights in conjunction with a specified compound, protein or
     biological material.

          (vi) The Company uses, and has used, commercially reasonable efforts
     to maintain the confidentiality of its trade secrets.

          (q) Voting Requirements.  The affirmative vote of holders of a
     majority of the outstanding shares of Company Common Stock at the
     Stockholders' Meeting or any adjournment or postponement thereof to adopt
     this Agreement (the "Stockholder Approval") is the only vote of the holders
     of any class or series of the Company's capital stock necessary to adopt
     this Agreement and approve the transactions contemplated hereby.

          (r) State Takeover Statutes; Company Certificate and Company By-laws
     Provisions.  The Board of Directors of the Company has unanimously approved
     the terms of this Agreement and the Option Agreement and the consummation
     of the Merger and the other transactions contemplated by this Agreement and
     the Option Agreement, and such approval represents all the action necessary
     to render inapplicable to this Agreement, the Option Agreement, the Merger
     and the other transactions contemplated by this Agreement and the Option
     Agreement, the provisions of (i) Section 203 of the DGCL ("Section 203") to
     the extent, if any, Section 203 would otherwise be applicable to this
     Agreement, the Option Agreement, the Merger and the other transactions
     contemplated by this Agreement and the Option Agreement and (ii) Article 10
     of the Company Certificate ("Article 10") and Section 10 of the Company
     By-laws ("Section 10") to the extent, if any, Article 10 or Section 10
     would otherwise be applicable to this Agreement, the Option Agreement, the
     Merger and the other transactions contemplated by this Agreement and the
     Option Agreement. No other state takeover statute or similar statute or
     regulation or similar provision of the Company Certificate or the Company
     By-laws applies or purports to apply to this Agreement, the Option
     Agreement, the Merger or the other transactions contemplated by this
     Agreement and the Option Agreement.

          (s) Brokers and Other Advisors.  No broker, investment banker,
     financial advisor or other person, other than JPMorgan, a division of Chase
     Securities Inc., and Merrill Lynch & Co., the fees and expenses of which
     will be paid by the Company, is entitled to any broker's, finder's,
     financial advisor's or other similar fee or commission in connection with
     the transactions contemplated by this Agreement and the Option Agreement
     based upon arrangements made by or on behalf of the Company. The Company
     has delivered to Parent true and complete copies of all agreements under
     which any such fees or expenses are payable and all indemnification and
     other agreements related to the engagement of the persons to whom such fees
     are payable.

          (t) Opinions of Financial Advisors.  The Company has received the
     opinions of Chase Securities Inc. and Merrill Lynch, Pierce, Fenner & Smith
     Incorporated, each dated the date hereof and each to the effect that, as of
     such date, the Exchange Ratio is fair from a financial point of view to the
     holders of shares of Company Common Stock, signed copies of which opinions
     have been, or will promptly be, delivered to Parent.

          (u) Accounting Matters.  Neither the Company nor any of its Affiliates
     has taken or agreed to take any action that would prevent Parent from
     accounting for the business combination to be effected by the Merger as a
     pooling of interests.

          (v) Certain Agreements.  Section 3.01(v) of the Company Disclosure
     Schedule sets forth, as of the date hereof, a complete and accurate list of
     all material contracts or agreements to which the Company or any of its
     Subsidiaries is a party that relate to the products listed in Part 1 of
                                       1-16
   97

     Section 3.01(v) of the Company Disclosure Schedule (the "Listed Products"),
     and pursuant to which (i) the Company or its Subsidiaries has granted to a
     third party rights to market a Listed Product, (ii) the Company or its
     Subsidiaries are developing a Listed Product for marketing by a third
     party, (iii) the Company or its Subsidiaries have been granted rights to
     develop, promote and/or market a Listed Product by a third party or (iv)
     the Company or its Subsidiaries are obligated to supply a Listed Product to
     a third party or a third party is obligated to supply a Listed Product to
     the Company or its Subsidiaries. The Company has made available to Parent a
     true and complete copy of each such contract or agreement.

          (w) Rights Agreement.  The Company has taken all actions necessary to
     cause the Rights Agreement dated as of December 17, 1999, between the
     Company and BankBoston, N.A., as rights agent (the "Rights Agreement"), to
     be amended to (i) render the Rights Agreement inapplicable to this
     Agreement, the Option Agreement, the Merger and the other transactions
     contemplated by this Agreement and the Option Agreement, (ii) ensure that
     (x) none of Parent, Merger Sub or any other Subsidiary of Parent is an
     Acquiring Person (as defined in the Rights Agreement) pursuant to the
     Rights Agreement and (y) a Distribution Date, a Triggering Event or a
     Shares Acquisition Date (as such terms are defined in the Rights Agreement)
     does not occur, in the case of clauses (x) and (y), solely by reason of the
     execution of this Agreement or the Option Agreement or the consummation of
     the Merger or the other transactions contemplated by this Agreement and the
     Option Agreement and (iii) provide that the Final Expiration Date (as
     defined in the Rights Agreement) shall occur immediately prior to the
     Effective Time.

          (x) Regulatory Compliance.  (i) As to all products subject to the FDCA
     and the FDA regulations thereunder that are manufactured, tested,
     distributed and/or marketed by the Company or any of its Subsidiaries (each
     such product, a "Pharmaceutical Product"), the Company and each of its
     Subsidiaries are manufacturing, testing, distributing or marketing, as the
     case may be, each such Pharmaceutical Product in compliance with all
     applicable requirements under the FDCA and similar Legal Provisions,
     including those relating to investigational use, premarket clearance, good
     manufacturing practices, labeling, advertising, record keeping, filing of
     reports and security, except for instances of noncompliance or possible
     noncompliance that individually or in the aggregate have not had and could
     not reasonably be expected to have a Material Adverse Effect. Neither the
     Company nor any of its Subsidiaries has received any adverse written notice
     within the past two years from the FDA or any other similar foreign
     Governmental Entity (A) regarding the approvability or approval of a
     Pharmaceutical Product or the labeling of any products of the Company or
     any Subsidiary of the Company or (B) alleging any violation of any Legal
     Provision by the Company or any of its Subsidiaries which, in the case of
     either clause (A) or (B), individually or in the aggregate has had or could
     reasonably be expected to have a Material Adverse Effect.

          (ii) No Pharmaceutical Product has been recalled, withdrawn, suspended
     or discontinued as a result of any action by the FDA or any other similar
     foreign Governmental Entity by the Company or any of its Subsidiaries or,
     to the Knowledge of the Company, any licensee of any Pharmaceutical
     Product, in the United States or outside the United States (whether
     voluntarily or otherwise), in each case within the past five years. No
     proceedings in the United States or outside of the United States of which
     the Company has Knowledge (whether completed or pending) seeking the
     recall, withdrawal, suspension or seizure of any Pharmaceutical Product are
     pending against the Company or any of its Subsidiaries or, to the Knowledge
     of the Company, any licensee of any Pharmaceutical Product nor have any
     such proceedings been pending at any prior time, in each case which,
     individually or in the aggregate, has had or could reasonably be expected
     to have a Material Adverse Effect.

          (iii) As to each biological or drug of the Company or any of its
     Subsidiaries for which a biological license application, new drug
     application, investigational new drug application or similar state or
     foreign regulatory application has been approved, the Company and its
     Subsidiaries are in compliance with the applicable provisions of 21 U.S.C.
     sec.sec. 331, 355, 356a and 356b or 21 C.F.R. Parts 202, 203, 312 and 314,
     respectively, and similar Legal Provisions and all terms and conditions of
     such applications, except for failures to be in compliance that,
     individually or in the aggregate, have

                                       1-17
   98

     not had and could not reasonably be expected to have a Material Adverse
     Effect. As to each such drug, the Company and any relevant Subsidiary of
     the Company, and the officers, employees or agents of the Company or such
     Subsidiary, have included in the application for such drug, where required,
     the certification described in 21 U.S.C. sec. 335a(k)(1) or any similar
     Legal Provision and the list described in 21 U.S.C. sec. 335a(k)(2) or any
     similar Legal Provision, and each such certification and list was true and
     accurate when made and remains true and accurate, except for such
     inaccuracies which, individually or in the aggregate, have not had and
     could not reasonably be expected to have a Material Adverse Effect. In
     addition, the Company and its Subsidiaries are in substantial compliance
     with all applicable registration and listing requirements set forth in 21
     U.S.C. sec. 360 and 21 C.F.R. Part 207 and all similar Legal Provisions.

          (iv) No article of any biological or drug manufactured and/or
     distributed by the Company or any of its Subsidiaries is (A) adulterated
     within the meaning of 21 U.S.C. sec. 351 (or similar Legal Provisions), (B)
     misbranded within the meaning of 21 U.S.C. sec. 352 (or similar Legal
     Provisions) or (C) a product that is in violation of 21 U.S.C. sec. 355 (or
     similar Legal Provisions), except for instances of noncompliance or
     possible noncompliance with the foregoing that individually or in the
     aggregate have not had and could not reasonably be expected to have a
     Material Adverse Effect.

          (v) Except for instances that individually or in the aggregate have
     not had and could not reasonably be expected to have a Material Adverse
     Effect, (i) neither the Company nor any of its Subsidiaries, nor, to the
     Knowledge of the Company, any officer, employee or agent of the Company or
     any of its Subsidiaries, has made an untrue statement of a material fact or
     fraudulent statement to the FDA or any other Governmental Entity, failed to
     disclose a material fact required to be disclosed to the FDA or any other
     Governmental Entity, or committed an act, made a statement, or failed to
     make a statement that, at the time such disclosure was made, could
     reasonably be expected to provide a basis for the FDA or any other
     Governmental Entity to invoke with respect to the Company its policy
     respecting "Fraud, Untrue Statements of Material Facts, Bribery, and
     Illegal Gratuities", set forth in 56 Fed. Reg. 46191 (September 10, 1991)
     or any similar policy, and (ii) neither the Company nor any of its
     Subsidiaries, nor, to the Knowledge of the Company, any officer, Key
     Employee or agent of the Company or any of its Subsidiaries, has been
     convicted of any crime or engaged in any conduct for which debarment is
     mandated by 21 U.S.C. sec. 335a(a) or any similar Legal Provision or
     authorized by 21 U.S.C. sec. 335a(b) or any similar Legal Provision.

          (vi) Neither the Company nor any of its Subsidiaries has received any
     written notice within the past two years that the FDA or any other
     Governmental Entity has commenced, or threatened to initiate, any action to
     withdraw its approval or request the recall of any Pharmaceutical Product,
     or commenced, or overtly threatened to initiate, any action to enjoin
     production of any Pharmaceutical Product.

          (y) Company Grantor Trust.  Prior to the execution and delivery of
     this Agreement, the Company has amended the Grantor Trust Agreement dated
     as of March 10, 1999, between the Company and Wachovia Bank, N.A. (the
     "EEPP Trust Agreement") to provide that: (i) Sections 1(h), 1(j) and 15(b)
     of the EEPP Trust Agreement (as in effect prior to such amendment) have
     been deleted; (ii) a new Section 15(a)(3) has been added to the EEPP Trust
     Agreement that reads as follows: "Notwithstanding anything to the contrary
     in Section 15(a)(1) or Section 15(a)(2) or any other provision of this
     Agreement, neither a Threatened Change in Control nor a Change in Control
     shall have occurred (or be deemed to have occurred) as a result of the
     execution and delivery of the Agreement and Plan of Merger dated as of
     March 26, 2001, among Johnson & Johnson, Express Merger Sub Inc. and
     Employer (the "Merger Agreement") or the Stock Option Agreement dated as of
     March 26, 2001, by and between Johnson & Johnson and Employer (the "Option
     Agreement"), or the consummation of the transactions contemplated by the
     Merger Agreement or the Option Agreement" and (iii) no contributions to the
     Trust (as such term is defined in the EEPP Trust Agreement) shall be made
     by the Company or any of its Subsidiaries as a result of the execution and
     delivery of this Agreement or the Option Agreement or the consummation of
     the transactions contemplated by this Agreement or the Option Agreement.

                                       1-18
   99

     SECTION 3.02.  Representations and Warranties of Parent and Merger
Sub.  Except as disclosed in the Parent SEC Documents filed by Parent and
publicly available prior to the date of this Agreement (the "Filed Parent SEC
Documents") or as set forth in the disclosure schedule delivered by Parent to
the Company prior to the execution of this Agreement (the "Parent Disclosure
Schedule"), Parent and Merger Sub represent and warrant to the Company as
follows:

          (a) Organization, Standing and Corporate Power.  Each of Parent and
     Merger Sub is a corporation duly organized, validly existing and in good
     standing under the laws of the jurisdiction in which it is incorporated and
     has all requisite corporate power and authority to carry on its business as
     now being conducted. Each of Parent and Merger Sub is duly qualified or
     licensed to do business and is in good standing in each jurisdiction in
     which the nature of its business or the ownership, leasing or operation of
     its properties makes such qualification or licensing necessary, other than
     in such jurisdictions where the failure to be so qualified or licensed
     individually or in the aggregate has not had and could not reasonably be
     expected to have a Parent Material Adverse Effect. Parent has made
     available to the Company complete and correct copies of its Restated
     Certificate of Incorporation and By-laws and the Certificate of
     Incorporation and By-laws of Merger Sub, in each case as amended to the
     date hereof.

          (b) Authority; Noncontravention.  Each of Parent and Merger Sub has
     all requisite corporate power and authority to enter into this Agreement
     (and, in the case of Parent, the Option Agreement) and to consummate the
     transactions contemplated by this Agreement (and, in the case of Parent,
     those contemplated by the Option Agreement). The execution and delivery of
     this Agreement (and, in the case of Parent, the Option Agreement) and the
     consummation of the transactions contemplated by this Agreement (and, in
     the case of Parent, those contemplated by the Option Agreement) have been
     duly authorized by all necessary corporate action on the part of Parent and
     Merger Sub and no other corporate proceedings on the part of Parent or
     Merger Sub are necessary to authorize this Agreement (and, in the case of
     Parent, the Option Agreement) or to consummate the transactions
     contemplated hereby (and, in the case of Parent, those contemplated by the
     Option Agreement). This Agreement (and, in the case of Parent, the Option
     Agreement) has been duly executed and delivered by Parent and Merger Sub,
     as applicable, and, assuming the due authorization, execution and delivery
     by the Company, constitutes a legal, valid and binding obligation of Parent
     and Merger Sub, as applicable, enforceable against Parent and Merger Sub,
     as applicable, in accordance with its terms. The execution and delivery of
     this Agreement and the Option Agreement do not, and the consummation of the
     Merger and the other transactions contemplated by this Agreement and the
     Option Agreement and compliance with the provisions of this Agreement and
     the Option Agreement will not, conflict with, or result in any violation or
     breach of, or default (with or without notice or lapse of time, or both)
     under, or give rise to a right of termination, cancelation or acceleration
     of any obligation or to the loss of a benefit under, or result in the
     creation of any Lien upon any of the properties or other assets of Parent
     or Merger Sub under (x) the Restated Certificate of Incorporation or
     By-laws of Parent or the Certificate of Incorporation or By-laws of Merger
     Sub, (y) any loan or credit agreement, bond, debenture, note, mortgage,
     indenture, lease or other contract, agreement, obligation, commitment,
     arrangement, understanding, instrument, permit or license, whether oral or
     written, to which Parent or Merger Sub is a party or any of their
     respective properties or other assets is subject or (z) subject to the
     governmental filings and other matters referred to in the following
     sentence, any (A) statute, law, ordinance, rule or regulation or (B) order,
     writ, injunction, decree, judgment or stipulation, in each case applicable
     to Parent or Merger Sub or their respective properties or other assets,
     other than, in the case of clauses (y) and (z), any such conflicts,
     violations, breaches, defaults, rights, losses or Liens that individually
     or in the aggregate have not had and could not reasonably be expected to
     have a Parent Material Adverse Effect. No consent, approval, order or
     authorization of, action by or in respect of, or registration, declaration
     or filing with, any Governmental Entity is required by or with respect to
     Parent or Merger Sub in connection with the execution and delivery of this
     Agreement (and, in the case of Parent, the Option Agreement) by Parent and
     Merger Sub or the consummation by Parent and Merger Sub of the Merger or
     the other transactions contemplated by this Agreement (and, in the case of
     Parent, those contemplated by the

                                       1-19
   100

     Option Agreement), except for (1)(A) the filing of a premerger notification
     and report form by Parent under the HSR Act, (B) the receipt of a decision
     under Article 6(1)(b) or 8(2) of the EC Merger Regulation declaring the
     Merger compatible with the EC Common Market and (C) and any other
     applicable filings and approvals under similar foreign antitrust laws and
     regulations, (2) the filing with the SEC of (A) the Form S-4 and (B) such
     reports under Section 13(a), 13(d), 15(d) or 16(a) of the Exchange Act as
     may be required in connection with this Agreement, the Option Agreement and
     the transactions contemplated by this Agreement or the Option Agreement,
     (3) the filing of the Certificate of Merger with the Secretary of State of
     the State of Delaware, (4) such filings with and approvals of the NYSE to
     permit the shares of Parent Common Stock issuable to the stockholders of
     the Company as contemplated by this Agreement to be listed on the NYSE and
     (5) such other consents, approvals, orders, authorizations, registrations,
     declarations and filings the failure of which to be obtained or made
     individually or in the aggregate has not had and could not reasonably be
     expected to have a Parent Material Adverse Effect.

          (c) Parent SEC Documents.  Parent has filed all reports, schedules,
     forms, statements and other documents (including exhibits and other
     information incorporated therein) with the SEC required to be filed by
     Parent since January 1, 1999 (such documents, together with any documents
     filed during such period by Parent with the SEC on a voluntary basis on
     Current Reports on Form 8-K, the "Parent SEC Documents"). As of their
     respective dates, the Parent SEC Documents complied in all material
     respects with the requirements of the Securities Act or the Exchange Act,
     as the case may be, and the rules and regulations of the SEC promulgated
     thereunder applicable to such Parent SEC Documents, and none of the Parent
     SEC Documents contained any untrue statement of a material fact or omitted
     to state a material fact required to be stated therein or necessary in
     order to make the statements therein, in light of the circumstances under
     which they were made, not misleading. Except to the extent that information
     contained in any Parent SEC Document has been revised or superseded by a
     later-filed Parent SEC Document, none of the Parent SEC Documents contains
     any untrue statement of a material fact or omits to state any material fact
     required to be stated therein or necessary in order to make the statements
     therein, in light of the circumstances under which they were made, not
     misleading.

          (d) Information Supplied.  None of the information supplied or to be
     supplied by Parent or Merger Sub specifically for inclusion or
     incorporation by reference in (i) the Form S-4 will, at the time the Form
     S-4 is filed with the SEC, at any time it is amended or supplemented and at
     the time it becomes effective under the Securities Act, contain any untrue
     statement of a material fact or omit to state any material fact required to
     be stated therein or necessary to make the statements therein, in light of
     the circumstances under which they are made, not misleading, or (ii) the
     Proxy Statement will, at the date it is first mailed to the stockholders of
     the Company and at the time of the Stockholders' Meeting, contain any
     untrue statement of a material fact or omit to state any material fact
     required to be stated therein or necessary in order to make the statements
     therein, in light of the circumstances under which they are made, not
     misleading. The Form S-4 will comply as to form in all material respects
     with the requirements of the Securities Act and the rules and regulations
     thereunder, except that no representation or warranty is made by Parent or
     Merger Sub with respect to statements made or incorporated by reference
     therein based on information supplied by the Company specifically for
     inclusion or incorporation by reference in the Form S-4.

          (e) Accounting Matters.  Neither Parent nor any of its Affiliates has
     taken or agreed to take any action that would prevent Parent from
     accounting for the business combination to be effected by the Merger as a
     pooling of interests.

          (f) Tax Matters.  Neither Parent, Merger Sub nor any other Affiliate
     of Parent has taken or agreed to take any action or knows of any fact or
     circumstance that is reasonably likely to prevent the Merger from
     qualifying as a reorganization within the meaning of Section 368(a) of the
     Code.

                                       1-20
   101

          (g) Interim Operations of Merger Sub.  Merger Sub was formed solely
     for the purpose of engaging in the transactions contemplated hereby, has
     engaged in no other business activities and has conducted its operations
     only as contemplated hereby.

          (h) Parent Shareholder Approval.  This Agreement and the transactions
     contemplated hereby, including the issuance of shares of Parent Common
     Stock pursuant to Article II hereof, do not require the approval of the
     holders of any shares of capital stock of Parent.

          (i) Parent Common Stock.  All outstanding shares of Parent Common
     Stock are, and all shares of Parent Common Stock which may be issued
     pursuant to this Agreement shall when issued in accordance with this
     Agreement be, duly authorized, validly issued, fully paid and nonassessable
     and not subject to preemptive rights.

          (j) Brokers.  No broker, investment banker, financial advisor or other
     person, other than Goldman, Sachs & Co., the fees and expenses of which
     will be paid by Parent, is entitled to any broker's, finder's, financial
     advisor's or other similar fee or commission in connection with the
     transactions contemplated by this Agreement based upon arrangements made by
     or on behalf of Parent.

          (k) Capital Structure.  As of the date of this Agreement, the
     authorized capital stock of Parent consists of 2,160,000,000 shares of
     Parent Common Stock and 2,000,000 shares of preferred stock, without par
     value, of Parent ("Parent Preferred Stock"). At the close of business on
     March 22, 2001, (i) 1,396,867,342 shares of Parent Common Stock were issued
     and outstanding, (ii) 138,053,932 shares of Parent Common Stock were held
     by Parent in its treasury, (iii) no shares of Parent Preferred Stock had
     been designated or issued and (iv) 86,231,943 shares of Parent Common Stock
     were subject to outstanding options to purchase shares of Parent Common
     Stock granted under Parent's stock incentive plans. Except as set forth
     above in this Section 3.02(k), at the close of business on March 22, 2001,
     there were not issued or outstanding (A) any shares of capital stock or
     other voting securities of Parent, (B) any securities of Parent convertible
     into or exchangeable or exercisable for shares of capital stock or voting
     securities of Parent or (C) any warrants, calls, options or other rights to
     acquire from Parent, or any obligation of Parent to issue, any shares of
     capital stock, voting securities or securities convertible into or
     exchangeable or exercisable for capital stock or voting securities of
     Parent. Except as set forth above in this Section 3.02(k), at the close of
     business on March 22, 2001, no bonds, debentures, notes or other
     indebtedness of Parent having the right to vote (or convertible into, or
     exchangeable for, securities having the right to vote) on any matters on
     which the shareholders of Parent may vote are issued or outstanding. The
     authorized capital stock of Sub consists of 1,000 shares of common stock,
     par value $.01 per share, of which 1,000 shares are issued and outstanding,
     all of which shares are beneficially owned by Parent.

          (l) Intellectual Property Rights.  Each of Parent and its Subsidiaries
     owns or has the right to use all Intellectual Property Rights which are
     material to the conduct of the business of Parent and its Subsidiaries,
     taken as a whole, in each case free and clear of all Liens. Neither the
     manufacture, marketing, license, sale or use by Parent of any product
     violates any license or agreement between Parent or any of its Subsidiaries
     and any other person and there is no pending or, to the Knowledge of
     Parent, threatened claim or litigation contesting the validity, ownership
     or right to use, sell, license or dispose of any such Intellectual Property
     Rights relating to any product or asserting that the proposed use, sale,
     license or disposition thereof, or the manufacture, use or sale of any
     product by Parent or any of its Subsidiaries, conflicts with the rights of
     any other person, in each case which, individually or in the aggregate, has
     had or could reasonably be expected to have a Parent Material Adverse
     Effect.

          (m) Regulatory Compliance.  To the Knowledge of Parent, the testing,
     manufacture, storage, distribution, use, promotion and sale of products of
     Parent or any Subsidiary of Parent by Parent, such Subsidiary and their
     respective contractors have been performed and is performed in compliance
     with all applicable requirements under the FDCA and similar Legal
     Provisions, including those relating to investigational use, premarket
     clearance, good manufacturing practices, labeling, advertis-

                                       1-21
   102

     ing, record keeping, filing of reports and security, except for such
     instances of noncompliance or possible noncompliance that individually or
     in the aggregate have not had and could not reasonably be expected to have
     a Parent Material Adverse Effect. Neither Parent nor any of its
     Subsidiaries has received any adverse written notice within the past two
     years that the FDA or any other similar foreign Governmental Entity has
     commenced, or threatened to initiate, any action to withdraw its approval
     or request the recall of any product of Parent or any of its Subsidiaries,
     or commenced, or overtly threatened to initiate, any action to enjoin
     production of any such product, except where such action could not
     reasonably be expected to have a Parent Material Adverse Effect.

          (n) Litigation.  There is no suit, action or proceeding pending or, to
     the Knowledge of Parent, threatened against or affecting Parent or any of
     its Subsidiaries that individually or in the aggregate has had or could
     reasonably be expected to have a Parent Material Adverse Effect, nor is
     there any judgment, decree, injunction, rule or order of any Governmental
     Entity or arbitrator outstanding against, or, to the Knowledge of Parent,
     investigation by any Governmental Entity involving, Parent or any of its
     Subsidiaries that individually or in the aggregate has had or could
     reasonably be expected to have a Parent Material Adverse Effect.

          (o) Absence of Changes.  Except for liabilities incurred in connection
     with this Agreement, since the date of the most recent audited financial
     statements included in the Filed Parent SEC Documents, there has not been
     any Parent Material Adverse Change.

                                   ARTICLE IV

                   COVENANTS RELATING TO CONDUCT OF BUSINESS

     SECTION 4.01.  Conduct of Business.  (a) Conduct of Business by the
Company.  During the period from the date of this Agreement to the Effective
Time, the Company shall, and shall cause each of its Subsidiaries to, carry on
its business in the ordinary course consistent with past practice and in
compliance with all applicable laws and regulations and, to the extent
consistent therewith, use all commercially reasonable efforts to preserve intact
its current business organizations, keep available the services of its current
officers, employees and consultants and preserve its relationships with
customers, suppliers, licensors, licensees, distributors and others having
business dealings with it with the intention that its goodwill and ongoing
business shall be unimpaired at the Effective Time. Without limiting the
generality of the foregoing, during the period from the date of this Agreement
to the Effective Time, except as provided in Section 4.01(a) of the Company
Disclosure Schedule, the Company shall not, and shall not permit any of its
Subsidiaries to, without Parent's prior written consent:

          (i) (x) declare, set aside or pay any dividends on, or make any other
     distributions (whether in cash, stock or property) in respect of, any of
     its capital stock, other than dividends or distributions by a direct or
     indirect wholly owned Subsidiary of the Company to its parent, (y) split,
     combine or reclassify any of its capital stock or issue or authorize the
     issuance of any other securities in respect of, in lieu of or in
     substitution for shares of its capital stock or (z) purchase, redeem or
     otherwise acquire any shares of its capital stock or any other securities
     thereof or any rights, warrants or options to acquire any such shares or
     other securities;

          (ii) issue, deliver, sell, grant, pledge or otherwise encumber or
     subject to any Lien any shares of its capital stock, any other voting
     securities or any securities convertible into, or any rights, warrants or
     options to acquire, any such shares, voting securities or convertible
     securities, or any "phantom" stock, "phantom" stock rights, stock
     appreciation rights or stock based performance units (other than (w) the
     issuance of shares of Company Common Stock upon the exercise of Stock
     Options outstanding on the date hereof or granted after the date hereof in
     accordance with clause (z) below in accordance with their terms on the date
     hereof (or on the date of grant, if later), (x) the issuance of shares of
     Company Common Stock upon the conversion of the Convertible Notes
     outstanding on the date hereof in accordance with their terms on the date
     hereof, (y) the issuance of shares of Company Common Stock pursuant to an
     exercise of the Option granted under the Option Agreement or (z)

                                       1-22
   103

     (1) the grant to newly hired or promoted employees of options to acquire
     shares of Company Common Stock and (2) after consultation with Parent, the
     grant to existing employees of options to acquire shares of Company Common
     Stock consisting of the Company's annual option grants, in the case of
     either clause (1) or (2), in accordance with the Company's ordinary course
     of business consistent with the Company guidelines in respect of option
     grants as described in Section 4.01(a)(ii)(z) of the Company Disclosure
     Schedule);

          (iii) amend the Company Certificate or the Company By-laws or other
     comparable charter or organizational documents;

          (iv) directly or indirectly acquire (x) by merging or consolidating
     with, or by purchasing assets of, or by any other manner, any person or
     division, business or equity interest of any person or (y) any assets that,
     individually, have a purchase price in excess of $3,000,000 or, in the
     aggregate, have a purchase price in excess of $15,000,000, except for
     purchases of raw materials or supplies in the ordinary course of business
     consistent with past practice;

          (v) sell, lease, license, mortgage, sell and leaseback or otherwise
     encumber or subject to any Lien or otherwise dispose of any of its
     properties or other assets or any interests therein (including
     securitizations), except for sales of inventory in the ordinary course of
     business consistent with past practice;

          (vi) (x) incur any indebtedness for borrowed money or guarantee any
     such indebtedness of another person, issue or sell any debt securities or
     warrants or other rights to acquire any debt securities of the Company or
     any of its Subsidiaries, guarantee any debt securities of another person,
     enter into any "keep well" or other agreement to maintain any financial
     statement condition of another person or enter into any arrangement having
     the economic effect of any of the foregoing, except for short-term
     borrowings incurred in the ordinary course of business consistent with past
     practice or (y) make any loans, advances or capital contributions to, or
     investments in, any other person, other than in the ordinary course of
     business consistent with past practice or to or in any direct or indirect
     wholly owned Subsidiary of the Company;

          (vii) except for projects contemplated in the Company's 2001 capital
     assets budget, a true and complete copy of which has been previously
     provided by the Company to Parent, make any new capital expenditure or
     expenditures which, individually, is in excess of $2,000,000 or, in the
     aggregate, are in excess of $10,000,000;

          (viii) (v) pay, discharge, settle or satisfy any claims, liabilities,
     obligations or litigation (absolute, accrued, asserted or unasserted,
     contingent or otherwise), other than the payment, discharge, settlement or
     satisfaction in the ordinary course of business consistent with past
     practice or in accordance with their terms, of liabilities disclosed,
     reflected or reserved against in the most recent financial statements (or
     the notes thereto) of the Company included in the Filed Company SEC
     Documents or incurred since the date of such financial statements in the
     ordinary course of business consistent with past practice, (w) cancel any
     material indebtedness, (x) waive or assign any claims or rights of
     substantial value, (y) waive any benefits of, or agree to modify in any
     respect, any standstill or similar agreement to which the Company or any of
     its Subsidiaries is a party or (z) other than in the ordinary course of
     business consistent with past practice, waive any material benefit of, or
     agree to modify in any material respect, any confidentiality or similar
     agreement to which the Company or any of its Subsidiaries is a party;

          (ix) except in the ordinary course of business consistent with past
     practice, modify, amend or terminate any material contract or agreement to
     which the Company or any of its Subsidiaries is a party or waive, release
     or assign any material rights or claims thereunder;

          (x) enter into any contracts, agreements, binding arrangements or
     understandings relating to the research, development, distribution, supply,
     license, co-promotion or manufacturing by third parties of products of the
     Company or any Subsidiary of the Company or products licensed by the
     Company or any Subsidiary of the Company, other than (A) pursuant to any
     such contracts, agreements,

                                       1-23
   104

     arrangements or understandings currently in place (that have been disclosed
     in writing to Parent prior to the date hereof) in accordance with their
     terms as of the date hereof, (B) contracts, agreements, binding
     arrangements or understandings relating to research or development or
     pursuant to which the Company or any of its Subsidiaries obtains the supply
     of ingredients or components of products, in each case entered into in the
     ordinary course of business consistent with past practice and that do not
     provide for the grant of any licenses or marketing rights under any
     Intellectual Property Rights of the Company or any of its Subsidiaries and
     (C) contracts, agreements, binding arrangements or understandings relating
     to research or development entered into in the ordinary course of business
     consistent with past practice and any license agreements or arrangements
     entered into in the ordinary course of business consistent with past
     practice in connection therewith, provided that, in the case of this clause
     (C), (I) the Company or such Subsidiary consults with Parent a reasonable
     period of time prior to entering into any such contract, agreement, binding
     arrangement or understanding and (II) such associated license agreement or
     arrangement is limited to the use of the Company's Intellectual Property
     Rights in the field of drug delivery in conjunction with any substance,
     material, chemical, formulation or composition which contains as an active
     ingredient a compound, protein or other biological material that is
     proprietary to the licensee thereunder;

          (xi) except as otherwise contemplated by this Agreement or as required
     to comply with applicable law, (A) adopt, enter into, terminate or amend in
     any material respect (I) any collective bargaining agreement or Benefit
     Plan or (II) any Benefit Agreement or other agreement, plan or policy
     involving the Company or any of its Subsidiaries and one or more of their
     respective current or former directors, officers, employees or consultants,
     (B) increase in any manner the compensation, bonus or fringe or other
     benefits of, or pay any bonus to, any current or former director, officer,
     employee or consultant (except for normal increases of cash compensation,
     cash bonuses or fringe benefits or perquisites in the ordinary course of
     business consistent with past practice that, in the aggregate, do not
     materially increase the benefits or compensation expenses of the Company
     and its Subsidiaries, taken as a whole), (C) pay any benefit or amount not
     required under any Benefit Plan or Benefit Agreement or any other benefit
     plan or arrangement of the Company or any of its Subsidiaries as in effect
     on the date of this Agreement, (D) increase in any material manner the
     severance or termination pay of any current or former director, officer or
     Key Employee of the Company or any of its Subsidiaries or increase the
     severance or termination pay of any other employees of the Company or any
     of its Subsidiaries in a manner that results in the aggregate in any
     material increase in the severance or termination pay expenses of the
     Company and its Subsidiaries, (E) grant any awards under any bonus,
     incentive, performance or other compensation plan or arrangement or Benefit
     Plan (including the grant of stock options, "phantom" stock, stock
     appreciation rights, "phantom" stock rights, stock based or stock related
     awards, performance units or restricted stock or the removal of existing
     restrictions in any Benefit Plans or agreements or awards made thereunder)
     except as permitted by Section 4.01(a)(ii)(z), (F) amend or modify any
     Stock Option, except as specifically provided in Section 5.06(a) or Section
     5.16(i), (G) take any action to fund or in any other way secure the payment
     of compensation or benefits under any employee plan, agreement, contract or
     arrangement or Benefit Plan, (H) take any action to accelerate the vesting
     or payment of any compensation or benefit under any Benefit Plan, other
     than non-discretionary actions required by the terms of any existing plans,
     agreements, contracts, arrangements or Benefit Plans, or (I) materially
     change any actuarial or other assumption used to calculate funding
     obligations with respect to any Pension Plan or change the manner in which
     contributions to any Pension Plan are made or the basis on which such
     contributions are determined;

          (xii) except as otherwise contemplated by this Agreement, enter into
     any agreement of a nature that would be required to be filed as an exhibit
     to Form 10-K under the Exchange Act;

          (xiii) revalue any material assets of the Company or any of its
     Subsidiaries or, except as required by GAAP, make any change in accounting
     methods, principles or practices;

                                       1-24
   105

          (xiv) other than license agreements or arrangements permitted by
     Section 4.01(a)(x), sell, transfer or license to any person or otherwise
     extend, amend or modify any rights to the Intellectual Property Rights of
     the Company or any of its Subsidiaries; or

          (xv) authorize any of, or commit, propose or agree to take any of, the
     foregoing actions.

     (b) Other Actions.  The Company and Parent shall not, and shall not permit
any of their respective Subsidiaries to, take any action that would, or that
could reasonably be expected to, result in (i) any of the representations and
warranties of such party set forth in this Agreement or the Option Agreement
that are qualified by materiality becoming untrue, (ii) any of such
representations and warranties that are not so qualified becoming untrue in any
material respect or (iii) any of the conditions to the Merger set forth in
Article VI not being satisfied.

     (c) Advice of Changes; Filings.  The Company and Parent shall promptly
advise the other party orally and in writing of (i) any representation or
warranty made by it (and, in the case of Parent, made by Merger Sub) contained
in this Agreement or the Option Agreement that is qualified as to materiality
becoming untrue or inaccurate in any respect or any such representation or
warranty that is not so qualified becoming untrue or inaccurate in any material
respect or (ii) the failure of it (and, in the case of Parent, of Merger Sub) to
comply with or satisfy in any material respect any covenant, condition or
agreement to be complied with or satisfied by it under this Agreement or the
Option Agreement; provided, however, that no such notification shall affect the
representations, warranties, covenants or agreements of the parties (or remedies
with respect thereto) or the conditions to the obligations of the parties under
this Agreement or the Option Agreement. The Company and Parent shall promptly
provide the other copies of all filings made by such party with any Governmental
Entity in connection with this Agreement and the Option Agreement and the
transactions contemplated hereby and thereby, other than the portions of such
filings that include confidential information not directly related to the
transactions contemplated by this Agreement or the Option Agreement.

     (d) Certain Tax Matters.  From the date hereof until the Effective Time,
(i) the Company and its Subsidiaries shall file all tax returns and reports
("Post-Signing Returns") required to be filed by it (after taking into account
any applicable extensions); (ii) the Company and its Subsidiaries shall timely
pay all material taxes due and payable with respect to such Post-Signing Returns
that are so filed; (iii) the Company and its Subsidiaries shall make provision
for all material taxes payable by the Company or any such Subsidiary consistent
with its regular accounting practices for which no Post-Signing Return is due
prior to the Effective Time; (iv) the Company shall promptly notify Parent of
any action, suit, proceeding, claim or audit (collectively, "Actions") pending
against or with respect to the Company or any of its Subsidiaries by any
Federal, state or foreign taxing authority in respect of any tax and shall not
settle or compromise any such Action without Parent's prior written consent; and
(v) neither the Company nor any of its Subsidiaries shall make any tax election
material to the Company without Parent's prior written consent.

     SECTION 4.02.  No Solicitation.  (a) The Company shall not, nor shall it
authorize or permit any of its Subsidiaries, any of their respective directors,
officers or employees or any investment banker, financial advisor, attorney,
accountant or other advisor, agent or representative (collectively,
"Representatives") retained by it or any of its Subsidiaries to, directly or
indirectly through another person, (i) solicit, initiate or encourage, or take
any other action to facilitate, any inquiries or the making of any proposal that
constitutes or could reasonably be expected to lead to a Takeover Proposal or
(ii) participate in any discussions or negotiations regarding, or furnish to any
person any information, or otherwise cooperate in any way with, any Takeover
Proposal. Without limiting the foregoing, it is agreed that any violation of the
restrictions set forth in the preceding sentence by any Representative of the
Company or any of its Subsidiaries shall be a breach of this Section 4.02(a) by
the Company. The Company shall, and shall cause its Subsidiaries to, immediately
cease and cause to be terminated all existing discussions or negotiations with
any person conducted heretofore with respect to any Takeover Proposal and
request the prompt return or destruction of all confidential information
previously furnished. Notwithstanding the foregoing, at any time prior to
obtaining the Stockholder Approval, in response to a bona fide written

                                       1-25
   106

Takeover Proposal that the Board of Directors of the Company determines in good
faith (after consultation with outside counsel and a financial advisor of
nationally recognized reputation) constitutes or is reasonably likely to lead to
a Superior Proposal, and which Takeover Proposal was unsolicited and made after
the date hereof and did not otherwise result from a breach of this Section
4.02(a), the Company may, if its Board of Directors determines in good faith
(after consultation with outside counsel) that it is required to do so in order
to comply with its fiduciary duties to the stockholders of the Company under
applicable law, and subject to compliance with Section 4.02(c) and after giving
Parent written notice of such determination, (x) furnish information with
respect to the Company and its Subsidiaries to the person making such Takeover
Proposal (and its Representatives) pursuant to a customary confidentiality
agreement not less restrictive of such person than the Confidentiality
Agreement, provided that all such information has previously been provided to
Parent or is provided to Parent prior to or substantially concurrent with the
time it is provided to such person, and (y) participate in discussions or
negotiations with the person making such Takeover Proposal (and its
Representatives) regarding such Takeover Proposal.

     The term "Takeover Proposal" means (i) any proposal or offer for a merger,
consolidation, dissolution, recapitalization or other business combination
involving the Company, (ii) any proposal for the issuance of 15% or more of the
equity securities of the Company as consideration for the assets or securities
of another person or (iii) any proposal or offer to acquire in any manner,
directly or indirectly, 15% or more of the equity securities of the Company or
assets (including equity securities of any Subsidiary of the Company) that
represent 15% or more of the total consolidated assets of the Company, in each
case other than the transactions contemplated by this Agreement or the Option
Agreement.

     The term "Superior Proposal" means any bona fide offer made by a third
party that if consummated would result in such person (or its shareholders)
owning, directly or indirectly, all or substantially all of the shares of
Company Common Stock then outstanding (or of the surviving entity in a merger or
the direct or indirect parent of the surviving entity in a merger) or all or
substantially all the assets of the Company, which the Board of Directors of the
Company determines in good faith (after consultation with a financial advisor of
nationally recognized reputation) to be (i) more favorable to the stockholders
of the Company from a financial point of view than the Merger (taking into
account all the terms and conditions of such proposal and this Agreement
(including any changes to the financial terms of this Agreement proposed by
Parent in response to such offer or otherwise)) and (ii) reasonably capable of
being completed, taking into account all financial, legal, regulatory and other
aspects of such proposal.

     (b) Neither the Board of Directors of the Company nor any committee thereof
shall (i)(A) withdraw (or modify in a manner adverse to Parent), or propose to
withdraw (or modify in a manner adverse to Parent), the approval, recommendation
or declaration of advisability by such Board of Directors or any such committee
thereof of this Agreement, the Option Agreement or the Merger or (B) recommend,
adopt or approve, or propose publicly to recommend, adopt or approve, any
Takeover Proposal (any action described in this clause (i) being referred to as
a "Company Adverse Recommendation Change") or (ii) approve or recommend, or
propose to approve or recommend, or allow the Company or any of its Subsidiaries
to execute or enter into, any letter of intent, memorandum of understanding,
agreement in principle, merger agreement, acquisition agreement, option
agreement, joint venture agreement, partnership agreement or other similar
agreement constituting or related to any Takeover Proposal. Notwithstanding the
foregoing, at any time prior to obtaining the Stockholder Approval, the Board of
Directors of the Company may make a Company Adverse Recommendation Change if
such Board of Directors determines in good faith (after consultation with
outside counsel) that it is required to do so in order to comply with its
fiduciary duties to the stockholders of the Company under applicable law;
provided, however, that no Company Adverse Recommendation Change may be made in
response to a Superior Proposal until after the third business day following
Parent's receipt of written notice (a "Notice of Adverse Recommendation") from
the Company advising Parent that the Board of Directors of the Company intends
to make such a Company Adverse Recommendation Change and specifying the terms
and conditions of such Superior Proposal (it being understood and agreed that
any amendment to the financial terms or any other material term of such Superior
Proposal shall require a

                                       1-26
   107

new Notice of Adverse Recommendation and a new three business day period). In
determining whether to make a Company Adverse Recommendation Change in response
to a Superior Proposal, the Board of Directors of the Company shall take into
account any changes to the terms of this Agreement proposed by Parent in
response to a Notice of Adverse Recommendation or otherwise.

     (c) In addition to the obligations of the Company set forth in paragraphs
(a) and (b) of this Section 4.02, the Company shall promptly advise Parent
orally and in writing of any bona fide Takeover Proposal, the material terms and
conditions of any such Takeover Proposal (including any changes thereto) and the
identity of the person making any such Takeover Proposal. The Company shall (i)
keep Parent fully informed of the status and details (including any change to
the terms thereof) of any such Takeover Proposal or inquiry and (ii) provide to
Parent as soon as practicable after receipt or delivery thereof with copies of
all correspondence and other written material sent or provided to the Company or
any of its Subsidiaries from any person that describes any of the terms or
conditions of any Takeover Proposal.

     (d) Nothing contained in this Section 4.02 shall prohibit the Company from
(x) taking and disclosing to its stockholders a position contemplated by Rule
14e-2(a) or Item 1012(a) of Regulation M-A promulgated under the Exchange Act or
(y) making any required disclosure to the stockholders of the Company if, in the
good faith judgment of the Board of Directors of the Company (after consultation
with outside counsel) failure to so disclose would constitute a violation of
applicable law; provided, however, that in no event shall the Company or its
Board of Directors or any committee thereof take, or agree or resolve to take,
any action prohibited by Section 4.02(b).

                                   ARTICLE V

                             ADDITIONAL AGREEMENTS

     SECTION 5.01.  Preparation of the Form S-4 and the Proxy Statement;
Stockholders' Meeting. (a) As soon as practicable following the date of this
Agreement, the Company and Parent shall prepare and Parent shall file with the
SEC the Form S-4, in which the Proxy Statement will be included as a prospectus.
Each of the Company and Parent shall use its commercially reasonable efforts to
have the Form S-4 declared effective under the Securities Act as promptly as
practicable after such filing. The Company shall use its commercially reasonable
efforts to cause the Proxy Statement to be mailed to the stockholders of the
Company as promptly as practicable after the Form S-4 is declared effective
under the Securities Act. Parent shall also take any action (other than
qualifying to do business in any jurisdiction in which it is not now so
qualified or filing a general consent to service of process) required to be
taken under any applicable state securities laws in connection with the issuance
of shares of Parent Common Stock in the Merger, and the Company shall furnish
all information concerning the Company and the holders of shares of Company
Common Stock as may be reasonably requested by Parent in connection with any
such action and the preparation, filing and distribution of the Proxy Statement.
No filing of, or amendment or supplement to, the Form S-4 will be made by
Parent, and no filing of, or amendment or supplement to the Proxy Statement will
made by the Company, in each case without providing the other party a reasonable
opportunity to review and comment thereon. If at any time prior to the Effective
Time any information relating to the Company or Parent, or any of their
respective Affiliates, directors or officers, should be discovered by the
Company or Parent which should be set forth in an amendment or supplement to
either the Form S-4 or the Proxy Statement, so that either such document would
not include any misstatement of a material fact or omit to state any material
fact necessary to make the statements therein, in light of the circumstances
under which they were made, not misleading, the party which discovers such
information shall promptly notify the other parties hereto and an appropriate
amendment or supplement describing such information shall be promptly filed with
the SEC and, to the extent required by law, disseminated to the stockholders of
the Company. The parties shall notify each other promptly of the receipt of any
comments from the SEC or the staff of the SEC and of any request by the SEC or
the staff of the SEC for amendments or supplements to the Proxy Statement or the
Form S-4 or for additional information and shall supply each other with copies
of (i) all correspondence

                                       1-27
   108

between it or any of its Representatives, on the one hand, and the SEC or the
staff of the SEC, on the other hand, with respect to the Proxy Statement, the
Form S-4 or the Merger and (ii) all orders of the SEC relating to the Form S-4.

     (b) The Company shall, as soon as practicable following the date of this
Agreement, establish a record date for, duly call, give notice of, convene and
hold a meeting of its stockholders (the "Stockholders' Meeting") solely for the
purpose of obtaining the Stockholder Approval. Subject to Section 4.02(b), the
Company shall, through its Board of Directors, recommend to its stockholders
adoption of this Agreement. Without limiting the generality of the foregoing,
the Company's obligations pursuant to the first sentence of this Section 5.01(b)
shall not be affected by (i) the commencement, public proposal, public
disclosure or communication to the Company of any Takeover Proposal or (ii) the
withdrawal or modification by the Board of Directors of the Company or any
committee thereof of such Board of Directors' or such committee's approval or
recommendation of this Agreement, the Option Agreement or the Merger.

     SECTION 5.02.  Letter of the Company's Accountants.  The Company shall use
its commercially reasonable efforts to cause to be delivered to Parent a letter
from Ernst & Young LLP, the Company's independent auditors, addressed to Parent
and the Company, dated as of the Closing Date, stating that (i) Ernst & Young
LLP concurs with the Company's management's conclusion that, subject to
customary qualifications, the Company meets the requirements to be a party to a
pooling of interests transaction for financial reporting purposes under Opinion
16 of the Accounting Principles Board and applicable SEC rules and regulations
and (ii) the basis for such concurrence is Ernst & Young LLP's belief that the
criteria for such accounting treatment relative to the Company, which can be
assessed at that time, have been met.

     SECTION 5.03.  Letter of Parent's Accountants.  Parent shall use its
commercially reasonable efforts to cause to be delivered to the Company a letter
from PricewaterhouseCoopers LLP, Parent's independent public accountants,
addressed to the Company and Parent, dated as of the Closing Date, stating that
(i) PricewaterhouseCoopers LLP concurs with Parent's management's conclusion
that, subject to customary qualifications, the Merger qualifies for pooling of
interests treatment for financial reporting purposes under Opinion 16 of the
Accounting Principles Board and applicable SEC rules and regulations and (ii)
the basis for such concurrence is PricewaterhouseCoopers LLP's belief that the
criteria which can be assessed at that time for such accounting treatment have
been met.

     SECTION 5.04.  Access to Information; Confidentiality.  (a) The Company
shall afford to Parent, and to Parent's officers, employees, accountants,
counsel, financial advisors and other Representatives, reasonable access during
normal business hours during the period prior to the Effective Time or the
termination of this Agreement to all its and its Subsidiaries' properties,
books, contracts, commitments, personnel and records and, during such period,
the Company shall furnish promptly to Parent (a) a copy of each report,
schedule, registration statement and other document filed by it during such
period pursuant to the requirements of Federal or state securities laws and (b)
all other information concerning its and its Subsidiaries' business, properties
and personnel as Parent may reasonably request. Except for disclosures expressly
permitted by the terms of the letter agreement dated as of February 23, 2001,
between Parent and the Company (as it may be amended from time to time, the
"Confidentiality Agreement"), Parent shall hold, and shall cause its officers,
employees, accountants, counsel, financial advisors and other Representatives to
hold, all information received from the Company, directly or indirectly, in
confidence in accordance with the Confidentiality Agreement.

     (b) Subject to the Confidentiality Agreement, Parent shall provide to the
Company, from time to time prior to the Effective Time or the termination of
this Agreement, such information as the Company shall reasonably request to
evaluate Parent and its business, financial condition, operations and prospects.
Except for disclosures expressly permitted by the terms of the Confidentiality
Agreement, the Company shall hold, and shall cause its officers, employees,
accountants, counsel, financial advisors and other Representatives to hold, all
information received from Parent, directly or indirectly, in confidence in
accordance with the Confidentiality Agreement.

                                       1-28
   109

     (c) No investigation pursuant to this Section 5.04 or information provided
or received by any party hereto pursuant to this Agreement will affect any of
the representations or warranties of the parties hereto contained in this
Agreement or the conditions hereunder to the obligations of the parties hereto.

     SECTION 5.05.  Commercially Reasonable Efforts.  Upon the terms and subject
to the conditions set forth in this Agreement, each of the parties agrees to use
its commercially reasonable efforts to take, or cause to be taken, all actions,
and to do, or cause to be done, and to assist and cooperate with the other
parties in doing, all things necessary, proper or advisable to consummate and
make effective, in the most expeditious manner practicable, the Merger and the
other transactions contemplated by this Agreement and the Option Agreement,
including using commercially reasonable efforts to accomplish the following: (i)
the taking of all acts necessary to cause the conditions to Closing to be
satisfied as promptly as practicable, (ii) the obtaining of all necessary
actions or nonactions, waivers, consents and approvals from Governmental
Entities and the making of all necessary registrations and filings (including
filings with Governmental Entities, if any) and the taking of all steps as may
be necessary to obtain an approval or waiver from, or to avoid an action or
proceeding by any Governmental Entity, (iii) the obtaining of all necessary
consents, approvals or waivers from third parties, (iv) the defending of any
lawsuits or other legal proceedings, whether judicial or administrative,
challenging this Agreement or the Option Agreement or the consummation of the
transactions contemplated hereby or thereby, including seeking to have any stay
or temporary restraining order entered by any court or other Governmental Entity
vacated or reversed and (v) the execution and delivery of any additional
instruments necessary to consummate the transactions contemplated by, and to
fully carry out the purposes of, this Agreement and the Option Agreement. In
connection with and without limiting the foregoing, the Company and its Board of
Directors shall (1) take all action necessary to ensure that no state takeover
statute or similar statute or regulation is or becomes applicable to this
Agreement, the Option Agreement, the Merger or any of the other transactions
contemplated by this Agreement and the Option Agreement and (2) if any state
takeover statute or similar statute becomes applicable to this Agreement, the
Option Agreement, the Merger or any of the other transactions contemplated by
this Agreement and the Option Agreement, take all action necessary to ensure
that the Merger and the other transactions contemplated by this Agreement and
the Option Agreement may be consummated as promptly as practicable on the terms
contemplated by this Agreement and the Option Agreement and otherwise to
minimize the effect of such statute or regulation on this Agreement, the Option
Agreement, the Merger and the other transactions contemplated by this Agreement
and the Option Agreement. Nothing in this Agreement shall be deemed to require
Parent to agree to, or proffer to, divest or hold separate any significant
assets or any significant portion of any business of Parent, the Company or the
pharmaceutical business of Parent.

     SECTION 5.06.  Stock Options.  (a) Before the Closing, the Board of
Directors of the Company (or, if appropriate, any committee of the Board of
Directors of the Company administering the Company Stock Plans) shall adopt such
resolutions or take such other actions as may be required to effect the
following:

          (i) adjust the terms of all outstanding Stock Options granted under
     the Company's Amended and Restated Stock Plan, the Company's Amended and
     Restated 1985 Stock Option Plan, the Company's Amended and Restated
     Employee Stock Purchase Plan, the Company's Supplemental Employee Stock
     Purchase Plan, the Company's Nonstatutory Stock Option Plan, the SEQUUS
     Pharmaceuticals, Inc. 1987 Employee Stock Option Plan, the SEQUUS
     Pharmaceuticals, Inc. 1987 Consultant Stock Option Plan, the SEQUUS
     Pharmaceuticals, Inc. 1990 Director Stock Option Plan and the SEQUUS
     Pharmaceuticals, Inc. Equity Incentive Plan (collectively, the "Company
     Stock Plans"), whether vested or unvested, as necessary to provide that, at
     the Effective Time, each Stock Option outstanding immediately prior to the
     Effective Time shall be amended and converted into an option to acquire, on
     the same terms and conditions as were applicable under the Stock Option,
     the number of shares of Parent Common Stock (rounded down to the nearest
     whole share) determined by multiplying the number of shares of Company
     Common Stock subject to such Stock Option by the Exchange Ratio, at a price
     per share of Parent Common Stock equal to (A) the aggregate exercise price
     for the shares of Company Common Stock otherwise purchasable pursuant to
     such

                                       1-29
   110

     Stock Option divided by (B) the aggregate number of shares of Parent Common
     Stock deemed purchasable pursuant to such Stock Option (each, as so
     adjusted, an "Adjusted Option"); provided that such exercise price shall be
     rounded up to the nearest whole cent; provided, further, that
     notwithstanding the foregoing, each right granted under the Company's
     Employee Stock Purchase Plan and the Company's Supplemental Employee Stock
     Purchase Plan (collectively, the "Purchase Plans") shall be adjusted in
     accordance with the provisions of Section 5.16(h); and

          (ii) make such other changes to the Company Stock Plans as Parent and
     the Company may agree are appropriate to give effect to the Merger.

     (b) The adjustments provided herein with respect to any Stock Options that
are "incentive stock options" as defined in Section 422 of the Code shall be and
are intended to be effected in a manner which is consistent with Section 424(a)
of the Code.

     (c) At the Effective Time, by virtue of the Merger and without the need of
any further corporate action, Parent shall assume the Company Stock Plans, with
the result that all obligations of the Company under the Company Stock Plans,
including with respect to Stock Options outstanding at the Effective Time, shall
be obligations of Parent following the Effective Time.

     (d) As soon as practicable (but in any event not more than three business
days) after the Effective Time, Parent shall prepare and file with the SEC a
registration statement on Form S-8 (or another appropriate form) registering a
number of shares of Parent Common Stock equal to the number of shares of Parent
Common Stock subject to the Adjusted Options. Such registration statement shall
be kept effective (and the current status of the prospectus or prospectuses
required thereby shall be maintained) at least for so long as any Adjusted
Options or any unsettled awards granted under the Company Stock Plans after the
Effective Time, may remain outstanding.

     (e) As soon as practicable after the Effective Time, Parent shall deliver
to the holders of Stock Options appropriate notices setting forth such holders'
rights pursuant to the respective Company Stock Plans and the agreements
evidencing the grants of such Stock Options and that such Stock Options and
agreements have been assumed by Parent and shall continue in effect on the same
terms and conditions (subject to the adjustments required by this Section 5.06
after giving effect to the Merger).

     (f) Except as otherwise contemplated by this Section 5.06 and except to the
extent required under the respective terms of the Stock Options, all
restrictions or limitations on transfer and vesting with respect to Stock
Options awarded under the Company Stock Plans or any other plan, program or
arrangement of the Company or any of its Subsidiaries, to the extent that such
restrictions or limitations shall not have already lapsed, shall remain in full
force and effect with respect to such Stock Options after giving effect to the
Merger and the assumption by Parent as set forth above.

     SECTION 5.07.  Indemnification, Exculpation and Insurance; Company Grantor
Trust.  (a) All rights to indemnification and exculpation from liabilities for
acts or omissions occurring at or prior to the Effective Time now existing in
favor of the current or former directors or officers of the Company as provided
in the Company Certificate, the Company By-laws or any indemnification agreement
between such directors or officers and the Company (in each case, as in effect
on the date hereof) shall be assumed by the Surviving Corporation in the Merger,
without further action, as of the Effective Time and shall survive the Merger
and shall continue in full force and effect in accordance with their terms.

     (b) In the event that the Surviving Corporation or any of its successors or
assigns (i) consolidates with or merges into any other person and is not the
continuing or surviving corporation or entity of such consolidation or merger or
(ii) transfers or conveys all or substantially all of its properties and other
assets to any person, then, and in each such case, Parent shall cause proper
provision to be made so that the successors and assigns of the Surviving
Corporation shall expressly assume the obligations set forth in this Section
5.07. In the event the Surviving Corporation transfers any material portion of
its assets, in a single transaction or in a series of transactions, Parent will
either guarantee the indemnification obligations referred to in Section 5.07(a)
or take such other action to insure that the ability of the Surviving

                                       1-30
   111

Corporation, legal and financial, to satisfy such indemnification obligations
will not be diminished in any material respect.

     (c) For six years after the Effective Time, Parent shall maintain in effect
the Company's current directors' and officers' liability insurance in respect of
acts or omissions occurring at or prior to the Effective Time, covering each
person currently covered by the Company's directors' and officers' liability
insurance policy (a true and complete copy of which has been heretofore
delivered to Parent), on terms with respect to such coverage and amount no less
favorable than those of such policy in effect on the date hereof; provided,
however, that Parent may substitute therefor policies of Parent containing terms
with respect to coverage and amount no less favorable to such directors and
officers; provided further, however, that in satisfying its obligation under
this Section 5.07(c) Parent shall not be obligated to pay aggregate premiums in
excess of 200% of the amount paid by the Company in its last full fiscal year
(which premiums are hereby represented and warranted by the Company to be
$521,917.50), it being understood and agreed that Parent shall nevertheless be
obligated to provide such coverage as may be obtained for such 200% amount.

     (d) Parent shall, from and after and contingent upon the occurrence of, the
Effective Time, guarantee all liabilities of the Surviving Corporation for the
performance of its obligations under the Executive Estate Protection Plan and
the EEPP Trust Agreement. For so long as such obligation to guarantee remains in
full force and effect, the Company agrees that without the consent of Parent it
will not amend the EEPP Trust Agreement or make any contributions to the Trust
created under the EEPP Trust Agreement.

     (e) The provisions of this Section 5.07 (i) are intended to be for the
benefit of, and will be enforceable by, (x) each indemnified party, his or her
heirs and his or her representatives and (y) each Participant and each
Beneficiary (as such terms are defined in the EEPP Trust Agreement) and (ii) are
in addition to, and not in substitution for, any other rights, including in the
case of any indemnified party, to indemnification or contribution, that any such
person may have by contract or otherwise.

     SECTION 5.08.  Fees and Expenses.  (a) Except as provided in paragraph (b)
of this Section 5.08, all fees and expenses incurred in connection with this
Agreement, the Merger and the other transactions contemplated by this Agreement
shall be paid by the party incurring such fees or expenses, whether or not the
Merger is consummated, except that each of Parent and the Company shall bear and
pay one-half of (i) the costs and expenses incurred in connection with filing,
printing and mailing the Proxy Statement and the Form S-4 and (ii) the filing
fees for the premerger notification and report forms under the HSR Act and any
similar foreign antitrust laws.

     (b) In the event that (i) (A) this Agreement is terminated by Parent
pursuant to Section 7.01(e) (if the Company Adverse Recommendation Change was
made in response to a Superior Proposal) and (B) within 12 months after such
termination, the Company enters into a definitive agreement to consummate, or
consummates, the transactions contemplated by any Takeover Proposal or (ii) (A)
a Takeover Proposal shall have been made to the Company or shall have been made
directly to the stockholders of the Company generally or shall have otherwise
become publicly known or any person shall have publicly announced an intention
(whether or not conditional) to make a Takeover Proposal, (B) this Agreement is
terminated by either Parent or the Company pursuant to Section 7.01(b)(i) or
Section 7.01(b)(iii) and (C) within 12 months after such termination, the
Company enters into a definitive agreement to consummate, or consummates, the
transactions contemplated by any Takeover Proposal, then the Company shall pay
Parent a fee equal to $180,000,000 (the "Termination Fee") by wire transfer of
same-day funds, on the date of the first to occur of the events referred to in
clause (i)(B) or (ii)(C). For purposes of clauses (i)(B) and (ii)(C) of the
immediately preceding sentence only, the term "Takeover Proposal" shall have the
meaning assigned to such term in Section 4.02(a) except that all references to
"15%" therein shall be deemed to be references to "30%".

     (c) The Company acknowledges and agrees that the agreements contained in
Section 5.08(b) are an integral part of the transactions contemplated by this
Agreement, and that, without these agreements, Parent would not enter into this
Agreement; accordingly, if the Company fails promptly to pay the amount

                                       1-31
   112

due pursuant to Section 5.08(b), and, in order to obtain such payment, Parent
commences a suit that results in a judgment against the Company for the
Termination Fee, the Company shall pay to Parent its costs and expenses
(including attorneys' fees and expenses) in connection with such suit, together
with interest on the amount of the Termination Fee from the date such payment
was required to be made until the date of payment at the prime rate of Citibank,
N.A. in effect on the date such payment was required to be made.

     SECTION 5.09.  Public Announcements.  Parent and the Company shall consult
with each other before issuing, and give each other the opportunity to review
and comment upon, any press release or other public statements with respect to
the transactions contemplated by this Agreement and the Option Agreement,
including the Merger, and shall not issue any such press release or make any
such public statement prior to such consultation, except as may be required by
applicable law, court process or by obligations pursuant to any listing
agreement with any national securities exchange or national securities quotation
system. The parties agree that the initial press release to be issued with
respect to the transactions contemplated by this Agreement and the Option
Agreement shall be in the form heretofore agreed to by the parties.

     SECTION 5.10.  Affiliates.  (a) As soon as practicable after the date
hereof, the Company shall deliver to Parent a letter identifying all persons who
are at the time this Agreement is submitted for adoption by the stockholders of
the Company, "affiliates" of the Company for purposes of Rule 145 under the
Securities Act or for purposes of qualifying the Merger for pooling of interests
accounting treatment under Opinion 16 of the Accounting Principles Board and
applicable SEC rules and regulations. The Company shall use its commercially
reasonable efforts to cause each such person to deliver to Parent at least 30
days prior to the Closing Date a written agreement substantially in the form
attached as Exhibit B hereto.

     (b) Parent shall use its commercially reasonable efforts to cause all
persons who are, in Parent's reasonable judgment, "affiliates" of Parent for
purposes of qualifying the Merger for pooling of interests accounting treatment
under Opinion 16 of the Accounting Principles Board and applicable SEC rules and
regulations to comply with the fourth paragraph of Exhibit B hereto.

     SECTION 5.11.  Stock Exchange Listing.  To the extent Parent does not issue
treasury shares in the Merger which are already listed, Parent shall use its
commercially reasonable efforts to cause the shares of Parent Common Stock to be
issued in the Merger to be approved for listing on the NYSE, subject to official
notice of issuance, prior to the Closing Date. The Company shall use its
commercially reasonable efforts to cause the shares of Company Common Stock
issuable pursuant to the Option Agreement to be approved for listing on the NYSE
as promptly as practicable after the date hereof, and in any event prior to the
termination of this Agreement under circumstances where the Option granted under
the Option Agreement is or may become exercisable by Parent.

     SECTION 5.12.  Pooling of Interests.  Each of the Company and Parent shall
use its commercially reasonable efforts to cause the Merger to be accounted for
as a pooling of interests under Opinion 16 of the Accounting Principles Board
and applicable SEC rules and regulations, and such accounting treatment to be
accepted by each of the Company's and Parent's independent public accountants,
and by the SEC, respectively, and neither the Company nor Parent shall
voluntarily take any action that would cause such accounting treatment not to be
obtained.

     SECTION 5.13.  Tax Treatment.  Each of Parent and the Company shall use its
commercially reasonable efforts to cause the Merger to qualify as a
reorganization within the meaning of Section 368(a) of the Code and to obtain
the opinion of counsel referred to in Section 6.03(c), including by executing
the letters of representation referred to therein and delivering such letters
prior to (i) the filing of the Form S-4 with the SEC and (ii) the Closing.

     SECTION 5.14.  Stockholder Litigation.  The Company shall give Parent the
opportunity to participate in the defense or settlement of any stockholder
litigation against the Company and/or its directors relating to the transactions
contemplated by this Agreement or the Option Agreement, and no

                                       1-32
   113

such settlement shall be agreed to without Parent's prior consent, which consent
shall not be unreasonably withheld or delayed.

     SECTION 5.15.  Rights Agreement.  The Board of Directors of the Company
shall take all further action (in addition to that referred to in Section
3.01(w)) requested by Parent in order to render the rights (the "Rights") issued
pursuant to the Rights Agreement to purchase Series RP Preferred Stock of the
Company inapplicable to the Merger and the other transactions contemplated by
this Agreement and the Option Agreement. Except as provided above with respect
to the Merger and the other transactions contemplated by this Agreement and the
Option Agreement, the Board of Directors of the Company shall not, without the
prior written consent of Parent, (a) amend the Rights Agreement or (b) take any
action with respect to, or make any determination under, the Rights Agreement,
including a redemption of the Rights or any action to facilitate a Takeover
Proposal.

     SECTION 5.16.  Employee Matters.  (a) For a period ending not earlier than
December 31, 2002, employees of the Company and its Subsidiaries who continue
their employment after the Effective Time (the "Affected Employees") shall be
provided base salary or hourly wage rates that are no less than those provided
for such employees immediately prior to the Effective Time.

     (b) For a period ending not earlier than December 31, 2001, the Affected
Employees shall receive employee benefits pursuant to the Benefit Plans listed
on Section 5.16(b) of the Company Disclosure Schedule according to their terms
as in effect immediately prior to the Effective Time. It is the intention of
Parent that until at least December 31, 2002, the Affected Employees shall
receive employee benefits pursuant to the Benefit Plans listed on Section
5.16(b) of the Company Disclosure Schedule according to their terms as in effect
immediately prior to the Effective Time, unless there is a good business reason
to change any such plan. In any event, from January 1, 2002 through December 31,
2002, the Affected Employees shall be provided employee benefits that are no
less favorable in the aggregate than the benefits provided to such employees
under the Benefit Plans listed on Section 5.16(b) of the Company Disclosure
Schedule as in effect immediately prior to the Effective Time. The provisions of
this Section 5.16(b) shall be subject to the provisions of Sections 5.06(a) and
5.16(i). Neither Parent nor the Surviving Corporation shall have any obligation
to issue, or adopt any plans or arrangement providing for the issuance of,
shares of capital stock, warrants, options, stock appreciation rights or other
rights in respect of any shares of capital stock of any entity or any securities
convertible or exchangeable into such shares pursuant to any such plans or
arrangements. Neither any plans or arrangements of the Company providing for
such issuance, nor the Company's bonus leave program, shall be taken into
account in determining whether employee benefits are no less favorable in the
aggregate. Notwithstanding anything to the contrary in this Agreement, neither
Parent nor the Surviving Corporation shall be required to continue the Company's
bonus leave program following the Effective Time for any participants other than
individuals who are employed by the Company and its Subsidiaries immediately
prior to the Effective Time. In the event that Parent and the Surviving
Corporation discontinue the Company's bonus leave program after December 31,
2001, Parent agrees that it shall provide, or shall cause the Surviving
Corporation to provide, to each participant in the Company's bonus leave program
who as of December 31, 2001 (the "Bonus Credit Date") has earned partial service
credit toward a paid bonus leave thereunder, either (x) a paid leave for the
number of days equal to the product (rounded down to the nearest whole day) of
the number of days of paid bonus leave that would have been provided under the
Company's bonus leave program if the participant had accrued the full bonus
leave as of the Bonus Credit Date, multiplied by a fraction, the numerator of
which is the number of completed calendar months (with 15 or more calendar days
of accrued service credit in any month being treated as a full completed
calendar month) of service credit towards the paid bonus leave accrued through
the Bonus Credit Date, and the denominator of which is 96, or (y) a payment in
cash in an amount equal to the participant's annual base salary multiplied by a
fraction, the numerator of which is the number of days determined under the
immediately preceding clause (x) and the denominator of which is 365. Upon the
termination of employment during the period after the Effective Time but prior
to the Bonus Credit Date of any participant in the Company's bonus leave
program, Parent shall pay or cause the Surviving Corporation to pay to such
terminating employee

                                       1-33
   114

the value of all service credit earned toward bonus leave, such value to be
calculated in the same manner as set forth in the foregoing sentence.

     (c) With respect to any benefit plan for which Parent or its Subsidiaries
file a Form 5500 and with respect to Parent's vacation program, Parent shall,
and shall cause the Surviving Corporation to, recognize the service with the
Company and its Subsidiaries prior to the Effective Time of Affected Employees
for purposes of such plan or program; provided, however, that (i) Parent shall
not be required to recognize such service under its short-term disability,
retiree medical or retiree life insurance benefit plans, (ii) under Parent's
defined benefit pension plan, such service shall be recognized for purposes of
eligibility and vesting but not for benefit accrual purposes, (iii) no provision
hereunder shall be construed to reduce the annual accrual under the Personal
Time Off, or PTO, program of the Company and its Subsidiaries immediately prior
to the Effective Time which such employee would be eligible to receive on or
after the Effective Time and (iv) no provision hereunder shall be construed to
require Parent or any of its Subsidiaries to provide any such benefit on or
after the Effective Time.

     (d) Neither the Company nor any of its Subsidiaries shall take any action
on or prior to the Effective Time to alter, change, modify or impair the terms
and conditions of employment of any European-based employees without the prior
written consent of Parent.

     (e) The Company and its Subsidiaries shall comply with all obligations to
notify and consult with recognized employee representatives in connection with
the transactions contemplated by this Agreement.

     (f) Prior to the Effective Time, the Company shall take all such steps as
may be required to cause the transactions contemplated by Section 5.06 and any
other dispositions of Company equity securities (including derivative
securities) in connection with this Agreement or the transactions contemplated
hereby by each individual who is a director or officer of the Company, to be
exempt under Rule 16b-3 promulgated under the Exchange Act, such steps to be
taken in accordance with the interpretive letter dated January 12, 1999, issued
by the SEC to Skadden, Arps, Slate, Meagher & Flom LLP.

     (g) Nothing contained herein shall be construed as requiring Parent or the
Surviving Corporation to continue any specific plans or to continue the
employment of any specific person.

     (h) With respect to any welfare plan in which employees of the Company and
its Subsidiaries are eligible to participate after the Effective Time, Parent
shall, and shall cause the Surviving Corporation to, (i) waive all limitations
as to preexisting conditions, exclusions and waiting periods with respect to
participation and coverage requirements applicable to such employees to the
extent such conditions were satisfied under the welfare plans of the Company and
its Subsidiaries prior to the Effective Time, and (ii) provide each such
employee with credit for any co-payments and deductibles paid prior to the
Effective Time in satisfying any analogous deductible or out-of-pocket
requirements to the extent applicable under any such plan.

     (i) Before the Closing, the Board of Directors of the Company (or, if
appropriate, any committee of the Board of Directors of the Company
administering the Purchase Plans), shall adopt such resolutions or take such
other actions as may be required to cause (i) no further contributions to be
permitted to be made to the Purchase Plans following the Effective Time by any
participant with respect to any outstanding enrollments in respect of the
then-current offering periods under the Purchase Plans, (ii) as of the Effective
Time, each outstanding right to purchase shares of Company Common Stock under
the Purchase Plans to be converted into a right to purchase, on the same terms
and conditions as were applicable under such right, the number of shares of
Parent Common Stock (rounded down to the nearest whole share) determined by
multiplying the number of shares of Company Common Stock for which such purchase
right would otherwise have been exercisable determined as of the relevant grant
date by the Exchange Ratio, at a purchase price per share equal to 85% of the
lesser of (A) the fair market value of a share of Company Common Stock on the
applicable Enrollment Date or Lower Price Enrollment Date (each as defined in
the applicable Purchase Plan), divided by the Exchange Ratio and (B) the fair
market value of a share of Parent Common Stock on the applicable Purchase Date
(as defined in the applicable Purchase Plan) and (iii) immediately following the
first Purchase Date that occurs following the Effective

                                       1-34
   115

Time, each Purchase Plan and all then outstanding enrollments in respect of the
then current offering period thereunder to be terminated.

     (j) Parent and the Company agree to implement the arrangements described in
Section 5.16(j) of the Company Disclosure Schedule.

     SECTION 5.17.  Convertible Notes.  (a) At the Effective Time, Parent shall
enter into a supplemental indenture satisfying the requirements of Section 11.14
of the Indenture dated as of July 1, 1994, between the Company and The Chase
Manhattan Bank, N.A., as trustee, relating to the Notes (the "Note Indenture"),
and the Company shall use commercially reasonable efforts to cause such trustee
to enter into such supplemental indenture. Parent, the Company, and, after the
Effective Time, the Surviving Corporation shall take any other action required
to be taken pursuant to the Note Indenture.

     (b) At the Effective Time, Parent shall enter into a supplemental indenture
satisfying the requirements of Section 4.11 of the Indenture dated as of July
28, 2000, between the Company and The Chase Manhattan Bank and Trust Company,
National Association, as Trustee, relating to the Debentures (the "Debenture
Indenture"), and the Company shall use commercially reasonable efforts to cause
such trustee to execute such supplemental indenture. Parent, the Company and,
after the Effective Time, the Surviving Corporation shall take any other action
required to be taken pursuant to the Debenture Indenture.

                                   ARTICLE VI

                              CONDITIONS PRECEDENT

     SECTION 6.01.  Conditions to Each Party's Obligation to Effect the
Merger.  The respective obligation of each party to effect the Merger is subject
to the satisfaction or waiver on or prior to the Closing Date of the following
conditions:

          (a) Stockholder Approval.  The Stockholder Approval shall have been
     obtained.

          (b) NYSE Listing.  The shares of Parent Common Stock issuable to the
     stockholders of the Company and to holders of Adjusted Options as
     contemplated by this Agreement and the shares of Parent Common Stock that
     may be issuable to holders of the Convertible Notes shall have been
     approved for listing on the NYSE, subject to official notice of issuance.

          (c) Antitrust.  The waiting period (and any extension thereof)
     applicable to the Merger under the HSR Act shall have been terminated or
     shall have expired, and the European Commission shall have issued a
     decision under Article 6(1)(b) or 8(2) of the EC Merger Regulation (or
     shall be deemed to have done so under Article 10(6) of the EC Merger
     Regulation) declaring the Merger compatible with the EC Common Market.

          (d) No Injunctions or Restraints.  No temporary restraining order,
     preliminary or permanent injunction or other judgment or order issued by
     any court of competent jurisdiction or other statute, law, rule, legal
     restraint or prohibition (collectively, "Restraints") shall be in effect
     preventing the consummation of the Merger; provided, however, that each of
     the parties has used its commercially reasonable efforts to prevent the
     entry of any such Restraints and to appeal as promptly as possible any such
     Restraints that may be entered.

          (e) Form S-4.  The Form S-4 shall have become effective under the
     Securities Act and shall not be the subject of any stop order or
     proceedings seeking a stop order.

          (f) Pooling Letters.  Parent and the Company shall have received
     letters from Ernst & Young LLP and PricewaterhouseCoopers LLP, in each case
     dated as of the Closing Date and addressed to Parent and the Company,
     stating in substance the matters to be stated by Ernst & Young LLP and
     PricewaterhouseCoopers LLP, pursuant to Sections 5.02 and 5.03,
     respectively.

                                       1-35
   116

     SECTION 6.02.  Conditions to Obligations of Parent and Merger Sub.  The
obligations of Parent and Merger Sub to effect the Merger are further subject to
the satisfaction or waiver on or prior to the Closing Date of the following
conditions:

          (a) Representations and Warranties.  (i) The representations and
     warranties of the Company contained in Sections 3.01(c) and 3.01(r) shall
     be true and correct in all material respects as of the date of this
     Agreement and as of the Closing Date as though made on the Closing Date,
     except to the extent such representations and warranties expressly relate
     to an earlier date, in which case as of such earlier date, (ii) the
     representations and warranties of the Company contained in Sections
     3.01(g)(iv), 3.01(i)(y) and 3.01(v) shall be true and correct as of the
     date of this Agreement and as of the Closing Date as though made on the
     Closing Date, except to the extent such representations and warranties
     expressly relate to an earlier date, in which case as of such earlier date,
     and except further to the extent that the facts or matters as to which such
     representations and warranties are not so true and correct as of such
     dates, individually or in the aggregate, could not reasonably be expected
     to have a material adverse effect on the reasonably expected benefits of
     the Merger to Parent and (iii) all other representations and warranties of
     the Company contained in this Agreement shall be true and correct as of the
     date of this Agreement and as of the Closing Date as though made on the
     Closing Date, except to the extent such representations and warranties
     expressly relate to an earlier date, in which case as of such earlier date,
     and except further to the extent that the facts or matters as to which such
     representations and warranties are not so true and correct as of such dates
     (without giving effect to any qualifications or limitations as to
     materiality or Material Adverse Effect set forth therein), individually or
     in the aggregate, have not had and could not reasonably be expected to have
     a Material Adverse Effect. Parent shall have received a certificate signed
     on behalf of the Company by the chief executive officer and the chief
     financial officer of the Company to such effect.

          (b) Performance of Obligations of the Company.  The Company shall have
     performed in all material respects all obligations required to be performed
     by it under this Agreement at or prior to the Closing Date, and Parent
     shall have received a certificate signed on behalf of the Company by the
     chief executive officer and the chief financial officer of the Company to
     such effect.

          (c) Letters from Company Affiliates.  Parent shall have received from
     each person named in the letter referred to in Section 5.10(a) an executed
     copy of an agreement substantially in the form of Exhibit B hereto.

          (d) No Governmental Litigation.  There shall not be pending or
     threatened any suit, action or proceeding by any Governmental Entity (i)
     challenging the acquisition by Parent or Merger Sub of any shares of
     Company Common Stock, seeking to restrain or prohibit the consummation of
     the Merger, or seeking to place limitations on the ownership of shares of
     Company Common Stock (or shares of common stock of the Surviving
     Corporation) by Parent or Merger Sub or seeking to obtain from the Company,
     Parent or Merger Sub any damages that are material in relation to the
     Company, (ii) seeking to prohibit or materially limit the ownership or
     operation by the Company or any of its Subsidiaries or by Parent or any of
     its Subsidiaries of any material portion of any business or of any assets
     of the Company and its Subsidiaries, taken as a whole, or Parent and its
     Subsidiaries, taken as a whole, or to compel the Company or any of its
     Subsidiaries or Parent or any of its Subsidiaries to divest or hold
     separate any material portion of any business or of any assets of the
     Company and its Subsidiaries, taken as a whole, or Parent and its
     Subsidiaries, taken as a whole, as a result of the Merger, (iii) seeking to
     prohibit Parent or any of its Subsidiaries from effectively controlling in
     any material respect the business or operations of the Company or any of
     its Subsidiaries or (iv) otherwise having, or being reasonably expected to
     have, a Material Adverse Effect.

                                       1-36
   117

     SECTION 6.03.  Conditions to Obligation of the Company.  The obligation of
the Company to effect the Merger is further subject to the satisfaction or
waiver on or prior to the Closing Date of the following conditions:

          (a) Representations and Warranties.  The representations and
     warranties of Parent and Merger Sub contained in this Agreement that are
     qualified as to materiality shall be true and correct, and the
     representations and warranties of Parent and Merger Sub contained in this
     Agreement that are not so qualified shall be true and correct in all
     material respects, in each case as of the date of this Agreement and as of
     the Closing Date as though made on the Closing Date, except to the extent
     such representations and warranties expressly relate to an earlier date, in
     which case as of such earlier date, and except further to the extent that
     the facts or matters as to which such representations and warranties are
     not so true and correct as of such dates (without giving effect to any
     qualifications or limitations as to materiality or Parent Material Adverse
     Effect set forth therein), individually or in the aggregate, have not had
     and could not reasonably be expected to have a Parent Material Adverse
     Effect. The Company shall have received a certificate signed on behalf of
     Parent by an executive officer of Parent to such effect.

          (b) Performance of Obligations of Parent and Merger Sub.  Parent and
     Merger Sub shall have performed in all material respects all obligations
     required to be performed by them under this Agreement at or prior to the
     Closing Date, and the Company shall have received a certificate signed on
     behalf of Parent by an executive officer of Parent to such effect.

          (c) Tax Opinion.  The Company shall have received from Heller Ehrman
     White & McAuliffe LLP, tax counsel to the Company, on the Closing Date, an
     opinion dated as of the Closing Date and stating that the Merger will be
     treated for United States Federal income tax purposes as a "reorganization"
     within the meaning of Section 368(a) of the Code. The issuance of such
     opinion shall be conditioned upon the receipt by such tax counsel of
     representation letters from each of the Company and Parent in the forms
     included as Sections 5.13(a) and 5.13(b), respectively, of the Company
     Disclosure Schedule.

     SECTION 6.04.  Frustration of Closing Conditions.  None of the Company,
Parent or Merger Sub may rely on the failure of any condition set forth in
Section 6.01, 6.02 or 6.03, as the case may be, to be satisfied if such failure
was caused by such party's failure to use its commercially reasonable efforts to
consummate the Merger and the other transactions contemplated by this Agreement
and the Option Agreement, as required by and subject to Section 5.05. None of
Parent, Merger Sub or the Company may rely on the failure of the condition set
forth in Section 6.01(f) to be satisfied if such failure was caused by the
failure of an "affiliate" of such person for purposes of qualifying the Merger
for pooling of interests accounting treatment (or, in the case of Merger Sub, an
"affiliate" of Parent) to comply with the fourth paragraph of Exhibit B hereto.

                                  ARTICLE VII

                       TERMINATION, AMENDMENT AND WAIVER

     SECTION 7.01.  Termination.  This Agreement may be terminated at any time
prior to the Effective Time, whether before or after receipt of the Stockholder
Approval:

          (a) by mutual written consent of Parent and the Company;

          (b) by either Parent or the Company:

             (i) if the Merger shall not have been consummated on or before
        December 31, 2001; provided, however, that the right to terminate this
        Agreement under this Section 7.01(b)(i) shall not be available to any
        party whose action or failure to act has been a principal cause of or
        resulted in the failure of the Merger to be consummated on or before
        such date;

                                       1-37
   118

             (ii) if any Restraint having the effect set forth in Section
        6.01(d) shall be in effect and shall have become final and
        nonappealable; or

             (iii) if the Stockholder Approval shall not have been obtained at
        the Stockholders' Meeting duly convened therefor or at any adjournment
        or postponement thereof;

          (c) by Parent, if the Company shall have breached or failed to perform
     any of its representations, warranties, covenants or agreements set forth
     in this Agreement, which breach or failure to perform (A) would give rise
     to the failure of a condition set forth in Section 6.02(a) or 6.02(b) and
     (B) is incapable of being cured by the Company within 30 calendar days
     following receipt of written notice of such breach or failure to perform
     from Parent;

          (d) by the Company, if Parent shall have breached or failed to perform
     any of its representations, warranties, covenants or agreements set forth
     in this Agreement, which breach or failure to perform (A) would give rise
     to the failure of a condition set forth in Section 6.03(a) or 6.03(b) and
     (B) is incapable of being cured by Parent within 30 calendar days following
     receipt of written notice of such breach or failure to perform from the
     Company; or

          (e) by Parent, in the event that a Company Adverse Recommendation
     Change shall have occurred.

     SECTION 7.02.  Effect of Termination.  In the event of termination of this
Agreement by either the Company or Parent as provided in Section 7.01, this
Agreement shall forthwith become void and have no effect, without any liability
or obligation on the part of Parent, Merger Sub or the Company, other than the
provisions of Section 3.01(s), Section 3.02(j), the last sentence of Sections
5.04(a) and (b), Section 5.08, this Section 7.02 and Article VIII, which
provisions shall survive such termination, and except to the extent that such
termination results from the wilful and material breach by a party of any of its
representations, warranties, covenants or agreements set forth in this
Agreement.

     SECTION 7.03.  Amendment.  This Agreement may be amended by the parties
hereto at any time before or after receipt of the Stockholder Approval;
provided, however, that after such approval has been obtained, there shall be
made no amendment that by law requires further approval by the stockholders of
the Company or the approval of the shareholders of Parent without such approval
having been obtained. This Agreement may not be amended except by an instrument
in writing signed on behalf of each of the parties hereto.

     SECTION 7.04.  Extension; Waiver.  At any time prior to the Effective Time,
the parties may (a) extend the time for the performance of any of the
obligations or other acts of the other parties, (b) waive any inaccuracies in
the representations and warranties contained herein or in any document delivered
pursuant hereto or (c) subject to the proviso to the first sentence of Section
7.03, waive compliance with any of the agreements or conditions contained
herein. Any agreement on the part of a party to any such extension or waiver
shall be valid only if set forth in an instrument in writing signed on behalf of
such party. The failure of any party to this Agreement to assert any of its
rights under this Agreement or otherwise shall not constitute a waiver of such
rights.

     SECTION 7.05.  Procedure for Termination or Amendment.  A termination of
this Agreement pursuant to Section 7.01 or an amendment of this Agreement
pursuant to Section 7.03 shall, in order to be effective, require, in the case
of Parent or the Company, action by its Board of Directors or, with respect to
any amendment of this Agreement pursuant to Section 7.03, the duly authorized
committee or other designee of its Board of Directors to the extent permitted by
law.

                                  ARTICLE VIII

                               GENERAL PROVISIONS

     SECTION 8.01.  Nonsurvival of Representations and Warranties.  None of the
representations and warranties in this Agreement or in any instrument delivered
pursuant to this Agreement shall survive the

                                       1-38
   119

Effective Time. This Section 8.01 shall not limit any covenant or agreement of
the parties which by its terms contemplates performance after the Effective
Time.

     SECTION 8.02.  Notices.  Except for notices that are specifically required
by the terms of this Agreement to be delivered orally, all notices, requests,
claims, demands and other communications hereunder shall be in writing and shall
be deemed given if delivered personally, telecopied (which is confirmed) or sent
by overnight courier (providing proof of delivery) to the parties at the
following addresses (or at such other address for a party as shall be specified
by like notice):

     if to Parent or Merger Sub, to:

       Johnson & Johnson
       One Johnson & Johnson Plaza
       New Brunswick, NJ 08933

        Telecopy No.: (732) 524-2788

        Attention: Office of General Counsel

     with a copy to:

       Cravath, Swaine & Moore
       Worldwide Plaza
       825 Eighth Avenue
       New York, NY 10019

        Telecopy No.: (212) 474-3700

        Attention: Robert I. Townsend, III, Esq.

     if to the Company, to:

       ALZA Corporation
       1900 Charleston Road
       Mountain View, CA 94043

        Telecopy No.: (650) 564-7848

        Attention: General Counsel

     with a copy to:

       Heller Ehrman White & McAuliffe LLP
       275 Middlefield Road
       Menlo Park, CA 94025

       Telecopy No.: (650) 324-0638
       Attention: Sarah A. O'Dowd, Esq.

     SECTION 8.03.  Definitions.  For purposes of this Agreement:

          (a) an "Affiliate" of any person means another person that directly or
     indirectly, through one or more intermediaries, controls, is controlled by,
     or is under common control with, such first person;

          (b) "Knowledge" of any person that is not an individual means, with
     respect to any matter in question, the knowledge of such person's executive
     officers and other officers having primary responsibility for such matter;

          (c) "Material Adverse Change" or "Material Adverse Effect" means any
     change, effect, event, occurrence or state of facts (or any development or
     developments which individually or in the aggregate could reasonably be
     expected to result in any change or effect) that is materially adverse to
     the business, properties, assets, liabilities (contingent or otherwise),
     financial condition or results of operations of the Company and its
     Subsidiaries, taken as a whole, other than any change, effect,

                                       1-39
   120

     event, occurrence, state of facts or development (i) relating to the
     economy in general or (ii) relating to the industry in which the Company
     operates in general and not specifically relating to the Company;

          (d) "Parent Material Adverse Effect" or "Parent Material Adverse
     Change" means any change, effect, event, occurrence or state of facts (or
     any development or developments which individually or in the aggregate
     could reasonably be expected to result in any change or effect) that is
     materially adverse to the business, properties, assets, liabilities
     (contingent or otherwise), financial condition or results of operations of
     Parent and its Subsidiaries, taken as a whole, other than any change,
     effect, event, occurrence, state of facts or development (i) relating to
     the economy in general or (ii) relating to the industries in which Parent
     operates in general and not specifically relating to Parent;

          (e) "person" means an individual, corporation, partnership, limited
     liability company, joint venture, association, trust, unincorporated
     organization or other entity; and

          (f) a "Subsidiary" of any person means another person, an amount of
     the voting securities, other voting rights or voting partnership interests
     of which is sufficient to elect at least a majority of its board of
     directors or other governing body (or, if there are no such voting
     interests, 50% or more of the equity interests of which) is owned directly
     or indirectly by such first person; provided, however, that in the case of
     the Company, the term "Subsidiary" shall not include P/A Charleston Road,
     LLC.

     SECTION 8.04.  Interpretation.  (a) When a reference is made in this
Agreement to an Article, a Section, Exhibit or Schedule, such reference shall be
to an Article of, a Section of, or an Exhibit or Schedule to, this Agreement
unless otherwise indicated. The table of contents and headings contained in this
Agreement are for reference purposes only and shall not affect in any way the
meaning or interpretation of this Agreement. Whenever the words "include",
"includes" or "including" are used in this Agreement, they shall be deemed to be
followed by the words "without limitation". The words "hereof", "herein" and
"hereunder" and words of similar import when used in this Agreement shall refer
to this Agreement as a whole and not to any particular provision of this
Agreement. All terms defined in this Agreement shall have the defined meanings
when used in any certificate or other document made or delivered pursuant hereto
unless otherwise defined therein. The definitions contained in this Agreement
are applicable to the singular as well as the plural forms of such terms and to
the masculine as well as to the feminine and neuter genders of such term. Any
agreement, instrument or statute defined or referred to herein or in any
agreement or instrument that is referred to herein means such agreement,
instrument or statute as from time to time amended, modified or supplemented,
including (in the case of agreements or instruments) by waiver or consent and
(in the case of statutes) by succession of comparable successor statutes and
references to all attachments thereto and instruments incorporated therein.
References to a person are also to its permitted successors and assigns.

     (b) Any matter disclosed in any section of the Company Disclosure Schedule
or the Parent Disclosure Schedule, as the case may be, shall be deemed disclosed
for all purposes and all sections of the Company Disclosure Schedule or the
Parent Disclosure Schedule, as the case may be, to the extent that it is readily
apparent on the face of the Company Disclosure Schedule or the Parent Disclosure
Schedule, as the case may be, that such matter is relevant to another section of
the Company Disclosure Schedule or the Parent Disclosure Schedule, as the case
may be.

     SECTION 8.05.  Counterparts.  This Agreement may be executed in one or more
counterparts, all of which shall be considered one and the same agreement and
shall become effective when one or more counterparts have been signed by each of
the parties and delivered to the other parties.

     SECTION 8.06.  Entire Agreement; No Third-Party Beneficiaries.  This
Agreement, the Option Agreement and the Confidentiality Agreement (a) constitute
the entire agreement, and supersede all prior agreements and understandings,
both written and oral, among the parties with respect to the subject matter of
this Agreement, the Option Agreement and the Confidentiality Agreement and (b)
except for the

                                       1-40
   121

provisions of Article II and Section 5.07, are not intended to confer upon any
person other than the parties any rights or remedies.

     SECTION 8.07.  Governing Law.  This Agreement shall be governed by, and
construed in accordance with, the laws of the State of Delaware, regardless of
the laws that might otherwise govern under applicable principles of conflicts of
laws thereof.

     SECTION 8.08.  Assignment.  Neither this Agreement nor any of the rights,
interests or obligations hereunder shall be assigned, in whole or in part, by
operation of law or otherwise by any of the parties without the prior written
consent of the other parties, except that Merger Sub may assign, in its sole
discretion, any of or all its rights, interests and obligations under this
Agreement to Parent or to any direct or indirect wholly owned Subsidiary of
Parent, but no such assignment shall relieve Merger Sub of any of its
obligations hereunder. Subject to the preceding sentence, this Agreement will be
binding upon, inure to the benefit of, and be enforceable by, the parties and
their respective successors and assigns.

     SECTION 8.09.  Specific Enforcement; Consent to Jurisdiction.  The parties
agree that irreparable damage would occur and that the parties would not have
any adequate remedy at law in the event that any of the provisions of this
Agreement were not performed in accordance with their specific terms or were
otherwise breached. It is accordingly agreed that the parties shall be entitled
to an injunction or injunctions to prevent breaches of this Agreement and to
enforce specifically the terms and provisions of this Agreement in any Federal
court located in the State of Delaware or in any state court in the State of
Delaware, this being in addition to any other remedy to which they are entitled
at law or in equity. In addition, each of the parties hereto (a) consents to
submit itself to the personal jurisdiction of any Federal court located in the
State of Delaware or of any state court located in the State of Delaware in the
event any dispute arises out of this Agreement or the transactions contemplated
by this Agreement, (b) agrees that it will not attempt to deny or defeat such
personal jurisdiction by motion or other request for leave from any such court
and (c) agrees that it will not bring any action relating to this Agreement or
the transactions contemplated by this Agreement in any court other than a
Federal court located in the State of Delaware or a state court located in the
State of Delaware.

     SECTION 8.10.  Severability.  If any term or other provision of this
Agreement is invalid, illegal or incapable of being enforced by any rule of law
or public policy, all other conditions and provisions of this Agreement shall
nevertheless remain in full force and effect. Upon such determination that any
term other provision is invalid, illegal or incapable of being enforced, the
parties hereto shall negotiate in good faith to modify this Agreement so as to
effect the original intent of the parties as closely as possible to the fullest
extent permitted by applicable law in an acceptable manner to the end that the
transactions contemplated hereby are fulfilled to the extent possible.

                                       1-41
   122

     IN WITNESS WHEREOF, Parent, Merger Sub and the Company have caused this
Agreement to be signed by their respective officers thereunto duly authorized,
all as of the date first written above.

                                          JOHNSON & JOHNSON,

                                          by /s/ R. S. LARSON
                                            ------------------------------------
                                             Name: R. S. Larson
                                             Title: Chairman and Chief Executive
                                             Officer

                                          EXPRESS MERGER SUB INC.,

                                          by /s/ JAMES R. HILTON
                                            ------------------------------------
                                             Name: James R. Hilton
                                             Title: President

                                          ALZA CORPORATION,

                                          by /s/ ERNEST MARIO
                                            ------------------------------------
                                             Name: Ernest Mario
                                             Title: Chairman and Chief Executive
                                             Officer

                                       1-42
   123

                                                                         ANNEX I
                                                         TO THE MERGER AGREEMENT

                             INDEX OF DEFINED TERMS



TERM
----
                                                           
Actions.....................................................  Section 4.01(d)
Adjusted Option.............................................  Section 5.06
Affected Employee...........................................  Section 5.16(a)
Affiliate...................................................  Section 8.03(a)
Agreement...................................................  Preamble
Article 10..................................................  Section 3.01(r)
Benefit Agreements..........................................  Section 3.01(g)
Benefit Plans...............................................  Section 3.01(k)
Bonus Credit Date...........................................  Section 5.16(b)
Certificate.................................................  Section 2.01(c)
Certificate of Merger.......................................  Section 1.03
Closing.....................................................  Section 1.02
Closing Date................................................  Section 1.02
Code........................................................  Preamble
Commonly Controlled Entity..................................  Section 3.01(k)
Company.....................................................  Preamble
Company Adverse Recommendation Change.......................  Section 4.02(b)
Company By-laws.............................................  Section 3.01(a)
Company Certificate.........................................  Section 3.01(a)
Company Common Stock........................................  Preamble
Company Disclosure Schedule.................................  Section 3.01
Company Preferred Stock.....................................  Section 3.01(c)
Company SEC Documents.......................................  Section 3.01(e)
Company Stock Plans.........................................  Section 5.06(a)
Confidentiality Agreement...................................  Section 5.04(a)
Convertible Notes...........................................  Section 3.01(c)
Debentures..................................................  Section 3.01(c)
Debenture Indenture.........................................  Section 5.17(b)
DGCL........................................................  Section 1.01
EC Merger Regulation........................................  Section 3.01(d)
Effective Time..............................................  Section 1.03
Environmental Laws..........................................  Section 3.01(j)
EEPP Trust Agreement........................................  Section 3.01(y)
ERISA.......................................................  Section 3.01(l)
Exchange Act................................................  Section 3.01(d)
Exchange Agent..............................................  Section 2.02(a)
Exchange Fund...............................................  Section 2.02(a)
Exchange Ratio..............................................  Section 2.01(c)
FDA.........................................................  Section 3.01(j)
FDCA........................................................  Section 3.01(j)
Filed Company SEC Documents.................................  Section 3.01(e)
Filed Parent SEC Documents..................................  Section 3.02
Form S-4....................................................  Section 3.01(f)
GAAP........................................................  Section 3.01(e)
Governmental Entity.........................................  Section 3.01(d)
Hazardous Materials.........................................  Section 3.01(j)
HSR Act.....................................................  Section 3.01(d)


                                       1-43
   124



TERM
----
                                                           
Intellectual Property Rights................................  Section 3.01(p)
IRS.........................................................  Section 3.01(l)
Key Employee................................................  Section 3.01(g)
Knowledge...................................................  Section 8.03(b)
Legal Provisions............................................  Section 3.01(j)
Liens.......................................................  Section 3.01(b)
Listed Products.............................................  Section 3.01(v)
Material Adverse Change.....................................  Section 8.03(c)
Material Adverse Effect.....................................  Section 8.03(c)
Merger......................................................  Preamble
Merger Consideration........................................  Section 2.01(c)
Merger Sub..................................................  Preamble
Notes.......................................................  Section 3.01(c)
Note Indenture..............................................  Section 5.17(a)
Notice of Adverse Recommendation............................  Section 4.02(b)
NYSE........................................................  Section 2.02(e)
Option......................................................  Preamble
Option Agreement............................................  Preamble
Parachute Gross Up Payment..................................  Section 3.01(m)
Parent......................................................  Preamble
Parent Common Stock.........................................  Preamble
Parent Disclosure Schedule..................................  Section 3.02
Parent Material Adverse Change..............................  Section 8.03(d)
Parent Material Adverse Effect..............................  Section 8.03(d)
Parent Preferred Stock......................................  Section 3.01(k)
Parent SEC Documents........................................  Section 3.02(c)
Pension Plan................................................  Section 3.01(l)
Permits.....................................................  Section 3.01(j)
person......................................................  Section 8.03(e)
Pharmaceutical Product......................................  Section 3.01(x)
Post-Signing Returns........................................  Section 4.01(d)
Proxy Statement.............................................  Section 3.01(d)
Purchase Plans..............................................  Section 5.06(a)
Representatives.............................................  Section 4.02(a)
Release.....................................................  Section 3.01(j)
Restraints..................................................  Section 6.01(d)
Rights......................................................  Section 5.15
Rights Agreement............................................  Section 3.01(w)
SEC.........................................................  Section 3.01(d)
Section 10..................................................  Section 3.10(r)
Section 203.................................................  Section 3.10(r)
Securities Act..............................................  Section 3.01(e)
Stockholder Approval........................................  Section 3.01(q)
Stockholders' Meeting.......................................  Section 5.01(b)
Stock Options...............................................  Section 3.01(c)
Subsidiary..................................................  Section 8.03(f)
Superior Proposal...........................................  Section 4.02(a)
Surviving Corporation.......................................  Section 1.01
Takeover Proposal...........................................  Section 4.02(a)
taxes.......................................................  Section 3.01(n)
Termination Fee.............................................  Section 5.08(b)


                                       1-44
   125

                                                                       EXHIBIT A
                                                         TO THE MERGER AGREEMENT

       FORM OF CERTIFICATE OF INCORPORATION OF THE SURVIVING CORPORATION

     First:  The name of the corporation (hereinafter called the "Corporation")
is ALZA Corporation.

     Second:  The address, including street, number, city, and county, of the
registered office of the Corporation in the State of Delaware is 2711
Centerville Road, Suite 400, Wilmington, Delaware 19808, County of New Castle;
and the name of the registered agent of the Corporation in the State of Delaware
at such address is Corporation Service Company.

     Third:  The purpose of the Corporation is to engage in any lawful act or
activity for which corporations may be organized under the General Corporation
Law of the State of Delaware.

     Fourth:  The aggregate number of shares which the Corporation shall have
authority to issue is 1,000 shares of Common Stock, par value $0.01 per share.

     Fifth:  In furtherance and not in limitation of the powers conferred upon
it by law, the Board of Directors of the Corporation is expressly authorized to
adopt, amend or repeal the By-laws of the Corporation.

     Sixth:  To the fullest extent permitted by the General Corporation Law of
the State of Delaware as it now exists and as it may hereafter be amended, no
director shall be personally liable to the Corporation or any of its
stockholders for monetary damages for breach of fiduciary duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
Corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (iii)
pursuant to Section 174 of the General Corporation Law of the State of Delaware
or (iv) for any transaction from which the director derived an improper personal
benefit. Any repeal or modification of this Article SIXTH shall not adversely
affect any right or protection of a director of the Corporation existing at the
time of such repeal or modification with respect to acts or omissions occurring
prior to such repeal or modification.

     Seventh:  The Corporation shall, to the fullest extent permitted by the
provisions of Section 145 of the General Corporation Law of the State of
Delaware, as the same may be amended and supplemented, indemnify any and all
persons whom it shall have power to indemnify under said Section from and
against any and all of the expenses, liabilities, or other matters referred to
in or covered by said Section, and the indemnification provided for herein shall
not be deemed exclusive of any other rights to which those indemnified may be
entitled under any By-law, agreement, vote of stockholders or disinterested
directors or otherwise and shall continue as to a person who has ceased to be a
director, officer, employee, or agent and shall inure to the benefit of the
heirs, executors, and administrators of such a person. Any repeal or
modification of this Article SEVENTH shall not adversely affect any right to
indemnification of any persons existing at the time such repeal or modification
with respect to any matter occurring prior to such repeal or modification.

     Eighth:  Unless and except to the extent that the By-laws of the
Corporation shall so require, the election of directors of the Corporation need
not be by written ballot.

                                       1-45
   126

                                                                       EXHIBIT B
                                                         TO THE MERGER AGREEMENT

                            FORM OF AFFILIATE LETTER

Dear Sirs:

     The undersigned, a holder of shares of common stock, par value $0.005 per
share ("Company Common Stock"), of ALZA Corporation, a Delaware corporation (the
"Company"), acknowledges that the undersigned may be deemed an "affiliate" of
the Company within the meaning of Rule 145 ("Rule 145") promulgated under the
Securities Act of 1933, as amended (the "Securities Act"), by the Securities and
Exchange Commission (the "SEC") and may be deemed an "affiliate" of the Company
for purposes of qualifying the Merger (as defined below) for pooling of
interests accounting treatment under Opinion 16 of the Accounting Principles
Board and applicable SEC rules and regulations, although nothing contained
herein should be construed as an admission of either such fact. Pursuant to the
terms of the Agreement and Plan of Merger dated as of March 26, 2001, among
Johnson & Johnson, a New Jersey corporation ("Parent"), Express Merger Sub Inc.,
a Delaware corporation and a wholly owned subsidiary of Parent ("Merger Sub"),
and the Company, Merger Sub will be merged with and into the Company (the
"Merger"), and in connection with the Merger, the undersigned is entitled to
receive common stock, par value $1.00 per share ("Parent Common Stock"), of
Parent.

     If in fact the undersigned were an affiliate under the Securities Act, the
undersigned's ability to sell, assign or transfer the shares of Parent Common
Stock received by the undersigned in exchange for any shares of Company Common
Stock in connection with the Merger may be restricted unless such transaction is
registered under the Securities Act or an exemption from such registration is
available. The undersigned understands that such exemptions are limited and the
undersigned has obtained or will obtain advice of counsel as to the nature and
conditions of such exemptions, including information with respect to the
applicability to the sale of such securities of Rules 144 and 145(d) promulgated
under the Securities Act. The undersigned understands that Parent will not be
required to maintain the effectiveness of any registration statement under the
Securities Act for the purposes of resale of Parent Common Stock by the
undersigned.

     The undersigned hereby represents to and covenants with Parent that the
undersigned will not sell, assign or transfer any of the shares of Parent Common
Stock received by the undersigned in exchange for shares of Company Common Stock
in connection with the Merger except (i) pursuant to an effective registration
statement under the Securities Act, (ii) in conformity with the volume and other
limitations of Rule 145 or (iii) in a transaction which, in the opinion of
counsel to the undersigned, such counsel to be reasonably satisfactory to Parent
and such opinion to be in form and substance reasonably satisfactory to Parent,
or as described in a "no-action" or interpretive letter from the Staff of the
SEC specifically issued with respect to a transaction to be engaged in by the
undersigned, is not required to be registered under the Securities Act.

     The undersigned hereby further represents to and covenants with Parent that
the undersigned has not, within the 30 days prior to the Closing Date, sold,
transferred or otherwise disposed of any shares of Company Common Stock held by
the undersigned and that the undersigned will not sell, transfer or otherwise
dispose of any Parent Common Stock received by the undersigned in connection
with the Merger until after such time as results covering at least 30 days of
post-Merger combined operations of the Company and Parent have been published by
Parent, in the form of a quarterly earnings report, an effective registration
statement filed with the SEC, a report to the SEC on Form 10-K, 10-Q or 8-K, or
any other public filing or announcement which includes such combined results of
operations (the "Pooling Restricted Period"), except as would not otherwise
reasonably be expected to adversely affect the qualification of the Merger as a
pooling of interests.

     Notwithstanding anything to the contrary contained in the immediately
preceding paragraph, the undesigned will be permitted, during the Pooling
Restricted Period, (i) to sell, exchange, transfer, pledge or otherwise dispose
of or grant any option, establish any "short" or "put"-equivalent position with
respect to or enter into any similar transaction (through derivatives or
otherwise) intended to have the effect, directly or indirectly, of reducing the
undersigned's risk relative to any shares of Company Common Stock

                                       1-46
   127

or Parent Common Stock received by the undersigned in connection with the Merger
(a "Transfer") equal to the lesser of (A) 10% of the Company Common Stock, or
equivalent post-Merger Parent Common Stock, owned by the undersigned and (B) the
undersigned's pro rata portion of 1% of the total number of outstanding shares
of Company Common Stock, or equivalent post-merger Parent Common Stock, owned by
the undersigned and all other stockholders of the Company (in each of clause (A)
and (B) above as measured as of the date of such Transfer and subject to
confirmation of such calculation by Parent), and (ii) to make bona fide
charitable contributions of gifts of such securities; provided, however, that
the transferee(s) of such charitable contributions or gifts agree(s) in writing
to hold such securities during the Pooling Restricted Period.

     In the event of a sale or other disposition by the undersigned of the
shares of Parent Common Stock pursuant to Rule 145, the undersigned will supply
Parent with evidence of compliance with such Rule, in the form of a letter in
the form of Annex I hereto or the opinion of counsel or no-action letter
referred to above. The undersigned understands that Parent may instruct its
transfer agent to withhold the transfer of any shares of Parent Common Stock
disposed of by the undersigned, but that (provided such transfer is not
prohibited by any other provision of this letter agreement) upon receipt of such
evidence of compliance, Parent shall cause the transfer agent to effectuate the
transfer of the shares of Parent Common Stock sold as indicated in such letter.

     Parent covenants that it will take all such actions as may be reasonably
available to it to permit the sale or other disposition of the shares of Parent
Common Stock by the undersigned under Rule 145 in accordance with the terms
thereof.

     The undersigned acknowledges and agrees that the legend set forth below
will be placed on certificates representing the shares of Parent Common Stock
received by the undersigned in connection with the Merger or held by a
transferee thereof, which legend will be removed by delivery of substitute
certificates upon receipt of an opinion in form and substance reasonably
satisfactory to Parent from counsel reasonably satisfactory to Parent to the
effect that such legend is no longer required for purposes of the Securities
Act.

     There will be placed on the certificates for Parent Common Stock issued to
the undersigned in connection with the Merger, or any substitutions therefor, a
legend stating in substance:

          "The shares represented by this certificate were issued pursuant to a
     business combination which is being accounted for as a pooling of
     interests, in a transaction to which Rule 145 promulgated under the
     Securities Act of 1933 applies. The shares have not been acquired by the
     holder with a view to, or for resale in connection with, any distribution
     thereof within the meaning of the Securities Act of 1933. The shares may
     not be sold, pledged or otherwise transferred (i) until such time as
     Johnson & Johnson shall have published financial results covering at least
     30 days of combined operations after the Effective Time and (ii) except in
     accordance with an exemption from the registration requirements of the
     Securities Act of 1933."

     It is understood and agreed that certificates with the legend set forth
above will be substituted by delivery of certificates without such legends if
(i) one year shall have elapsed from the date the undersigned acquired the
Parent Common Stock received in the Merger and the provisions of Rule 145(c)(2)
are then available, (ii) two years shall have elapsed from the date the
undersigned acquired the Parent Common Stock received in the Merger and the
provisions of Rule 145(d)(3) are then available or (iii) Parent has received
either a written opinion of counsel, which opinion of counsel shall be
reasonably satisfactory to Parent, or a "no action" letter obtained by the
undersigned from the SEC, to the effect that the restrictions imposed by Rule
145 under the Securities Act no longer apply to the undersigned.

     The undersigned acknowledges that (i) the undersigned has carefully read
this letter and understands the requirements hereof and the limitations imposed
upon the distribution, sale, transfer or other disposition of Parent Common
Stock and (ii) the receipt by Parent of this letter is an inducement to Parent's
obligations to consummate the Merger.

                                          Very truly yours,
Dated:

                                       1-47
   128

                                                                         ANNEX I
                                                                    TO EXHIBIT B

[Name]                                                                    [Date]

     On             , the undersigned sold the securities of Johnson & Johnson
("Parent") described below in the space provided for that purpose (the
"Securities"). The Securities were received by the undersigned in connection
with the merger of Express Merger Sub Inc., a Delaware corporation, with and
into ALZA Corporation, a Delaware corporation.

     Based upon the most recent report or statement filed by Parent with the
Securities and Exchange Commission, the Securities sold by the undersigned were
within the prescribed limitations set forth in paragraph (e) of Rule 144
promulgated under the Securities Act of 1933, as amended (the "Securities Act").

     The undersigned hereby represents that the Securities were sold in
"brokers' transactions" within the meaning of Section 4(4) of the Securities Act
or in transactions directly with a "market maker" as that term is defined in
Section 3(a)(38) of the Securities Exchange Act of 1934, as amended. The
undersigned further represents that the undersigned has not solicited or
arranged for the solicitation of orders to buy the Securities, and that the
undersigned has not made any payment in connection with the offer or sale of the
Securities to any person other than to the broker who executed the order in
respect of such sale.

                                          Very truly yours,

            [Space to be provided for description of the Securities]

                                       1-48
   129

                                                                         ANNEX 2

                              STOCK OPTION AGREEMENT dated as of March 26, 2001
                         (this "Agreement"), by and between ALZA Corporation, a
                         Delaware corporation ("Issuer"), and Johnson & Johnson,
                         a New Jersey corporation ("Grantee").

                                    RECITALS

     A. Grantee, Express Merger Sub Inc., a Delaware corporation and wholly
owned Subsidiary of Grantee ("Sub"), and Issuer have entered into an Agreement
and Plan of Merger dated as of the date hereof (the "Merger Agreement"),
providing for, among other things, the merger of Sub with and into Issuer, with
Issuer as the surviving corporation in the Merger and becoming a wholly owned
Subsidiary of Grantee; and

     B. As a condition and inducement to Grantee's willingness to enter into the
Merger Agreement, Grantee has requested that Issuer agree, and Issuer has
agreed, to grant Grantee the Option (as defined below).

     NOW, THEREFORE, in consideration of the foregoing and the respective
representations, warranties, covenants and agreements set forth herein, Issuer
and Grantee agree as follows:

     1. Grant of Option.  Subject to the terms and conditions set forth herein,
Issuer hereby grants to Grantee an irrevocable option (the "Option") to purchase
up to 47,466,356 shares (as such number may be adjusted pursuant to Section 6,
the "Option Shares") of common stock, par value $0.005 per share, of Issuer (the
"Issuer Common Stock") at a purchase price of $41.84 per Option Share (as such
price may be adjusted pursuant to Section 6, the "Purchase Price") provided,
however, that in no event may the number of Option Shares exceed 19.9% of the
issued and outstanding shares of Issuer Common Stock at the time of exercise
without giving effect to the issuance of Option Shares.

     2. Exercise of Option.  (a) Subject to the provisions of Section 2(c),
Grantee may exercise the Option, with respect to any or all of the Option
Shares, at any time or times after the occurrence of any event as a result of
which Grantee is entitled to receive the Termination Fee pursuant to Section
5.08(b) of the Merger Agreement (a "Purchase Event"); provided, however, that
(i) except as provided in the last sentence of this Section 2(a), the Option
will terminate and be of no further force and effect upon the earliest to occur
of (A) the Effective Time, (B) 12 months after the first occurrence of a
Purchase Event, and (C) termination of the Merger Agreement in accordance with
its terms prior to the occurrence of a Purchase Event, unless, in the case of
clause (C), Grantee has the right to receive the Termination Fee following such
termination upon the occurrence of certain events, in which case the Option will
not terminate until the later of (x) 10 business days following the time such
Termination Fee becomes payable and (y) the expiration of the period in which
Grantee has such right to receive the Termination Fee, and (ii) any purchase of
Option Shares upon exercise of the Option will be subject to compliance with the
HSR Act and the obtaining or making of any consents, approvals, orders,
notifications, filings or authorizations, the failure of which to have obtained
or made would have the effect of making the issuance of Option Shares to Grantee
violate any law or regulation to which Issuer is subject (the "Regulatory
Approvals"). Notwithstanding the termination of the Option, Grantee will be
entitled to purchase the Option Shares if it has exercised the Option in
accordance with the terms hereof prior to the termination of the Option and the
termination of the Option will not affect any rights hereunder which by their
terms do not terminate or expire prior to or as of such termination.

     (b) In the event that Grantee is entitled to and wishes to exercise the
Option, Grantee shall send to Issuer a written notice (an "Exercise Notice"; the
date of which being herein referred to as the "Notice Date") to that effect,
which Exercise Notice shall specify the number of Option Shares, if any, Grantee
wishes to purchase pursuant to this Section 2(b), the number of Option Shares,
if any, with respect to which Grantee wishes to exercise its Cash-Out Right (as
defined below) pursuant to Section 6(c), the denominations of the certificate or
certificates evidencing the Option Shares which Grantee wishes to
                                       2-1
   130

purchase pursuant to this Section 2(b) and a date (an "Option Closing Date"),
which, subject to the following sentence, shall not be earlier than three
business days nor later than 10 business days from the Notice Date for the
closing of such purchase (an "Option Closing"). Any Option Closing shall be at
an agreed location and time in New York, New York on the applicable Option
Closing Date or at such later date as may be necessary so as to comply with
clause (ii) of the proviso to the first sentence of Section 2(a).

     (c) Notwithstanding anything to the contrary contained herein, any exercise
of the Option and purchase of Option Shares shall be subject to compliance with
applicable laws and regulations, which may prohibit the purchase of all the
Option Shares specified in the Exercise Notice without first obtaining or making
certain Regulatory Approvals. In such event, if the Option is otherwise
exercisable and Grantee wishes to exercise the Option, the Option may be
exercised in accordance with Section 2(b) and Grantee shall acquire the maximum
number of Option Shares specified in the Exercise Notice that Grantee is then
permitted to acquire under the applicable laws and regulations, and if Grantee
thereafter obtains the Regulatory Approvals to acquire the remaining balance of
the Option Shares specified in the Exercise Notice, then Grantee shall be
entitled to acquire such remaining balance. Issuer agrees to use its
commercially reasonable efforts to assist Grantee in seeking the Regulatory
Approvals.

     In the event (i) Grantee receives notice that a Regulatory Approval
required for the purchase of any Option Shares will not be issued or granted or
(ii) such Regulatory Approval has not been issued or granted within six months
of the date of the Exercise Notice, Grantee shall have the right to exercise its
Cash-Out Right pursuant to Section 6(c) with respect to the Option Shares for
which such Regulatory Approval will not be issued or granted or has not been
issued or granted.

     3. Payment and Delivery of Certificates.  (a) At any Option Closing,
Grantee will pay to Issuer in immediately available funds by wire transfer to a
bank account designated in writing by Issuer an amount equal to the Purchase
Price multiplied by the number of Option Shares to be purchased at such Option
Closing.

     (b) At any Option Closing, simultaneously with the delivery of immediately
available funds as provided in Section 3(a), Issuer will deliver to Grantee a
certificate or certificates representing the Option Shares to be purchased at
such Option Closing, which Option Shares will be free and clear of all Liens. If
at the time of issuance of Option Shares pursuant to an exercise of the Option
hereunder, Issuer shall have issued any securities similar to rights under a
stockholder rights plan, then each Option Share issued pursuant to such exercise
will also represent such a corresponding right with terms substantially the same
as and at least as favorable to Grantee as are provided under any such
stockholder rights plan then in effect.

     (c) Certificates representing the Option Shares delivered at an Option
Closing will have typed or printed thereon a restrictive legend which will read
substantially as follows:

          "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
     REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY BE
     REOFFERED OR SOLD ONLY IF SO REGISTERED OR IF AN EXEMPTION FROM SUCH
     REGISTRATION IS AVAILABLE. SUCH SECURITIES ARE ALSO SUBJECT TO ADDITIONAL
     RESTRICTIONS ON TRANSFER AS SET FORTH IN THE STOCK OPTION AGREEMENT DATED
     AS OF MARCH 26, 2001, A COPY OF WHICH MAY BE OBTAINED FROM THE SECRETARY OF
     ALZA CORPORATION, AT ITS PRINCIPAL EXECUTIVE OFFICES."

It is understood and agreed that (i) the reference to restrictions arising under
the Securities Act in the above legend will be removed by delivery of substitute
certificate(s) without such reference if such Option Shares have been registered
pursuant to the Securities Act, such Option Shares have been sold in reliance on
and in accordance with Rule 144 under the Securities Act or Grantee has
delivered to Issuer a copy of a letter from the staff of the SEC, or an opinion
of counsel in form and substance reasonably satisfactory to Issuer and its
counsel, to the effect that such legend is not required for purposes of the
Securities Act

                                       2-2
   131

and (ii) the reference to restrictions pursuant to this Agreement in the above
legend will be removed by delivery of substitute certificate(s) without such
reference if the Option Shares evidenced by certificate(s) containing such
reference have been sold or transferred in compliance with the provisions of
this Agreement under circumstances that do not require the retention of such
reference.

     4. Representations and Warranties of Issuer.  Issuer hereby represents and
warrants to Grantee as follows:

     Authorized Stock.  Issuer has taken all necessary corporate and other
action to authorize and reserve and, subject to the expiration or termination of
any required waiting period under the HSR Act, to permit it to issue, and, at
all times from the date hereof until the obligation to deliver Option Shares
upon an exercise of the Option terminates, shall have reserved for issuance,
upon exercise of the Option, shares of Issuer Common Stock necessary for Grantee
to exercise the Option, and Issuer will take all necessary corporate action to
authorize and reserve for issuance all additional shares of Issuer Common Stock
or other securities which may be issuable pursuant to Section 6 upon exercise of
the Option. The shares of Issuer Common Stock to be issued upon due exercise of
the Option, including all additional shares of Issuer Common Stock or other
securities which may be issuable upon exercise of the Option or any other
securities which may be issuable pursuant to Section 6, upon issuance pursuant
hereto, will be duly and validly issued, fully paid and nonassessable, and will
be delivered free and clear of all Liens, including without limitation any
preemptive rights of any stockholder of Issuer.

     5. Representations and Warranties of Grantee.  Grantee hereby represents
and warrants to Issuer that:

     Purchase Not for Distribution.  Any Option Shares or other securities
acquired by Grantee upon exercise of the Option will not be transferred or
otherwise disposed of except in a transaction registered, or exempt from
registration, under the Securities Act.

     6. Adjustment upon Changes in Capitalization, Etc.  (a) In the event of any
change in Issuer Common Stock by reason of a stock dividend, split-up, merger,
recapitalization, combination, exchange of shares, or similar transaction, the
type and number of shares or securities subject to the Option, and the Purchase
Price thereof, will be adjusted appropriately, and proper provision will be made
in the agreements governing such transaction, so that Grantee will receive upon
exercise of the Option the number and class of shares or other securities or
property that Grantee would have received in respect of Issuer Common Stock if
the Option had been exercised immediately prior to such event or the record date
therefor, as applicable. Subject to Section 1, and without limiting the parties'
relative rights and obligations under the Merger Agreement, if any additional
shares of Issuer Common Stock are issued after the date of this Agreement (other
than pursuant to an event described in the first sentence of this Section 6(a))
or if the number of outstanding shares of Issuer Common Stock is reduced, the
number of shares of Issuer Common Stock subject to the Option will be adjusted
so that, after such issuance or reduction, it equals the same percentage of the
aggregate number of shares of Issuer Common Stock issued and outstanding after
giving effect to such issuance or reduction as immediately prior to such
issuance or reduction, in each case without giving effect to any shares subject
to the Option.

     (b) Without limiting the parties' relative rights and obligations under the
Merger Agreement, in the event that Issuer enters into an agreement (i) to
consolidate with or merge into any person, other than Grantee or one of its
Subsidiaries, and Issuer will not be the continuing or surviving corporation in
such consolidation or merger, (ii) to permit any person, other than Grantee or
one of its Subsidiaries, to merge into Issuer and Issuer will be the continuing
or surviving corporation, but in connection with such merger, the shares of
Issuer Common Stock outstanding immediately prior to the consummation of such
merger will be changed into or exchanged for stock or other securities of Issuer
or any other person or cash or any other property, or the shares of Issuer
Common Stock outstanding immediately prior to the consummation of such merger
will, after such merger, represent less than 50% of the outstanding voting
securities of the merged company, or (iii) to sell or otherwise transfer all or
substantially all of its assets to any person, other than Grantee or one of its
Subsidiaries, then, and in each such case, the agreement governing such
transaction shall make proper provision so that the Option will, upon the
consummation of any such
                                       2-3
   132

transaction and upon the terms and conditions set forth herein, be converted
into, or exchanged for, an option with identical terms appropriately adjusted to
acquire the number and class of shares or other securities or property that
Grantee would have received in respect of Issuer Common Stock if the Option had
been exercised in full with respect to all Option Shares then purchasable
immediately prior to such consolidation, merger, sale, or transfer, or the
record date therefor, as applicable, and make any other necessary adjustments.

     (c) If, at any time during the period commencing on a Purchase Event and
ending on the termination of the Option in accordance with Section 2, Grantee
sends to Issuer an Exercise Notice indicating Grantee's election to exercise its
right (the "Cash-Out Right") pursuant to this Section 6(c), then Issuer shall
pay to Grantee, on the Option Closing Date, in exchange for the cancellation of
the Option with respect to such number of Option Shares as Grantee specifies in
the Exercise Notice, an amount in cash equal to such number of Option Shares
multiplied by the difference between (i) the average closing price, for the 10
trading days commencing on the 12th trading day immediately preceding the Notice
Date, per share of Issuer Common Stock as reported on the New York Stock
Exchange, Inc. ("NYSE") Composite Transactions Tape (or, if not listed on the
NYSE, as reported on any other national securities exchange or national
securities quotation system on which the Issuer Common Stock is listed or
quoted, as reported in The Wall Street Journal (Northeast edition), or, if not
reported therein, as reported in any other authoritative source) (the "Closing
Price") and (ii) the Purchase Price. Notwithstanding the termination of the
Option, Grantee will be entitled to exercise its rights under this Section 6(c)
if Grantee has exercised such rights in accordance with the terms hereof prior
to the termination of the Option.

     7. Profit Limitations.  (a) Notwithstanding any other provision of this
Agreement, in no event shall the Total Option Profit (as defined below) exceed
in the aggregate $180,000,000 (such amount, the "Profit Limit") and, if any
payment to be made to Grantee otherwise would cause the Profit Limit to be
exceeded, Grantee, at its election and in its sole discretion, shall (i) reduce
the number of shares of Issuer Common Stock subject to the Option, (ii) deliver
to Issuer for cancellation Option Shares previously purchased by Grantee, (iii)
pay cash to Issuer or (iv) take any combination of the foregoing actions, so
that the Total Option Profit shall not exceed the Profit Limit after taking into
account all the foregoing actions taken by Grantee.

     (b) Notwithstanding any other provision of this Agreement, the Option may
not be exercised for a number of shares of Issuer Common Stock as would, as of
the date of exercise, result in a Notional Total Option Profit (as defined
below) that would exceed in the aggregate the Profit Limit and, if the Notional
Total Option Profit otherwise would exceed such amount, Grantee, at its election
and in its sole discretion, shall on or prior to the date of exercise (i) reduce
the number of shares of Issuer Common Stock subject to such exercise, (ii)
deliver to Issuer for cancellation Option Shares previously purchased by
Grantee, (iii) pay cash to Issuer or (iv) take any combination of the foregoing
actions, so that the Notional Total Option Profit shall not exceed the Profit
Limit after taking into account all the foregoing actions taken by Grantee,
provided that this paragraph (b) shall not be construed as to restrict any
exercise of the Option that is not prohibited hereby on any subsequent date.

     (c) As used herein, the term "Total Option Profit" shall mean the aggregate
amount (before taxes) of the following: (i) any amount received by Grantee
pursuant to the Cash-Out Right and (ii)(x) the net consideration, if any,
received by Grantee pursuant to the sale of Option Shares (or any other
securities into which such Option Shares are converted or exchanged) to any
unaffiliated party, valuing any non-cash consideration at its fair market value
(as defined below), less (y) the aggregate Purchase Price and any cash paid by
Grantee to Issuer pursuant to Section 7(a)(iii) or Section 7(b)(iii), as the
case may be.

     (d) As used herein, the term "Notional Total Option Profit" with respect to
any number of shares of Issuer Common Stock as to which Grantee may propose to
exercise the Option shall be the aggregate of (i) the Total Option Profit
determined under paragraph (c) above with respect to prior exercises of the
Option and (ii) Total Option Profit determined under paragraph (c) above with
respect to (x) such number of shares of Issuer Common Stock as to which Grantee
proposes to exercise the Option and

                                       2-4
   133

(y) all other shares of Issuer Common Stock held by Grantee and its Affiliates
as of such date that were acquired by Grantee or its Affiliates pursuant to a
prior exercise of the Option, assuming that all such shares were sold for cash
at the closing market price for the Issuer Common Stock as of the close of
business on the preceding trading day (less customary brokerage commissions or
underwriting discounts).

     (e) As used herein, the "fair market value" of any non-cash consideration
consisting of:

          (i) securities listed on a national securities exchange or traded on
     The Nasdaq National Market ("Nasdaq") shall be equal to the average closing
     price per share of such security as reported on such exchange or Nasdaq for
     the five trading days after the date of determination; and

          (ii) consideration which is other than cash or securities of the form
     specified in clause (i) above shall be agreed upon in good faith by the
     parties or, in the absence of such agreement, determined by a nationally
     recognized independent investment banking firm mutually agreed upon by the
     parties within five business days of the event requiring selection of such
     banking firm, provided that if the parties are unable to agree within two
     business days after the date of such event as to the investment banking
     firm, then the parties shall each select one investment banking firm, and
     those firms shall select a third nationally recognized independent
     investment banking firm, which third firm shall make such determination.

     8. Registration Rights.  Issuer will, if requested by Grantee at any time
and from time to time within two years of the exercise of the Option, as
promptly as practicable (but in no event later than 90 days after receipt of
such request) prepare and file up to three registration statements ("demand
registration statements") under the Securities Act if such registration is
necessary in order to permit the sale or other disposition of any or all shares
of securities that have been acquired by or are issuable to Grantee upon
exercise of the Option in accordance with the intended method of sale or other
disposition stated by Grantee, including a "shelf" registration statement under
Rule 415 under the Securities Act or any successor provision, and Issuer will
use its best efforts to qualify such shares or other securities under any
applicable state securities laws. Grantee agrees to use its commercially
reasonable efforts to cause, and to cause any underwriters of any sale or other
disposition to cause, any sale or other disposition pursuant to such
registration statement to be effected on a widely distributed basis so that upon
consummation thereof no purchaser or transferee will own beneficially more than
5% of the then-outstanding voting power of Issuer. Issuer will use its
commercially reasonable efforts to cause each such registration statement to
become effective, to obtain all consents or waivers of other parties which are
required therefor, and to keep such registration statement effective for such
period not in excess of 150 calendar days from the day such registration
statement first becomes effective as may be reasonably necessary to effect such
sale or other disposition. The obligations of Issuer hereunder to file a
registration statement and to maintain its effectiveness may be suspended for up
to 90 calendar days in the aggregate if the Board of Directors of Issuer shall
have determined that the filing of such registration statement or the
maintenance of its effectiveness would require premature disclosure of material
nonpublic information that would materially and adversely affect Issuer or
otherwise interfere with or adversely affect any pending or proposed offering of
securities of Issuer or any other material transaction involving Issuer. Any
registration statement prepared and filed under this Section 8, and any sale
covered thereby, will be at Issuer's expense except for underwriting discounts
or commissions, brokers' fees and the fees and disbursements of Grantee's
counsel related thereto. Grantee will provide all information reasonably
requested by Issuer for inclusion in any registration statement to be filed
hereunder. If, during the time periods referred to in the first sentence of this
Section 8, Issuer effects a registration under the Securities Act of Issuer
Common Stock for its own account or for any other stockholders of Issuer (other
than on Form S-4 or Form S-8, or any successor form), it will allow Grantee the
right to participate in such registration (a "Piggyback Registration"), and such
participation will not affect the obligation of Issuer to effect demand
registration statements for Grantee under this Section 8; provided that, if the
managing underwriters of such offering advise Issuer in writing that in their
opinion the number of shares of Issuer Common Stock requested to be included in
such registration exceeds the number which can be sold in such offering, Issuer
will include only that portion of the shares requested to be included therein by
Grantee that may, in the written opinion of the managing underwriters, be
included therein without adversely affecting the success of the
                                       2-5
   134

offering. In connection with any registration pursuant to this Section 8, Issuer
and Grantee will provide each other and any underwriter of the offering with
customary representations, warranties, covenants, indemnification and
contribution in connection with such registration. Issuer may wit hdraw any
Piggyback Registration without the consent of Grantee.

     9. Transfers.  Shares of Issuer Common Stock acquired by Grantee pursuant
to an exercise of the Option may not be sold, assigned, transferred, or
otherwise disposed of except (i) in an underwritten public offering as provided
in Section 8 or (ii) to any purchaser or transferee who would not, to the
knowledge of Grantee after reasonable inquiry, immediately following such sale,
assignment, transfer or disposal, beneficially own more than 5% of the
then-outstanding voting power of the Issuer; provided, however, that Grantee
shall be permitted to sell any shares of Issuer Common Stock acquired pursuant
to an exercise of the Option if such sale is made pursuant to a tender or
exchange offer that has been approved or recommended by a majority of the
members of the Board of Directors of Issuer (which majority shall include a
majority of directors who were directors as of the date hereof).

     10. Listing.  If the Issuer Common Stock or any other securities to be
acquired upon exercise of the Option are then listed on the NYSE (or any other
national securities exchange or approved for quotation on any national
securities quotation system), Issuer, upon the request of Grantee, shall
promptly file an application to list the shares of Issuer Common Stock or other
securities to be acquired upon exercise of the Option on the NYSE (or any such
other national securities exchange or file an application to have approved for
quotation on any such national securities quotation system) and will use its
commercially reasonable efforts to obtain approval of such listing (or
quotation) as promptly as practicable.

     11. Loss or Mutilation.  Upon receipt by Issuer of evidence reasonably
satisfactory to it of the loss, theft, destruction or mutilation of this
Agreement, and (in the case of loss, theft or destruction) of reasonably
satisfactory indemnification, and upon surrender and cancellation of this
Agreement, if mutilated, Issuer will execute and deliver a new Agreement of like
tenor and date.

     12. Miscellaneous.  (a) Expenses.  Except as otherwise provided in this
Agreement or in the Merger Agreement, each of the parties hereto will bear and
pay all costs and expenses incurred by it or on its behalf in connection with
the transactions contemplated hereunder, including fees and expenses of its own
financial consultants, investment bankers, accountants, and counsel.

     (b) Amendment.  This Agreement may not be amended, except by an instrument
in writing signed on behalf of each of the parties.

     (c) Extension; Waiver.  Any agreement on the part of a party to waive any
provision of this Agreement, or to extend the time for performance, will be
valid only if set forth in an instrument in writing signed on behalf of such
party. The failure of any party to this Agreement to assert any of its rights
under this Agreement or otherwise will not constitute a waiver of such rights.

     (d) Entire Agreement; No Third-Party Beneficiaries.  This Agreement, the
Merger Agreement (including the documents and instruments attached thereto as
exhibits or schedules or delivered in connection therewith) and the
Confidentiality Agreement (i) constitute the entire agreement, and supersede all
prior agreements and understandings, both written and oral, between the parties
with respect to the subject matter of this Agreement, and (ii) except as
provided in Section 8.06 of the Merger Agreement, are not intended to confer
upon any person other than the parties any rights or remedies.

     (e) Governing Law.  This Agreement will be governed by, and construed in
accordance with, the laws of the State of Delaware, regardless of the laws that
might otherwise govern under applicable principles of conflict of laws thereof.

     (f) Notices.  All notices, requests, claims, demands and other
communications under this Agreement shall be sent in the manner and to the
addresses set forth in the Merger Agreement.

     (g) Assignment.  Neither this Agreement, the Option nor any of the rights,
interests or obligations under this Agreement may be assigned or delegated, in
whole or in part, by operation of law or otherwise, by Issuer or Grantee without
the prior written consent of the other, except that Grantee may assign, in its
                                       2-6
   135

sole discretion, any of or all its rights, interests and obligations under this
Agreement to any direct or indirect wholly owned Subsidiary of Grantee, but no
such assignment shall relieve Grantee of any of its obligations hereunder. Any
assignment or delegation in violation of the preceding sentence shall be void.
Subject to the first and second sentences of this Section 12(g), this Agreement
will be binding upon, inure to the benefit of, and be enforceable by, the
parties and their respective successors and assigns.

     (h) Further Assurances.  In the event of any exercise of the Option by
Grantee, Issuer and Grantee shall execute and deliver all other documents and
instruments and take all other actions that may be reasonably necessary in order
to consummate the transactions provided for by such exercise.

     (i) Specific Enforcement; Consent to Jurisdiction.  The parties agree that
irreparable damage would occur and that the parties would not have any adequate
remedy at law in the event that any of the provisions of this Agreement were not
performed in accordance with their specific terms or were otherwise breached. It
is accordingly agreed that the parties shall be entitled to an injunction or
injunctions to prevent breaches of this Agreement and to enforce specifically
the terms and provisions of this Agreement in any Federal court located in the
State of Delaware or in any state court located in the State of Delaware, the
foregoing being in addition to any other remedy to which they are entitled at
law or in equity. In addition, each of the parties hereto (i) consents to submit
itself to the personal jurisdiction of any Federal court located in the State of
Delaware or any state court located in the State of Delaware in the event any
dispute arises out of this Agreement or any of the transactions contemplated by
this Agreement, (ii) agrees that it will not attempt to deny or defeat such
personal jurisdiction by motion or other request for leave from any such court
and (iii) agrees that it will not bring any action relating to this Agreement or
any of the transactions contemplated by this Agreement in any court other than a
Federal court sitting in the State of Delaware or a state court located in the
State of Delaware.

     (j) Severability.  If any term or other provision of this Agreement is
invalid, illegal or incapable of being enforced by any rule of law or public
policy, all other conditions and provisions of this Agreement shall nevertheless
remain in full force and effect. Upon such determination that any term or other
provision is invalid, illegal or incapable of being enforced, the parties hereto
shall negotiate in good faith to modify this Agreement so as to effect the
original intent of the parties as closely as possible to the fullest extent
permitted by applicable law in an acceptable manner to the end that the
transactions contemplated hereby are fulfilled to the extent possible.

     (k) Defined Terms.  All terms used but not defined herein shall have the
meanings ascribed to such terms in the Merger Agreement.

                                       2-7
   136

     IN WITNESS WHEREOF, Issuer and Grantee have caused this Agreement to be
signed by their respective officers thereunto duly authorized as of the day and
year first written above.

                                          ALZA CORPORATION,

                                          by /s/ ERNEST MARIO
                                            ------------------------------------
                                             Name: Ernest Mario
                                             Title: Chairman and Chief Executive
                                             Officer

                                          JOHNSON & JOHNSON,

                                          by /s/ R. S. LARSEN
                                            ------------------------------------
                                             Name: R. S. Larsen
                                             Title: Chairman and Chief Executive
                                             Officer

                                       2-8
   137

                                                                         ANNEX 3

                                                                  March 26, 2001

The Board of Directors
ALZA Corporation
1900 Charleston Road
Mountain View, CA 94043

Members of the Board of Directors:

     You have requested our opinion as to the fairness, from a financial point
of view, to the holders of common stock, par value $.005 per share (the "Company
Common Stock"), of ALZA Corporation (the "Company") of the Exchange Ratio (as
defined below) in the proposed merger (the "Merger") of the Company with a
wholly-owned subsidiary of Johnson & Johnson (the "Merger Partner"). Pursuant to
an Agreement and Plan of Merger (the "Agreement"), among the Company, the Merger
Partner and a subsidiary of the Merger Partner, the Company will become a
wholly-owned subsidiary of the Merger Partner, and each outstanding share of
Company Common Stock, other than shares of Company Common Stock held in treasury
or owned by the Merger Partner, will be converted into the right to receive .49
shares (the "Exchange Ratio") of the Merger Partner's common stock, par value
$1.00 per share (the "Merger Partner Common Stock").

     In arriving at our opinion, we have (i) reviewed a draft of the Agreement
dated March 26, 2001; (ii) reviewed certain publicly available business and
financial information concerning the Company and the Merger Partner and the
industries in which they operate; (iii) compared the proposed financial terms of
the Merger with the publicly available financial terms of certain transactions
involving companies we deemed relevant and the consideration received for such
companies; (iv) compared the financial and operating performance of the Company
and the Merger Partner with publicly available information concerning certain
other companies we deemed relevant and reviewed the current and historical
market prices of the Company Common Stock and the Merger Partner Common Stock
and certain publicly traded securities of such other companies; (v) reviewed
certain internal financial analyses and forecast prepared by the management of
the Company relating to its business; and (vi) performed such other financial
studies and analyses and considered such other information as we deemed
appropriate for the purposes of this opinion.

     In addition, we have held discussions with certain members of the
management of the Company and the Merger Partner with respect to certain aspects
of the Merger, and the past and current business operations of the Company and
the Merger Partner, the financial condition and future prospects and operations
of the Company and the Merger Partner, and certain other matters we believed
necessary or appropriate to our inquiry. We did not receive any forecast from
the Merger Partner as to its projected financial performance other than guidance
that we could rely on consensus research analyst earnings estimates for year
2001.

     In giving our opinion, we have relied upon and assumed, without independent
verification, the accuracy and completeness of all information that was publicly
available or was furnished to us by the Company and the Merger Partner or
otherwise reviewed by us, and we have not assumed any responsibility or
liability therefor. We have not conducted any valuation or appraisal of any
assets or liabilities, nor have any such valuations or appraisals been provided
to us. In relying on financial analyses and forecasts provided to us, we have
assumed that they have been reasonably prepared based on assumptions reflecting
the best currently available estimates and judgments by management as to the
expected future results of operations and financial condition of the Company and
the Merger Partner to which such analyses or forecasts relate. We have also
assumed that the Merger will qualify as a tax-free reorganization for United
States federal income tax purposes and be accounted for as a pooling of
interests under United States generally accepted accounting principles, and that
the Merger and the other transactions contemplated by the Agreement will be
consummated as described in the Agreement. We

                                       3-1
   138

have also assumed that the definitive Agreement will not differ in any material
respects from the draft thereof furnished to us. We have further assumed that
all material governmental, regulatory or other consents and approvals necessary
for the consummation of the Merger will be obtained without any adverse effect
on the Company or the Merger Partner or on the contemplated benefits of the
Merger.

     Our opinion is necessarily based on economic, market and other conditions
as in effect on, and the information made available to us as of, the date
hereof. It should be understood that subsequent developments may affect this
opinion and that we do not have any obligation to update, revise, or reaffirm
this opinion. Our opinion is limited to the fairness, from a financial point of
view, to the holders of the Company Common Stock of the Exchange Ratio in the
proposed Merger and we express no opinion as to the underlying decision by the
Company to engage in the Merger. We are expressing no opinion herein as to the
price at which the Company Common Stock or the Merger Partner Common Stock will
trade at any future time.

     We note that we were not authorized to and did not solicit any expressions
of interest from any other parties with respect to the sale of all or any part
of the Company or any other alternative transaction.

     We have acted as financial advisor to the Company with respect to the
proposed Merger and will receive a fee from the Company for our services. We
will also receive an additional fee if the proposed Merger is consummated. In
the past, we have acted as financial advisor to the Company and we and our
affiliates have also provided financial advisory and financing services to the
Merger Partner, and may continue to do so and have received, and may receive,
fees for such services. In the ordinary course of our businesses, we and our
affiliates may actively trade the debt and equity securities of the Company or
the Merger Partner for our own account or for the accounts of customers and,
accordingly, we may at any time hold long or short positions in such securities.
As of March 23, 2001, we and our affiliates held approximately 5.8% of the
outstanding shares of Company Common Stock primarily for the account of
customers.

     On the basis of and subject to the foregoing, it is our opinion as of the
date hereof that the Exchange Ratio in the proposed Merger is fair, from a
financial point of view, to the holders of the Company Common Stock.

     This letter is provided to the Board of Directors of the Company in
connection with and for the purposes of its evaluation of the Merger. This
opinion does not constitute a recommendation to any stockholder of the Company
as to how such stockholder should vote with respect to the Merger or any other
matter. This opinion may not be disclosed, referred to, or communicated (in
whole or in part) to any third party for any purpose whatsoever except with our
prior written approval. This opinion may be reproduced in full in any proxy or
information statement mailed to stockholders of the Company but may not
otherwise be disclosed publicly in any manner without our prior written
approval.

                                          Very truly yours,

                                          CHASE SECURITIES INC.

                                       3-2
   139

                                                                         ANNEX 4

                                                             March 26, 2001

Board of Directors
ALZA Corporation
1900 Charleston Road
P.O. Box 7210
Mountain View, CA 94039

Members of the Board of Directors:

     ALZA Corporation (the "Company"), Johnson & Johnson (the "Acquiror") and
Express Merger Sub Inc., a newly formed, wholly owned subsidiary of the Acquiror
(the "Acquisition Sub"), propose to enter into an Agreement and Plan of Merger
(the "Agreement"), pursuant to which the Acquisition Sub will be merged with the
Company in a transaction (the "Merger") in which each outstanding share of the
Company's common stock, par value $.005 per share (the "Company Shares"), will
be converted into the right to receive 0.49 shares (the "Exchange Ratio") of the
common stock of the Acquiror, par value $1.00 per share (the "Acquiror Shares").

     You have asked us whether, in our opinion, the Exchange Ratio to be
received by holders of the Company Shares pursuant to the Merger is fair from a
financial point of view to the holders of the Company Shares, other than the
Acquiror and its affiliates.

     In arriving at the opinion set forth below, we have, among other things:

     1. Reviewed certain publicly available business and financial information
        relating to the Company and the Acquiror that we deemed to be relevant;

     2. Reviewed certain information, including financial forecasts, relating to
        the business, earnings, cash flow, assets, liabilities and prospects of
        the Company furnished to us by the Company;

     3. Conducted discussions with members of senior management of the Company
        and the Acquiror concerning the matters described in clauses 1 and 2
        above, as well as their business and prospects before giving effect to
        the Merger (and, in the case of the prospects of the Acquiror, the
        Acquiror instructed Merrill Lynch to rely on public analysts' estimates
        as the most reasonable estimates for the future operating performance of
        the Acquiror);

     4. Reviewed the market prices and valuation multiples for the Company
        Shares and the Acquiror Shares and compared them with those of certain
        publicly traded companies that we deemed to be relevant;

     5. Compared the proposed financial terms of the Merger with the financial
        terms of certain other transactions that we deemed to be relevant;

     6. Participated in certain discussions and negotiations among
        representatives of the Company and the Acquiror and their financial and
        legal advisors;

     7. Reviewed the potential pro forma impact of the Merger;

     8. Reviewed a draft dated March 26, 2001 of the Agreement; and

     9. Reviewed such other financial studies and analyses and took into account
        such other matters as we deemed necessary, including our assessment of
        general economic, market and monetary conditions.

     In preparing our opinion, we have assumed and relied on the accuracy and
completeness of all information supplied or otherwise made available to us,
discussed with or reviewed by or for us, or publicly available, and we have not
assumed any responsibility for independently verifying such information or
undertaking an independent evaluation or appraisal of any of the assets or
liabilities of the Company or the

                                       4-1
   140

Acquiror or been furnished with any such evaluation or appraisal. In addition,
we have not assumed any obligation to conduct any physical inspection of the
properties or facilities of the Company or the Acquiror. With respect to the
financial forecast information furnished to or discussed with us by the Company
and the financial forecast guidance furnished to us by the Acquiror, we have
assumed that they have been reasonably prepared and reflect the best currently
available estimates and judgment of the Company's or the Acquiror's management
as to the expected future financial performance of the Company or the Acquiror,
as the case may be. We have further assumed that the Merger will be accounted
for as a pooling of interests under generally accepted accounting principles and
that it will qualify as a tax-free reorganization for U.S. federal income tax
purposes. We have also assumed that the final form of the Agreement will be
substantially similar to the last draft reviewed by us.

     Our opinion is necessarily based upon market, economic and other conditions
as they exist and can be evaluated on, and on the information made available to
us as of, the date hereof. We have assumed that in the course of obtaining the
necessary regulatory or other consents or approvals (contractual or otherwise)
for the Merger, no restrictions, including any divestiture requirements or
amendments or modifications, will be imposed that will have a material adverse
effect on the contemplated benefits of the Merger.

     In connection with the preparation of this opinion, we have not been
authorized by the Company or the Board of Directors to solicit, nor have we
solicited, third-party indications of interest for the acquisition of all or any
part of the Company.

     We are acting as financial advisor to the Company in connection with the
Merger and will receive a fee from the Company for our services, a significant
portion of which is contingent upon the consummation of the Merger. In addition,
the Company has agreed to indemnify us for certain liabilities arising out of
our engagement. We have, in the past, provided financial advisory and financing
services to the Company and the Acquiror and may continue to do so and have
received, and may receive, fees for the rendering of such services. In addition,
in the ordinary course of our business, we may actively trade the Company Shares
and other securities of the Company, as well as the Acquiror Shares and other
securities of the Acquiror, for our own account and for the accounts of
customers and, accordingly, may at any time hold a long or short position in
such securities.

     This opinion is for the use and benefit of the Board of Directors of the
Company. Our opinion does not address the merits of the underlying decision by
the Company to engage in the Merger and does not constitute a recommendation to
any shareholder as to how such shareholder should vote on the proposed Merger or
any matter related thereto.

     We are not expressing any opinion herein as to the prices at which the
Company Shares or the Acquiror Shares will trade following the announcement or
consummation of the Merger.

     On the basis of and subject to the foregoing, we are of the opinion that,
as of the date hereof, the Exchange Ratio is fair from a financial point of view
to the holders of the Company Shares, other than the Acquiror and its
affiliates.

                                          Very truly yours,

                                          MERRILL LYNCH, PIERCE, FENNER & SMITH
                                                     INCORPORATED

                                       4-2
   141

                                    PART II

                   INFORMATION NOT REQUIRED IN THE PROSPECTUS

ITEM 20.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

     The New Jersey Business Corporation Act (the "NJBCA") provides that a New
Jersey corporation has the power to indemnify a director or officer against his
or her expenses and liabilities in connection with any proceeding involving the
director or officer by reason of his or her being or having been such a director
or officer, other than a proceeding by or in the right of the corporation, if
such director or officer acted in good faith and in a manner he or she
reasonably believed to be in or not opposed to the best interests of the
corporation; and with respect to any criminal proceeding, such director or
officer had no reasonable cause to believe his or her conduct was unlawful.

     The indemnification and advancement of expenses shall not exclude any other
rights, including the right to be indemnified against liabilities and expenses
incurred in proceedings by or in the right of the corporation, to which a
director or officer may be entitled under a certificate of incorporation,
by-law, agreement, vote of shareholders, or otherwise; provided, that no
indemnification shall be made to or on behalf of a director or officer if a
judgment or other final adjudication adverse to the director or officer
establishes that his or her acts or omissions (a) were in breach of his or her
duty of loyalty to the corporation or its shareholders, (b) were not in good
faith or involved a knowing violation of law or (c) resulted in receipt by the
director or officer of an improper personal benefit.

     The registrant's restated certificate of incorporation provides that, to
the full extent that the laws of the State of New Jersey permit the limitation
or elimination of the liability of directors or officers, no director or officer
of the registrant shall be personally liable to the registrant or its
stockholders for damages for breach of any duty owed to the registrant or its
stockholders.

     The by-laws of the registrant provide that to the full extent permitted by
the laws of the State of New Jersey, the registrant shall indemnify any person
(an "Indemnitee") who was or is involved in any manner (including, without
limitation, as a party or witness) in any threatened, pending or completed
investigation, claim, action, suit or proceeding, whether civil, criminal,
administrative, arbitrative, legislative or investigative (including, without
limitation, any action, suit or proceeding by or in the right of the registrant
to procure a judgment in its favor) (a "Proceeding"), or who is threatened with
being so involved, by reason of the fact that he or she is or was a director or
officer of the registrant or, while serving as a director or officer of the
registrant, is or was at the request of the registrant also serving as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise (including, without limitation, any employee
benefit plan), against all expenses (including attorneys' fees), judgments,
fines, penalties, excise taxes and amounts paid in settlement actually and
reasonably incurred by the Indemnitee in connection with such Proceeding,
provided that, there shall be no indemnification under such by-laws with respect
to any settlement or other nonadjudicated disposition of any threatened or
pending Proceeding unless the registrant has given its prior consent to such
settlement or disposition. The right of indemnification created by the by-laws
shall be a contract right enforceable by an Indemnitee against the registrant,
and it shall not be exclusive of any other rights to which an Indemnitee may
otherwise be entitled. The indemnification provisions of the by-laws shall inure
to the benefit of the heirs and legal representatives of an Indemnitee and shall
be applicable to Proceedings commenced or continuing after the adoption of the
by-laws, whether arising from acts or omissions occurring before or after such
adoption. No amendment, alteration, change, addition or repeal of or to the
by-laws shall deprive any Indemnitee of any rights under the by-laws with
respect to any act or omission of such Indemnitee occurring prior to such
amendment, alteration, change, addition or repeal.

     The registrant enters into indemnification agreements with its directors
and officers and enters into insurance agreements on its own behalf. The
indemnification agreements provide that the registrant agrees to hold harmless
and indemnify its directors and officers to the fullest extent authorized or
permitted by the NJBCA, or any other applicable law, or by any amendment thereof
or other statutory provisions authorizing or permitting such indemnification
that is adopted after the date hereof. Without limiting the
                                       II-1
   142

generality of the foregoing, the registrant agrees to hold harmless and
indemnify its directors and officers to the fullest extent permitted by
applicable law against any and all expenses, judgments, fines, and amounts paid
in settlement actually and reasonably incurred by its directors and officers in
connection with the defense of any present or future threatened, pending, or
completed claim, action, suit, or proceeding by reason of the fact that they
were, are, shall be, or shall have been a director or officer of the registrant,
or are or were serving, shall serve, or shall have served, at the request of the
registrant, as a director or officer of another corporation, partnership, joint
venture, trust, employee benefit plan, or other enterprise.

ITEM 21.  EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

     (a) See Exhibit Index.

     (b) Not applicable.

     (c) Not applicable.

ITEM 22.  UNDERTAKINGS

     (a) The undersigned registrant hereby undertakes:

          (1) To file, during any period in which offers or sales are being
     made, a post-effective amendment to this Registration Statement:

             (i) To include any prospectus required by Section 10(a)(3) of the
        Securities Act of 1933.

             (ii) To reflect in the prospectus any facts or events arising after
        the effective date of the Registration Statement (or the most recent
        post-effective amendment thereof) which, individually or in the
        aggregate, represent a fundamental change in the information set forth
        in the Registration Statement. Notwithstanding the foregoing, any
        increase or decrease in volume of securities offered (if the total
        dollar value of securities offered would not exceed that which was
        registered) and any deviation from the low or high end of the estimated
        maximum offering range may be reflected in the form of prospectus filed
        with the Commission pursuant to Rule 424(b) if, in the aggregate, the
        changes in volume and price represent no more than a 20% change in the
        maximum aggregate offering price set forth in the "Calculation of
        Registration Fee" table in the effective Registration Statement.

             (iii) To include any material information with respect to the plan
        of distribution not previously disclosed in the Registration Statement
        or any material change to such information in the Registration
        Statement.

          (2) That, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof.

          (3) To remove from registration by means of a post-effective amendment
     any of the securities being registered which remain unsold at the
     termination of the offering.

     (b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
Registration Statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

                                       II-2
   143

     (c)(1) The undersigned registrant hereby undertakes as follows: that prior
to any public reoffering of the securities registered hereunder through use of a
prospectus which is a part of this Registration Statement, by any person or
party who is deemed to be an underwriter within the meaning of Rule 145(c), the
issuer undertakes that such reoffering prospectus will contain the information
called for by the applicable registration form with respect to reofferings by
persons who may be deemed underwriters, in addition to the information called
for by the other items of the applicable form.

     (2) The registrant undertakes that every prospectus (i) that is filed
pursuant to paragraph (c)(1) immediately preceding, or (ii) that purports to
meet the requirements of Section 10(a)(3) of the Securities Act of 1933 and is
used in connection with an offering of securities subject to Rule 415, will be
filed as a part of an amendment to the Registration Statement and will not be
used until such amendment is effective, and that, for purposes of determining
any liability under the Securities Act of 1933, each such post-effective
amendment shall be deemed to be a new registration statement relating to the
securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.

     (d) Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act of 1933 and is, therefore, unenforceable. In the event that a
claim for indemnification against such liabilities (other than the payment by
the registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling person
in connection with the securities being registered, the registrant will, unless
in the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act of 1933 and will be governed by the final adjudication of such
issue.

     (e) The undersigned registrant hereby undertakes to respond to requests for
information that is incorporated by reference into the prospectus pursuant to
items 4, 10(b), 11 or 13 of this Form, within one business day of receipt of
such request, and to send the incorporated documents by first class mail or
other equally prompt means. This includes information contained in documents
filed subsequent to the effective date of the Registration Statement through the
date of responding to the request.

     (f) The undersigned registrant hereby undertakes to supply by means of a
post-effective amendment all information concerning a transaction, and the
company being acquired involved therein, that was not the subject of and
included in the Registration Statement when it became effective.

                                       II-3
   144

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act, the registrant has duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in New Brunswick, New Jersey on the 23rd
day of April, 2001.

                                          JOHNSON & JOHNSON,

                                          By: /s/ R.S. LARSEN
                                            ------------------------------------
                                              Name: R.S. Larsen
                                              Title: Chairman, Board of
                                                     Directors; Chief Executive
                                                     Officer and Chairman,
                                                     Executive Committee

                                       II-4
   145

                               POWER OF ATTORNEY

     Each person whose signature appears below hereby constitutes and appoints
J. R. Hilton and M. H. Ullmann, and each of them, as his or her true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution,
for him or her and in his or her name, place and stead, in any and all
capacities, to sign any and all amendments (including pre-effective and
post-effective amendments) to this Registration Statement and all documents
relating thereto, including any subsequent Registration Statements pursuant to
Rule 462 promulgated under the Securities Act of 1933, as amended, and to file
the same, with all exhibits thereto, and other documents in connection
therewith, with the Securities and Exchange Commission granting unto said
attorneys-in-fact and agents, and each of them, full power and authority to do
and perform each and every act and thing necessary or advisable to be done in
and about the premises, as fully to all intents and purposes as he or she might
or could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents, or any of them, or their substitute or
substitutes, may lawfully do or cause to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.



                SIGNATURE                                     TITLE                          DATE
                ---------                                     -----                          ----
                                                                                  
/s/ R. S. LARSEN                            Chairman, Board of Directors; Chief         April 23, 2001
------------------------------------------    Executive Officer and Chairman,
(R. S. Larsen)                                Executive Committee (Principal Executive
                                              Officer)

/s/ R. J. DARRETTA                          Member, Executive Committee; Vice           April 23, 2001
------------------------------------------    President, Finance (Principal Financial
(R. J. Darretta)                              Officer)

/s/ C. E. LOCKETT                           Controller (Principal Accounting Officer)   April 23, 2001
------------------------------------------
(C. E. Lockett)

                                            Director
------------------------------------------
(G. N. Burrow)

/s/ J. G. COONEY                            Director                                    April 23, 2001
------------------------------------------
(J. G. Cooney)

/s/ J. G. CULLEN                            Director                                    April 23, 2001
------------------------------------------
(J. G. Cullen)

/s/ M. J. FOLKMAN                           Director                                    April 23, 2001
------------------------------------------
(M. J. Folkman)

/s/ A. D. JORDAN                            Director                                    April 23, 2001
------------------------------------------
(A. D. Jordan)

/s/ A. G. LANGBO                            Director                                    April 23, 2001
------------------------------------------
(A. G. Langbo)

/s/ J. T. LENEHAN                           Director                                    April 23, 2001
------------------------------------------
(J. T. Lenehan)

/s/ J. S. MAYO                              Director                                    April 23, 2001
------------------------------------------
(J. S. Mayo)


                                       II-5
   146



                SIGNATURE                                     TITLE                          DATE
                ---------                                     -----                          ----

                                                                                  
/s/ L. F. MULLIN                            Director                                    April 23, 2001
------------------------------------------
(L. F. Mullin)

/s/ H. B. SCHACHT                           Director                                    April 23, 2001
------------------------------------------
(H. B. Schacht)

/s/ M. F. SINGER                            Director                                    April 23, 2001
------------------------------------------
(M. F. Singer)

/s/ J. W. SNOW                              Director                                    April 23, 2001
------------------------------------------
(J. W. Snow)

/s/ W. C. WELDON                            Director                                    April 23, 2001
------------------------------------------
(W. C. Weldon)

/s/ R. N. WILSON                            Director                                    April 23, 2001
------------------------------------------
(R. N. Wilson)


                                       II-6
   147

                                 EXHIBIT INDEX



EXHIBITS
--------
         
    2.1     Agreement and Plan of Merger dated as of March 26, 2001,
            among Johnson & Johnson, Express Merger Sub Inc. and ALZA
            Corporation (included as Annex 1 to the proxy
            statement/prospectus which is a part of this Registration
            Statement).
    4.1*    Provisions of the Restated Certificate of Incorporation of
            Johnson & Johnson dated May 21, 1996, that define the rights
            of security holders of Johnson & Johnson (incorporated by
            reference to Exhibit 3(a)(iii) to Johnson & Johnson's Annual
            Report on Form 10-K for the year ended December 29, 1996).
    4.2*    Provisions of the By-laws of Johnson & Johnson, as amended
            effective April 23, 1999, that define the rights of security
            holders of Johnson & Johnson (incorporated by reference to
            Exhibit 3 to Johnson & Johnson's Quarterly Report on Form
            10-Q for the quarterly period ended July 4, 1999).
    5.1     Opinion of Joseph S. Orban, Esq., Associate General Counsel
            of Johnson & Johnson, regarding the legality of the
            securities being issued.
    8.1**   Form of opinion of Heller Ehrman White & McAuliffe LLP
            regarding certain tax matters.
   23.1     Consent of PricewaterhouseCoopers LLP.
   23.2     Consent of Ernst & Young LLP, Independent Auditors.
   23.3     Consent of Joseph S. Orban, Esq., Associate General Counsel
            of Johnson & Johnson (included in Exhibit 5.1).
   23.4**   Consent of Heller Ehrman White & McAuliffe LLP (included in
            Exhibit 8.1).
   23.5     Consent of Chase Securities Inc.
   23.6     Consent of Merrill Lynch, Pierce, Fenner & Smith
            Incorporated.
   24.1     Power of Attorney (included on the signature page of this
            Registration Statement).
   99.1     Form of Proxy Card of ALZA Corporation.
   99.2     Stock Option Agreement dated as of March 26, 2001, between
            Johnson & Johnson and ALZA Corporation (included as Annex 2
            to the proxy statement/prospectus which is a part of this
            Registration Statement).


---------------
 * Incorporated by reference.

** To be filed by amendment.