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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
Form 10-K/T
     
o
  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
    For the fiscal year ended           .
 
or
 
þ
  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
 
    For the transition period from July 1, 2005 to December 31, 2005
Commission file number 0-18443
MEDICIS PHARMACEUTICAL CORPORATION
(Exact name of registrant as specified in its charter)
     
Delaware
  52-1574808
(State of other jurisdiction
of incorporation or organization)
  (I.R.S. Employer
Identification No.)
8125 North Hayden Road,
Scottsdale, Arizona
(Address of principal executive office)
  85258-2463
(Zip Code)
Registrant’s telephone number, including area code:
(602) 808-8800
Securities registered pursuant to Section 12(b) of the Act: Class A common stock, $0.014 par value
     
New York Stock Exchange
  Preference Share Purchase Rights
(Name of each exchange on which
registered)
  (Title of each Class)
Securities registered pursuant to Section 12(g) of the Act:
NONE
      Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.     Yes þ          No o
      Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.     Yes o          No þ
      Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.     Yes þ          Noo
      Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form or any amendment to this Form 10-K/ T     o.
      Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and large accelerated filer” in Rule 12b-2 of the Exchange Act. (Check one):
Large accelerated filer þ          Accelerated filer     o          Non-accelerated filer     o
      Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act) Yes     o          No þ
      The aggregate market value of the voting stock held on December 31, 2005 by non-affiliates of the registrant was $1,225,975,222 based on the closing price of $32.05 per share as reported on the New York Stock Exchange on December 30, 2005, the last business day of the registrant’s most recently completed second fiscal quarter (calculated by excluding all shares held by executive officers, directors and holders known to the registrant of five percent or more of the voting power of the registrant’s common stock, without conceding that such persons are “affiliates” of the registrant for purposes of the federal securities laws). As of March 10, 2006, there were 54,427,972, outstanding shares of Class A common stock.
      Documents incorporated by reference:
      Portions of the Proxy Statement for the registrant’s 2006 Annual Meeting of Shareholders (the “Proxy Statement”) are incorporated herein by reference in Part III of this Form 10-K/ T to the extent stated herein.
 
 


TABLE OF CONTENTS

PART I
Item 1. Business
Item 1A. Risk Factors
Item 1B. Unresolved Staff Comments
Item 2. Properties
Item 3. Legal Proceedings
Item 4. Submission of Matters to a Vote of Security Holders
Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
Item 6. Selected Financial Data
Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations
Item 7A. Quantitative and Qualitative Disclosure About Market Risk
Item 8. Financial Statements and Supplementary Data
Item 9. Changes in and Disagreements with Accountants and Financial Disclosure
Item 9A. Controls and Procedures
Item 9B. Other Information
PART III
Item 10. Directors and Executive Officers of the Registrant
Item 11. Executive Compensation
Item 12. Security Ownership of Certain Beneficial Owners and Management
Item 13. Certain Relationships and Related Transactions
Item 14. Principal Accountant Fees and Services
PART IV
Item 15. Exhibits, Financial Statement Schedules
SIGNATURES
MEDICIS PHARMACEUTICAL CORPORATION INDEX TO CONSOLIDATED FINANCIAL STATEMENTS
Report of Independent Registered Public Accounting Firm
CONSOLIDATED BALANCE SHEETS
CONSOLIDATED STATEMENTS OF INCOME
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
CONSOLIDATED STATEMENTS OF CASH FLOWS
MEDICIS PHARMACEUTICAL CORPORATION NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
SCHEDULE II -- VALUATION AND QUALIFYING ACCOUNTS
EX-10.40
EX-10.41
EX-12
EX-21.1
EX-23.1
Ex-31.1
EX-31.2
EX-32.1
EX-32.2


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PART I
Item 1.     Business
Change in Fiscal Year
      Effective December 31, 2005, Medicis Pharmaceutical Corporation (“Medicis”, the “Company”, or as used in the context of “we”, “us” or “our”) changed its fiscal year end from June 30 to December 31. This change was made to align our fiscal year end with other companies within our industry. This Form 10-K/ T is intended to cover the transition report for the period July 1, 2005 through December 31, 2005 (the “Transition Period”). Subsequent to this, our Form 10-K will cover the calendar year January 1 to December 31. We refer to the period beginning July 1, 2004 and ending June 30, 2005 as “fiscal 2005”, the period beginning July 1, 2003 and ending June 30, 2004 as “fiscal 2004” and the period beginning July 1, 2002 and ending June 30, 2003 as “fiscal 2003”.
The Company
      Medicis Pharmaceutical Corporation, together with its wholly owned subsidiaries, is a leading independent specialty pharmaceutical company focusing primarily on helping patients attain a healthy and youthful appearance and self-image through the development and marketing of products for the treatment of dermatological and aesthetic conditions in the United States and Canada, and podiatric conditions in the United States. We believe that annual U.S. pharmaceutical sales in the dermatological market exceed $5 billion. According to the American Society for Aesthetic Plastic Surgery, a national not-for-profit organization for education and research in cosmetic plastic surgery, nearly 11.5 million surgical and non-surgical cosmetic procedures were performed in the United States during 2005, including approximately 9.3 million non-surgical cosmetic procedures.
      We have built our business by executing a four-part growth strategy: promoting existing core brands, developing new products and important product line extensions, entering into strategic collaborations, and acquiring complementary products, technologies and businesses. Our core philosophy is to cultivate relationships of trust and confidence with the high prescribing dermatologists and podiatrists and the leading plastic surgeons in the United States.
      We offer a broad range of products addressing various conditions including acne, fungal infections, rosacea, hyperpigmentation, photoaging, psoriasis, eczema, skin and skin-structure infections, seborrheic dermatitis and cosmesis (improvement in the texture and appearance of skin). We currently offer 15 branded products. Our core brands are DYNACIN® (minocycline HCI), LOPROX® (ciclopirox), OMNICEF® (cefdinir), PLEXION® (sodium sulfacetamide/sulfur), RESTYLANE® (hyaluronic acid), TRIAZ® (benzoyl peroxide), and VANOStm (fluocinonide) Cream 0.1%. All of our core brands enjoy branded market leadership in the segments in which they compete. Because of the significance of these brands to our business, we concentrate our sales and marketing efforts in promoting them to physicians in our target markets. We also sell a number of other products that are considered less critical to our business.
      We also develop and obtain marketing and distribution rights to pharmaceutical agents in various stages of development. We have a variety of products under development, ranging from new products to existing product line extensions and reformulations of existing products. Our product development strategy involves the rapid evaluation and formulation of new therapeutics by obtaining preclinical safety and efficacy data, when possible, followed by rapid safety and efficacy testing in humans. In 2003, we expanded into the dermal aesthetic market through our acquisition of the exclusive United States and Canadian rights to market, distribute and commercialize the dermal restorative product lines known as RESTYLANE®, PERLANEtm and RESTYLANE FINE LINEStm. As a result of our increasing financial strength, we have begun adding long-term projects to our development pipeline. Historically, we have supplemented our research and development efforts by entering into research and development agreements with other pharmaceutical and biotechnology companies.

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      OMNICEF® is a trademark of Fujisawa Pharmaceutical Co. Ltd. and is used under a license from Abbott Laboratories, Inc. (“Abbott”). On April 1, 2005, Fujisawa Pharmaceutical Co. Ltd. merged with Yamanouchi Pharmaceutical Co. Ltd., creating Astelles Pharma, Inc.
Our Products
      We currently market 15 branded products. Our sales and marketing efforts are currently focused on our core brands, which, during the Transition Period and fiscal 2005, accounted for approximately 84% and 76%, respectively, of our total net revenues. The following chart details certain important features of our core brands:
         
Brand   Treatment   U.S. Market Impact
         
DYNACIN®
  Oral adjunctive treatment for severe acne   The number one branded minocycline product in the U.S., DYNACIN® tablets and capsules are available in a range of strengths
LOPROX®
  Topical treatment for certain fungal and yeast infections in adults   A leading antifungal agent, including the number one branded shampoo for seborrheic dermatitis
OMNICEF®
  A patented oral cephalosporin for skin and skin-structure infections   Superior kill rate compared to most frequently prescribed antibiotic for this indication
PLEXION®
  Topical treatments for acne vulgaris, acne rosacea and seborrheic dermatitis   Includes the leading branded prescription cleanser indicated for the treatment of rosacea, and the first prescription cleansing cloth for the treatment of acne and rosacea
RESTYLANE®
  Injectable gel for treatment of severe facial wrinkles and folds, such as nasolabial folds   Launched on January 6, 2004, following approval by the Food and Drug Administration (“FDA”) on December 12, 2003, is the leading worldwide injectible dermal filler
TRIAZ®
  Topical patented gel and cleanser and patent-pending pad treatments for acne   The leading branded prescription benzoyl peroxide product
VANOS tm
  Super-high potency topical corticosteroid for the treatment of plaque-type psoriasis in adult patients affecting up to 10% body surface area   Launched on April 19, 2005 following FDA approval on February 11, 2005
Prescription Pharmaceuticals
      Our principal branded pharmaceutical products are described below:
      DYNACIN® is an oral antibiotic, available in 50-mg., 75-mg. and 100-mg. tablet and capsule dosage forms, and is prescribed as an adjunctive therapy in severe acne. The most commonly prescribed systemic acne treatments are tetracycline and its derivatives, minocycline and doxycycline. Minocycline, the active ingredient in DYNACIN®, is widely prescribed for the treatment of acne for several reasons. It has a more convenient dosing schedule, two doses per day, as compared to other forms of tetracycline, which can require up to four doses per day. Other forms of tetracycline, including doxycycline, require ingestion on an empty stomach and have been reported to often cause gastric irritation and photosensitivity. In addition, resistance to several commonly used antibiotics, including erythromycin, clindamycin, doxycycline and tetracycline, by the primary bacterial organism responsible for acne has been documented. Our DYNACIN® products compete with branded products such as Doryx®, Adoxa®, Monodox®, and myractm, as well as various generic products. DYNACIN® capsules were launched in fiscal 1993 with 50-mg. and 100-mg. dosage forms available. We launched DYNACIN® capsules in a 75-mg. dosage form in fiscal 1999. During fiscal 2003, we launched

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DYNACIN® in tablet form in 75-mg. and 100-mg. dosages, and we launched the 50-mg. dosage in fiscal 2004.
      LOPROX® gel is a broad-spectrum prescription antifungal agent indicated for the topical treatment of interdigital tinea pedis, tinea corporis, and the topical treatment of seborrheic dermatitis of the scalp. Currently, LOPROX® Gel is the only gel approved in the United States for seborrheic dermatitis. In addition to the gel formulation of LOPROX®, we market LOPROX® cream and topical suspension for the topical treatment of tinea pedis, tinea corporis, tinea cruris, tinea versicolor and cutaneous candidiasis. LOPROX® works with a unique mode of action and has been shown to have fungistatic and fungicidal properties. The most frequently prescribed topical antifungal products in addition to LOPROX® include competitor products Spectazole®, Nizoral®, Oxistat® and Lotrisone® (steroid/antifungal combination). There are also generic versions of many of our LOPROX® products available in the market. During fiscal 2003, we launched LOPROX® Shampoo, which was the first prescription antifungal shampoo approved in the United States for the treatment of seborrheic dermatitis of the scalp, a common fungal infection.
      OMNICEF® is indicated for the treatment of uncomplicated skin and skin-structure infections. Studies show that OMNICEF® has superior pathogen eradication rates versus Cephalexin, the most frequently prescribed antibiotic for uncomplicated skin and skin-structure infections. OMNICEF® has been promoted to dermatologists and podiatrists since May 2001 pursuant to our exclusive co-promotion agreement with Abbott. In return, we receive commission revenue from Abbott based on prescriptions generated in these categories. Our agreement with Abbott expires in 2013.
      PLEXION® treats acne vulgaris, acne rosacea and seborrheic dermatitis with internally developed cleanser and topical therapies. Acne rosacea is a chronic skin condition causing inflammation and redness of the face. The active ingredients in our PLEXION® products are sodium sulfacetamide and sulfur. PLEXION®, the patented leading branded prescription cleanser indicated for the treatment of acne rosacea, was launched in fiscal 2000. The topical acne rosacea market is comprised of competitor products such as MetroGel®, MetroCream® and MetroLotion®. PLEXION TS®, a gentle topical suspension, was launched in fiscal 2001. In addition, during fiscal 2002 we launched PLEXION SCT®, a short contact therapy with a silica base that helps remove impurities from the skin pores. During fiscal 2005, we launched the first prescription cleansing cloth, PLEXION® Cleansing Cloths. Within its first three months on the market, PLEXION® Cleansing Cloths became the leading branded sodium sulfacetamide and sulfur cleansing formulation in new prescriptions.
      TRIAZ®, an internally developed topical therapy prescribed for the treatment of numerous forms and varying degrees of acne, is available as a patented gel or cleanser or in a patent-pending pad in three concentrations. TRIAZ® products are manufactured using the active ingredient benzoyl peroxide in a patented vehicle containing glycolic acid and zinc lactate. Studies conducted by third parties have shown that benzoyl peroxide is the most efficacious agent available for eradicating the bacteria that cause acne with no reported resistance. We introduced the TRIAZ® brand in fiscal 1996. In July 2003, we launched TRIAZ® Pads, the first and only benzoyl peroxide pad available in the U.S. indicated for the topical treatment of acne vulgaris.
      VANOStm cream, launched to dermatologists in April 2005 after approval by the FDA on February 11, 2005, is a super-high potency (Class I) topical corticosteroid indicated for the treatment of plaque-type psoriasis in adult patients. Plaque-type psoriasis is the most common form of psoriasis, a chronic, recurrent skin disorder affecting up to 2% of the United States population and characterized by scaling, often itching plaques in certain areas of the body that typically follow a course of exacerbation and remission. The active ingredient in VANOStm is fluocinonide 0.1%, and is the only fluocinonide available in the Class I category of topical corticosteroids. Physicians may already be familiar with the fluocinonide 0.05%, the active ingredient in another of our products, the Class II corticosteroid LIDEX®. Two double blind clinical studies have demonstrated the efficacy, safety and tolerability of VANOStm. Its base was formulated to have the cosmetic elegance of a cream, yet behave like an ointment on the skin. In addition, physicians have the flexibility of prescribing VANOStm either once or twice daily. Considering that plaque-type psoriasis is recognized as a major challenge for physicians, and that VANOStm is a new entry in its category, we believe VANOStm will

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be an important treatment option for patients that suffer from plaque-type psoriasis. On March 2, 2006, the FDA broadened the indication of VANOS, and it is now indicated as a primary therapy for all inflammatory and pruritic skin conditions in patients 12 years of age of older which are responsive to cortocosteroids. Such conditions include eczema and poison ivy, which occur commonly.
Dermal Restorative Products
      Our principal branded dermal restorative products are described below:
      RESTYLANE®, PERLANEtm, RESTYLANE FINE LINEStm and SubQtm are injectable, transparent, Non-Animal-Stabilized-Hyaluronic Acid (“NASHAtm”) gels, which require no patient sensitivity tests in advance of product administration. These “tissue tailored,” transparent, injectable products, which come in pre-packaged, glass syringes, have varying gel particle sizes which provide physicians with flexibility in treating fine lines and wrinkles and correcting deep facial folds. In the United States, the FDA regulates these products as medical devices. Medicis offers all four of these products in Canada, and began offering RESTYLANE® in the United States on January 6, 2004. PERLANEtm, RESTYLANE FINE LINEStm and SubQtm have not yet been approved by the FDA for use in the United States. SubQtm was approved for use in Canada on June 23, 2005. We acquired the exclusive U.S. and Canadian rights to these dermal restorative products from Q-Med AB, a Swedish biotechnology/medical device company and its affiliates (collectively “Q-Med”) through license agreements.
Research and Development
      We develop and obtain rights to pharmaceutical agents in various stages of development. Currently, we have a variety of products under development, ranging from new products to existing product line extensions and reformulations of existing products. Our product development strategy involves the rapid evaluation and formulation of new therapeutics by obtaining preclinical safety and efficacy data, when possible, followed by rapid safety and efficacy testing in humans. As a result of our increasing financial strength, we have begun adding long-term projects to our development pipeline. Historically, we have supplemented our research and development efforts by entering into research and development agreements with other pharmaceutical and biotechnology companies.
      On September 26, 2002, we entered into an exclusive license and development agreement with Dow Pharmaceutical Sciences, Inc. (“Dow”) for the development and commercialization of a patented dermatologic product. Under terms of the agreement, as amended, we made an initial payment of $5.4 million and a development milestone payment of $8.8 million to Dow during fiscal 2003, a development milestone payment of $2.4 million to Dow during fiscal 2004 and development milestone payments totaling $11.9 million to Dow during the Transition Period. In accordance with the agreement between the parties, Medicis is required to make a potential additional payment of $1.0 million upon the certification that a certain development milestone has occurred. All payments were recorded as charges to research and development expense in the periods in which the milestones were achieved.
      On July 15, 2004, we entered into an exclusive license agreement and other ancillary documents with Q-Med to market, distribute, sell and commercialize in the United States and Canada Q-Med’s product currently known as SubQtm. Q-Med has the exclusive right to manufacture SubQtm for Medicis. SubQtm is currently not approved for use in the United States. Under the terms of the license agreement, Medicis Aesthetics Holdings Inc., a wholly owned subsidiary of Medicis, licenses SubQtm for approximately $80.0 million, due as follows: approximately $30.0 million paid on July 15, 2004, which was recorded as research and development expense during the first quarter of fiscal 2005; approximately $10.0 million upon successful completion of certain clinical milestones; approximately $20.0 million upon the satisfaction of certain defined regulatory milestones; and approximately $20.0 million upon U.S. launch of SubQtm. We also will make additional milestone payments to Q-Med upon the achievement of certain commercial milestones. SubQtm is comprised of the same NASHAtm substance as RESTYLANE®, PERLANEtm and RESTYLANE FINE LINEStm with a larger gel particle size and has patent protection until at least 2015 in the United States.

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      On December 13, 2004, we entered into an exclusive development and license agreement and other ancillary agreements with Ansata Therapeutics, Inc. (“Ansata”). The development and license agreement grants us the exclusive, worldwide rights to Ansata’s early stage, proprietary antimicrobial peptide technology. In accordance with the development and license agreement, we paid $5.0 million upon signing of the contract and will pay approximately $9.0 million upon the successful completion of certain developmental milestones. Should we continue with the development of this technology, we will incur additional milestone payments beyond the development and license agreement. The initial $5.0 million payment was recorded as a charge to research and development expense during the second quarter of fiscal 2005.
      On January 28, 2005, we amended our strategic alliance with aaiPharma, Inc. (“aaiPharma”) previously initiated in June 2002 for the development, commercialization and license of a dermatologic product. The consummation of the amendment has not affected the timing of the development project. The amendment allowed for the immediate transfer of the work product as defined under the agreement, as well as the product’s management and development, to us, and provides that aaiPharma will continue to assist us with the development of the product on a fee for services basis. We will have no future financial obligations to pay aaiPharma on the attainment of clinical milestones, but we incurred approximately $8.3 million as a charge to research and development expense during the third quarter of fiscal 2005, as part of the amendment and the assumption of all liabilities associated with the project.
      We incurred total research and development costs for all of our sponsored and unreimbursed co-sponsored pharmaceutical projects for the Transition Period, the corresponding six-month period of 2004, fiscal 2005, fiscal 2004 and fiscal 2003 of $22.4 million, $45.1 million, $65.7 million, $16.5 million and $29.6 million, respectively. Research and development costs for the Transition Period include $11.9 million paid to Dow pursuant to the development agreement. Research and development costs for the corresponding six-month period of 2004 include $30.0 million related to our license agreement with Q-Med related to the SubQtm product, and $5.0 million related to our development and license agreement with Ansata. Research and development costs for fiscal 2005 include $30.0 million related to our license agreement with Q-Med related to the SubQtm product, $5.0 million related to our development and license agreement with Ansata and $8.3 million related to our research and development collaboration with aaiPharma. Research and development costs for fiscal 2004 include $2.4 million paid to Dow pursuant to the development agreement. Research and development costs for fiscal 2003 include $14.2 million paid to Dow pursuant to the development agreement, and $6.0 million related to our research and development collaboration with aaiPharma.
Sales and Marketing
      Our combined dedicated sales force, consisting of 163 employees as of December 31, 2005, focuses on high prescribing dermatologists, plastic surgeons and podiatrists. Since a relatively small number of physicians are responsible for writing a majority of dermatological and podiatric prescriptions and performing dermal aesthetic procedures, we believe that the size of our sales force is appropriate to reach our target physicians. Our therapeutic dermatology and podiatric sales forces consist of 110 employees who regularly call on approximately 9,300 dermatologists and 3,200 podiatrists. Our dermal aesthetic sales force consists of 53 employees who regularly call on leading plastic surgeons, facial plastic surgeons, dermatologists and dermatologic surgeons. We also have seven national account managers who regularly call on managed care organizations, large retail chains, formularies and related organizations.
      We cultivate relationships of trust and confidence with the high prescribing dermatologists and podiatrists and the leading plastic surgeons in the United States. We use a variety of marketing techniques to promote our products including sampling, journal advertising, promotional materials, specialty publications, coupons, money-back or product replacement guarantees, educational conferences and informational websites.
      We believe we have created an attractive incentive program for our sales force that is based upon goals in prescription growth and market share achievement.

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Warehousing and Distribution
      We utilize an independent national warehousing corporation to store and distribute our products from primarily two regional warehouses in Nevada and Georgia, as well as additional warehouses in Maryland and North Carolina. Upon the receipt of a purchase order through electronic data input (“EDI”), phone, mail or facsimile, the order is processed through our inventory management systems and is transmitted electronically to the appropriate warehouse for picking and packing. Upon shipment, the warehouse sends back to us via EDI the necessary information to automatically process the invoice in a timely manner.
Customers
      Our customers include certain of the nation’s leading wholesale pharmaceutical distributors, such as AmerisourceBergen Corporation (“AmerisourceBergen”), Cardinal Health, Inc. (“Cardinal”), McKesson Corporation (“McKesson”) and other major drug chains. During the Transition Period, the comparable six-month period in 2004, and the last three full fiscal years, these customers accounted for the following portions of our net revenues:
                                         
        Comparable            
        Six-Month            
    Transition   Period in   Fiscal   Fiscal   Fiscal
    Period   2004   2005   2004   2003
                     
McKesson
    54.9 %     50.8 %     51.2 %     36.9 %     20.2 %
Cardinal
    18.9 %     19.7 %     21.8 %     23.8 %     25.4 %
Quality King
    *       *       *       *       17.0 %
AmerisourceBergen
    *       *       *       *       15.5 %
 
less than 10%
      McKesson is our sole distributor of our RESTYLANE® products in the United States and Canada. RESTYLANE®, our highest-selling product during the Transition Period and fiscal 2005, was launched in the United States in January 2004.
Seasonality
      Our business, taken as a whole, is not materially affected by seasonal factors, although a substantial portion of our prescription product revenues has been recognized in the last month of each quarter and we schedule our inventory purchases to meet anticipated customer demand. As a result, relatively small delays in the receipt of manufactured products by us could result in revenues being deferred or lost.
Manufacturing
      We currently outsource all of our manufacturing needs, and we are required by the FDA to contract only with manufacturers who comply with current Good Manufacturing Practices (“cGMP”) regulations and other applicable laws and regulations. Typically our manufacturing contracts are short-term. We review our manufacturing arrangements on a regular basis and assess the viability of alternative manufacturers if our current manufacturers are unable to fulfill our needs.
      Patheon, Inc. (“Patheon”) manufactures the capsule form of our DYNACIN® branded products under a supply agreement that automatically renews on an annual basis, unless terminated by either party. Par Pharmaceutical, Inc. (“Par”) manufactures the tablet form of our DYNACIN® branded products in accordance with a supply agreement that expires in June 2012.
      Our PLEXION® and TRIAZ® branded products are manufactured by Contract Pharmaceuticals Limited pursuant to a manufacturing agreement that automatically renews on an annual basis, unless terminated by either party.
      Our LOPROX® gel branded products are manufactured by Aventis S.A. (“Aventis”) in accordance with a supply agreement that renews automatically on an annual basis, unless terminated by either party. Our

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LOPROX® TS and LOPROX® shampoo branded products are manufactured by Patheon under a supply agreement that automatically renews on an annual basis, unless terminated by either party. Our LOPROX® cream branded product is manufactured by both Aventis and Patheon.
      Our OMNICEF® branded product, which we promote through a license agreement with Abbott, is manufactured, warehoused and distributed by Abbott. The license agreement expires in 2013.
      Our RESTYLANE® branded product is manufactured by Q-Med pursuant to a long-term supply agreement that expires no earlier than 2013.
      Our VANOStm branded product is manufactured by Patheon under a supply agreement that automatically renews on an annual basis, unless terminated by either party.
Raw Materials
      We and the manufacturers of our products rely on suppliers of raw materials used in the production of our products. Some of these materials are available from only one source and others may become available from only one source. Any disruption in the supply of raw materials or an increase in the cost of raw materials to our manufacturers could have a significant effect on their ability to supply us with our products.
License and Royalty Agreements
      Pursuant to license agreements with third parties, we have acquired rights to manufacture, use or market certain of our existing products, as well as many of our development products and technologies. Such agreements typically contain provisions requiring us to use our best efforts or otherwise exercise diligence in pursuing market development for such products in order to maintain the rights granted under the agreements and may be canceled upon our failure to perform our payment or other obligations. In addition, we have licensed certain rights to manufacture, use and sell certain of our technologies outside the United States and Canada to various licensees.
Trademarks, Patents and Proprietary Rights
      We believe that trademark protection is an important part of establishing product and brand recognition. We own a number of registered trademarks and trademark applications. U.S. federal registrations for trademarks remain in force for 10 years and may be renewed every 10 years after issuance, provided the mark is still being used in commerce.
      We have obtained and licensed a number of patents covering key aspects of certain of our products, including a U.S. patent expiring in October 2015 covering various formulations of TRIAZ®, a U.S. patent expiring in 2015 covering RESTYLANE®, a U.S. patent expiring in 2020 covering PLEXION® cleanser formulation, a U.S. patent expiring in 2020 covering PLEXION® topical suspension and SCT formulations and a U.S. patent expiring in December 2021 covering VANOStm. We have patent applications pending relating to our PLEXION® cleansing cloths formulation and our LOPROX® gel and shampoo formulations. We are also pursuing several other U.S. and foreign patent applications.
      We rely and expect to continue to rely upon unpatented proprietary know-how and technological innovation in the development and manufacture of many of our principal products. Our policy is to require all our employees, consultants and advisors to enter into confidentiality agreements with us.
      Our success with our products will depend, in part, on our ability to obtain, and successfully defend if challenged, patent or other proprietary protection. However, the issuance of a patent is not conclusive as to its validity or as to the enforceable scope of the claims of the patent. Accordingly, our patents may not prevent other companies from developing similar or functionally equivalent products or from successfully challenging the validity of our patents. As a result, if our patent applications are not approved or, even if approved, such patents are circumvented or not upheld in a legal proceeding, our ability to competitively exploit our patented products and technologies may be significantly reduced. Also, such patents may or may not provide

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competitive advantages for their respective products or they may be challenged or circumvented by competitors, in which case our ability to commercially exploit these products may be diminished.
      From time to time, we may need to obtain licenses to patents and other proprietary rights held by third parties to develop, manufacture and market our products. If we are unable to timely obtain these licenses on commercially reasonable terms, our ability to commercially exploit such products may be inhibited or prevented.
Competition
      The pharmaceutical and dermal aesthetics industries are characterized by intense competition, rapid product development and technological change. As a result, competition is intense among manufacturers of prescription pharmaceuticals and dermal injection products, such as for our core brands.
      Many of our competitors are large, well-established pharmaceutical, chemical, cosmetic or health care companies with considerably greater financial, marketing, sales and technical resources than those available to us. Additionally, many of our present and potential competitors have research and development capabilities that may allow them to develop new or improved products that may compete with our product lines. Our products could be rendered obsolete or made uneconomical by the development of new products to treat the conditions addressed by our products, technological advances affecting the cost of production, or marketing or pricing actions by one or more of our competitors. Each of our products competes for a share of the existing market with numerous products that have become standard treatments recommended or prescribed by dermatologists and podiatrists and administered by plastic surgeons and aesthetic dermatologists.
      The largest competitors for our prescription dermatological products include Bristol-Myers Squibb, Galderma, GlaxoSmithKline, Johnson & Johnson, Pfizer, sanofi-aventis, Schering-Plough, Valeant Pharmaceuticals, Wyeth and others. Several of our core prescription brands compete or may compete in the near future with generic (non-branded) pharmaceuticals, which claim to offer equivalent therapeutic benefits at a lower cost. In some cases, insurers and other third-party payors seek to encourage the use of generic products, making branded products less attractive, from a cost perspective, to buyers. On July 18, 2004, Glades Pharmaceuticals, LLC (“Glades”), a wholly owned subsidiary of Stiefel Laboratories, Inc., announced the launch of myractm (minocycline hydrochloride tablets, USP), as a branded pharmaceutical product. Myractm tablets is a prescription product that competes directly with our DYNACIN® tablet products. During the third quarter of our fiscal 2005, myractm began being marketed as a generic product. On August 6, 2004, the FDA approved an Abbreviated New Drug Application (“ANDA”) submitted by Altana, Inc. (“Altana”) for its ciclopirox topical suspension, a generic version of our LOPROX® TS product. On December 29, 2004, the FDA approved an ANDA submitted by Altana for its ciclopirox cream, a generic version of our LOPROX® Cream product. On August 10, 2005, the FDA approved an ANDA submitted by Taro Pharmaceuticals U.S.A. Inc. (“Taro”) for its ciclopirox topical suspension, a generic version of our LOPROX® topical suspension. On March 7, 2006, the Perrigo Company announced that it received approval from the FDA to manufacture and market its ciclopirox olamine cream USP, 0.77%, a generic version of our LOPROX® Cream product.
      Our facial aesthetics products compete against Inamed Corporation (“Inamed”) and Allergan Inc. On December 6, 2005, Inamed announced that it had submitted the fourth and final module of its Premarket Approval Application for three formulations of Juvedermtm, a dermal filler product. Allergan Inc., the marketer of Botox®, is a larger company than Medicis, and has greater financial, marketing, sales and technical resources than those available to us. Allergan Inc. and Inamed are parties to a definitive merger agreement pursuant to which Allergan will acquire Inamed. In addition, there are several dermal filler products under development and/or in the FDA pipeline for approval which claim to offer equivalent or greater facial aesthetic benefits to RESTYLANE® and, if approved, the companies producing such products could charge less to doctors for their products.

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Government Regulation
      The manufacture and sale of biological products, drugs and medical devices are subject to regulation principally by the FDA, but also by other federal agencies and state and local authorities in the United States, and by comparable agencies in certain foreign countries. The Federal Trade Commission (“FTC”), the FDA and state and local authorities regulate the advertising of over-the-counter drugs and cosmetics. The Federal Food, Drugs and Cosmetics Act and the regulations promulgated thereunder, and other federal and state statutes and regulations, govern, among other things, the testing, manufacture, safety, effectiveness, labeling, storage, record keeping, approval, sale, distribution, advertising and promotion of our products.
      Our RESTYLANE® dermal filler product is a medical device intended for human use and is subject to regulation by the FDA in the United States. Unless an exemption applies, each medical device we market in the U.S. must have a Premarket Approval Application (“PMA”) in accordance with the Federal Food, Drug, and Cosmetic Act, as amended, or a 510(k) clearance (a demonstration that the new device is “substantially equivalent” to a device already on the market). FDA device regulations generally require reasonable assurance of safety and effectiveness prior to marketing, including safety and efficacy data obtained under clinical protocols approved under an Investigational Device Exemption (“IDE”) and require compliance with “quality systems regulations” (“QSRs”), as verified by detailed FDA investigations of manufacturing facilities. These regulations also require post-approval reporting of alleged product defects, recalls and certain adverse experiences to the FDA. FDA regulations divide medical devices into three classes. Class I devices are subject to general controls that require compliance with device establishment registration, product listing, labeling, QSRs and other general requirements that are also applicable to all classes of medical devices. Class II devices are subject to special controls in addition to general controls and generally require the submission of a premarket notification before marketing is permitted. Class III devices are subject to the most comprehensive regulation and in most cases require submission to the FDA of a PMA application that includes biocompatibility, manufacturing and clinical data supporting the safety and effectiveness of the device as well as compliance with the same provisions applicable to all medical devices such as QSRs. Annual reports must be submitted to the FDA, as well as descriptions of certain adverse events that are reported to the sponsor within specified timeframes of receipt of such reports. RESTYLANE® is regulated as a Class III medical device. RESTYLANE® has been approved by the FDA under a PMA.
      In general, products falling within the FDA’s definition of “new drugs” require premarket approval by the FDA. Products falling within the FDA’s definition of “cosmetics” or of “drugs” (if they are not also “new drugs”) and that are generally recognized as “safe and effective” do not require premarketing clearance although all drugs must comply with a host of post-market regulations, including manufacture under cGMP. The steps required before a “new drug” may be marketed in the United States include (i) preclinical laboratory and animal testing; (ii) manufacture under cGMP; (iii) submission to the FDA of an Investigational New Drug (or “IND”) application, which must become effective before clinical trials may commence; (iv) usually at least two adequate and well-controlled clinical trials to establish the safety and efficacy of the drug; (for some applications, the FDA may accept one large clinical trial) (v) submission to the FDA of a New Drug Application (or “NDA”); and (vi) FDA approval of the NDA before any commercial sale or shipment of the drug. In addition to obtaining FDA approval for each product, each drug-manufacturing establishment must be registered with, and approved by, the FDA.
      New drugs may also be approved by the agency pursuant to an ANDA for generic drugs if the same active ingredient has previously been approved by the agency and the original sponsor of the NDA no longer has patent protection or statutory marketing exclusivity. Approval of an ANDA does not require the submission of clinical data on the safety and effectiveness of the drug product. However, the applicant must provide dissolution and/or metabolic studies to show that the active ingredient in the generic drug sponsor’s application is comparably available to the patent as the original product in the NDA upon which the ANDA is based.
      Preclinical or biocompatibility testing is generally conducted on laboratory animals to evaluate the potential safety and toxicity of a drug. The results of these studies are submitted to the FDA as a part of an IND or IDE application, which must be approved before clinical trials in humans can begin. Typically, clinical

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evaluation of new drugs involves a time consuming and costly three-phase process. In Phase I, clinical trials are conducted with a small number of subjects to determine the early safety profile, the relationship of safety to dose, and the pattern of drug distribution and metabolism. In Phase II, one or more clinical trials are conducted with groups of patients afflicted with a specific disease to determine preliminary efficacy and expanded evidence of safety. In Phase III, at least two large-scale, multi-center, comparative trials are conducted with patients afflicted with a target disease to provide sufficient confirmatory data to support the efficacy and safety required by the FDA. The FDA closely monitors the progress of each of the three phases of clinical trials and may, at its discretion, re-evaluate, alter, suspend or terminate the testing based upon the data that have been accumulated to that point and its assessment of the risk/benefit ratio to the patient.
      FDA approval is required before a ‘new drug’ product may be marketed in the United States. However, many historically over-the-counter (“OTC”) drugs are exempt from the FDA’s premarket approval requirements. In 1972, the FDA instituted the ongoing OTC Drug Review to evaluate the safety and effectiveness of OTC drugs then in the market before enactment of the Drug Amendments of 1962. Through this process, the FDA issues monographs that set forth the specific active ingredients, dosages, indications and labeling statements for OTC drugs that the FDA will consider generally recognized as safe and effective and therefore not subject to premarket approval. Before issuance of a final OTC drug monograph as a federal regulation, OTC drugs are classified by the FDA in one of three categories: Category I ingredients which are deemed “safe and effective for over-the-counter use;” Category II ingredients which are deemed “not generally recognized as safe and effective for over-the-counter use;” and Category III ingredients which are deemed “possibly safe and effective with studies ongoing.” Based upon the results of these ongoing studies, the FDA must reclassify all Category III ingredients as either Category I or Category II before issuance of a final monograph. For certain categories of OTC drugs not yet subject to a final monograph, the FDA usually permits such drugs to continue to be marketed until a final monograph becomes effective, unless the drug will pose a potential health hazard to consumers. Stated differently, the FDA generally permits continued marketing only of Category I and III products during the pendency of a final monograph. Drugs subject to final monographs, as well as drugs that are subject only to proposed monographs, are subject to various FDA regulations concerning, for example, cGMP, general and specific OTC labeling requirements and prohibitions against promotion for conditions other than those stated in the labeling. OTC drug manufacturing facilities are subject to FDA inspection, and failure to comply with applicable regulatory requirements may lead to administrative or judicially imposed penalties.
      Each of the active ingredients in LOPROX® products and OMNICEF® products have been approved by the FDA under an NDA. The active ingredient in DYNACIN® branded products has been approved by the FDA under an ANDA. The active ingredient in the TRIAZ® products has been classified as a Category III ingredient under a tentative final FDA monograph for OTC use in treatment of labeled conditions. The FDA has requested, and a task force of the Non-Prescription Drug Manufacturers Association (or “NDMA”), a trade association of OTC drug manufacturers, has undertaken further studies to confirm that benzoyl peroxide, an active ingredient in the TRIAZ® products, is not a tumor promoter when tested in conjunction with UV light exposure. The TRIAZ® products, which we sell on a prescription basis, have the same ingredients at the same dosage levels as the OTC products. When the FDA issues the final monograph, one of several possible outcomes that may occur is that we may be required by the FDA to discontinue sales of TRIAZ® products until and unless we file an NDA covering such product. There can be no assurance as to the results of these studies or any FDA action to reclassify benzoyl peroxide. In addition, there can be no assurance that adverse test results would not result in withdrawal of TRIAZ® products from marketing. An adverse decision by the FDA with respect to the safety of benzoyl peroxide could result in the assertion of product liability claims against us and could have a material adverse effect on our business, financial condition and results of operations.
      Our TRIAZ® branded products must meet the composition and labeling requirements established by the FDA for products containing their respective basic ingredients. We believe that compliance with those established standards avoids the requirement for premarket clearance of these products. There can be no assurance that the FDA will not take a contrary position in the future. Our PLEXION® branded products,

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which contain the active ingredients sodium sulfacetamide and sulfur, are marketed under the FDA compliance policy entitled “Marketed New Drugs without Approved NDAs or ANDAs.”
      We believe that certain of our products, as they are promoted and intended by us for use, are exempt from being considered “new drugs” based upon the introduction date of their active ingredients and therefore do not require premarket clearance. There can be no assurance that the FDA will not take a contrary position in the future. If the FDA were to do so, we may be required to seek FDA approval for these products, market these products as over-the-counter products or withdraw such products from the market. We believe that these products are compliant with applicable regulations governing product safety, use of ingredients, labeling, promotion and manufacturing methods.
      We also will be subject to foreign regulatory authorities governing clinical trials and pharmaceutical sales for products we seek to market outside the United States. Whether or not FDA approval has been obtained, approval of a product by the comparable regulatory authorities of foreign countries must be obtained before marketing the product in those countries. The approval process varies from country to country, the approval process time required may be longer or shorter than that required for FDA approval, and any foreign regulatory agency may refuse to approve any product we submit for review.
Our History
      We filed our certificate of incorporation with the Secretary of State of Delaware on July 28, 1988. We completed our initial public offering during our fiscal year ended June 30, 1990, and launched our initial pharmaceutical products during our fiscal year ended June 30, 1991. During our fiscal year ended June 30, 2003, we acquired the exclusive U.S. and Canada license to the RESTYLANE® family of products.
Financial Information About Segments
      We operate in one significant business segment: Pharmaceuticals. Our current pharmaceutical franchises are divided between the dermatological and non-dermatological fields. Information on revenues, operating income, identifiable assets and supplemental revenue of our business franchises appears in the consolidated financial statements included in Item 8 hereof.
Employees
      At December 31, 2005, we had 356 full-time employees. No employees are subject to a collective bargaining agreement. We believe our relationship with our employees is good.
Available Information
      We make available free of charge on or through our Internet website, www.medicis.com, our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K, and all amendments to those reports, if any, filed or furnished pursuant to Section 13(a) of 15(d) of the Securities Exchange Act of 1934 as soon as reasonably practicable after they are electronically filed with, or furnished to, the Securities and Exchange Commission. We also make available free of charge on or through our website our Business Code of Conduct and Ethics, Corporate Governance Guidelines, Nominating and Corporate Governance Committee Charter, Compensation Committee Charter and Audit Committee Charter. The information contained on our website is not intended to be incorporated into this annual report on Form 10-K/T.
Item 1A. Risk Factors
      Our statements in this report, other reports that we file with the Securities and Exchange Commission, our press releases and in public statements of our officers and corporate spokespersons contain forward-looking statements Within the meaning of Section 27A of the Securities Act of 1933, Section 21 of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. You can identify these statements by the fact that they do not relate strictly to historical or current events, and contain words such as “anticipate,” “estimate,” “expect,” “project”, “intend,” “will”, “plan,” “believe”, “should”, “outlook”,

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“could”, “target” and other words of similar meaning in connection with discussion of future operating or financial performance. These include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, the outcome of contingencies such as legal proceedings and financial results. These statements are based on certain assumptions made by us based on our experience and perception of historical trends, current conditions, expected future developments and other factors we believe are appropriate in the circumstances. Such statements are subject to a number of assumptions, risks and uncertainties, many of which are beyond our control. These forward-looking statements reflect the current views of senior management with respect to future events and financial performance. No assurances can be given, however, that these activities, events or developments will occur or that such results will be achieved, and actual results may vary materially from those anticipated in any forward-looking statement. Any such forward-looking statements, whether made in this report or elsewhere, should be considered in context of the various disclosures made by us about our businesses including, without limitation, the risk factors discussed below. We do not plan to update any such forward-looking statements and expressly disclaim any duty to update the information contained in this filing except as required by law.
      We operate in a rapidly changing environment that involves a number of risks. The following discussion highlights some of these risks and others are discussed elsewhere in this report. These and other risks could materially and adversely affect our business, financial condition, prospects, operating results or cash flows.
Risks Related To Our Business
We derive a majority of our sales from our core products, and any factor adversely affecting sales of these products would harm our business, financial condition and results of operations
      We believe that the prescription volume of our core prescription products and sales of our dermal aesthetic product, RESTYLANE®, which we began selling in the United States on January 6, 2004, will continue to constitute a significant portion of our sales for the foreseeable future. Accordingly, any factor adversely affecting our sales related to these products, individually or collectively, could harm our business, financial condition and results of operations. On December 6, 2005, Inamed announced that it had submitted the fourth and final module of its Premarket Approval Application for three formulations of Juvedermtm, a dermal filler product that would compete with RESTYLANE® if approved by the FDA. Many of our core prescription products, including DYNACIN® and LOPROX®, are subject to generic competition or may be in the near future. On July 18, 2004, Glades announced the launch of myractm (minocycline hydrochloride tablets, USP), as a branded pharmaceutical product. Myractm tablets is a prescription product that competes directly with our DYNACIN® tablet products. During the third quarter of our fiscal 2005, myractm began being marketed as a generic product. On August 6, 2004, the FDA approved an ANDA submitted by Altana for its ciclopirox topical suspension, a generic version of our LOPROX® TS product. On December 29, 2004, the FDA approved an ANDA submitted by Altana for its ciclopirox cream, a generic version of our LOPROX® cream product. On August 10, 2005, the FDA approved an ANDA submitted by Taro Pharmaceuticals U.S.A. Inc. (“Taro”) for its ciclopirox topical suspension, a generic version of our LOPROX® topical suspension. On March 7, 2006, the Perrigo Company announced that it received approval from the FDA to manufacture and market its ciclopirox olamine cream USP, 0.77%, a generic version of our LOPROX® Cream product. Each of our core products could be rendered obsolete or uneconomical by competitive changes, including generic competition.
      Sales related to our core prescription products and RESTYLANE® could also be adversely affected by other factors, including:
  •  manufacturing or supply interruptions;
 
  •  the development of new competitive pharmaceuticals and technological advances to treat the conditions addressed by our core products, including the introduction of new products into the marketplace;
 
  •  marketing or pricing actions by one or more of our competitors;

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  •  regulatory action by the FDA and other government regulatory agencies;
 
  •  changes in the prescribing or procedural practices of dermatologists, plastic surgeons and/or podiatrists;
 
  •  changes in the reimbursement or substitution policies of third-party payors or retail pharmacies;
 
  •  product liability claims;
 
  •  the outcome of disputes relating to trademarks, patents, license agreements and other rights;
 
  •  changes in state and federal law that adversely affect our ability to market our products to dermatologists, plastic surgeons and/or podiatrists; and
 
  •  restrictions on travel affecting the ability of our sales force to market to prescribing physicians and plastic surgeons in person.
      If we do not comply with applicable regulatory requirements, such violations could result in warning letters, non-approval, suspensions of regulatory approvals, civil penalties and criminal fines, product seizures and recalls, operating restrictions, injunctions and criminal prosecution. The government has notified us that we have been named as a defendant in a qui tam (whistleblower) lawsuit filed under the False Claims Act. We are cooperating with the government in its investigation, which relates to our marketing and promotion of LOPROX® products to pediatricians prior to our May 2004 disposition of our pediatric sales division.
Our operating results and financial condition may fluctuate
      Our operating results and financial condition may fluctuate from quarter to quarter and year to year for a number of reasons. The following events or occurrences, among others, could cause fluctuations in our financial performance from period to period:
  •  development of new competitive products by others;
 
  •  the timing and receipt of FDA approvals;
 
  •  changes in the amount we spend to develop, acquire or license new products, technologies or businesses;
 
  •  untimely contingent research and development payments under our third-party product development agreements;
 
  •  changes in the amount we spend to promote our products;
 
  •  delays between our expenditures to acquire new products, technologies or businesses and the generation of revenues from those acquired products, technologies or businesses;
 
  •  changes in treatment practices of physicians that currently prescribe our products;
 
  •  changes in reimbursement policies of health plans and other similar health insurers, including changes that affect newly developed or newly acquired products;
 
  •  increases in the cost of raw materials used to manufacture our products;
 
  •  manufacturing and supply interruptions, including failure to comply with manufacturing specifications;
 
  •  changes in prescription levels and the effect of economic changes in hurricane and other natural disaster-affected areas;
 
  •  the impact on our employees, customers, patients, manufacturers, suppliers, vendors, and other companies we do business with and the resulting impact on the results of operations associated with the possible mutation of the avian form of influenza from birds or other animal species to humans, current human morbidity, and mortality levels persist following such potential mutation;
 
  •  the mix of products that we sell during any time period;

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  •  lower than expected demand for our products;
 
  •  our responses to price competition;
 
  •  expenditures as a result of legal actions;
 
  •  market acceptance of our products;
 
  •  the impairment and write-down of goodwill or other intangible assets;
 
  •  implementation of new or revised accounting or tax rules or policies;
 
  •  disposition of core products, technologies and other rights;
 
  •  termination or expiration of, or the outcome of disputes relating to, trademarks, patents, license agreements and other rights;
 
  •  increases in insurance rates for existing products and the cost of insurance for new products;
 
  •  general economic and industry conditions, including changes in interest rates affecting returns on cash balances and investments that affect customer demand;
 
  •  seasonality of demand for our products;
 
  •  our level of research and development activities;
 
  •  new accounting standards and/or changes to existing accounting standards that would have a material effect on our consolidated financial position, results of operations or cash flows;
 
  •  costs and outcomes of any tax audits or any litigation involving intellectual property, customers or other issues; and
 
  •  timing of revenue recognition related to licensing agreements and/or strategic collaborations.
      As a result, we believe that period-to-period comparisons of our results of operations are not necessarily meaningful, and these comparisons should not be relied upon as an indication of future performance. The above factors may cause our operating results to fluctuate and adversely affect our financial condition and results of operations.
We will be unable to meet our anticipated development and commercialization timelines if clinical trials for our products are unsuccessful or delayed
      The production and marketing of our products and our ongoing research and development, pre-clinical testing and clinical trials activities are subject to extensive regulation and review by numerous governmental authorities. Before obtaining regulatory approvals for the commercial sale of any products, we and/or our partners must demonstrate through pre-clinical testing and clinical trials that our products are safe and effective for use in humans. Conducting clinical trials is a lengthy, time-consuming and expensive process. In addition to testing and approval procedures, extensive regulations also govern marketing, manufacturing, distribution, labeling and record-keeping procedures.
      Completion of clinical trials may take several years or more. Our commencement and rate of completion of clinical trials may be delayed by many factors, including:
  •  lack of efficacy during the clinical trials;
 
  •  unforeseen safety issues;
 
  •  slower than expected patient recruitment;
 
  •  government or regulatory delays; and
 
  •  unanticipated requests from the FDA for new or additional information.

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      The results from pre-clinical testing and early clinical trials are often not predictive of results obtained in later clinical trials. A number of new products have shown promising results in clinical trials, but subsequently failed to establish sufficient safety and efficacy data to obtain necessary regulatory approvals. Data obtained from pre-clinical and clinical activities are susceptible to varying interpretations, which may delay, limit or prevent regulatory approval. In addition, regulatory delays or rejections may be encountered as a result of many factors, including perceived defects in the design of the clinical trials and changes in regulatory policy during the period of product development. Any delays in, or termination of, our clinical trials could materially and adversely affect our development and commercialization timelines, which could adversely affect our financial condition, results of operations and cash flows.
If we are unable to secure and protect our intellectual property and proprietary rights, or if our intellectual property rights are found to infringe upon the intellectual property rights of other parties, our business could suffer
      Our success depends in part on our ability to obtain patents or rights to patents, protect trade secrets, operate without infringing upon the proprietary rights of others, and prevent others from infringing on our patents, trademarks, service marks and other intellectual property rights.
      We believe that the protection of our trademarks and service marks is an important factor in product recognition and in our ability to maintain or increase market share. If we do not adequately protect our rights in our various trademarks and service marks from infringement, their value to us could be lost or diminished. If the marks we use are found to infringe upon the trademark or service mark of another company, we could be forced to stop using those marks and, as a result, we could lose the value of those marks and could be liable for damages caused by an infringement.
      The patents and patent applications in which we have an interest may be challenged as to their validity or enforceability. Challenges may result in potentially significant harm to our business. The cost of responding to these challenges and the inherent costs to defend the validity of our patents, including the prosecution of infringements and the related litigation, could be substantial. Such litigation also could require a substantial commitment of our management’s time.
      We are pursuing several United States patent applications; although we cannot be sure that any of these patents will ever be issued. We also have acquired rights under certain patents and patent applications in connection with our licenses to distribute products and by assignment of rights to patents and patent applications from certain of our consultants and officers. These patents and patent applications may be subject to claims of rights by third parties. If there are conflicting claims to the same patent or patent application, we may not prevail and, even if we do have some rights in a patent or patent application, those rights may not be sufficient for the marketing and distribution of products covered by the patent or patent application.
      The ownership of a patent or an interest in a patent does not always provide significant protection. Others may independently develop similar technologies or design around the patented aspects of our technology. We only conduct patent searches to determine whether our products infringe upon any existing patents when we think such searches are appropriate. As a result, the products and technologies we currently market, and those we may market in the future, may infringe on patents and other rights owned by others. If we are unsuccessful in any challenge to the marketing and sale of our products or technologies, we may be required to license the disputed rights, if the holder of those rights is willing to license such rights, otherwise we may be required to cease marketing the challenged products, or to modify our products to avoid infringing upon those rights. A claim or finding of infringement regarding one of our products could harm our business, financial condition and results of operations. The costs of responding to infringement claims could be substantial and could require a substantial commitment of our management’s time. The expiration of patents may expose our products to additional competition.
      We also rely upon trade secrets, unpatented proprietary know-how and continuing technological innovation in developing and manufacturing many of our core products. It is our policy to require all of our employees, consultants and advisors to enter into confidentiality agreements prohibiting them from taking or disclosing our proprietary information and technology. Nevertheless, these agreements may not provide

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meaningful protection for our trade secrets and proprietary know-how if they are used or disclosed. Despite all of the precautions we may take, people who are not parties to confidentiality agreements may obtain access to our trade secrets or know-how. In addition, others may independently develop similar or equivalent trade secrets or know-how.
If Q-Med is unable to protect its intellectual property and proprietary rights with respect to our dermal aesthetic enhancement products, our business could suffer
      RESTYLANE®, PERLANEtm and RESTYLANE FINE LINEStm currently have patent protection in the United States until 2015, and the exclusivity period of the license granted to us by Q-Med will terminate on the later of (i) the expiration of the last patent covering the products or (ii) upon the licensed know-how becoming publicly known. If the validity or enforceability of these patents is successfully challenged, the cost to us could be significant and our business may be harmed. For example, if any such challenges are successful, Q-Med may be unable to supply products to us. As a result, we may be unable to market, distribute and commercialize the products or it may no longer be profitable for us to do so.
We may not be able to collect all scheduled license payments from BioMarin
      As part of our asset purchase agreement, license agreement and securities purchase agreement with BioMarin Pharmaceutical Inc. (“BioMarin”) discussed in Note 7 to our consolidated financial statements, BioMarin will make license payments to us of $2.1 million per quarter for four quarters beginning in July 2005; $1.75 million per quarter for the subsequent eight quarters beginning in July 2006; and $1.5 million per quarter for the subsequent four quarters beginning in July 2008. While we did receive all scheduled quarterly license payments during the Transition Period and during the fiscal year ending June 30, 2005, we cannot give any assurances as to BioMarin’s continuing ability to make payments to us. Currently, our revenue recognition of these payments is on a cash basis. In addition, we cannot give any assurances as to BioMarin’s ability to make the $70.6 million payment to us in 2009 for the purchase of all of the outstanding shares of Ascent Pediatrics.
We depend upon our key personnel and our ability to attract, train, and retain employees
      Our success depends significantly on the continued individual and collective contributions of our senior management team. We have not entered into employment agreements with any of our key managers, with the exception of our Chairman and Chief Executive Officer. The loss of the services of any member of our senior management or the inability to hire and retain experienced management personnel could adversely affect our ability to execute our business plan and harm our operating results. In addition, our future success depends on our ability to hire, train and retain skilled employees. Competition for these employees is intense.
Our continued growth depends upon our ability to develop new products
      We have internally developed potential pharmaceutical compounds and agents. We also have acquired the rights to certain potential compounds and agents in various stages of development. We currently have a variety of new products in various stages of research and development and are working on possible improvements, extensions and reformulations of some existing products. These research and development activities, as well as the clinical testing and regulatory approval process, which must be completed before commercial quantities of these developments can be sold, will require significant commitments of personnel and financial resources. We cannot assure you that we will be able to develop a product or technology in a timely manner, or at all. Delays in the research, development, testing or approval processes will cause a corresponding delay in revenue generation from those products. Regardless of whether they are ever released to the market, the expense of such processes will have already been incurred.
      We reevaluate our research and development efforts regularly to assess whether our efforts to develop a particular product or technology are progressing at a rate that justifies our continued expenditures. On the basis of these reevaluations, we have abandoned in the past, and may abandon in the future, our efforts on a particular product or technology. Products that we research or develop may not be successfully commercial-

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ized. If we fail to take a product or technology from the development stage to market on a timely basis, we may incur significant expenses without a near-term financial return.
      We have in the past, and may in the future, supplement our internal research and development by entering into research and development agreements with other pharmaceutical companies. We may, upon entering into such agreements, be required to make significant up-front payments to fund the projects. We cannot be sure, however, that we will be able to locate adequate research partners or that supplemental research will be available on terms acceptable to us in the future. If we are unable to enter into additional research partnership arrangements, we may incur additional costs to continue research and development internally or abandon certain projects. Even if we are able to enter into collaborations, we cannot assure you that these arrangements will result in successful product development or commercialization.
      There is also a risk that our products may not gain market acceptance among physicians, patients and the medical community generally. The degree of market acceptance of any medical device or other product that we develop will depend on a number of factors, including demonstrated clinical efficacy and safety, cost-effectiveness, potential advantages over alternative products, and our marketing and distribution capabilities. Physicians will not recommend our products until clinical data or other factors demonstrate their safety and efficacy compared to other competing products. Even if the clinical safety and efficacy of using our products is established, physicians may elect to not recommend using them for any number of other reasons, including whether our products best meet the particular needs of the individual patient.
We may acquire companies in the future and these acquisitions could disrupt our business
      As part of our business strategy, we regularly consider and, as appropriate, make acquisitions of technologies, products and businesses that we believe are complementary to our business. Acquisitions typically entail many risks and could result in difficulties in integrating the operations, personnel, technologies and products of the companies acquired, some of which may result in significant charges to earnings. If we are unable to successfully integrate our acquisitions with our existing business, we may not obtain the advantages that the acquisitions were intended to create, which may materially adversely affect our business, results of operations, financial condition and cash flows, our ability to develop and introduce new products and the market price of our stock. In addition, in connection with acquisitions, we could experience disruption in our business or employee base, or key employees of companies that we acquire may seek employment elsewhere, including with our competitors.
We may not be able to identify and acquire products, technologies and businesses on acceptable terms, if at all, which may constrain our growth
      Our strategy for continued growth includes the acquisition of products, technologies and businesses. These acquisitions could involve acquiring other pharmaceutical companies’ assets, products or technologies. In addition, we may seek to obtain licenses or other rights to develop, manufacture and distribute products. We cannot be certain that we will be able to identify suitable acquisition or licensing candidates, if they will be accretive in the near future, or if any will be available on acceptable terms. Other pharmaceutical companies, with greater financial, marketing and sales resources than we have, have also tried to grow through similar acquisition and licensing strategies. Because of their greater resources, our competitors may be able to offer better terms for an acquisition or license than we can offer, or they may be able to demonstrate a greater ability to market licensed products. In addition, even if we identify potential acquisitions and enter into definitive agreements relating to such acquisitions, we may not be able to consummate planned acquisitions on the terms originally agreed upon or at all. For example, on March 20, 2005, we entered into an agreement and plan of merger with Inamed, pursuant to which we agreed to acquire Inamed pursuant to the terms of such agreement. On December 13, 2005, we entered into a merger termination agreement with Inamed following Allergan Inc.’s exchange offer for all outstanding shares of Inamed, which was commenced on November 21, 2005.

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Our success depends on our ability to manage our growth
      We recently experienced a period of rapid growth from both acquisitions and internal expansion of our operations. This growth has placed significant demands on our human and financial resources. We must continue to improve our operational, financial and management information controls and systems and effectively motivate, train and manage our employees to properly manage this growth. Even if these steps are taken, we cannot be sure that our recent acquisitions will be integrated successfully into our business operations. If we are not able to successfully integrate our acquisitions, we may not obtain the advantages that the acquisitions were intended to create. In addition, if we do not manage this growth effectively, maintain the quality of our products despite the demands on our resources and retain key personnel, our business could be harmed.
We depend on licenses from others, and any loss of such licenses could harm our business, market share and profitability
      We have acquired the rights to manufacture, use and market certain products, including certain of our core products. We also expect to continue to obtain licenses for other products and technologies in the future. Our license agreements generally require us to develop a market for the licensed products. If we do not develop these markets within specified time frames, the licensors may be entitled to terminate these license agreements.
      We may fail to fulfill our obligations under any particular license agreement for various reasons, including insufficient resources to adequately develop and market a product, and lack of market development despite our diligence and lack of product acceptance. Our failure to fulfill our obligations could result in the loss of our rights under a license agreement.
      Our inability to continue the distribution of any particular licensed product could harm our business, market share and profitability. Also, certain products we license are used in connection with other products we own or license. A loss of a license in such circumstances could materially harm our ability to market and distribute these other products.
      Our growth and acquisition strategy depends upon the successful integration of licensed products with our existing products. Therefore, any loss, limitation or flaw in a licensed product could impair our ability to market and sell our products, delay new product development and introduction, and harm our reputation. These problems, individually or together, could harm our business and results of operations.
We depend on a limited number of customers, and if we lose any of them, our business could be harmed
      Our customers include some of the United States’ leading wholesale pharmaceutical distributors, such as AmerisourceBergen, Cardinal, McKesson, and major drug chains. During the Transition Period, McKesson and Cardinal accounted for 54.9% and 18.9%, respectively, of our net revenues. During fiscal 2005, McKesson and Cardinal accounted for 51.2%, and 21.8%, respectively, of our net revenues. The loss of any of these customers’ accounts or a material reduction in their purchases could harm our business, financial condition or results of operations. In addition, we may face pricing pressure from our customers.
The consolidation of drug wholesalers could increase competition and pricing pressures throughout the pharmaceutical industry
      We sell our pharmaceutical products primarily through major wholesalers. These customers comprise a significant part of the distribution network for pharmaceutical products in the United States. This distribution network is continuing to undergo significant consolidation marked by mergers and acquisitions. As a result, a smaller number of large wholesale distributors control a significant share of the market. In addition, the number of independent drug stores and small chains has decreased as retail consolidation has occurred. Further consolidation among, or any financial difficulties of, distributors or retailers could result in the combination or elimination of warehouses which may result in product returns to our company, cause a reduction in the inventory levels of distributors and retailers, result in reductions in purchases of our products,

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increase competitive and pricing pressures on pharmaceutical manufacturers, any of which could harm our business, financial condition and results of operations.
We rely on others to manufacture our products
      Currently, we outsource our entire product manufacturing needs. Typically, our manufacturing contracts are short-term. We are dependent upon renewing agreements with our existing manufacturers or finding replacement manufacturers to satisfy our requirements. As a result, we cannot be certain that manufacturing sources will continue to be available or that we can continue to outsource the manufacturing of our products on reasonable or acceptable terms.
      The underlying cost to us for manufacturing our products is established in our agreements with these outside manufacturers. Because of the short-term nature of these agreements, our expenses for manufacturing are not fixed and could change from contract to contract. If the cost of production increases, our gross margins could be negatively affected.
      In addition, we rely on outside manufacturers to provide us with an adequate and reliable supply of our products on a timely basis. Loss of a supplier or any difficulties that arise in the supply chain could significantly affect our inventories and supply of products available for sale. We do not have alternative sources of supply for all of our products. If a primary supplier of any of our core products is unable to fulfill our requirements for any reason, it could reduce our sales, margins and market share, as well as harm our overall business and financial results. If we are unable to supply sufficient amounts of our products on a timely basis, our revenues and market share could decrease and, correspondingly, our profitability could decrease.
      Under several exclusive supply agreements, with certain exceptions, we must purchase most of our product supply from specific manufacturers. If any of these exclusive manufacturer or supplier relationships were terminated, we would be forced to find a replacement manufacturer or supplier. The FDA requires that all manufacturers used by pharmaceutical companies comply with the FDA’s regulations, including the cGMP regulations applicable to manufacturing processes. The cGMP validation of a new facility and the approval of that manufacturer for a new drug product may take a year or more before manufacture can begin at the facility. Delays in obtaining FDA validation of a replacement manufacturing facility could cause an interruption in the supply of our products. Although we have business interruption insurance covering the loss of income for up to 12 months, which may mitigate the harm to us from the interruption of the manufacturing of our largest selling products caused by certain events, the loss of a manufacturer could still cause a reduction in our sales, margins and market share, as well as harm our overall business and financial results.
Our reliance on third-party manufacturers and suppliers can be disruptive to our inventory supply
      We and the manufacturers of our products rely on suppliers of raw materials used in the production of our products. Some of these materials are available from only one source and others may become available from only one source. Any disruption in the supply of raw materials or an increase in the cost of raw materials to our manufacturers could have a significant effect on their ability to supply us with our products.
      We try to maintain inventory levels that are no greater than necessary to meet our current projections. Any interruption in the supply of finished products could hinder our ability to timely distribute finished products. If we are unable to obtain adequate product supplies to satisfy our customers’ orders, we may lose those orders and our customers may cancel other orders and stock and sell competing products. This, in turn, could cause a loss of our market share and reduce our revenues.
We could experience difficulties in obtaining supplies of RESTYLANE®, PERLANETM, RESTYLANE FINE LINESTM and SubQTM
      The manufacturing process to create bulk non-animal stabilized hyaluronic acid necessary to produce RESTYLANE®, PERLANEtm, RESTYLANE FINE LINEStm and SubQtm products is technically complex and requires significant lead-time. Any failure by us to accurately forecast demand for finished product

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could result in an interruption in the supply of RESTYLANE®, PERLANEtm, RESTYLANE FINE LINEStm and SubQtm products and a resulting decrease in sales of the products.
      We depend exclusively on Q-Med for our supply of RESTYLANE®, PERLANEtm, RESTYLANE FINE LINEStm and SubQtm products. There are currently no alternative suppliers of these products. Q-Med has committed to supply RESTYLANE® to us under a long-term license that is subject to customary conditions and our delivery of specified milestone payments. Q-Med manufactures RESTYLANE®, PERLANEtm, RESTYLANE FINE LINEStm and SubQtm at its facility in Uppsala, Sweden. We cannot be certain that Q-Med will be able to meet our current or future supply requirements. Any impairment of Q-Med’s manufacturing capacities could significantly affect our inventories and our supply of products available for sale.
Supply interruptions may disrupt our inventory levels and the availability of our products
      Numerous factors could cause interruptions in the supply of our finished products, including:
  •  timing, scheduling and prioritization of production by our contract manufacturers;
 
  •  labor interruptions;
 
  •  changes in our sources for manufacturing;
 
  •  the timing and delivery of domestic and international shipments;
 
  •  our failure to locate and obtain replacement manufacturers as needed on a timely basis;
 
  •  conditions affecting the cost and availability of raw materials; and
 
  •  hurricanes and other natural disasters.
      We estimate customer demand for our prescription products primarily through use of third party syndicated data sources which track prescriptions written by health care providers and dispensed by licensed pharmacies. These data are extrapolations from information provided only by certain pharmacies, and are estimates of historical demand levels. We observe trends from these data, and coupled with certain proprietary information, prepare demand forecasts that are the basis for purchase orders for finished and component inventory from our third party manufacturers and suppliers. There is no such timely data for the aesthetics market, in particular RESTYLANE®, our highest-selling product during the Transition Period and fiscal 2005. Our forecasts may fail to accurately anticipate ultimate customer demand for products. Overestimates of demand may result in excessive inventory production; underestimates may result in inadequate supply of our products in channels of distribution.
      We sell our products primarily to major wholesalers and retail pharmacy chains. Consistent with pharmaceutical industry patterns, approximately 80% of our revenues are derived from three major drug wholesale concerns. While we attempt to estimate inventory levels of our products at our major wholesale customers, using historical prescription information and historical purchase patterns, this process is inherently imprecise. Rarely do wholesale customers provide us complete inventory levels at regional distribution centers, or within their national distribution systems. We rely wholly upon our wholesale and drug chain customers to effect the distribution allocation of our products.
      We periodically offer promotions to wholesale and chain drugstore customers to encourage dispensing of our products, consistent with prescriptions written by licensed health care providers. Because many of our products compete in multi-source markets, it is important for us to ensure the licensed health care providers’ dispensing instructions are fulfilled with our branded products and are not substituted with a generic product or another therapeutic alternative product which may be contrary to the licensed health care providers’ recommended prescribed Medicis brand. We believe that a critical component of our brand protection program is maintenance of full product availability at drugstore and wholesale customers. We believe such availability reduces the probability of local and regional product substitutions, shortages and backorders, which could result in lost sales. We expect to continue providing favorable terms to wholesale and retail drug chain

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customers as may be necessary to ensure the fullest possible distribution of our branded products within the pharmaceutical chain of commerce.
      We cannot control or influence greatly the purchasing patterns of our wholesale and retail drug chain customers. These are highly sophisticated customers that purchase our products in a manner consistent with their industry practices and, presumably, based upon their projected demand levels. Purchases by any given customer, during any given period, may be above or below actual prescription volumes of any of our products during the same period, resulting in fluctuations in product inventory in the distribution channel.
Fluctuations in demand for our products create inventory maintenance uncertainties
      As a result of customer buying patterns, a substantial portion of our prescription revenues has traditionally been recognized in the last month of each quarter, and we schedule our inventory purchases to meet anticipated customer demand. As a result, relatively small delays in the receipt of manufactured products by us could result in revenues being deferred or lost. Our operating expenses are based upon anticipated sales levels, and a high percentage of our operating expenses are relatively fixed in the short term. Consequently, variations in the timing of revenue recognition could cause significant fluctuations in operating results from period to period and may result in unanticipated periodic earnings shortfalls or losses.
We selectively outsource certain non-sales and non-marketing services, and cannot assure you that we will be able to obtain adequate supplies of such services on acceptable terms
      To enable us to focus on our core marketing and sales activities, we selectively outsource certain non-sales and non-marketing functions, such as laboratory research, manufacturing and warehousing. As we expand our activities in these areas, additional financial resources are expected to be utilized. We typically do not enter into long-term manufacturing contracts with third party manufacturers. Whether or not such contracts exist, we cannot assure you that we will be able to obtain adequate supplies of such services or products in a timely fashion, on acceptable terms, or at all.
Importation of products from Canada and other countries into the United States may lower the prices we receive for our products
      Our products are subject to competition from lower priced versions of our products and competing products from Canada and other countries where government price controls or other market dynamics result in lower prices. The ability of patients and other customers to obtain these lower priced imports has grown significantly as a result of the Internet, an expansion of pharmacies in Canada and elsewhere targeted to American purchasers, the increase in United States-based businesses affiliated with Canadian pharmacies marketing to American purchasers, and other factors. Most of these foreign imports are illegal under current United States law. However, the volume of imports continues to rise due to the limited enforcement resources of the FDA and the United States Customs Service, and there is increased political pressure to permit the imports as a mechanism for expanding access to lower priced medicines.
      In December 2003, Congress enacted the Medicare Prescription Drug, Improvement and Modernization Act of 2003. This law contains provisions that may change United States import laws and expand consumers’ ability to import lower priced versions of our and competing products from Canada, where there are government price controls. These changes to United States import laws will not take effect unless and until the Secretary of Health and Human Services certifies that the changes will lead to substantial savings for consumers and will not create a public health safety issue. The former Secretary of Health and Human Services did not make such a certification. However, it is possible that the current Secretary or a subsequent Secretary could make the certification in the future. As directed by Congress, a task force on drug importation recently conducted a comprehensive study regarding the circumstances under which drug importation could be safely conducted and the consequences of importation on the health, medical costs and development of new medicines for United States consumers. The task force issued its report in December 2004, finding that there are significant safety and economic issues that must be addressed before importation of prescription drugs is permitted, and the current Secretary has not yet announced any plans to make the required certification. In

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addition, federal legislative proposals have been made to implement the changes to the United States import laws without any certification, and to broaden permissible imports in other ways. Even if the changes to the United States import laws do not take effect, and other changes are not enacted, imports from Canada and elsewhere may continue to increase due to market and political forces, and the limited enforcement resources of the FDA, the United States Customs Service and other government agencies.
      The importation of foreign products adversely affects our profitability in the United States. This impact could become more significant in the future, and the impact could be even greater if there is a further change in the law or if state or local governments take further steps to facilitate the importation of products from abroad.
If we become subject to product liability claims, our earnings and financial condition could suffer
      We are exposed to risks of product liability claims from allegations that our products resulted in adverse effects to the patient or others. These risks exist even with respect to those products that are approved for commercial sale by the FDA and manufactured in facilities licensed and regulated by the FDA.
      In addition to our desire to reduce the scope of our potential exposure to these types of claims, many of our customers require us to maintain product liability insurance as a condition of conducting business with us. We currently carry product liability insurance in the amount of $50.0 million per claim and $50.0 million in the aggregate on a claims-made basis. Nevertheless, this insurance may not be sufficient to cover all claims made against us. Insurance coverage is expensive and may be difficult to obtain. As a result, we cannot be certain that our current coverage will continue to be available in the future on reasonable terms, if at all. If we are liable for any product liability claims in excess of our coverage or outside of our coverage, the cost and expense of such liability could cause our earnings and financial condition to suffer.
Rising insurance costs could negatively impact profitability
      The cost of insurance, including workers compensation, product liability and general liability insurance, have risen significantly in recent years and may increase in the future. In response, we may increase deductibles and/or decrease certain coverages to mitigate these costs. These increases, and our increased risk due to increased deductibles and reduced coverages, could have a negative impact on our results of operations, financial condition and cash flows.
If we suffer negative publicity concerning the safety of our products, our sales may be harmed and we may be forced to withdraw products
      Physicians and potential patients may have a number of concerns about the safety of our products, whether or not such concerns have a basis in generally accepted science or peer-reviewed scientific research. Negative publicity, whether accurate or inaccurate, concerning our products could reduce market or governmental acceptance of our products and could result in decreased product demand or product withdrawal. In addition, significant negative publicity could result in an increased number of product liability claims, whether or not these claims are supported by applicable law.
RESTYLANE® is a consumer product and as such, it is susceptible to changes in popular trends and applicable laws, which could adversely affect sales or product margins of RESTYLANE®
      RESTYLANE® is a consumer product. If we fail to anticipate, identify or react to competitive products or if consumer preferences in the cosmetic marketplace shift to other treatments for the treatment of fine lines, wrinkles and deep facial folds, we may experience a decline in demand for RESTYLANE®. In addition, the popular media has at times in the past produced, and may continue in the future to produce, negative reports regarding the efficacy, safety or side effects of facial aesthetic products. Consumer perceptions of RESTYLANE® may be negatively impacted by these reports and other reasons.
      Demand for RESTYLANE® may be materially adversely affected by changing economic conditions. Generally, the costs of cosmetic procedures are borne by individuals without reimbursement from their

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medical insurance providers or government programs. Individuals may be less willing to incur the costs of these procedures in weak or uncertain economic environments, and demand for RESTYLANE® could be adversely affected.
We may not be able to repurchase the Old Notes and New Notes when required
      In June 2002, we sold Contingent Convertible Senior Notes, due in 2032 (the “Old Notes”), in the amount of $400.0 million. In August 2003, we exchanged approximately $230.8 million in principal of these Old Notes for approximately $283.9 million of our Contingent Convertible Senior Notes due in 2033 (the “New Notes”).
      On June 4, 2007, 2012 and 2017 and upon the occurrence of a change in control, holders of the remaining Old Notes may require us to offer to repurchase their Old Notes for cash. On June 4, 2008, 2013 and 2018 and upon the occurrence of a change in control, holders of the New Notes may require us to offer to repurchase their New Notes for cash. We may not have sufficient funds at the time of any such events to make the required repurchases.
      The source of funds for any repurchase required as a result of any such events will be our available cash or cash generated from operating activities or other sources, including borrowings, sales of assets, sales of equity or funds provided by a new controlling entity. We cannot assure you, however, that sufficient funds will be available at the time of any such events to make any required repurchases of the Notes tendered. Furthermore, the use of available cash to fund the repurchase of the Old Notes or New Notes may impair our ability to obtain additional financing in the future.
Our publicly-filed reports are reviewed by the Securities and Exchange Commission (the “SEC”) from time to time and any significant changes required as a result of any such review may result in material liability to us, and have a material adverse impact on the trading price of our common stock
      The reports of publicly-traded companies are subject to review by the SEC from time to time for the purpose of assisting companies in complying with applicable disclosure requirements and to enhance the overall effectiveness of companies’ public filings, and comprehensive reviews of such reports are now required at least every three years under the Sarbanes-Oxley Act of 2002. SEC reviews may be initiated at any time. While we believe that our previously filed SEC reports comply, and we intend that all future reports will comply in all material respects with the published rules and regulations of the SEC, we could be required to modify or reformulate information contained in prior filings as a result of an SEC review. Any modification or reformulation of information contained in such reports could be significant and result in material liability to us and have a material adverse impact on the trading price of our common stock.
Risks Related to Our Industry
The growth of managed care organizations, other third-party reimbursement policies, state regulatory agencies and retailer fulfillment policies may harm our pricing, which may reduce our market share and margins
      Our operating results and business success depend in large part on the availability of adequate third-party payor reimbursement to patients for our prescription-brand products. These third-party payors include governmental entities such as Medicaid, private health insurers and managed care organizations. Because of the size of the patient population covered by managed care organizations, marketing of prescription drugs to them and the pharmacy benefit managers that serve many of these organizations has become important to our business.
      The trend toward managed healthcare in the United States and the growth of managed care organizations could significantly influence the purchase of pharmaceutical products, resulting in lower prices and a reduction in product demand. Managed care organizations and other third party payors try to negotiate the pricing of medical services and products to control their costs. Managed care organizations and pharmacy benefit managers typically develop formularies to reduce their cost for medications. Formularies can be based on the

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prices and therapeutic benefits of the available products. Due to their lower costs, generic products are often favored. The breadth of the products covered by formularies varies considerably from one managed care organization to another, and many formularies include alternative and competitive products for treatment of particular medical conditions. Exclusion of a product from a formulary can lead to its sharply reduced usage in the managed care organization patient population. Payment or reimbursement of only a portion of the cost of our prescription products could make our products less attractive, from a net-cost perspective, to patients, suppliers and prescribing physicians. We cannot be certain that the reimbursement policies of these entities will be adequate for our pharmaceutical products to compete on a price basis. If our products are not included within an adequate number of formularies or adequate reimbursement levels are not provided, or if those policies increasingly favor generic products, our market share and gross margins could be harmed, as could our business, financial condition, results of operations and cash flows.
      In addition, healthcare reform could affect our ability to sell our products and may have a material adverse effect on our business, results of operations, financial condition and cash flows.
      Some of our products are not of a type generally eligible for reimbursement. It is possible that products manufactured by others could address the same effects as our products and be subject to reimbursement. If this were the case, some of our products may be unable to compete on a price basis. In addition, decisions by state regulatory agencies, including state pharmacy boards, and/or retail pharmacies may require substitution of generic for branded products, may prefer competitors’ products over our own, and may impair our pricing and thereby constrain our market share and growth.
      Managed care initiatives to control costs have influenced primary-care physicians to refer fewer patients to dermatologists and other specialists. Further reductions in these referrals could reduce the size of our potential market, and harm our business, financial condition, results of operations and cash flows.
We are subject to extensive governmental regulation
      Pharmaceutical companies are subject to significant regulation by a number of national, state and local governments and agencies. The FDA administers requirements covering testing, manufacturing, safety, effectiveness, labeling, storage, record keeping, approval, sampling, advertising and promotion of our products. Several states have also instituted laws and regulations covering some of these same areas. In addition, the FTC and state and local authorities regulate the advertising of over-the-counter drugs and cosmetics. Failure to comply with applicable regulatory requirements could, among other things, result in:
  •  fines;
 
  •  changes to advertising;
 
  •  suspensions of regulatory approvals of products;
 
  •  product recalls;
 
  •  delays in product distribution, marketing and sale; and
 
  •  civil or criminal sanctions.
      Our prescription and over-the-counter products receive FDA review regarding their safety and effectiveness. However, the FDA is permitted to revisit and change its prior determinations. We cannot be sure that the FDA will not change its position with regard to the safety or effectiveness of our products. If the FDA’s position changes, we may be required to change our labeling or formulations or cease to manufacture and market the challenged products. Even prior to any formal regulatory action, we could voluntarily decide to cease distribution and sale or recall any of our products if concerns about their safety or effectiveness develop.
      Before marketing any drug that is considered a “new drug” by the FDA, the FDA must provide its approval of the product. All products which are considered drugs which are not “new drugs” and that generally are recognized by the FDA as safe and effective for use do not require the FDA’s approval. We believe that some of our products, as they are promoted and intended for use, are exempt from treatment as “new drugs” and are not subject to approval by the FDA. The FDA, however, could take a contrary position, and we could

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be required to seek FDA approval of those products and the marketing of those products. We could also be required to withdraw those products from the market.
      Sales representative activities may also be subject to the Voluntary Compliance Guidance issued for pharmaceutical manufacturers by the Office of Inspector General (“OIG”) of the Department of Health and Human Services, as well as state laws and regulations. We have established compliance program policies and training programs for our sales force, which we believe are appropriate. The OIG and/or state law enforcement entities, however, could take a contrary position, and we could be required to modify our sales representative activities.
If we market products in a manner that violates health care fraud and abuse laws, we may be subject to civil or criminal penalties
      Federal health care program anti-kickback statutes prohibit, among other things, knowingly and willfully offering, paying, soliciting or receiving remuneration to induce, or in return for purchasing, leasing, ordering or arranging for the purchase, lease or order of any health care item or service reimbursable under Medicare, Medicaid, or other federally financed health care programs. This statute has been interpreted to apply to arrangements between pharmaceutical manufacturers on one hand and prescribers, purchasers and formulary managers on the other. Although there are a number of statutory exemptions and regulatory safe harbors protecting certain common activities from prosecution, the exemptions and safe harbors are drawn narrowly, and practices that involve remuneration intended to induce prescribing, purchasing, or recommending may be subject to scrutiny if they do not qualify for an exemption or safe harbor. Although we believe that we are in compliance, our practices may be determined to fail to meet all of the criteria for safe harbor protection from anti-kickback liability. For example, we have been notified by the government that we have been named as a defendant in a qui tam (whistleblower) lawsuit filed under the federal False Claims Act, related to our marketing and promotion of LOPROX® products to pediatricians. See Item 3. Legal Proceedings of this Form 10-K/ T.
      Federal false claims laws prohibit any person from knowingly presenting, or causing to be presented, a false claim for payment to the federal government, or knowingly making, or causing to be made, a false statement to get a false claim paid. Pharmaceutical companies have been prosecuted under these laws for a variety of alleged promotional and marketing activities, such as allegedly providing free product to customers with the expectation that the customers would bill federal programs for the product; reporting to pricing services inflated average wholesale prices that were then used by federal programs to set reimbursement rates; engaging in off-label promotion that caused claims to be submitted to Medicaid for non-covered off-label uses; and submitting inflated best price information to the Medicaid Rebate Program. The majority of states also have statutes or regulations similar to the federal anti-kickback law and false claims laws, which apply to items and services reimbursed under Medicaid and other state programs, or, in several states, apply regardless of the payor. Sanctions under these federal and state laws may include civil monetary penalties, exclusion of a manufacturer’s products from reimbursement under government programs, criminal fines, and imprisonment. Because of the breadth of these laws and the narrowness of the safe harbors, it is possible that some of our business activities could be subject to challenge under one or more of such laws.
Obtaining FDA and other regulatory approvals is time consuming, expensive and uncertain
      The process of obtaining FDA and other regulatory approvals is time consuming and expensive. Clinical trials are required and the marketing and manufacturing of pharmaceutical products are subject to rigorous testing procedures. We may not be able to obtain FDA approval to conduct clinical trials or to manufacture or market any of the products we develop, acquire or license on a timely basis or at all. Moreover, the costs to obtain approvals could be considerable, and the failure to obtain or delays in obtaining an approval could significantly harm our business performance and financial results. Even if pre-marketing approval from the FDA is received, the FDA is authorized to impose post-marketing requirements such as:
  •  testing and surveillance to monitor the product and its continued compliance with regulatory requirements;

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  •  submitting products for inspection and, if any inspection reveals that the product is not in compliance, prohibiting the sale of all products from the same lot;
 
  •  suspending manufacturing;
 
  •  switching status from prescription to over-the-counter drug;
 
  •  recalling products; and
 
  •  withdrawing marketing clearance.
      In their regulation of advertising, the FDA and FTC from time to time issue correspondence to pharmaceutical companies alleging that some advertising or promotional practices are false, misleading or deceptive. The FDA has the power to impose a wide array of sanctions on companies for such advertising practices, and the receipt of correspondence from the FDA alleging these practices could result in the following:
  •  incurring substantial expenses, including fines, penalties, legal fees and costs to comply with the FDA’s requirements;
 
  •  changes in the methods of marketing and selling products;
 
  •  taking FDA-mandated corrective action, which may include placing advertisements or sending letters to physicians rescinding previous advertisements or promotion; and
 
  •  disruption in the distribution of products and loss of sales until compliance with the FDA’s position is obtained.
      In recent years, various legislative proposals have been offered in Congress and in some state legislatures that include major changes in the health care system. These proposals have included price or patient reimbursement constraints on medicines, restrictions on access to certain products, reimportation of products from Canada or other sources and mandatory substitution of generic for branded products. We cannot predict the outcome of such initiatives, and it is difficult to predict the future impact of the broad and expanding legislative and regulatory requirements affecting us.
We face significant competition within our industry
      The pharmaceutical and dermal aesthetics industries are highly competitive. Competition in our industry occurs on a variety of fronts, including:
  •  developing and bringing new products to market before others;
 
  •  developing new technologies to improve existing products;
 
  •  developing new products to provide the same benefits as existing products at less cost; and
 
  •  developing new products to provide benefits superior to those of existing products.
      The intensely competitive environment requires an ongoing, extensive search for technological innovations and the ability to market products effectively. Consequently, we must continue to develop and introduce products in a timely and cost-efficient manner to effectively compete in the marketplace and maintain our revenue and gross margins.
      Our competitors vary depending upon product categories. Many of our competitors are large, well-established companies in the fields of pharmaceuticals, chemicals, cosmetics and health care. Among our largest competitors are Allergan, Bristol-Myers Squibb, Galderma, GlaxoSmithKline, Inamed, Johnson & Johnson, Pfizer, sanofi-aventis, Schering-Plough, Valeant Pharmaceuticals, Wyeth and others.
      Many of these companies have greater resources than we do to devote to marketing, sales, research and development and acquisitions. As a result, they have a greater ability to undertake more extensive research and development, marketing and pricing policy programs. It is possible that our competitors may develop new or improved products to treat the same conditions as our products or make technological advances reducing

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their cost of production so that they may engage in price competition through aggressive pricing policies to secure a greater market share to our detriment. These competitors also may develop products that make our current or future products obsolete. Any of these events could significantly harm our business, financial condition and results of operations, including reducing our market share, gross margins, and cash flows.
      We sell and distribute prescription brands, medical devices and over-the-counter products. Each of these products competes with products produced by others to treat the same conditions. Several of our prescription products compete with generic pharmaceuticals, which claim to offer equivalent benefit at a lower cost. In some cases, insurers and other health care payment organizations try to encourage the use of these less expensive generic brands through their prescription benefits coverage and reimbursement policies. These organizations may make the generic alternative more attractive to the patient by providing different amounts of reimbursement so that the net cost of the generic product to the patient is less than the net cost of our prescription brand product. Aggressive pricing policies by our generic product competitors and the prescription benefits policies of third party payors could cause us to lose market share or force us to reduce our gross margins in response.
      There are several dermal filler products under development and/or in the FDA pipeline for approval which claim to offer equivalent or greater facial aesthetic benefits to RESTYLANE® and, if approved, the companies producing such products could charge less to doctors for their products.
Item 1B. Unresolved Staff Comments
      We have received no written comments regarding our periodic or current reports from the staff of the SEC that were issued 180 days or more preceding the end of the Transition Period and that remain unresolved.
Item 2. Properties
      Our office space in Scottsdale, Arizona has approximately 75,000 square feet under an amended lease agreement that expires in December 2010. The average annual expense under the amended lease agreement is approximately $2.1 million. The lease contains certain rent escalation clauses and, upon expiration, can be renewed for two additional periods of five years each.
      Medicis Aesthetics Canada Ltd., a wholly owned subsidiary, presently leases approximately 3,600 square feet of office space in Toronto, Ontario, Canada, under a lease agreement that expires in February 2008.
      Rent expense was approximately $1.2 million, $1.1 million, $2.3 million, $2.1 million and $1.5 million for the Transition Period, the comparable six-month period in 2004 and fiscal 2005, fiscal 2004 and fiscal 2003, respectively. We believe these properties are adequate for our current purposes, and we are currently pursuing additional headquarter office space to accommodate our expected long-term growth.
Item 3. Legal Proceedings
      On November 9, 2001, prior to its merger with our company, Ascent received notice that Triumph-Connecticut Limited Partnership and related parties (“Triumph”) had brought a civil action against it in the Business Session of the Superior Court of the Commonwealth of Massachusetts. In the action, the Triumph group claimed that the execution by Ascent of the merger agreement and the consummation of the merger without the consent of the Triumph group or the payment to the Triumph group of a specified amount breached the terms of a January 1997 securities purchase agreement, the terms of warrants issued to the Triumph group, an implied covenant of good faith and fair dealing, and certain deceptive trade laws. The Triumph group sought damages in an amount not less than $22.1 million, plus treble damages. A hearing on cross-motions for summary judgment was held on October 16, 2003. On April 9, 2004, the court ruled on the cross-motions in Ascent’s favor. Triumph’s cross-motion for summary judgment was denied and Ascent’s cross-motion for summary judgment was granted on all claims. The court entered its order dismissing the lawsuit on April 13, 2004. Triumph filed a notice of appeal on May 6, 2004. Both Triumph and Ascent filed appellate briefs. The Massachusetts Appeals Court held a hearing regarding Triumph’s appeal on April 15,

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2005. On November 14, 2005, the Massachusetts Appeals Court issued a decision and order affirming the grant of summary judgment in favor of Ascent on all claims. Triumph did not file a timely request for further appellate review from the Massachusetts Supreme Judicial Court. Accordingly, the Appeals Court issued its “rescript” to the Massachusetts Superior Court and on December 28, 2005, the Superior Court entered judgment for defendant Ascent. This matter is closed. We are in the process of distributing the accumulated contingent purchase price payments of $27.4 million to the former shareholders of Ascent, as they were withheld pending final resolution of this matter.
      On June 21, 2004, the United States International Trade Commission (“ITC”) instituted an investigation pursuant to Section 337 of the Tariff Act of 1930, as amended, at the request of Inamed. The investigation identified Medicis Aesthetics, Inc., a wholly owned subsidiary of our company, and Q-Med as respondents in the investigation regarding Inamed’s allegation of infringement of its U.S. Patent No. 4,803,075, dated February 7, 1989, by the dermal filler, RESTYLANE®. On September 16, 2004, Inamed moved to add our distributor, McKesson Corporation (“McKesson”), as a respondent. The motion was granted by the Administrative Law Judge (“ALJ”) and affirmed by the ITC during November 2004. Inamed also filed a parallel infringement action against us and Q-Med in the U.S. District Court of the Southern District of California regarding the same patent. Inamed amended its complaint to add McKesson as a party to this action as well. This action was stayed pending the outcome of the ITC investigation. Pursuant to the Agreement and Plan of Merger (the “Merger Agreement”) and related transactions entered into by Medicis, Inamed and a wholly-owned subsidiary of Medicis on March 20, 2005, Inamed filed a motion to dismiss with prejudice Inamed’s patent infringement action. In addition, Inamed consented to the dismissal of the ITC matter, which has been granted and has been made final. The matters are closed.
      The government notified us on December 14, 2004, that it is investigating claims that we violated the federal False Claims Act. We are fully cooperating with the government in its investigation, which relates to our marketing and promotion of LOPROX® products to pediatricians prior to our May 2004, disposition of the Company’s pediatric sales division.
      On October 27, 2005, we filed suit against Upsher-Smith Laboratories, Inc. of Plymouth, Minnesota and against Prasco Laboratories of Cincinnati, Ohio for infringement of Patent No. 6,905,675 entitled “Sulfur Containing Dermatological Compositions and Methods for Reducing Malodors in Dermatological Compositions” covering our sodium sulfacetamide/sulfur technology. This intellectual property is related to our PLEXION® Cleanser product. The suit was filed in the U.S. District Court for the District of Arizona, and seeks an award of damages, as well as a preliminary and a permanent injunction. We are in the midst of accelerated discovery. A hearing on our preliminary injunction motion was heard on March 8th and 9th, 2006.
      We record contingent liabilities resulting from claims against us when it is probable (as that word is defined in Statement of Financial Accounting Standards No. 5) that a liability has been incurred and the amount of the loss is reasonably estimable. We disclose material contingent liabilities when there is a reasonable possibility that the ultimate loss will exceed the recorded liability. Estimating probable losses requires analysis of multiple factors, in some cases including judgments about the potential actions of third-party claimants and courts. Therefore, actual losses in any future period are inherently uncertain. In all of the cases noted where we are the defendant, we believe we have meritorious defenses to the claims in these actions and resolution of these matters will not have a material adverse effect on our business, financial condition, or results of operation; however, the results of the proceedings are uncertain, and there can be no assurance to that effect.

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Item 4. Submission of Matters to a Vote of Security Holders
      On December 19, 2005, the Company held its 2005 Annual Meeting of Shareholders (the “Annual Meeting”). The holders of 50,551,674 shares of Class A Common Stock were present in person or represented by proxy at the meeting. The following is a summary of the results of the voting by the Company’s shareholders at the Annual Meeting:
        1) Election of Directors
 
        The stockholders elected the following persons to serve as directors of the Company for a term of three years, or until their successors are duly elected and qualified or until their earlier resignation or removal. Votes were cast as follows:
                 
    Number of Votes
     
    For   Withheld
         
Spencer Davidson
    30,806,330       19,745,344  
Stuart Diamond
    29,640,722       20,910,952  
Peter S. Knight, Esq. 
    30,874,639       19,677,035  
        The directors of the Company whose terms of office continued were Mr. Jonah Shacknai, Mr. Arthur G. Altschul, Jr., Mr. Michael A. Pietrangelo, Mr. Philip S. Schein, M.D. and Ms. Lottie H. Shackelford.
 
        2) The stockholders approved the appointment of Ernst & Young LLP as independent auditors for the Transition Period ending December 31, 2005. Votes were cast as follows:
         
For   Against   Abstain
         
50,405,690
  134,354   11,630
        3) Three proposals contained in our proxy statement were not acted upon at the Annual Meeting as a result of the termination of our Agreement and Plan of Merger with Inamed Corporation, dated March 20, 2005. These proposals were: (i) the issuance of shares of Medicis Class A common stock pursuant to the agreement and plan of merger, (ii) an amendment to our certificate of incorporation to increase the number of authorized shares of Medicis Class A common stock from 150,000,000 to 300,000,000 and change our name from “Medicis Pharmaceutical Corporation” to “Medicis” and (iii) authorization to postpone or adjourn the Annual Meeting to permit further solicitation of proxies if there were not sufficient votes at the time of the Annual Meeting in favor of the other matters being voted upon.

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PART II
Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
Description of Registrant’s Securities, Price Range of Common Stock and Dividends Declared
      Medicis’ Class A common stock trades on the New York Stock Exchange under the symbol “MRX”. The following table sets forth the high and low sale prices for our Class A common stock on the New York Stock Exchange for the fiscal periods indicated. Prices have been restated to reflect the 2 for 1 stock split effected in the form of a stock dividend that occurred on January 23, 2004:
                           
            Dividends
    High   Low   Declared
             
TRANSITION PERIOD
                       
 
Three Months Ended September 30, 2005
  $ 35.45     $ 31.08     $ 0.03  
 
Three Months Ended December 31, 2005
    35.16       26.30       0.03  
FISCAL YEAR ENDED JUNE 30, 2005
                       
 
First Quarter
  $ 40.65     $ 32.85     $ 0.03  
 
Second Quarter
    41.00       34.64       0.03  
 
Third Quarter
    37.67       28.69       0.03  
 
Fourth Quarter
    31.97       26.80       0.03  
FISCAL YEAR ENDED JUNE 30, 2004
                       
 
First Quarter
  $ 32.00     $ 27.27     $ 0.025  
 
Second Quarter
    36.01       27.81       0.025  
 
Third Quarter
    41.50       33.86       0.025  
 
Fourth Quarter
    45.26       38.45       0.025  
      On March 10, 2006, the last reported sale price on the New York Stock Exchange for Medicis’ Class A common stock was $28.93 per share. As of such date, there were approximately 223 holders of record of Class A common stock.
Dividend Policy
      Since the beginning of fiscal 2004, we have paid quarterly cash dividends aggregating approximately $15.2 million on our common stock. In addition, on December 14, 2005, we declared a cash dividend of $0.03 per issued and outstanding share of common stock payable on January 31, 2006 to our stockholders of record at the close of business on January 3, 2006. Prior to these dividends, we had not paid a cash dividend on our common stock, and we have not adopted a dividend policy. Any future determinations to pay cash dividends will be at the discretion of our Board of Directors and will be dependent upon our financial condition, operating results, capital requirements and other factors that our Board of Directors deems relevant.
      Our 1.5% Contingent Convertible Senior Notes due 2033 require an adjustment to the conversion price if the cumulative aggregate of all current and prior dividend increases above $0.025 per share would result in at least a one percent (1%) increase in the conversion price. This threshold has not been reached and no adjustment to the conversion price has been made.
Recent Sales of Unregistered Securities
      None.
Equity Compensation Plan Information
      Information required to be included about our equity compensation plan is incorporated by reference to the material under the caption “Equity Compensation Plan Information” in the proxy statement for our 2006 annual meeting of stockholders.

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Item 6. Selected Financial Data
      The following table sets forth selected consolidated financial data for the Transition Period, the corresponding six-month period in 2004 and the year ended December 31, 2005. The data for the Transition Period is derived from our audited consolidated financial statements and accompanying notes, while the data for the corresponding six-month period in 2004 and the year ended December 31, 2005 is derived from our unaudited consolidated financial statements. The comparability of the periods presented is impacted by certain product rights and business acquisitions and dispositions. Gross profit does not include amortization of the related intangibles.
                           
        Six Months    
        Ended   Year Ended
    Transition   December 31,   December 31,
    Period   2004   2005
             
    (In thousands, except per share amounts)
Statements of Operations Data:
                       
Net product revenues
  $ 155,569     $ 146,999     $ 313,684  
Net contract revenues
    8,385       34,168       46,002  
                   
Net revenues
    163,954       181,167       359,686  
Gross profit(a)
    139,843       153,897       307,398  
Operating expenses:
                       
 
Selling, general and administrative
    89,360 (b)     65,736 (e)     158,778 (g)
 
Research and development
    22,367 (c)     45,140 (f)     42,903 (h)
 
Depreciation and amortization
    12,420       10,222       24,548  
                   
Total operating expenses
    124,147       121,098       226,229  
                   
Operating income
    15,696       32,799       81,169  
Other:
                       
 
Other income, net
    59,801 (d)           59,801 (d)
 
Net interest income (expense)
    4,726       (248 )     5,804  
 
Income tax expense
    (30,502 )     (11,328 )     (53,288 )
                   
Net income
  $ 49,721     $ 21,223     $ 93,486  
                   
Basic net income per share
  $ 0.92     $ 0.38     $ 1.72  
                   
Diluted net income per share
  $ 0.76     $ 0.34     $ 1.44 (i)
                   
Cash dividend declared per common share
  $ 0.06     $ 0.06     $ 0.12  
                   
Basic common shares outstanding
    54,323       55,972       54,290  
                   
Diluted common shares outstanding
    69,772       72,160       69,558 (i)
                   
 
(a) Amounts exclude $10.9 million, $8.9 million and $21.6 million of amortization expense related to acquired intangible assets for the Transition Period, the six months ended December 31, 2004, and the year ended December 31, 2005.
 
(b) Includes approximately $13.9 million of compensation expense related to stock options and restricted stock recognized during the Transition Period, a charge of approximately $9.2 million for the write-down of a long-lived asset and approximately $0.7 million of integration planning costs incurred related to the proposed Inamed transaction during the three months ended September 30, 2005.
 
(c) Includes approximately $11.9 million related to a research and development collaboration with Dow and approximately $1.0 million of compensation expense related to stock options and restricted stock.

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(d) Represents a termination fee of $90.5 million received from Inamed upon the termination of the proposed merger with Inamed, net of a termination fee paid to an investment banker and the expensing of accumulated transactions costs of $27.0 million, and integration costs incurred during the three months ended December 31, 2005 of $3.7 million.
 
(e) Includes approximately $1.3 million of professional fees related to research and development collaborations with Ansata and Q-Med.
 
(f) Includes $5.0 million paid to Ansata related to an exclusive development and license agreement and $30.0 million paid to Q-Med related to an exclusive license agreement for the development of SubQtm.
 
(g) Includes approximately $13.9 million of compensation expense related to stock options and restricted stock recognized during the Transition Period, a charge of approximately $9.2 million for the write-down of a long-lived asset and approximately $6.0 million of integration planning costs incurred related to the proposed Inamed transaction during the three months ended June 30, 2005 and three months ended September 30, 2005.
 
(h) Includes approximately $8.3 million paid to aaiPharma related to a research and development collaboration, $11.9 million related to a research and development collaboration with Dow and approximately $1.0 million of compensation expense related to stock options and restricted stock.
 
(i) Diluted net income per common share for the unaudited year ended December 31, 2005 was calculated by using the average of the periodic diluted common shares outstanding during the year. For the period from January 1, 2005 to June 30, 2005, diluted common shares outstanding was calculated using APB Opinion No. 25, while for the period from July 1, 2005 to December 31, 2005, diluted common shares outstanding was calculated using SFAS 123R. The Company adopted SFAS No. 123R effective July 1, 2005.
      The balance sheet data as of December 31, 2004, and the cash flow data for the six months ended December 31, 2004, is unaudited.
                 
    December 31,
     
    2005   2004
         
    (In thousands)
Balance Sheet Data:
               
Cash, cash equivalents and short-term investments
  $ 742,532 (a)   $ 532,518  
Working capital
    692,453       552,391  
Total assets
    1,145,954       979,871  
Long-term debt
    453,065       453,065  
Stockholders’ equity
    543,487       444,826  
                 
        Six Months
    Transition   Ended
    Period   Dec. 31, 2004
         
    (In thousands)
Cash Flow Data:
               
Net cash provided by operating activities
  $ 147,990     $ 45,465  
Net cash provided by investing activities
    123,665       76,158  
Net cash used in by financing activities
    (2,792 )     (137,447 )
 
(a) Increase in cash, cash equivalents and short-term investments from December 31, 2004 to December 31, 2005 includes the receipt of a termination fee of $90.5 million received from Inamed upon the termination of the proposed merger with Inamed, net of expenses related to the proposed transaction.

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      The following selected consolidated financial data for the five-year period ended June 30, 2005 is derived from our audited consolidated financial statements and accompanying notes. The comparability of the years presented is impacted by certain product rights and business acquisitions and dispositions. All business acquisitions were accounted for under the purchase method and accordingly, the results of operations reflect the financial results of each business acquisition from the date of the acquisition. Certain business acquisitions resulted in the write-off of in-process research and development resulting from an independent valuation. Gross profit does not include amortization of the related intangibles. All share and per share data have been restated to reflect the 2 for 1 stock split effected in the form of a stock dividend that occurred on January 23, 2004.
                                           
    Fiscal Year Ended June 30,
     
    2005   2004   2003   2002   2001
                     
    (In thousands, except per share amounts)
Statements of Operations Data:
                                       
Net product revenues
  $ 305,114     $ 291,607     $ 241,909     $ 211,248     $ 159,677  
Net contract revenues
    71,785       12,115       5,630       1,559       8,125  
                               
Net revenues
    376,899       303,722       247,539       212,807       167,802  
Gross profit(a)
    321,452       257,116       209,279       177,042       137,105  
Operating expenses:
                                       
 
Selling, general and administrative
    135,154 (b)     118,253       91,648       77,314       59,508  
 
Research and development
    65,676 (c)     16,494 (d)     29,568 (e)     15,132 (f)     25,515 (g)
 
In-process research and development
                      6,217        
 
Depreciation and amortization
    22,350       16,794       10,125       7,928       8,261  
                               
Total operating expenses
    223,180       151,541       131,341       106,591       93,284  
                               
Operating income
    98,272       105,575       77,938       70,451       43,821  
Other:
                                       
 
Net interest income (expense)
    830       (758 )     (278 )     8,533       15,504  
 
Loss on early extinguishment of debt
          (58,660 )                  
 
Income tax expense
    (34,112 )     (15,317 )     (26,404 )     (28,960 )     (18,905 )
                               
Net income
  $ 64,990     $ 30,840     $ 51,256     $ 50,024     $ 40,420  
                               
Basic net income per share
  $ 1.18     $ 0.55     $ 0.94     $ 0.83     $ 0.67  
                               
Diluted net income per share
  $ 1.01     $ 0.52     $ 0.84     $ 0.79     $ 0.64  
                               
Cash dividend declared per common share
  $ 0.12     $ 0.10     $ 0.025              
                               
Basic common shares outstanding
    55,196       55,618       54,376       60,536       60,268  
                               
Diluted common shares outstanding
    70,909       72,481       70,191       63,828       63,388  
                               
 
(a) Amounts exclude $19.6 million, $14.9 million, $9.2 million, $7.1 million and $7.6 million for amortization expense related to acquired intangible assets in fiscal 2005, 2004, 2003, 2002 and 2001, respectively.
 
(b) Includes approximately $5.3 million of business integration planning costs related to the proposed merger with Inamed, and approximately $1.3 million of professional fees related to research and development collaborations with aaiPharma, Ansata and Q-Med.

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(c) Includes approximately $8.3 million paid to aaiPharma related to a research and development collaboration, $5.0 million paid to Ansata related to an exclusive development and license agreement and $30.0 million paid to Q-Med related to an exclusive license agreement for the development of SubQtm.
 
(d) Includes approximately $2.4 million paid to Dow for a research and development collaboration.
 
(e) Includes $14.2 million paid to Dow for a research and development collaboration and approximately $6.0 million paid to aaiPharma for a research and development collaboration.
 
(f) Includes $7.7 million paid to aaiPharma for a research and development collaboration.
 
(g) Includes $17.0 million paid to Corixa Corporation for a development, commercialization and licensing agreement.
                                         
    June 30,
     
    2005   2004   2003   2002   2001
                     
    (In thousands)
Balance Sheet Data:
                                       
Cash, cash equivalents, restricted cash and short-term investments
  $ 603,568     $ 634,040     $ 552,663     $ 577,576     $ 334,157  
Working capital
    600,070       666,743       576,781       611,259       358,468  
Total assets
    1,043,251       1,078,384       932,841       876,273       550,007  
Long-term debt
    453,065       453,067       400,000       400,000        
Stockholders’ equity
    486,346       555,303       461,121       429,059       503,453  
                                         
    Fiscal Year Ended June 30,
     
    2005   2004   2003   2002   2001
                     
    (In thousands)
Cash Flow Data:
                                       
Net cash provided by operating activities
  $ 129,981     $ 127,964     $ 84,667     $ 73,542     $ 71,120  
Net cash provided by (used in) investing activities
    140,487       (166,341 )     (113,709 )     (341,660 )     (97,981 )
Net cash (used in) provided by financing activities
    (139,793 )     40,621       (23,343 )     254,938       12,548  

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Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations
      The following Management’s Discussion and Analysis of Financial Condition and Results of Operations (“MD&A”) summarizes the significant factors affecting our results of operations, liquidity, capital resources and contractual obligations, as well as discusses our critical accounting policies and estimates. You should read the following discussion and analysis together with our consolidated financial statements, including the related notes, which are included in this report on Form 10-K/T. Certain information contained in the discussion and analysis set forth below and elsewhere in this report, including information with respect to our plans and strategy for our business and related financing, includes forward-looking statements that involve risks and uncertainties. See “Risk Factors” in Item 1A of this Form 10-K/T for a discussion of important factors that could cause actual results to differ materially from the results described in or implied by the forward-looking statements in this report. Our MD&A is composed of four major sections; Executive Summary, Results of Operations, Liquidity and Capital Resources and Critical Accounting Policies and Estimates.
Change in Fiscal Year
      On December 12, 2005, our Board of Directors resolved to change our fiscal year end from June 30 to December 31, effective December 31, 2005. This change was made to align our fiscal year end with other companies within our industry. Our six-month results discussed below relate to the transitional six-month fiscal period ended December 31, 2005 (the “Transition Period”). We refer to the period beginning July 1, 2004 and ending June 30, 2005 as “fiscal 2005”, the period beginning July 1, 2003 and ending June 30, 2004 as “fiscal 2004” and the period beginning July 1, 2002 and ending June 30, 2003 as “fiscal 2003”.
Executive Summary
      We are a leading independent specialty pharmaceutical company focusing primarily on helping patients attain a healthy and youthful appearance and self-image through the development and marketing of products in the U.S. for the treatment of dermatological, aesthetic and podiatric conditions. We also market products in Canada for the treatment of dermatological and aesthetic conditions. We offer a broad range of products addressing various conditions or aesthetics improvements, including dermal fillers, acne, fungal infections, rosacea, hyperpigmentation, photoaging, psoriasis, eczema, skin and skin-structure infections, seborrheic dermatitis and cosmesis (improvement in the texture and appearance of skin).
      Our current product lines are divided between the dermatological and non-dermatological fields. Our dermatological field represents products for the treatment of acne and acne-related dermatological conditions and non-acne dermatological conditions. Our non-dermatological field represents products for the treatment of asthma (until May 2004), urea cycle disorder and contract revenue. Our acne and acne-related dermatological product lines include core brands DYNACIN®, PLEXION® and TRIAZ®. Our non-acne dermatological product lines include core brands LOPROX®, OMNICEF®, RESTYLANE® and VANOStm. Our non-dermatological product lines include AMMONUL®, BUPHENYL® and ORAPRED®. ORAPRED® was one of the Company’s core brands until it was licensed to BioMarin in May 2004. Our non-dermatological field also includes contract revenues associated with licensing and authorized generic agreements.
Key Aspects of Our Business
      We derive a majority of our prescription volume from our core prescription products: DYNACIN®, LOPROX®, OMNICEF®, PLEXION®, TRIAZ® and VANOStm. We believe that sales of our core prescription products and sales of our dermal aesthetic product, RESTYLANE®, which we began selling in the U.S. on January 6, 2004, will continue to constitute a significant portion of our sales for the foreseeable future.
      We have built our business by executing a four-part growth strategy: promoting existing core brands, developing new products and important product line extensions, entering into strategic collaborations and acquiring complementary products, technologies and businesses. Our core philosophy is to cultivate relation-

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ships of trust and confidence with the high prescribing dermatologists and podiatrists and the leading plastic surgeons in the United States.
      As a result of customer buying patterns, a substantial portion of our product revenues has been recognized in the last month of each quarter, and we schedule our inventory purchases to meet anticipated customer demand. As a result, relatively small delays in the receipt of manufactured products by us could result in revenues being deferred or lost. Our operating expenses are based upon anticipated sales levels, and a high percentage of our operating expenses are relatively fixed in the short term. Consequently, variations in the timing of revenue recognition could cause significant fluctuations in operating results from period to period and may result in unanticipated periodic earnings shortfalls or losses.
      We estimate customer demand for our prescription products primarily through use of third party syndicated data sources which track prescriptions written by health care providers and dispensed by licensed pharmacies. The data represents extrapolations from information provided only by certain pharmacies and are estimates of historical demand levels. We estimate customer demand for our non-prescription products primarily through internal data that we compile. We observe trends from these data, and, coupled with certain proprietary information, prepare demand forecasts that are the basis for purchase orders for finished and component inventory from our third party manufacturers and suppliers. Our forecasts may fail to accurately anticipate ultimate customer demand for our products. Overestimates of demand may result in excessive inventory production and underestimates may result in inadequate supply of our products in channels of distribution.
      We sell our products primarily to major wholesalers and retail pharmacy chains. Consistent with pharmaceutical industry patterns, approximately 80% of our revenues are derived from three major drug wholesale concerns. While we attempt to estimate inventory levels of our products at our major wholesale customers by using historical prescription information and historical purchase patterns, this process is inherently imprecise. Rarely do wholesale customers provide us complete inventory levels at regional distribution centers, or within their national distribution systems. We rely wholly upon our wholesale and drug chain customers to effect the distribution allocation of our products. Based upon historically consistent purchasing patterns of our major wholesale customers, we believe our estimates of trade inventory levels of our products are reasonable. We further believe that inventories of our products among wholesale customers, taken as a whole, are similar to those of other specialty pharmaceutical companies, and that our trade practices, which periodically involve volume discounts and early payment discounts, are typical of the industry.
      We periodically offer promotions to wholesale and chain drugstore customers to encourage dispensing of our products, consistent with prescriptions written by licensed health care providers. Because many of our products compete in multi-source markets, it is important for us to ensure the licensed health care providers’ dispensing instructions are fulfilled with our branded products and are not substituted with a generic product or another therapeutic alternative product which may be contrary to the licensed health care providers’ recommended and prescribed Medicis brand. We believe that a critical component of our brand protection program is maintenance of full product availability at drugstore and wholesale customers. We believe such availability reduces the probability of local and regional product substitutions, shortages and backorders, which could result in lost sales. We expect to continue providing favorable terms to wholesale and retail drug chain customers as may be necessary to ensure the fullest possible distribution of our branded products within the pharmaceutical chain of commerce.
      We cannot control or significantly influence the purchasing patterns of our wholesale and retail drug chain customers. They are highly sophisticated customers that purchase products in a manner consistent with their industry practices and, presumably, based upon their projected demand levels. Purchases by any given customer, during any given period, may be above or below actual prescription volumes of any of our products during the same period, resulting in fluctuations of product inventory in the distribution channel.

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      As described in more detail below, the following significant events and transactions occurred during the Transition Period, and affected our results of operations, our cash flows and our financial condition:
  •  Termination of the proposed definitive merger agreement with Inamed Corporation;
 
  •  Adoption of SFAS No. 123R; and
 
  •  Write-down of a long-lived asset due to impairment.
Termination of the Proposed Definitive Merger Agreement with Inamed Corporation
      On March 20, 2005, Medicis and Inamed Corporation (“Inamed”) entered into an Agreement and Plan of Merger (the “Agreement”). Inamed is a global healthcare company that develops, manufactures, and markets breast implants for aesthetic augmentation and reconstructive surgery following a mastectomy, a range of dermal products to correct facial wrinkles, the BioEnterics® LAP-BAND® System designed to treat severe and morbid obesity, and the BioEnterics® Intragastric Balloon (BIB®) system for the treatment of obesity. Under the terms of the Agreement, Inamed was to merge with and into a subsidiary of Medicis and each share of Inamed common stock would have been converted into the right to receive 1.4205 shares of Medicis common stock and $30.00 in cash. The completion of the transaction was subject to several customary conditions, including the receipt of applicable approvals from Medicis’ and Inamed’s stockholders, the absence of any material adverse effect on either party’s business and the receipt of regulatory approvals.
      On December 13, 2005, we entered into a merger termination agreement with Inamed following Allergan Inc.’s exchange offer for all outstanding shares of Inamed, which was commenced on November 21, 2005, pursuant to which Medicis and Inamed agreed to terminate the Agreement. In accordance with the terms of the Agreement and the merger termination agreement, Inamed paid Medicis a termination fee of $90.0 million, plus $0.5 million in expense reimbursement fees on December 13, 2005.
      From the inception of the proposed transaction with Inamed through the termination of the Agreement, we had incurred approximately $14.0 million of professional and other costs related to the transaction. These costs, which were maintained in other long-term assets in our consolidated balance sheet during the transaction approval process, were expensed upon termination of the Agreement. As a result of the termination, we were required to pay Deutsche Bank Trust Company Americas a fee pursuant to a provision in the merger engagement letter with them whereby they were entitled to a portion of the termination fee. We also incurred business integration costs related to the transaction, including the planning for and implementation of integration activities. These costs were expensed as incurred. During the Transition Period, we incurred approximately $4.4 million of business integration planning costs. These costs were primarily consulting and other professional fees.
      During the Transition Period, we recognized a net benefit related to the above items of approximately $59.1 million. This is summarized as follows (in millions):
         
Termination fee received from Inamed, including expense reimbursement fees
  $ 90.5  
Less:
       
Transaction costs expensed, including legal and advisory fees
    27.0  
Integration planning costs
    4.4  
       
    $ 59.1  
       
      Approximately $0.7 million of the integration planning costs, incurred during the three months ended September 30, 2005, are included in selling, general and administrative expenses in the accompanying consolidated statements of income. Approximately $59.8 million of the net benefit related to the above items, including $3.7 million of integration planning costs incurred during the three months ended December 31, 2005, is included in other income, net, in the accompanying consolidated statements of income.
      The total net benefit we recognized from the inception of the proposed transaction through the termination of the Agreement was approximately $53.8 million. This includes the $59.1 million benefit

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recognized during the Transition Period, partially offset by approximately $5.3 million of integration planning costs incurred during the three months ended June 30, 2005.
Adoption of SFAS No. 123R
      In December 2004, the FASB issued Statement of Financial Accounting Standards No. 123, “Accounting for Stock-Based Compensation” (“SFAS No. 123R”), which requires companies to measure and recognize compensation expense for all share-based payments at fair value. Share-based payments include stock option and nonvested share grants. We grant options to purchase common stock to some of our employees and directors under various plans at prices equal to the market value of the stock on the dates the options were granted. We historically have accounted for stock options using the method prescribed in Accounting Principles Board Opinion No. 25, “Accounting for Stock Issued to Employees,” (“APB Opinion No. 25”) whereby stock options are granted at market price and no compensation cost is recognized, and disclosed the pro forma effect on net earnings assuming compensation cost had been recognized in accordance with SFAS No. 123. SFAS No. 123R, which was effective for us beginning in the first quarter of the Transition Period, eliminates the ability to account for share-based compensation transactions using APB Opinion No. 25, and generally requires that such transactions be accounted for using prescribed fair-value-based methods. SFAS No. 123R permits public companies to adopt its requirements using one of two methods: (a) a “modified prospective” method in which compensation costs are recognized beginning with the effective date based on the requirements of SFAS No. 123R for all share-based payments granted or modified after the effective date, and based on the requirements of SFAS No. 123 for all awards granted to employees prior to the effective date of SFAS No. 123R that remain unvested on the effective date or (b) a “modified retrospective” method which includes the requirements of the modified prospective method described above, but also permits companies to restate based on the amounts previously recognized under SFAS No. 123 for purposes of pro forma disclosures either for all periods presented or prior interim periods of the year of adoption. We decided to adopt SFAS No. 123R using the modified prospective method. SFAS No. 123R also requires the benefits of tax deductions in excess of recognized compensation cost to be reported as a financing cash flow, rather than as an operating cash flow as required under historical literature.
      During the six months ended December 31, 2005, we recognized approximately $14.9 million (before income tax expense) of compensation expense related to the expensing of stock options and restricted stock in accordance with SFAS No. 123R. Approximately $13.9 million and $1.0 million is included in selling, general and administrative expenses and research and development expenses, respectively, in the accompanying consolidated statements of income. Basic and diluted net income per common share for the Transition Period would have been $1.12 and $0.92, respectively, if the Company had not adopted SFAS No. 123R, compared to reported basic and diluted net income per common share of $0.92 and $0.76, respectively.
Write-down of a Long-lived Asset Due to Impairment
      We assess the potential impairment of long-lived assets on a periodic basis and when events or changes in circumstances indicate that the carrying value of the assets may not be recoverable. Factors that we consider in deciding when to perform an impairment review include significant under-performance of a product line in relation to expectations, significant negative industry or economic trends, and significant changes or planned changes in our use of the assets. Recoverability of assets that will continue to be used in our operations is measured by comparing the carrying amount of the asset grouping to our estimate of the related total future net cash flows. If an asset carrying value is not recoverable through the related cash flows, the asset is considered to be impaired. The impairment is measured by the difference between the asset grouping’s carrying amount and its fair value, based on the best information available, including market prices or discounted cash flow analysis.
      During the quarter ended December 31, 2005, a long-lived asset related to our DYNACIN® capsule products was determined to be impaired based on our analysis of the long-lived asset’s carrying value and projected future cash flows. Factors affecting the long-lived asset’s future cash flows included our promotional focus on our DYNACIN® tablet products, and competitive pressures in the marketplace. As a result of the impairment analysis, we recorded a write-down of approximately $9.2 million related to this long-lived asset,

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which is included in selling, general and administrative expenses in the accompanying consolidated statements of income.
Results of Operations
      The following table sets forth certain data as a percentage of net revenues for the periods indicated.
                                         
        Six Months    
        Ended   Fiscal Year Ended
    Transition   December 31,    
    Period(a)   2004(b)   2005(c)   2004(d)   2003(e)
                     
        (Unaudited)            
Net revenues
    100.0 %     100.0 %     100.0 %     100.0 %     100.0 %
Gross profit(f)
    85.3       84.9       85.3       84.7       84.5  
Operating expenses
    75.7       66.8       59.2       49.9       53.1  
Operating income
    9.6       18.1       26.1       34.8       31.5  
Other income, net
    36.5                          
Interest income (expense), net
    2.9       (0.1 )     0.2       (0.2 )     (0.1 )
Loss on early extinguishment of debt
                      (19.3 )      
                               
Income tax expense
    (18.7 )     (6.3 )     (9.1 )     (5.0 )     (10.7 )
                               
Net income
    30.3 %     11.7 %     17.2 %     10.2 %     20.7 %
                               
 
(a) Included in operating expenses is $14.9 million (9.1%) of net revenues) of compensation expense related to stock options and restricted stock, a charge of approximately $9.2 million (5.6% of net revenues) for the write-down of a long-lived asset, and $0.7 million (0.4% of net revenues) related to integration planning costs incurred during the three months ended September 30, 2005 related to the proposed merger with Inamed. Included in other income, net, is $59.8 million (36.5% of net revenue) related to a termination fee of $90.5 million received from Inamed upon the termination of the proposed merger with Inamed, net of a fee paid to an investment banker and the expensing of accumulated transaction costs of $27.0 million, and integration planning costs incurred during the three months ended December 31, 2005 of $3.7 million.
 
(b) Included in operating expenses is $5.5 million (3.1% of net revenues) related to our exclusive development and license agreement with Ansata for proprietary technology and $30.7 million (17.0% of net revenues) related to our exclusive license agreement with Q-Med for the development of SubQtm.
 
(c) Included in operating expenses is $5.3 million (1.4% of net revenues) of business integration planning costs related to the proposed merger with Inamed, $8.3 million (2.2% of net revenues) related to a research and development collaboration with aaiPharma, $5.5 million (1.5% of net revenues) related to our exclusive development and license agreement with Ansata for proprietary technology and $30.7 million (8.2% of net revenues) related to our exclusive license agreement with Q-Med for the development of SubQtm.
 
(d) Included in operating expenses is a $2.4 million payment (0.8% of net revenues) to Dow for a research and development collaboration.
 
(e) Included in operating expenses is $14.2 million in payments (5.7% of net revenues) to Dow for a research and development collaboration and a $6.0 million payment (2.4% of net revenues) to aaiPharma for a research and development collaboration.
 
(f) Gross profit does not include amortization of the related intangibles as such expense is included in operating expenses.

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Six Months Ended December 31, 2005 Compared To Six Months Ended December 31, 2004
Net Revenues
      The following table sets forth the net revenues for the Transition Period and December 31, 2004 (the “comparable 2004 six months”), along with the percentage of net revenues for each of our product categories (amounts in millions):
                                   
        Comparable        
    Transition   2004   $   %
    Period   Six Months   Change   Change
                 
Net product revenues
  $ 155.6     $ 147.0     $ 8.6       5.8 %
Net contract revenues
    8.4       34.2       (25.8 )     (75.5 )%
                         
 
Net revenues
  $ 164.0     $ 181.2     $ (17.2 )     (9.5 )%
                         
                           
        Comparable    
    Transition   2004    
    Period   Six Months   Change
             
Acne and acne-related dermatological products
    28.1 %     32.8 %     (4.7 )%
Non-acne dermatological products
    58.9 %     44.4 %     14.5 %
Non-dermatological products
    13.0 %     22.8 %     (9.8 )%
                   
 
Total net revenues
    100.0 %     100.0 %      
                   
      Our total net revenues decreased during the Transition Period primarily as a result of a decrease in net contract revenues associated with licensing agreements and authorized generic agreements. Net contract revenues decreased primarily due to a decrease in contract revenues during the Transition Period related to our outlicensing of the ORAPRED® brand pursuant to the terms of our license agreement with BioMarin. Core brand revenues, which are included in net product revenues and includes revenues associated with RESTYLANE®, DYNACIN®, LOPROX®, OMNICEF®, PLEXION®, TRIAZ® and VANOStm, represented approximately $138.3 million, or approximately 84.4% of net revenues, during the Transition Period, a slight decrease of approximately 0.3%, compared to core brand revenues of approximately $138.7 million, or approximately 76.6% of net revenues, for the comparable 2004 six months. Net revenues associated with our acne and acne-related dermatological products decreased as a percentage of net revenues and decreased in net dollars by 22.6% during the Transition Period as compared to the comparable 2004 six months, primarily due to generic competition with our DYNACIN® brand of products. Net revenues associated with our non-acne dermatological products increased as a percentage of net revenues, and increased in net dollars by 20.0% during the Transition Period, primarily due to the launch of VANOS in April 2005, and an increase in sales of RESTYLANE®. Net revenues associated with our non-dermatological products decreased as a percentage of net revenues and decreased in net dollars by 48.1% during the Transition Period, primarily due to the decrease in ORAPRED® contract revenues discussed above.
Gross Profit
      Gross profit represents our net revenues less our cost of product revenue. Our cost of product revenue includes our acquisition cost for the products we purchase from our third party manufacturers and royalty payments made to third parties. Amortization of intangible assets related to products sold is not included in gross profit. Product mix plays a significant role in our quarterly and annual gross profit as a percentage of net revenues. Different products generate different gross profit margins, and the relative mix of higher gross profit products and lower gross profit products can affect our total gross profit.

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      The following table sets forth our gross profit for the Transition Period and comparable 2004 six months, along with the percentage of net revenues represented by such gross profit (amounts in millions):
                                 
        Comparable        
    Transition   2004   $   %
    Period   Six Months   Change   Change
                 
Gross profit
  $ 139.8     $ 153.9     $ (14.1 )     (9.1 )%
% of net revenues
    85.3 %     84.9 %                
      The decrease in gross profit during the Transition Period as compared to the comparable 2004 six months was due to the decrease in our net revenues, while the increase in gross profit as a percentage of net revenues was primarily due to the different mix of products sold during the Transition Period as compared to the comparable 2004 six months.
Selling, General and Administrative Expenses
      The following table sets forth our selling, general and administrative expenses for the Transition Period and comparable 2004 six months, along with the percentage of net revenues represented by selling, general and administrative expenses (amounts in millions):
                                 
        Comparable        
    Transition   2004   $   %
    Period   Six Months   Change   Change
                 
Selling, general and administrative
  $ 89.4     $ 65.7     $ 23.7       35.9 %
% of net revenues
    54.5 %     36.3 %                
Share-based compensation expense included in selling, general and administrative
  $ 13.9     $ 0.3     $ 13.6       5,416.1 %
      The increase in selling, general and administrative expenses during the Transition Period from the comparable 2004 six months was attributable to $13.6 million of additional share-based compensation expense recognized upon our adoption of SFAS No. 123R, a charge of approximately $9.2 million for the write-down of a long-lived asset, $0.7 million of integration costs related to the proposed merger with Inamed incurred during the three months ended September 30, 2005, and $1.5 million of additional selling, general and administrative expenses incurred during the Transition Period, partially offset by approximately $1.3 million of professional fees related to a research and development agreements with Q-Med (for the development of SubQtm) and Ansata incurred during the comparable 2004 six months.
Research and Development Expenses
      The following table sets forth our research and development expenses for the Transition Period and comparable 2004 six months (amounts in millions):
                                 
        Comparable        
    Transition   2004   $   %
    Period   Six Months   Change   Change
                 
Research and development
  $ 22.4     $ 45.1     $ (22.7 )     (50.4 )%
Charges included in research and development
    11.9       35.0       (23.1 )     (65.9 )%
Share-based compensation expense included in research and development
    1.0             1.0       100.0 %
      Included in research and development expenses for the Transition Period was approximately $11.9 million of milestone payments related to the license and development agreement with Dow for a patented dermatological product and approximately $1.0 million of compensation expense for stock options and restricted stock recognized upon our adoption of SFAS No. 123R. Included in research and development expenses for the comparable 2004 six months was approximately $30.0 million related to the SubQtm license agreement and $5.0 million related to the Ansata development and license agreement. Absent these charges, research and development expenses decreased $0.7 million, or 7.1%, to $9.4 million during the Transition Period from $10.1 million during the comparable 2004 six months. This decrease was due to the timing of

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various research and development projects. We expect research and development expenses to continue to fluctuate from quarter to quarter based on the timing of the achievement of development milestones under license and development agreements, as well as the timing of other development projects and the funds available to support these projects.
Depreciation and Amortization Expenses
      Depreciation and amortization expenses during the Transition Period increased $2.2 million, or 21.5%, to $12.4 million from $10.2 million during the comparable 2004 six months. This increase was primarily due to increased amortization that began during the third quarter of fiscal 2005 related to certain intangible assets whose useful lives were determined to be shorter than originally estimated.
Other Income, net
      Other income, net, during the Transition Period represented a termination fee received from Inamed as a result of the termination of the proposed merger, net of the expensing of accumulated transaction costs related to the transaction and integration planning costs incurred during the three months ended December 31, 2005. The net amount of these items is summarized as follows (in millions):
         
Termination fee received from Inamed, including expense reimbursement fees
  $ 90.5  
Less:
       
Transaction costs expensed, including legal and advisory fees
    27.0  
Integration planning costs incurred during the three months ended December 31, 2005
    3.7  
       
    $ 59.8  
       
Interest Income
      Interest income during the Transition Period increased $5.0 million, or 98.2%, to $10.1 million from $5.1 million during the comparable 2004 six months, primarily due to an increase in funds available for investment and an increase in the interest rates achieved by our invested funds during the Transition Period. The increase in interest rates achieved was partially due to a shift from non-taxable to taxable investments, which yield higher rates.
Interest Expense
      Interest expense during the Transition Period remained consistent with the comparable 2004 six months, at $5.3 million. Our interest expense during the Transition Period and the comparable 2004 six months consisted of interest expense on our Old Notes, which accrue interest at 2.5% per annum, our New Notes, which accrue interest at 1.5% per annum, and amortization of fees and other origination costs related to the issuance of the Old Notes and New Notes. See Note 13 in our accompanying consolidated financial statements for further discussion on the Old Notes and New Notes.
Income Tax Expense
      The following table sets forth our income tax expense and the resulting effective tax rate stated as a percentage of pre-tax income for the Transition Period and comparable 2004 six months (dollar amounts in millions):
                                 
        Comparable        
    Transition   2004   $   %
    Period   Six Months   Change   Change
                 
Income tax expense
  $ 30.5     $ 11.3     $ 19.2       169.3%  
Effective tax rate
    38.0 %     34.8 %                
      Income taxes are determined using an annual effective tax rate, which generally differs from the U.S. Federal statutory rate, primarily because of state and local income taxes, tax-exempt interest, charitable

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contribution deductions and research and development tax credits available in the U.S. Our effective tax rate may be subject to fluctuations during the fiscal year as new information is obtained which may affect the assumptions we use to estimate our annual effective tax rate, including factors such as our mix of pre-tax earnings in the various tax jurisdictions in which we operate, changes in valuation allowances against deferred tax assets, reserves for tax audit issues and settlements, utilization of research and development tax credits and changes in tax laws in jurisdictions where we conduct operations. We recognize deferred tax assets and liabilities for temporary differences between the financial reporting basis and the tax basis of our assets and liabilities. We record valuation allowances against our deferred tax assets to reduce the net carrying values to amounts that management believes is more likely than not to be realized.
      Income tax expense during the Transition Period increased 169.3%, or $19.2 million, to $30.5 million, from $11.3 million in the comparable 2004 six months. The increase in income tax expense was primarily due to the increase in our pre-tax income for the same period. The increase in our Transition Period effective tax rate from the comparable 2004 six months effective tax rate was primarily due to: (i) an increase in the relative weighting of interest income in our mix of taxable and tax-exempt investments and (ii) the adoption of SFAS No. 123R which precludes the recognition of tax benefits relating to the expensing of share-based awards that are not ordinarily designed to result in a tax deduction.
Fiscal Year Ended June 30, 2005 Compared To Fiscal Year Ended June 30, 2004
Net Revenues
      The following table sets forth the net revenues for the fiscal years ended June 30, 2005 (“fiscal 2005”) and June 30, 2004 (“fiscal 2004”), along with the percentage of net revenues for each of our product categories (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2005   2004   Change   Change
                 
Net revenues
  $ 376.9     $ 303.7     $ 73.2       24.1%  
                           
    Fiscal   Fiscal    
    2005   2004   Change
             
Acne and acne-related dermatological products
    29.5 %     30.5 %     (1.0 )%
Non-acne dermatological products
    47.1 %     50.9 %     (3.8 )%
Non-dermatological products
    23.4 %     18.6 %     4.8 %
                   
 
Total net revenues
    100.0 %     100.0 %      
                   
      Our total net revenues increased during fiscal 2005 primarily as a result of growth in sales of the PLEXION®, RESTYLANE® and VANOStm products and an increase in contract revenue. Core brand revenues, which includes revenues associated with RESTYLANE®, DYNACIN®, LOPROX®, OMNICEF®, PLEXION®, TRIAZ® and VANOStm represented approximately $284.6 million, or approximately 75.5% of net revenues, during fiscal 2005, an increase of approximately 8.3%, compared to core brand revenues of approximately $262.7 million, or approximately 86.5% of net revenues, for fiscal 2004. Core brand revenues for fiscal 2004 included net revenues of ORAPRED®, which was licensed to BioMarin in May 2004. Net revenues associated with our Acne and acne-related dermatological products decreased as a percentage of net revenues, but increased in net dollars by 20.0% primarily due to an increase in PLEXION® net revenues due to the launch of PLEXION® Cleansing Cloths during the first quarter of fiscal 2005. Net revenues associated with our Non-acne dermatological products decreased as a percentage of net revenues, but increased in net dollars by 14.8% during fiscal 2005, primarily due to the launch of RESTYLANE® in the United States in January 2004 and the launch of VANOStm in April 2005, partially offset by a decrease in LOPROX® net revenues due to increased competition from generic products launched during fiscal 2005. Net revenues associated with our Non-dermatological products increased as a percentage of net revenues primarily due to the increase in contract revenues associated with the outlicensing of the ORAPRED® and LUSTRA® brands, which was greater than the revenues generated by those products for the comparable period during

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fiscal 2004. Contract revenue during fiscal 2005 included fees derived from authorized generics launched on our behalf.
Gross Profit
      Gross profit represents our net revenues less our cost of product revenue. Our cost of product revenue includes our acquisition cost for the products we purchase from our third party manufacturers and royalty payments made to third parties. Amortization of intangible assets related to acquired products is not included in gross profit. Amortization expense related to these intangibles for fiscal 2005 and fiscal 2004 was approximately $19.6 million and $14.9 million, respectively. Product mix plays a significant role in our quarterly and annual gross profit as a percentage of net revenues. Different products generate different gross profit margins, and the relative mix of higher gross profit products and lower gross profit products can affect our total gross profit.
      The following table sets forth our gross profit for fiscal 2005 and fiscal 2004, along with the percentage of net revenues represented by such gross profit (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2005   2004   Change   Change
                 
Gross profit
  $ 321.5     $ 257.1     $ 64.4       25.0%  
% of net revenues
    85.3 %     84.7 %                
      The increase in gross profit during fiscal 2005 as compared to fiscal 2004 was due to the increase in our net revenues, while the increase in gross profit as a percentage of net revenues was primarily due to the different mix of products sold during fiscal 2005 as compared to during fiscal 2004, and an increase in contract revenue during fiscal 2005 as compared to during fiscal 2004.
Selling, General and Administrative Expenses
      The following table sets forth our selling, general and administrative expenses for fiscal 2005 and fiscal 2004, along with the percentage of net revenues represented by selling, general and administrative expenses (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2005   2004   Change   Change
                 
Selling, general and administrative
  $ 135.2     $ 118.3     $ 16.9       14.3%  
% of net revenues
    35.9 %     38.9 %                
      The increase in selling, general and administrative expenses from fiscal 2004 to fiscal 2005 was primarily attributable to incremental costs associated with RESTYLANE®, $5.3 million of business integration planning costs related to the proposed merger with Inamed and approximately $1.3 million of professional fees related to research and development collaborations. The decrease in selling, general and administrative expenses as a percentage of net revenues from fiscal 2004 to fiscal 2005 was due to net revenues during fiscal 2005 outpacing the increase in selling, general and administrative spending. A pre-market approval application for RESTYLANE® was approved by the FDA on December 12, 2003, followed by the product launch and first U.S. commercial sales of RESTYLANE® on January 6, 2004. During fiscal 2004, we incurred incremental costs associated with the establishment of a sales and marketing strategy for RESTYLANE®, prior to the commercial launch of the product.

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Research and Development Expenses
      The following table sets forth our research and development expenses for fiscal 2005 and fiscal 2004 (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $    
    2005   2004   Change   % Change
                 
Research and development
  $ 65.7     $ 16.5     $ 49.2       298.2%  
Charges included in research and development associated with research and development transactions
    43.3       2.4       40.9       1,686.2%  
      Included in research and development expenses for fiscal 2005 was approximately $8.3 million related to the aaiPharma research and development collaboration, $30.0 million related to the SubQtm license agreement and $5.0 million related to the Ansata development and license agreement. Included in research and development expenses for fiscal 2004 was a $2.4 million milestone payment under a license and development agreement with Dow for a patented dermatological product. Absent these charges, research and development expenses increased $8.3 million, or 59.2%, to $22.4 million during fiscal 2005 from $14.1 million during fiscal 2004. This increase was due to the timing of various research and development projects. We expect research and development expenses to fluctuate from quarter to quarter based on the timing of the achievement of development milestones under license and development agreements, as well as the timing of other development projects and the funds available to support these projects.
Depreciation and Amortization Expenses
      Depreciation and amortization expenses during fiscal 2005 increased $5.5 million, or 33.1%, to $22.3 million from $16.8 million during fiscal 2004. This increase was primarily due to the amortization of expenses related to the $53.3 million and $19.4 million milestone payments made to Q-Med in December 2003 and May 2004, respectively, which are being amortized over the period from the date of payment through January 2018 and increased amortization related to certain intangible assets whose useful lives were determined to be shorter than originally estimated.
Interest Income
      Interest income during fiscal 2005 increased $1.5 million, or 14.1%, to $11.5 million from $10.0 million during fiscal 2004, primarily due to an increase in the rates achieved by our invested funds during fiscal 2005.
Interest Expense
      Interest expense during fiscal 2005 decreased $0.2 million, or 1.6%, to $10.6 million from $10.8 million during fiscal 2004. This decrease was due to the August 2003 exchange of a portion of our Old Notes, which accrue interest at 2.5% per annum, for our New Notes, which accrue interest at 1.5% per annum.
Income Tax Expense
      The following table sets forth our income tax expense and the resulting effective tax rate stated as a percentage of pre-tax income for fiscal 2005 and fiscal 2004 (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2005   2004   Change   Change
                 
Income tax expense
  $ 34.1     $ 15.3     $ 18.8       122.7%  
Effective tax rate
    34.4 %     33.2 %                
      The increase in income tax expense from fiscal 2004 to fiscal 2005 was primarily due to the increase in pretax earnings over the same period. Excluding the loss on early extinguishment of debt in fiscal 2004, our adjusted effective tax rate for fiscal 2004 was 35%. The effective rate is lower than the expected combined federal and state income tax rates due primarily to tax-exempt interest income and contributions to charitable programs that receive favorable tax treatment. Our full year effective tax rate may increase in fiscal 2006

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compared to our effective tax rate in fiscal 2005 due to expected changes in the mix of earnings, the adoption of Financial Accounting Standards Board (“FASB”) Statement No. 123R, “Share-Based Payment” (“SFAS No. 123R”), and the expiration of the U.S. research and development tax credit, the latter of which is currently expected to sunset on December 31, 2005.
Fiscal Year Ended June 30, 2004 Compared To Fiscal Year Ended June 30, 2003
Net Revenues
      The following table sets forth the net revenues for the fiscal years ended June 30, 2004 (“fiscal 2004”) and June 30, 2003 (“fiscal 2003”), along with the percentage of net revenues for each of our product categories (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2004   2003   Change   Change
                 
Net revenues
  $ 303.7     $ 247.5     $ 56.2       22.7 %
                           
    Fiscal   Fiscal    
    2004   2003   Change
             
Acne and acne-related dermatological products
    30.5 %     33.6 %     (3.1 )%
Non-acne dermatological Products
    50.9 %     36.7 %     14.2 %
Non-dermatological products
    18.6 %     29.7 %     (11.1 )%
                   
 
Total net revenues
    100.0 %     100.0 %      
                   
      Our total net revenues increased during fiscal 2004 primarily as a result of growth in sales of the DYNACIN®, LOPROX®, RESTYLANE® and TRIAZ® products. The Acne and acne-related dermatological product net revenues decreased as a percentage of net revenues, but increased in net dollars by 11.5% primarily due to the introduction of DYNACIN® in tablet form in May 2003 and the introduction of TRIAZ® in pad form in July 2003. The Non-acne dermatological product net revenues increased as a percentage of net revenues during fiscal 2004 primarily due to the launch of RESTYLANE® in the United States in January 2004 and the introduction of LOPROX® Shampoo in March 2003. The Non-dermatological product net revenues decreased as a percentage of net revenues primarily due to the increase in net revenues in the other products, and decreased net revenues of ORAPRED®. The Non-dermatological product net revenues decreased 23.4% from fiscal 2003 to fiscal 2004. ORAPRED® was licensed to BioMarin as of May 18, 2004, and the licensing revenue recognized during fiscal 2004 subsequent to that date was less than the ORAPRED® product revenue for the comparable period during fiscal 2003.
Gross Profit
      Gross profit represents our net revenues less our cost of product revenue. Our cost of product revenue includes our acquisition cost for the products we purchase from our third party manufacturers and royalty payments made to third parties. Amortization of intangible assets related to products sold is not included in gross profit. Product mix plays a significant role in our quarterly and annual gross profit as a percentage of net revenues. Different products generate different gross profit margins, and the relative mix of higher gross product profit products and lower gross profit products can affect our total gross profit.
      The following table sets forth our gross profit for fiscal years 2004 and 2003, along with the percentage of net revenues represented by such gross profit (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2004   2003   Change   Change
                 
Gross profit
  $ 257.1     $ 209.3     $ 47.8       22.9%  
% of net revenues
    84.7 %     84.5 %                

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      The increase in gross profit during fiscal 2004 as compared to fiscal 2003 was due to the increase in our net revenues, while the increase in gross profit as a percentage of net revenues was primarily due to the different mix of products sold during fiscal 2004 as compared to during fiscal 2003.
Selling, General and Administrative Expenses
      The following table sets forth our selling, general and administrative expenses for fiscal years 2004 and 2003, along with the percentage of net revenues represented by such selling, general and administrative expenses (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2004   2003   Change   Change
                 
Selling, general and administrative
  $ 118.3     $ 91.6     $ 26.7       29.0%  
% of net revenues
    38.9 %     37.0 %                
      The increase in selling, general and administrative expenses from fiscal 2003 to fiscal 2004 was primarily attributable to incremental costs associated with the establishment of a sales and marketing program for RESTYLANE®. We have incurred incremental costs associated with the hiring of a dedicated aesthetics sales force, additional headquarters personnel to support sales force efforts, including product management, customer service and training personnel, expenses associated with public relations, physician training and continuing medical education, and other administrative expenses. A pre-market approval application for RESTYLANE® was approved by the FDA on December 12, 2003, followed by the product launch and first U.S. commercial sales of RESTYLANE® on January 6, 2004.
Research and Development Expenses
      The following table sets forth our research and development expenses for fiscal years 2004 and 2003 (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2004   2003   Change   Change
                 
Research and development
  $ 16.5     $ 29.6     $ (13.1 )     (44.2 )%
Charges included in research and development associated with research and development transactions
    2.4       20.2       (17.8 )     (88.0 )%
      Included in research and development expenses for fiscal 2004 was a milestone payment of $2.4 million under a license and development agreement with Dow for a patented dermatological product. Included in fiscal 2003 research and development expense was $14.2 million in milestone payments under a license and development agreement with Dow for a patented dermatologic product, and a $6.0 million milestone payment to aaiPharma under an agreement for the development, commercialization and license of a key dermatologic product. Absent these charges, research and development expenses increased 50.1%, or $4.7 million, to $14.1 million during fiscal 2004 from $9.4 million during fiscal 2003. This increase is due to the timing of various research and development projects. We expect research and development expenses to fluctuate from quarter to quarter based on the timing of the achievement of development milestones under license and development agreements, as well as the timing of other development projects and the funds available to support these projects.
Depreciation and Amortization Expenses
      Depreciation and amortization expenses during fiscal 2004 increased 65.9%, or $6.7 million, to $16.8 million from $10.1 million during fiscal 2003. This increase was primarily due to the amortization of expenses associated with the acquisition of the RESTYLANE® family of products, which began in March 2003, and the amortization related to the $53.3 million and $19.4 million milestone payments made to Q-Med in December 2003 and May 2004, respectively, which are being amortized over 15 years.

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Interest Income
      Interest income during fiscal 2004 decreased 18.3%, or $2.2 million, to $10.1 million from $12.3 million during fiscal 2003, primarily due to a decrease in interest rate yields.
Interest Expense
      Interest expense during fiscal 2004 decreased 14.1%, or $1.8 million, to $10.8 million from $12.6 million during fiscal 2003. This decrease was due to the August 2003 exchange of a portion of our Old Notes, which accrue interest at 2.5% per annum, for our New Notes, which accrue interest at 1.5% per annum.
Loss on Early Extinguishment of Debt
      On August 14, 2003, we exchanged $230.8 million in principal amount of our Old Notes for $283.9 million in principal amount of our New Notes. As a result of the exchange, we recognized a loss on early extinguishment of debt totaling $58.7 million, consisting of a $53.1 million premium and a $5.6 million write-off of corresponding Old Notes fees.
Income Tax Expense
      The following table sets forth our income tax expense and the resulting effective tax rate stated as a percentage of pre-tax income for fiscal years 2004 and 2003 (dollar amounts in millions):
                                 
    Fiscal   Fiscal   $   %
    2004   2003   Change   Change
                 
Income tax expense
  $ 15.3     $ 26.4     $ (11.1 )     (42.0 )%
Effective tax rate
    33.2 %     34.0 %                
      The decrease in income tax expense and the effective tax rate from fiscal 2003 to fiscal 2004 was primarily due to the decrease in pretax earnings as a result of the loss on the early extinguishment of debt. Excluding the loss on early extinguishment of debt, our adjusted effective tax rate for fiscal 2004 was 35%. The increase in the adjusted effective tax rate to 35% in fiscal 2004 compared to the effective tax rate of 34% in fiscal 2003 is primarily attributable to a decrease in research and development credits associated with the decrease in research and development expenditures. The effective rate is lower than the expected combined federal and state income tax rates due to approximately $5.3 million and $5.9 million of tax-exempt interest income in fiscal 2004 and fiscal 2003, respectively, and contributions to charitable programs that receive favorable tax treatment. Our full year effective tax rate may increase in fiscal 2005 compared to our adjusted effective tax rate in fiscal 2004 due to expected changes in the mix of earnings and the expiration of the U.S. research and development tax credit.
Liquidity and Capital Resources
Overview
      The following table highlights selected cash flow components for the Transition Period and the comparable 2004 six months, and selected balance sheet components as of December 31, 2005 and June 30, 2005 (dollar amounts in millions):
                                   
        Comparable        
    Transition   2004   $   %
    Period   Six Months   Change   Change
                 
Cash provided by (used in):
                               
 
Operating activities
  $ 148.0     $ 45.5     $ 102.5       225.5 %
 
Investing activities
    123.7       76.2       47.5       62.4 %
 
Financing activities
    (2.8 )     (137.4 )     134.6       (98.0 )%

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    December 31,   June 30,   $   %
    2005   2005   Change   Change
                 
Cash, cash equivalents, restricted cash and short-term investments
  $ 742.5     $ 603.6     $ 138.9       23.0 %
Working capital
    692.5       600.1       92.4       15.4 %
2.5% contingent convertible senior notes due 2032
    169.2       169.2              
1.5% contingent convertible senior notes due 2033
    283.9       283.9              
      The following table highlights selected cash flow components for fiscal 2005 and fiscal 2004, and selected balance sheet components as of June 30, 2005 and June 30, 2004 (dollar amounts in millions):
                                   
    Fiscal   Fiscal       %
    2004   2003   $ Change   Change
                 
Cash provided by (used in):
                               
 
Operating activities
  $ 130.0     $ 128.0     $ 2.0       1.6 %
 
Investing activities
    140.5       (166.3 )     306.8       184.5 %
 
Financing activities
    (139.8 )     40.6       (180.4 )     (444.1 )%
                                 
    June 30,   June 30,   $   %
    2005   2004   Change   Change
                 
Cash, cash equivalents, restricted cash and short-term investments
  $ 603.6     $ 634.0     $ (30.4 )     (4.8 )%
Working capital
    600.1       666.7       (66.6 )     (10.0 )%
2.5% contingent convertible senior notes due 2032
    169.2       169.2              
1.5% contingent convertible senior notes due 2033
    283.9       283.9              
Working Capital
      Working capital as of December 31, 2005 and June 30, 2005 consisted of the following (dollar amounts in millions):
                                     
    December 31,   June 30,   $   %
    2005   2005   Change   Change
                 
Cash, cash equivalents and short-term investments
  $ 742.5     $ 603.6     $ 138.9       23.0 %
Accounts receivable, net
    46.7       47.2       (0.5 )     (1.1 )%
Inventories, net
    19.1       20.7       (1.6 )     (7.9 )%
Deferred tax assets, net
    12.7       11.0       1.7       15.8 %
Other current assets
    12.3       16.4       (4.1 )     (25.5 )%
                         
 
Total current assets
    833.3       698.9       134.4       19.2 %
Accounts payable
    57.7       30.8       26.9       87.2 %
Short-term contract obligation
    27.4       27.4             %
Income taxes payable
    31.5       10.2       21.3       207.9 %
Other current liabilities
    24.2       30.4       (6.2 )     (20.4 )%
                         
 
Total current liabilities
    140.8       98.8       42.0       42.5 %
                         
   
Working capital
  $ 692.5     $ 600.1     $ 92.4       15.4 %
                         
      We had cash, cash equivalents and short-term investments of $742.5 million and working capital of $692.5 million at December 31, 2005, as compared to $603.6 million and $600.1 million, respectively, at June 30, 2005. The increases were primarily due to the $90.5 million termination fee received from Inamed due to the termination of the proposed merger (before expenses), and other operating cash flows generated during the Transition Period.

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      Working capital as of June 30, 2005 and June 30, 2004 consisted of the following (dollar amounts in millions):
                                   
    June 30,   June 30,   $   %
    2005   2004   Change   Change
                 
Cash, cash equivalents and short-term investments
  $ 603.6     $ 634.0     $ (30.4 )     (4.8 )%
Accounts receivable, net
    47.2       47.9       (0.7 )     (1.3 )%
Inventories, net
    20.7       19.5       1.2       5.9 %
Deferred tax assets, net
    11.0       14.1       (3.1 )     (22.0 )%
Other current assets
    16.4       18.3       (1.9 )     (10.3 )%
                         
 
Total current assets
    698.9       733.8       (34.9 )     (4.8 )%
Accounts payable
    30.8       13.9       16.9       121.6 %
Short-term contract obligation
    27.4       17.9       9.5       53.2 %
Income taxes payable
    10.2       0.7       9.5       1,337.3 %
Other current liabilities
    30.4       34.6       (4.2 )     (12.2 )%
                         
 
Total current liabilities
    98.8       67.1       31.7       47.3 %
                         
Working capital
  $ 600.1     $ 666.7     $ (66.6 )     (10.0 )%
                         
      We had cash, cash equivalents and short-term investments of $603.6 million and working capital of $600.1 million at June 30, 2005, as compared to $634.0 million and $666.7 million, respectively, at June 30, 2004. The decreases were primarily due to $150.0 million of repurchases of our Class A common stock, $30.7 million paid in respect of the SubQtm license agreement during the first quarter of fiscal 2005 (including $0.7 million of related professional fees), $5.5 million paid in respect of the Ansata development and license agreement during the second quarter of fiscal 2005 (including $0.5 million of related professional fees) and $8.3 million paid in respect of the research and development collaboration with aaiPharma during the third quarter of fiscal 2005, partially offset by operating cash flow generated during fiscal 2005 and proceeds from the exercise of stock options received during fiscal 2005.
      Management believes existing cash and short-term investments, together with funds generated from operations, should be sufficient to meet operating requirements for the foreseeable future. Our cash and short-term investments are available for strategic investments, mergers and acquisitions, and other potential large-scale needs. In addition, we may consider issuing additional debt or equity securities in the future to fund potential acquisitions or investments, to refinance existing debt or for general corporate purposes. If a material acquisition or investment is completed, our operating results and financial condition could change materially in future periods. However, no assurance can be given that additional funds will be available on satisfactory terms, or at all, to fund such activities.
Operating Activities
      Net cash provided by operating activities during the Transition Period increased 225.5%, or $102.5 million, to $148.0 million from $45.5 million during the comparable 2004 six months. Our operating cash flow for the Transition Period was generated principally by our net earnings, (including the $90.5 million termination fee received from Inamed related to the termination of the proposed merger, before expenses), adjusted for non-cash charges including depreciation and amortization.
      Net cash provided by operating activities during fiscal 2005 increased 1.6%, or $2.0 million, to $130.0 million from $128.0 million during fiscal 2004. Our operating cash flow for fiscal 2005 was generated principally by our net earnings, adjusted for non-cash charges including depreciation and amortization.
Investing Activities
      Net cash provided by investing activities during the Transition Period was $123.7 million, as compared to $76.2 million during the comparable 2004 six months. Net cash provided by investing activities during the

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Transition Period included net dispositions and maturities of available-for-sale investments of approximately $130.7 million, as compared to approximately $81.2 million during the comparable 2004 six months.
      Net cash provided by investing activities during fiscal 2005 was $140.5 million, as compared to net cash used in investing activities during fiscal 2004 of $166.3 million. Net cash provided by investing activities during fiscal 2005 included net sales of available-for-sale investments of approximately $154.1 million, as compared to net purchases of available-for-sale investments of approximately $143.1 million during fiscal 2004. Net cash used in investing activities during fiscal 2004 included $84.1 million in payments for the purchase of product rights, including $72.7 million in milestone payments to Q-Med, as compared to $3.3 million in payments for the purchase of product rights during fiscal 2005.
      On December 12, 2003, the FDA approved RESTYLANE® for use in the United States, and a payment of $53.3 million was made to Q-Med upon the occurrence of this milestone. In May 2004, we paid $19.4 million to Q-Med as a result of certain cumulative commercial milestones being achieved. We will pay Q-Med approximately $29.1 million upon FDA approval of PERLANE®.
Financing Activities
      Net cash used in financing activities during the Transition Period was $2.8 million compared to $137.4 million during the comparable 2004 six months. The change is primarily attributable to the purchase of $150.0 million of our common stock during the comparable 2004 six months while no cash was used to purchase our common stock during the Transition Period, as well as $15.7 million of proceeds from the exercise of stock options received during the comparable 2004 six months, as compared to $0.4 million received during the Transition Period.
      Net cash used in financing activities during fiscal 2005 was $139.8 million compared to net cash provided by financing activities of $40.6 million during fiscal 2004. The change is primarily attributable to the purchase of $150.0 million of our common stock during fiscal 2005 while no cash was used to purchase our common stock during fiscal 2004, as well as $16.6 million of proceeds from the exercise of stock options received during fiscal 2005, as compared to $51.4 million received during fiscal 2004.
Contingent Convertible Senior Notes and Other Long-Term Commitments
      On August 14, 2003, we exchanged $230.8 million in principal amount of our Old Notes for $283.9 million in principal amount of our New Notes. Holders of Old Notes that accepted the Company’s exchange offer received $1,230 in principal amount of New Notes for each $1,000 in principal amount of Old Notes. The terms of the New Notes are similar to the terms of the Old Notes, but have a different interest rate, conversion rate and maturity date. Holders of Old Notes that chose to not exchange will continue to be subject to the terms of the Old Notes. See Note 13 of Notes to Consolidated Financial Statements for further discussion.
      The New Notes and the Old Notes are unsecured and do not contain any restrictions on the incurrence of additional indebtedness or the repurchase of our securities, and do not contain any financial covenants. The Old Notes do not contain any restrictions on the payment of dividends. The New Notes require an adjustment to the conversion price if the cumulative aggregate of all current and prior dividend increases above $0.025 per share would result in at least a one percent (1%) increase in the conversion price. This threshold has not been reached and no adjustment to the conversion price has been made.
      Except for the Old Notes, the New Notes and deferred tax liabilities, we have no long-term liabilities and had only $140.8 million of current liabilities at December 31, 2005. Our other commitments and planned expenditures consist principally of payments we will make in connection with strategic collaborations and research and development expenditures, and we will continue to invest in sales and marketing infrastructure.
      On March 20, 2005, Medicis entered into a Senior Secured Financing Commitment Letter with Deutsche Bank Trust Company Americas and Deutsche Securities Inc. (the “Letter”). Subject to the terms and conditions of the Letter, Deutsche Bank Trust Company Americas and Deutsche Securities Inc. (“Deutsche Bank”) committed to provide $650.0 million of senior secured financing to Medicis. The Letter

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provided that the committed financing would mature in seven years and bear interest at an adjustable rate plus LIBOR. The indebtedness would have been guaranteed by the Medicis’ domestic subsidiaries and secured by all assets and stock owned by Medicis and its domestic subsidiaries. The Letter included customary conditions to funding, including, without limitation, no material adverse change to the market for credit facilities similar in nature to the facility contemplated by the Letter that has had a material adverse effect on syndication, the absence of a material adverse effect on Inamed, certain ratings requirements, the accuracy of representations and warranties of the parties, and the absence of a material adverse effect on Inamed relating to the Securities and Exchange Commission’s investigation of Inamed as disclosed in Inamed’s Annual Report on Form 10-K for the year ended December 31, 2004. The Letter was entered into in connection with the execution of the Agreement and Plan of Merger with Inamed. As a result of the termination of our merger with Inamed on December 13, 2005, the Letter was cancelled.
      We have made available to BioMarin the ability to draw down on a Convertible Note up to $25.0 million beginning July 1, 2005 (the “Convertible Note”). The Convertible Note is convertible based on certain terms and conditions including a change of control provision. Money advanced under the Convertible Note is convertible into BioMarin shares at a strike price equal to the BioMarin average closing price for the 20 trading days prior to such advance. The Convertible Note matures on the option purchase date in 2009 as defined in the Securities Purchase Agreement entered into on May 18, 2004 (the “Securities Purchase Agreement”) but may be repaid by BioMarin at any time prior to the option purchase date. As of March 10, 2006, BioMarin has not requested any monies to be advanced under the Convertible Note, and no amounts are outstanding.
Repurchases of Common Stock
      In May 2003, our Board of Directors approved a new repurchase program that authorized the repurchase of up to $75.0 million of our common stock. This program provided for the repurchase of Class A common stock at such times as management determined. As of June 30, 2004, we had not repurchased any shares of our Class A common stock under this program. In August 2004, our Board of Directors approved a new program that replaced the May 2003 program, which authorized the repurchase of up to $150.0 million of our Class A common stock. During the first two quarters of fiscal 2005, we purchased a total of 3,921,086 shares of our Class A common stock in the open market at an average price of $38.25 per share, for an aggregate purchase price of approximately $150.0 million. As the purchase limit had been reached, the plan was terminated during the second quarter of fiscal 2005.
Dividends
      Since the beginning of fiscal 2004, we have paid quarterly cash dividends aggregating approximately $15.2 million on our common stock. In addition, on December 14, 2005, we declared a cash dividend of $0.03 per issued and outstanding share of common stock payable on January 31, 2006 to our stockholders of record at the close of business on January 3, 2006. Prior to these dividends, we had not paid a cash dividend on our common stock, and we have not adopted a dividend policy. Any future determinations to pay cash dividends will be at the discretion of our Board of Directors and will be dependent upon our financial condition, operating results, capital requirements and other factors that our Board of Directors deems relevant.
Line of Credit
      We have a revolving line of credit facility of up to $25.0 million from Wells Fargo Bank, N.A. The facility may be drawn upon by us, at our discretion, and is collateralized by certain short-term investments. Any outstanding balance of the credit facility bears interest at a floating rate of 150 basis points in excess of the 30-day London Interbank Offered Rate and expires in November 2006. The agreement requires us to comply with certain covenants, including covenants relating to our financial condition and results of operations; we are in compliance with such covenants. We have never drawn on this credit facility.

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Off-Balance Sheet Arrangements
      As of December 31, 2005, we are not involved in any off-balance sheet arrangements, as defined in Item 3(a)(4)(ii) of SEC Regulation S-K.
Contractual Obligations
      The following table summarizes our significant contractual obligations at December 31, 2005, and the effect such obligations are expected to have on our liquidity and cash flows in future periods. This table excludes amounts already recorded on our balance sheet as current liabilities at December 31, 2005 or certain other purchase obligations as discussed below (in thousands):
                                         
    Payments Due By Period
     
        More Than   More Than    
        1 Year and   3 Years and    
        Less Than   Less Than   Less Than   More Than
    Total   1 Year   3 Years   5 Years   5 Years
                     
Long-term debt
  $ 453,065     $     $     $     $ 453,065  
Interest on long-term debt
    229,178       8,488       16,975       16,975       186,740  
Operating leases
    10,605       2,112       4,217       4,276        
Other purchase obligations and commitments
    867       173       347       347        
                               
Total contractual obligations
  $ 693,715     $ 10,773     $ 21,539     $ 21,598     $ 639,805  
                               
      The long-term debt consists of the Company’s Old Notes and New Notes. The table above reflects the maturity date of debt. However, the Company may redeem some or all of the Old Notes and New Notes at any time on or after June 11, 2007 and June 11, 2008, respectively, at a redemption price, payable in cash, of 100% of the principal amount, plus accrued and unpaid interest, including contingent interest, if any. Holders of the Old Notes and New Notes may require the Company to repurchase all or a portion of their Old Notes on June 4, 2007, 2012 and 2017 and New Notes on June 4, 2008, 2013 and 2018, or upon a change in control, as defined in the indenture agreements governing the Old Notes and New Notes, at 100% of the principal amount of the Old Notes and New Notes, plus accrued and unpaid interest to the date of the repurchase, payable in cash.
      Interest on long-term debt includes interest payable on our Old Notes and New Notes, assuming the Old Notes and New Notes will not have any redemptions or conversions into shares of our Class A common stock until their respective maturities in 2032 and 2033, but does not include any contingent interest. The amount of interest ultimately paid in future years could change if any of the Old Notes or New Notes are converted or redeemed and/or if contingent interest becomes payable if certain future criteria are met.
      Other purchase obligations and commitments include payments due under research and development and consulting contracts.
      We have committed to make potential future “milestone” payments to third-parties as part of certain product development and license agreements. Payments under these agreements generally become due and payable only upon achievement of certain developmental, regulatory and/or commercial milestones. Because the achievement and timing of these milestones are not fixed or reasonably determinable, such contingencies have not been recorded on our consolidated balance sheets and are not included in the above table. The total amount of potential future milestone payments related to development and license agreements is approximately $101.8 million.
      Purchase orders for raw materials, finished goods and other goods and services are not included in the above table. We are not able to determine the aggregate amount of such purchase orders that represent contractual obligations, as purchase orders may represent authorizations to purchase rather than binding agreements. For the purpose of this table, contractual obligations for purchase of goods or services are defined as agreements that are enforceable and legally binding on us and that specify all significant terms, including:

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fixed or minimum quantities to be purchased; fixed, minimum or variable price provisions; and the approximate timing of the transaction. Our purchase orders are based on our current manufacturing needs and are fulfilled by our vendors with relatively short timetables. We do not have significant agreements for the purchase of raw materials or finished goods specifying minimum quantities or set prices that exceed our short-term expected requirements. We also enter into contracts for outsourced services; however, the obligations under these contracts were not significant and the contracts generally contain clauses allowing for cancellation without significant penalty.
      The expected timing of payment of the obligations discussed above is estimated based on current information. Timing of payments and actual amounts paid may be different depending on the time of receipt of goods or services or changes to agreed-upon amounts for some obligations.
Critical Accounting Policies and Estimates
      The discussion and analysis of our financial condition and results of operations are based upon our consolidated financial statements, which have been prepared in conformity with U.S. generally accepted accounting principles. The preparation of the consolidated financial statements requires us to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. On an ongoing basis, we evaluate our estimates related to sales allowances, chargebacks, rebates, returns and other pricing adjustments, depreciation and amortization and other contingencies and litigation. We base our estimates on historical experience and various other factors related to each circumstance. Actual results could differ from those estimates based upon future events, which could include, among other risks, changes in the regulations governing the manner in which we sell our products, changes in the health care environment and managed care consumption patterns. Our significant accounting policies are described in Note 2 to the consolidated financial statements included in this report. We believe the following critical accounting policies affect our most significant estimates and assumptions used in the preparation of our consolidated financial statements and are important in understanding our financial condition and results of operations.
Revenue Recognition
      Revenue from our product sales is recognized pursuant to Staff Accounting Bulletin No. 104 (SAB 104), “Revenue Recognition in Financial Statements.” Accordingly, revenue is recognized when all four of the following criteria are met: (i) persuasive evidence that an arrangement exists; (ii) delivery of the products has occurred; (iii) the selling price is both fixed and determinable; and (iv) collectibility is reasonably assured. Our customers consist primarily of large pharmaceutical wholesalers who sell directly into the retail channel.
      We do not provide any forms of price protection to our wholesale customers and permit product returns if the product is damaged, or if it is returned within six months prior to expiration or up to 12 months after expiration. Our customers consist principally of financially viable wholesalers, and depending on the customer, revenue is recognized based upon shipment (“FOB shipping point”) or receipt (“FOB destination”), net of estimated provisions.
      We enter into licensing arrangements with other parties whereby we receive contract revenue based on the terms of the agreement. The timing of revenue recognition is dependent on the level of our continuing involvement in the manufacture and delivery of licensed products. If we have continuing involvement, the revenue is deferred and recognized on a straight-line basis over the period of continuing involvement. In addition, if our licensing arrangements require no continuing involvement and payments are merely based on the passage of time, we will assess such payments for revenue recognition under the collectibility criteria of SAB 104.
Items Deducted From Gross Revenue
      Provisions for estimates for product returns and exchanges, sales discounts, chargebacks, managed care and Medicaid rebates and other adjustments are established as a reduction of product sales revenues at the time such revenues are recognized. These deductions from gross revenue are established by us as our best

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estimate at the time of sale based on historical experience adjusted to reflect known changes in the factors that impact such reserves. These deductions from gross revenue are generally reflected either as a direct reduction to accounts receivable through an allowance, or as an addition to accrued expenses if the payment is due to a party other than the wholesale or retail customer.
      Our accounting policies for revenue recognition have a significant impact on our reported results and rely on certain estimates that require complex and subjective judgment on the part of our management. If the levels of product returns and exchanges, cash discounts, chargebacks, managed care and Medicaid rebates and other adjustments fluctuate significantly and/or if our estimates do not adequately reserve for these reductions of gross product revenues, our reported net product revenues could be negatively affected.
Product Returns and Exchanges
      We account for returns and exchanges of product in accordance with SFAS 48, “Revenue Recognition When Right of Return Exists,” whereby an allowance is established based on our estimate of revenues recorded for which the related products are expected to be returned in the future. We determine our estimate of product returns and exchanges based on historical experience and other qualitative factors that could impact the level of future product returns and exchanges. These factors include estimated shelf life, competitive developments including introductions of generic products, product discontinuations and our introduction of new formulations of our products. Typically, these other factors that influence our allowance for product returns and exchanges do not change significantly from quarter to quarter. Historical experience and the other qualitative factors are assessed on a product-specific basis as part of our compilation of our estimate of future product returns and exchanges. Estimates for returns and exchanges of new products are based on historical experience of new products at various stages of their life cycle.
      Our actual experience and the qualitative factors that we use to determine the necessary allowance for future product returns and exchanges are susceptible to change based on unforeseen events and uncertainties. We review our allowance for product returns and exchanges quarterly to assess the trends being considered to estimate the allowance, and make changes to the allowance as necessary.
Sales Discounts
      We offer cash discounts to our customers as an incentive for prompt payment, generally approximately 2% of the sales price. We account for cash discounts by establishing an allowance reducing accounts receivable by the full amount of the discounts expected to be taken by the customers.
Contract Chargebacks
      We have agreements for contract pricing with several entities, whereby pricing on products is extended below wholesaler list price. These parties purchase products through wholesalers at the lower contract price, and the wholesalers charge the difference between their acquisition cost and the lower contract price back to us. We account for chargebacks by establishing an allowance reducing accounts receivable based on our estimate of chargeback claims attributable to a sale. We determine our estimate of chargebacks based on historical experience and changes to current contract prices. We also consider our claim processing lag time, and adjust the allowance periodically throughout each quarter to reflect actual experience.
Managed Care and Medicaid Rebates
      We establish and maintain reserves for amounts payable by us to managed care organizations and state Medicaid programs for the reimbursement of portions of the retail price of prescriptions filled that are covered by these programs. The amounts estimated to be paid relating to products sold are recognized as deductions from gross revenue and as additions to accrued expenses at the time of sale based on our best estimate of the expected prescription fill rate to these managed care and state Medicaid patients, using historical experience adjusted to reflect known changes in the factors that impact such reserves, including changes in formulary status and contractual pricing.

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Other
      In addition to the significant items deducted from gross revenue described above, we deduct other items from gross revenue. For example, we offer consumer rebates on many of our products and a consumer loyalty program for our RESTYLANE® dermal filler product. We generally account for these other items deducted from gross revenue by establishing an accrual based on our estimate of the adjustments attributable to a sale. We generally base our estimates for the accrual of these items deducted from gross sales on historical experience and other relevant factors. We adjust our accruals periodically throughout each quarter based on actual experience and changes in other factors, if any.
      We believe that our allowances and accruals for items that are deducted from gross revenue are reasonable and appropriate based on current facts and circumstances. However, it is possible that other parties applying reasonable judgment to the same facts and circumstances could develop different allowance and accrual amounts for items that are deducted from gross revenue. Additionally, changes in actual experience or changes in other qualitative factors could cause our allowances and accruals to fluctuate. A five percent change in the amounts related to the allowances and accruals described above would lead to an approximate $5.9 million annual effect on our income before income tax expense, based on the amount of sales allowances we recognized during fiscal 2005 related to the allowances and accruals described above.
Share-Based Compensation
      As part of our adoption of SFAS No. 123R as of July 1, 2005, we were required to recognize the fair value of share-based compensation awards as an expense. We apply the Black-Scholes option-pricing model in order to determine the fair value of stock options on the date of grant, and we apply judgment in estimating key assumptions that are important elements in the model, such as the expected stock-price volatility, expected stock option life and expected forfeiture rates. Our estimates of these important assumptions are based on historical data and judgment regarding market trends and factors.
      If actual results are not consistent with our assumptions and judgments used in estimating these factors, we may be required to record additional stock-based compensation expense or income tax expense, which could be material to our results of operations.
Long-lived Assets
      We assess the impairment of long-lived assets when events or changes in circumstances indicate that the carrying value of the assets may not be recoverable. Factors that we consider in deciding when to perform an impairment review include significant under-performance of a product line in relation to expectations, significant negative industry or economic trends, and significant changes or planned changes in our use of the assets. Recoverability of assets that will continue to be used in our operations is measured by comparing the carrying amount of the asset grouping to our estimate of the related total future net cash flows. If an asset carrying value is not recoverable through the related cash flows, the asset is considered to be impaired. The impairment is measured by the difference between the asset grouping’s carrying amount and its fair value, based on the best information available, including market prices or discounted cash flow analysis.
      When we determine that the useful lives of assets are shorter than we had originally estimated, and there are sufficient cash flows to support the carrying value of the assets, we accelerate the rate of amortization charges in order to fully amortize the assets over their new shorter useful lives.
      During the Transition Period, an impairment charge of approximately $9.2 million was recognized related to our review of long-lived assets. No acceleration of amortization was recorded during the Transition Period. This process requires the use of estimates and assumptions, which are subject to a high degree of judgment. If these assumptions change in the future, we may be required to record additional impairment charges for, and/or accelerate amortization of, long-lived assets.

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Income Taxes
      Income taxes are determined using an annual effective tax rate, which generally differs from the U.S. Federal statutory rate because of state and local income taxes, tax-exempt interest, charitable contribution deductions, nondeductible expenses and research and experimentation tax credits available in the U.S.. Our effective tax rate may be subject to fluctuations during the fiscal year as new information is obtained which may affect the assumptions we use to estimate our annual effective tax rate, including factors such as our mix of pre-tax earnings in the various tax jurisdictions in which we operate, valuation allowances against deferred tax assets, reserves for tax audit issues and settlements, utilization of research and experimentation tax credits and changes in tax laws in jurisdictions where we conduct operations. We recognize deferred tax assets and liabilities for temporary differences between the financial reporting basis and the tax basis of our assets and liabilities. We record valuation allowances against our deferred tax assets to reduce the net carrying value to an amount that management believes is more likely than not to be realized.
      Based on the Company’s historical pre-tax earnings, management believes it is more likely than not that the Company will realize the benefit of the existing net deferred tax assets at December 31, 2005. Management believes the existing net deductible temporary differences will reverse during periods in which the Company generates net taxable income; however, there can be no assurance that the Company will generate any earnings or any specific level of continuing earnings in future years. Certain tax planning or other strategies could be implemented, if necessary, to supplement income from operations to fully realize recorded tax benefits.
Research and Development Costs and Accounting for Strategic Collaborations
      All research and development costs, including payments related to products under development and research consulting agreements, are expensed as incurred. We may continue to make non-refundable payments to third parties for new technologies and for research and development work that has been completed. These payments may be expensed at the time of payment depending on the nature of the payment made.
      Our policy on accounting for costs of strategic collaborations determines the timing of our recognition of certain development costs. In addition, this policy determines whether the cost is classified as development expense or capitalized as an asset. We are required to form judgments with respect to the commercial status of such products in determining whether development costs meet the criteria for immediate expense or capitalization. For example, when we acquire certain products for which there is already an ANDA or NDA available, and there is net realizable value based on projected sales for these products, we capitalize the amount paid as an intangible asset. In addition, if we acquire product rights that are in the development phase and as to which we have no assurance that the third party is required to perform additional research efforts, we expense such payments.
Legal Contingencies
      We record contingent liabilities resulting from asserted and unasserted claims against us, when it is probable that a liability has been incurred and the amount of the loss is reasonably estimable. We disclose material contingent liabilities, when there is a reasonable possibility, that the ultimate loss will exceed the recorded liability. Estimating probable losses requires analysis of multiple factors, in some cases including judgments about the potential actions of third-party claimants and courts. Therefore, actual losses in any future period are inherently uncertain. We currently are involved in certain legal proceedings. We do not believe these proceedings will have a material adverse effect on our consolidated financial position. It is possible, however, that future results of operations for any particular quarterly or annual period could be materially affected by changes in our assumptions or the effectiveness of our strategies related to these proceedings.

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Recent Accounting Pronouncements
      In October 2005, the FASB issued FASB Staff Position (“FSP”) No. 123R-2, Practical Accommodation to the Application of Grant Date as Defined in FASB Statement No. 123R, to provide guidance on determining the grant date for an award as defined in SFAS No. 123R. This FSP stipulates that assuming all other criteria in the grant date definition are met, a mutual understanding of the key terms and conditions of an award to an individual employee is presumed to exist upon the award’s approval in accordance with the relevant corporate governance requirements, provided that the key terms and conditions of an award (a) cannot be negotiated by the recipient with the employer because the award is a unilateral grant, and (b) are expected to be communicated to an individual recipient within a relatively short time period from the date of approval. We have applied the principles set forth in this FSP upon its adoption of SFAS No. 123R.
      In November 2005, the FASB issued FSP No. 123R-3, Transition Election to Accounting for the Tax Effects of Share-Based Payment Awards. This FSP requires an entity to follow either the transition guidance for the additional-paid-in-capital pool as prescribed in SFAS No. 123R, or the alternative transition method as described in the FSP. An entity that adopts SFAS No. 123R using the modified prospective application may make a one-time election to adopt the transition method described in this FSP. This FSP became effective in November 2005. We will continue to evaluate the impact that the adoption of this FSP could have on our financial statements as we have until one year from the later of our initial adoption of SFAS No. 123R or the effective date of this FSP to evaluate our available transition alternatives and make our one-time election.
      In December 2004, the FASB issued SFAS No. 153, Exchanges of Nonmonetary Assets (“SFAS No. 153”), an amendment of APB Opinion No. 29 Accounting for Nonmonetary Transactions (“APB No. 29”). SFAS No. 153 eliminates the exception from fair value measurement for nonmonetary exchanges of similar productive assets in paragraph 21 (b) of APB No. 29, and replaces it with an exception for exchanges that do not have commercial substance. SFAS No. 153 specifies that a nonmonetary exchange has commercial substance if the future cash flows of the entity are expected to change significantly as a result of the exchange. SFAS No. 153 is effective for the fiscal periods beginning after June 15, 2005 and we will adopt this Statement in the first quarter of fiscal 2006. We currently does not anticipate that the effects of the statement will materially affect its consolidated financial position or consolidated results of operations upon adoption.
      In May 2005, the FASB issued SFAS No. 154, Accounting Changes and Error Corrections — A Replacement of APB Opinion No. 20 and FASB Statement No. 3 (“SFAS No. 154”). SFAS No. 154 requires the retrospective application to prior periods’ financial statements of changes in accounting principle, unless it is impractical to determine either the period-specific effects or cumulative effect of the accounting change. SFAS No. 154 also requires that a change in depreciation, amortization, or depletion method for long-lived non-financial assets be accounted for as a change in accounting estimate affected by a change in accounting principle. SFAS No. 154 is affective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005 and we will adopt this provision, as applicable, during fiscal year 2006.
      In November 2005, the FASB issued FSP FAS 115-1 and FAS 124-1, The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments (“FSP 115-1”), which provides guidance on determining when investments in certain debt and equity securities are considered impaired, whether that impairment is other-than-temporary, and on measuring such impairment loss. FSP 115-1 also includes accounting considerations subsequent to the recognition of other-than temporary impairment and requires certain disclosures about unrealized losses that have not been recognized as other-than-temporary impairments. FSP 115-1 is required to be applied to reporting periods beginning after December 15, 2005 and is required to be adopted by us in the first quarter of fiscal 2006. We are currently evaluating the effect that the adoption of FSP 115-1 will have on our consolidated results of operations and financial condition but do not expect it to have a material impact.
Item 7A. Quantitative and Qualitative Disclosure About Market Risk
      At December 31, 2005, $446.2 million of our cash equivalent investments are in money market securities that are reflected as cash equivalents, because all maturities are within 90 days. Included in money market

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securities are commercial paper, Federal agency discount notes and money market funds. Our interest rate risk with respect to these investments is limited due to the short-term duration of these arrangements and the yields earned, which approximate current interest rates.
      Our investment portfolio, consisting of fixed income securities that we hold on an available-for-sale basis, was approximately $295.5 million as of December 31, 2005, $425.8 million as of June 30, 2005, and $587.4 million as of June 30, 2004. These securities, like all fixed income instruments, are subject to interest rate risk and will decline in value if market interest rates increase. We have the ability to hold our fixed income investments until maturity and, therefore, we would not expect to recognize any material adverse impact in income or cash flows if market interest rates increase. The following table provides information about our available-for-sale securities that are sensitive to changes in interest rates. We have aggregated our available-for-sale securities for presentation purposes since they are all very similar in nature (dollar amounts in thousands):
Interest Rate Sensitivity
Principal Amount by Expected Maturity as of December 31, 2005
                                                 
    Financial Instruments Mature During Year Ended December 31,
     
    2006   2007   2008   2009   2010   Thereafter
                         
Available-for-sale securities
  $ 97,560     $ 20,883     $ 4,897     $ 2,464     $ 749     $ 167,350  
Weighted-average yield rate
    2.91 %     3.89 %     2.64 %     3.62 %     3.09 %     4.33 %
Contingent convertible senior notes due 2032
  $     $     $     $     $     $ 169,155  
Interest rate
                                  2.5 %
Contingent convertible senior notes due 2033
  $     $     $     $     $     $ 283,910  
Interest rate
                                  1.5 %
      Changes in interest rates do not affect interest expense incurred on our Contingent Convertible Senior Notes as the interest rates are fixed. We have not entered into derivative financial instruments. We have minimal operations outside of the United States and, accordingly, we have not been susceptible to significant risk from changes in foreign currencies.
      During the normal course of business we could be subjected to a variety of market risks, examples of which include, but are not limited to, interest rate movements and foreign currency fluctuations, as we discussed above, and collectibility of accounts receivable. We continuously assess these risks and have established policies and procedures to protect against the adverse effects of these and other potential exposures. Although we do not anticipate any material losses in these risk areas, no assurance can be made that material losses will not be incurred in these areas in the future.
Item 8. Financial Statements and Supplementary Data
      Our financial statements and related financial statement schedule at December 31, 2005, June 30, 2005 and June 30, 2004, and for the Transition Period, the comparable 2004 six months, and each of the three years in the period ended June 30, 2005 and the Independent Registered Public Accounting Firm’s Report are incorporated herein by reference to the financial statements set forth in Item 15 of Part IV of this report.
Item 9. Changes in and Disagreements with Accountants and Financial Disclosure
      None.
Item 9A. Controls and Procedures
      Medicis maintains disclosure controls and procedures that are designed to ensure that information required to be disclosed in reports filed by Medicis under the Securities Exchange Act of 1934, as amended, is

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recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms and that such information is accumulated and communicated to Medicis’ management, including its Chief Executive Officer and Chief Financial Officer, as appropriate, to allow for timely decisions regarding required disclosure. Our Chief Executive Officer and Chief Financial Officer evaluated, with the participation of other members of management, the effectiveness of Medicis’ disclosure controls and procedures (as defined in Exchange Act Rule 15d-15(e)), as of the end of the period covered by this Transition Report on Form 10-K/ T. Based on this evaluation, our Chief Executive Officer and Chief Financial Officer concluded that the Company’s disclosure controls and procedures were effective at the reasonable assurance level.
      Although the management of our Company, including the Chief Executive Officer and the Chief Financial Officer, believes that our disclosure controls and internal controls currently provide reasonable assurance that our desired control objectives have been met, management does not expect that our disclosure controls or internal controls will prevent all error and all fraud. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within our Company have been detected. These inherent limitations include the realities that judgments in decision-making can be faulty, and that breakdowns can occur because of simple error or mistake. Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the controls. The design of any system of controls is also based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions.
      There were no significant changes in our internal controls over financial reporting identified in connection with this evaluation that occurred during our last fiscal quarter that have materially affected, or are reasonably likely to materially affect, Medicis’ internal controls over financial reporting.
Management’s Report on Internal Control over Financial Reporting
      The management of Medicis Pharmaceutical Corporation is responsible for establishing and maintaining adequate internal control over financial reporting as such term is defined in Exchange Act Rules 13a-15(f) and 15d-15(f). Our internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with accounting principles generally accepted in the United States of America.
      Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.
      Under the supervision and with the participation of the Chief Executive Officer and Chief Financial Officer, management conducted an evaluation of the effectiveness of its internal control over financial reporting as of December 31, 2005. The framework on which such evaluation was based is contained in the report entitled “Internal Control — Integrated Framework” issued by the Committee of Sponsoring Organizations of the Treadway Commission (the “COSO Report”). Based on that evaluation and the criteria set forth in the COSO Report, management concluded that its internal control over financial reporting was effective as of December 31, 2005.
      Our independent registered public accounting firm, Ernst & Young LLP, who also audited our consolidated financial statements, audited management’s assessment and independently assessed the effectiveness of our internal control over financial reporting. Ernst & Young LLP has issued their attestation report, which is included in Item 15 of this Form 10-K/ T.

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Item 9B. Other Information
      None.
PART III
Item 10. Directors and Executive Officers of the Registrant
      The Company has adopted a written code of ethics, “Medicis Pharmaceutical Corporation Code of Business Conduct and Ethics,” which is applicable to all directors, officers and employees of the Company, including the Company’s principal executive officer, principal financial officer, principal accounting officer or controller and other executive officers identified pursuant to this Item 10 who perform similar functions (collectively, the “Selected Officers”). In accordance with the rules and regulations of the SEC, a copy of the code is available on the Company’s website. The Company will disclose any changes in or waivers from its code of ethics applicable to any Selected Officer on its website at http://www.medicis.com or by filing a Form 8-K.
      The Company has filed, as exhibits to this Annual Report on Form 10-K/ T for the year ended December 31, 2005, the certifications of its Chief Executive Officer and Chief Financial Officer required pursuant to Section 302 of the Sarbanes-Oxley Act of 2004.
      On December 30, 2005, the Company submitted to the New York Stock Exchange the Annual CEO Certification required pursuant to Section 303A.12(a) of the New York Stock Exchange Listed Company Manual.
      The information in the section entitled “Section 16(a) Beneficial Ownership Reporting Compliance”, “Directors, Director Nominees and Executive Officers” and “Committee Meetings” in the Proxy Statement is incorporated herein by reference.
Item 11. Executive Compensation
      The information to be included in the sections entitled “Executive Compensation” and “Director Compensation” in the Proxy Statement is incorporated herein by reference.
Item 12. Security Ownership of Certain Beneficial Owners and Management
      The information to be included in the section entitled “Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters” in the Proxy Statement is incorporated herein by reference.
Item 13. Certain Relationships and Related Transactions
      The information to be included in the sections entitled “Certain Relationships and Related Transactions” and “Compensation Committee Interlocks and Insider Participation” in the Proxy Statement is incorporated herein by reference.
Item 14. Principal Accountant Fees and Services
      The information to be included in the section entitled “Independent Registered Public Accounting Firm Fees” in the Proxy Statement is incorporated herein by reference.

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PART IV
Item 15. Exhibits, Financial Statement Schedules
               
            Page
             
(a)
  Documents filed as a part of this Report    
    (1)   Financial Statements:    
        Index to consolidated financial statements   F-1
        Reports of Independent Registered Public Accounting Firm   F-2
        Consolidated balance sheets as of December 31, 2005, June 30, 2005 and June 30, 2004   F-4
        Consolidated statements of income for the six months ended December 31, 2005 and 2004 (unaudited) and the fiscal years ended June 30, 2005, 2004 and 2003   F-6
        Consolidated statements of stockholders’ equity for the six months ended December 31, 2005 and the fiscal years ended June 30, 2005, 2004 and 2003   F-7
        Consolidated statements of cash flows for the six months ended December 31, 2005 and 2004 (unaudited) and the fiscal years ended June 30, 2005, 2004 and 2003   F-9
        Notes to consolidated financial statements   F-10
    (2)   Financial Statement Schedule:    
        Schedule II — Valuation and Qualifying Accounts   S-1
          This financial statement schedule should be read in conjunction with the consolidated financial statements. Financial statement schedules not included in this Annual Report on Form 10-K/T have been omitted because they are not applicable or the required information is shown in the financial statements or notes thereto.    
    (3)   Exhibits filed as part of this Report:    
         
Exhibit No.   Description
     
  2 .1   Agreement of Merger by and between the Company, Medicis Acquisition Corporation and GenDerm Corporation, dated November 28, 1997(11)
  2 .2   Agreement of Plan of Merger, dated as of October 1, 2001, by and among the Company, MPC Merger Corp. and Ascent Pediatrics, Inc.(17)
  3 .1   Certificate of Incorporation of the Company, as amended(23)
  3 .2   Amended and Restated By-Laws of the Company(13)
  4 .1   Amended and Restated Rights Agreement, dated as of August 17, 2005, between the Company and Wells Fargo Bank, N.A., as Rights Agent(26)
  4 .2   Indenture, dated as of August 19, 2003, by and between the Company, as issuer, and Deutsche Bank Trust Company Americas, as trustee(23)
  4 .3   Indenture, dated as of June 4, 2002, by and between the Company, as issuer, and Deutsche Bank Trust Company Americas, as trustee(19)
  4 .4   Supplemental Indenture dated as of February 1, 2005 to Indenture dated as of August 19, 2003 between the Company and Deutsche Bank Trust Company Americas as Trustee(25)
  4 .5   Registration Rights Agreement, dated as of June 4, 2002, by and between the Company and Deutsche Bank Securities Inc.(19)
  4 .6   Form of specimen certificate representing Class A common stock(1)
  10 .1   Asset Purchase Agreement among the Company, Ascent Pediatrics, Inc., BioMarin Pharmaceutical Inc., and BioMarin Pediatrics Inc., dated April 20, 2004(23)
  10 .2   Merger Termination Agreement, dated as of December 13, 2005, by and among the Company, Masterpiece Acquisition Corp., and Inamed Corporation(31)

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Exhibit No.   Description
     
  10 .3   Securities Purchase Agreement among the Company, Ascent Pediatrics, Inc., BioMarin Pharmaceutical Inc. and BioMarin Pediatrics Inc., dated May 18, 2004(23)
  10 .4   Termination Agreement dated October 19, 2005 between the Company and Michael A. Pietrangelo(28)
  10 .5   License Agreement among the Company, Ascent Pediatrics, Inc. and BioMarin Pediatrics Inc., dated May 18, 2004(23)
  10 .6   Medicis Pharmaceutical Corporation 1995 Stock Option Plan (incorporated by reference to Exhibit C to the definitive Proxy Statement for the 1995 Annual Meeting of Shareholders previously filed with the SEC, File No. 0-18443)
  10 .7(a)   Employment Agreement between the Company and Jonah Shacknai, dated July 24, 1996(8)
  10 .7(b)   Amendment to Employment Agreement by and between the Company and Jonah Shacknai, dated April 1, 1999(15)
  10 .7(c)   Amendment to Employment Agreement by and between the Company and Jonah Shacknai, dated February 21, 2001(15)
  10 .7(d)   Third Amendment, dated December 30, 2005, to Employment Agreement between the Company and Jonah Shacknai(32)
  10 .8   Medicis Pharmaceutical Corporation 2001 Senior Executive Restricted Stock Plan(30)
  10 .9(a)   Medicis Pharmaceutical Corporation 2002 Stock Option Plan(20)
  10 .9(b)   Amendment No. 1 to the Medicis Pharmaceutical Corporation 2002 Stock Option Plan, dated August 1, 2005(29)
  10 .10(a)   Medicis Pharmaceutical Corporation 2004 Stock Incentive Plan(27)
  10 .10(b)   Amendment No. 1 to the Medicis Pharmaceutical Corporation 2004 Stock Option Plan, dated August 1, 2005(29)
  10 .11(a)   Medicis Pharmaceutical Corporation 1998 Stock Option Plan(33)
  10 .11(b)   Amendment No. 1 to the Medicis Pharmaceutical Corporation 1998 Stock Option Plan, dated August 1, 2005(29)
  10 .11(c)   Amendment No. 2 to the Medicis Pharmaceutical Corporation 1998 Stock Option Plan, dated September 30, 2005(29)
  10 .12(a)   Medicis Pharmaceutical Corporation 1996 Stock Option Plan(34)
  10 .12(b)   Amendment No. 1 to the Medicis Pharmaceutical Corporation 1996 Stock Option Plan, dated August 1, 2005(29)
  10 .13   Waiver Letter dated March 18, 2005 between the Company and Q-Med AB(27)
  10 .14   Supply Agreement, dated October 21, 1992, between Schein Pharmaceutical and the Company(2)
  10 .15   Amendment to Manufacturing and Supply Agreement, dated March 2, 1993, between Schein Pharmaceutical and the Company(3)
  10 .16(a)   Credit and Security Agreement, dated August 3, 1995, between the Company and Norwest Business Credit, Inc.(5)
  10 .16(b)   First Amendment to Credit and Security Agreement, dated May 29, 1996, between the Company and Norwest Bank Arizona, N.A.(8)
  10 .16(c)   Second Amendment to Credit and Security Agreement, dated November 22, 1996, by and between the Company and Norwest Bank Arizona, N.A. as successor-in-interest to Norwest Business Credit, Inc.(10)
  10 .16(d)   Third Amendment to Credit and Security Agreement, dated November 22, 1998, by and between the Company and Norwest Bank Arizona, N.A., as successor-in-interest to Norwest Business Credit, Inc.(12)

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Exhibit No.   Description
     
  10 .16(e)   Fourth Amendment to Credit and Security Agreement, dated November 22, 2000, by and between the Company and Wells Fargo Bank Arizona, N.A., formerly known as Norwest Bank Arizona, N.A., as successor-in-interest to Norwest Business Credit, Inc.(16)
  10 .16(f)   Fifth Amendment to Credit and Security Agreement, dated November 22, 2002, by and between the Company and Wells Fargo Bank Arizona, N.A., formerly known as Norwest Bank Arizona, N.A., as successor-in-interest to Norwest Business Credit, Inc.(23)
  10 .17(a)   Patent Collateral Assignment and Security Agreement, dated August 3, 1995, by the Company to Norwest Business Credit, Inc.(6)
  10 .17(b)   First Amendment to Patent Collateral Assignment and Security Agreement, dated May 29, 1996, by the Company to Norwest Bank Arizona, N.A.(8)
  10 .17(c)   Amended and Restated Patent Collateral Assignment and Security Agreement, dated November 22, 1998, by the Company to Norwest Bank Arizona, N.A.(12)
  10 .18(a)   Trademark Collateral Assignment and Security Agreement, dated August 3, 1995, by the Company to Norwest Business Credit, Inc.(7)
  10 .18(b)   First Amendment to Trademark Collateral Assignment and Security Agreement, dated May 29, 1996, by the Company to Norwest Bank Arizona, N.A.(8)
  10 .18(c)   Amended and Restated Trademark, Tradename, and Service Mark Collateral Assignment and Security Agreement, dated November 22, 1998, by the Company to Norwest Bank Arizona, N.A.(12)
  10 .19   Assignment and Assumption of Loan Documents, dated May 29, 1996, from Norwest Business Credit, Inc., to and by Norwest Bank Arizona, N.A.(8)
  10 .20   Multiple Advance Note, dated May 29, 1996, from the Company to Norwest Bank Arizona, N.A.(8)
  10 .21   Asset Purchase Agreement dated November 15, 1998, by and among the Company and Hoechst Marion Roussel, Inc., Hoechst Marion Roussel Deutschland GMHB and Hoechst Marion Roussel, S.A.(12)
  10 .22   License and Option Agreement dated November 15, 1998, by and among the Company and Hoechst Marion Roussel, Inc., Hoechst Marion Roussel Deutschland GMBH and Hoechst Marion Roussel, S.A.(12)
  10 .23   Loprox Lotion Supply Agreement dated November 15, 1998, by and between the Company and Hoechst Marion Roussel, Inc.(12)
  10 .24   Supply Agreement dated November 15, 1998, by and between the Company and Hoechst Marion Roussel Deutschland GMBH(12)
  10 .25   Asset Purchase Agreement effective January 31, 1999, between the Company and Bioglan Pharma Plc(14)
  10 .26   Stock Purchase Agreement by and among the Company, Ucyclyd Pharma, Inc. and Syed E. Abidi, William Brusilow, Susan E. Brusilow and Norbert L. Wiech, dated April 19, 1999(14)
  10 .27   Asset Purchase Agreement by and between the Company and Bioglan Pharma Plc, dated June 29, 1999(14)
  10 .28   Asset Purchase Agreement by and among The Exorex Company, LLC, Bioglan Pharma Plc, the Company and IMX Pharmaceuticals, Inc., dated June 29, 1999(16)
  10 .29   Medicis Pharmaceutical Corporation Executive Retention Plan(14)
  10 .30   Asset Purchase Agreement between Warner Chilcott, plc and the Company, dated September 14, 1999(14)
  10 .31(a)   Share Purchase Agreement between Q-Med International B.V. and Startskottet 21914 AB (under proposed change of name to Medicis Sweden Holdings AB), dated February 10, 2003(21)

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Exhibit No.   Description
     
  10 .31(b)   Amendment No. 1 to Share Purchase Agreement between Q-Med International B.V. and Startskottet 21914 AB (under proposed change of name to Medicis Sweden Holdings AB), dated March 7, 2003(21)
  10 .32   Supply Agreement between Q-Med AB and the Company, dated March 7, 2003(21)
  10 .33   Amended and Restated Intellectual Property Agreement between Q-Med AB and HA North American Sales AB, dated March 7, 2003(21)
  10 .34   Supply Agreement between Medicis Aesthetics Holdings Inc., a wholly owned subsidiary of the Company, and Q-Med AB, dated July 15, 2004(23) Portions of this exhibit (indicated by asterisks) have been omitted pursuant to a request for confidential treatment pursuant to Rule 24b-2 under the Securities Exchange Act of 1934
  10 .35   Intellectual Property License Agreement between Q-Med AB and Medicis Aesthetics Holdings Inc., dated July 15, 2004(23) Portions of this exhibit (indicated by asterisks) have been omitted pursuant to a request for confidential treatment pursuant to Rule 24b-2 under the Securities Exchange Act of 1934
  10 .36   Note Agreement, dated as of October 1, 2001, by and among Ascent Pediatrics, Inc., the Company, Furman Selz Investors II L.P., FS Employee Investors LLC, FS Ascent Investments LLC, FS Parallel Fund L.P., BancBoston Ventures Inc. and Flynn Partners(17)
  10 .37   Voting Agreement, dated as of October 1, 2001, by and among the Company, MPC Merger Corp., FS Private Investments LLC, Furman Selz Investors II L.P., FS Employee Investors LLC, FS Ascent Investments LLC and FS Parallel Fund L.P.(17)
  10 .38   Exclusive Remedy Agreement, dated as of October 1, 2001, by and among the Company, Ascent Pediatrics, Inc., FS Private Investments LLC, Furman Selz Investors II L.P., FS Employee Investors LLC, FS Ascent Investments LLC and FS Parallel Fund L.P., BancBoston Ventures Inc., Flynn Partners, Raymond F. Baddour, Sc.D., Robert E. Baldini, Medical Science Partners L.P. and Emmett Clemente, Ph.D.(17)
  10 .39   Medicis Pharmaceutical Corporation 1992 Stock Option Plan(35)
  10 .40+   Form of Stock Option Agreement for Medicis Pharmaceutical Corporation 2004 Stock Incentive Plan
  10 .41+   Form of Restricted Stock Agreement for Medicis Pharmaceutical Corporation 2004 Stock Incentive Plan
   12+     Computation of Ratios of Earnings to Fixed Charges
  21 .1+   Subsidiaries
  23 .1+   Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm
  24 .1   Power of Attorney See signature page
  31 .1+   Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a) of the Securities Exchange Act, as amended
  31 .2+   Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a) of the Securities Exchange Act, as amended
  32 .1+   Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
  32 .2+   Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 
   +     Filed herewith
  (1)  Incorporated by reference to the Registration Statement on Form S-1 of the Registrant, File No. 33-32918, filed with the SEC on January 16, 1990
 
  (2)  Incorporated by reference to the Registration Statement on Form S-1 of the Company, File No. 33-54276, filed with the SEC on June 11, 1993

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  (3)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 1993, File No. 0-18443, filed with the SEC on October 13, 1993
 
  (4)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 1995, File No. 0-18443, previously filed with the SEC (the “1994 Form 10-K”)
 
  (5)  Incorporated by reference to the Company’s 1995 Form 10-K
 
  (6)  Incorporated by reference to the Company’s 1995 Form 10-K
 
  (7)  Incorporated by reference to the Company’s 1995 Form 10-K
 
  (8)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 1996, File No. 0-18443, previously filed with the SEC
 
  (9)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 1997, File No. 0-18443, previously filed with the SEC
(10)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended December 31, 1996, File No. 0-18443, previously filed with the SEC
 
(11)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on December 15, 1997
 
(12)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended December 31, 1998, File No. 0-18443, previously filed with the SEC
 
(13)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 1999, File No. 0-18443, previously filed with the SEC
 
(14)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 1999, File No. 0-18443, previously filed with the SEC
 
(15)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2001, File No. 0-18443, previously filed with the SEC
 
(16)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 2001, File No. 0-18443, previously filed with the SEC
 
(17)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on October 2, 2001
 
(18)  Incorporated by reference to the Company’s registration statement on Form 8-A12B/ A filed with the SEC on June 4, 2002
 
(19)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on June 6, 2002
 
(20)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 2002, File No. 0-18443, previously filed with the SEC
 
(21)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on March 10, 2003
 
(22)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended December 31, 2003, File No. 0-18443, previously filed with the SEC
 
(23)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 2004, File No. 0-18443, previously filed with the SEC
 
(24)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on March 21, 2005
 
(25)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2005, File No. 0-18443, previously filed with the SEC
 
(26)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on August 18, 2005
 
(27)  Incorporated by reference to the Company’s Annual Report on Form 10-K for the fiscal year ended June 30, 2005, File No. 0-18443, previously filed with the SEC

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(28)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on October 20, 2005
 
(29)  Incorporated by reference to the Company’s Annual Report on Form 10-K/A for the fiscal year ended June 30, 2005, File No. 0-18443, previously filed with the SEC on October 28, 2005
 
(30)  Incorporated by reference to the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2005, File No. 0-18443, previously filed with the SEC
 
(31)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on December 13, 2005
 
(32)  Incorporated by reference to the Company’s Current Report on Form 8-K filed with the SEC on January 3, 2006
 
(33)  Incorporated by reference to Appendix 1 to the Company’s definitive Proxy Statement for the 1998 Annual Meeting of Stockholders filed with the SEC on December 2, 1998
 
(34)  Incorporated by reference to Appendix 2 to the Company’s definitive Proxy Statement for the 1996 Annual Meeting of Stockholders filed with the SEC on October 23, 1996
 
(35)  Incorporated by reference to Exhibit B to the Company’s definitive Proxy Statement for the 1992 Annual Meeting of Stockholders previously filed with the SEC
(b)  The exhibits to this Form 10-K/T follow the Company’s Financial Statement Schedule included in this Form 10-K/T.
 
(c)  The Financial Statement Schedule to this Form 10-K/T appears on page S-1 of this Form 10-K/T.

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SIGNATURES
      Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
  MEDICIS PHARMACEUTICAL
CORPORATION
  By:  /s/ JONAH SHACKNAI
 
 
  Jonah Shacknai
  Chairman of the Board and
Chief Executive Officer
Date: March 16, 2006
POWER OF ATTORNEY
      KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Jonah Shacknai and Mark A. Prygocki, Sr., or either of them, as his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments to this Transition Report on Form 10-K/ T and any documents related to this report and filed pursuant to the Securities Exchange Act of 1934, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes may lawfully do or cause to be done by virtue hereof.
      Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the Registrant in the capacities and on the dates indicated.
             
Signature   Title   Date
         
 
/s/ JONAH SHACKNAI

Jonah Shacknai
  Chairman of the Board of Directors and Chief Executive Officer (Principal Executive Officer)   March 16, 2006
 
/s/ MARK A. PRYGOCKI, SR.

Mark A. Prygocki, Sr.
  Executive Vice President, Chief Financial Officer, Corporate Secretary and Treasurer (Principal Financial and Accounting Officer)   March 16, 2006
 
/s/ ARTHUR G. ALTSCHUL, JR.

Arthur G. Altschul, Jr.
  Director   March 16, 2006
 
/s/ SPENCER DAVIDSON

Spencer Davidson
  Director   March 16, 2006

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Signature   Title   Date
         
 
/s/ STUART DIAMOND

Stuart Diamond
  Director   March 16, 2006
 
/s/ PETER S. KNIGHT, ESQ.

Peter S. Knight, Esq.
  Director   March 16, 2006
 
/s/ MICHAEL A. PIETRANGELO

Michael A. Pietrangelo
  Director   March 16, 2006
 
/s/ PHILIP S. SCHEIN, M.D.

Philip S. Schein, M.D.
  Director   March 16, 2006
 
/s/ LOTTIE SHACKELFORD

Lottie Shackelford
  Director   March 16, 2006

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MEDICIS PHARMACEUTICAL CORPORATION
INDEX TO CONSOLIDATED FINANCIAL STATEMENTS
         
    Page
     
Reports of Independent Registered Public Accounting Firm
    F-2  
Consolidated Balance Sheets as of December 31, 2005, June 30, 2005 and June 30, 2004
    F-4  
Consolidated Statements of Income for the six months ended December 31, 2005 and 2004 (unaudited), and the fiscal years ended June 30, 2005, 2004 and 2003
    F-6  
Consolidated Statements of Stockholders’ Equity for the six months ended December 31, 2005 and the fiscal years ended June 30, 2005, 2004 and 2003
    F-7  
Consolidated Statements of Cash Flows for the six months ended December 31, 2005 and 2004 (unaudited) and the fiscal years ended June 30, 2005, 2004 and 2003
    F-9  
Notes to Consolidated Financial Statements
    F-10  
Schedule II — Valuation and Qualifying Accounts
    S-1  

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Report of Independent Registered Public Accounting Firm
To the Board of Directors and Stockholders of Medicis Pharmaceutical Corporation
      We have audited the accompanying consolidated balance sheets of Medicis Pharmaceutical Corporation and subsidiaries (the Company) as of December 31, 2005, June 30, 2005 and June 30, 2004, and the related consolidated statements of income, stockholders’ equity, and cash flows for the six months ended December 31, 2005 and each of the three years in the period ended June 30, 2005. Our audits also included the financial statement schedule listed in Item 15(a)(2). These financial statements and schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements and schedule based upon our audits.
      We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.
      In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Medicis Pharmaceutical Corporation and subsidiaries at December 31, 2005, June 30, 2005 and June 30, 2004, and the consolidated results of their operations and their cash flows for the six months ended December 31, 2005 and each of the three years in the period ended June 30, 2005, in conformity with U.S. generally accepted accounting principles. Also, in our opinion, the related financial statement schedule, when considered in relation to the basic financial statements taken as a whole, presents fairly in all material respects the information set forth therein.
      As discussed in Note 2 to the consolidated financial statements, on July 1, 2005, the Company changed its method of accounting for share-based compensation.
      We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the effectiveness of Medicis Pharmaceutical Corporation’s internal control over financial reporting as of December 31, 2005, based on criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated March 10, 2006 expressed an unqualified opinion thereon.
  /s/ Ernst & Young LLP
Phoenix, Arizona
March 10, 2006

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Report of Independent Registered Public Accounting Firm
To the Board of Directors and Stockholders of Medicis Pharmaceutical Corporation
      We have audited management’s assessment, included in the accompanying Management’s Report on Internal Control over Financial Reporting, that Medicis Pharmaceutical Corporation and subsidiaries (the Company) maintained effective internal control over financial reporting as of December 31, 2005, based on criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). Medicis Pharmaceutical Corporation’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting. Our responsibility is to express an opinion on management’s assessment and an opinion on the effectiveness of the Company’s internal control over financial reporting based on our audit.
      We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, evaluating management’s assessment, testing and evaluating the design and operating effectiveness of internal control, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.
      A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.
      Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.
      In our opinion, management’s assessment that Medicis Pharmaceutical Corporation maintained effective internal control over financial reporting as of December 31, 2005, is fairly stated, in all material respects, based on the COSO criteria. Also, in our opinion, Medicis Pharmaceutical Corporation maintained, in all material respects, effective internal control over financial reporting as of December 31, 2005, based on the COSO criteria.
      We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the December 31, 2005 consolidated financial statements of Medicis Pharmaceutical Corporation and subsidiaries and our report dated March 10, 2006 expressed an unqualified opinion thereon.
  /s/ Ernst & Young LLP
Phoenix, Arizona
March 10, 2006

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MEDICIS PHARMACEUTICAL CORPORATION
CONSOLIDATED BALANCE SHEETS
                               
        June 30,
    December 31,    
    2005   2005   2004
             
    (In thousands, except share amounts)
ASSETS
Current assets:
                       
 
Cash and cash equivalents
  $ 446,997     $ 177,785     $ 46,621  
 
Short-term investments
    295,535       425,783       587,419  
 
Accounts receivable, less allowances:
                       
   
December 31, 2005: $18,160; June 30, 2005:
                       
   
$19,073; June 30, 2004: $15,955
    46,697       47,220       47,858  
 
Inventories, net
    19,076       20,701       19,540  
 
Deferred tax assets, net
    12,738       11,001       14,104  
 
Other current assets
    12,241       16,435       18,321  
                   
   
Total current assets
    833,284       698,925       733,863  
Property and equipment, net
    5,416       6,143       5,842  
Intangible assets:
                       
 
Intangible assets related to product line acquisitions and business combinations
    311,406       326,780       324,345  
 
Other intangible assets
    4,888       4,507       3,647  
                   
      316,294       331,287       327,992  
 
Less: accumulated amortization
    76,458       71,749       51,961  
                   
     
Net intangible assets
    239,836       259,538       276,031  
Goodwill
    63,094       64,672       55,113  
Deferred financing costs, net
    4,325       5,397       7,535  
Other non-current assets
          8,576        
                   
    $ 1,145,955     $ 1,043,251     $ 1,078,384  
                   
See accompanying notes to consolidated financial statements.

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MEDICIS PHARMACEUTICAL CORPORATION
CONSOLIDATED BALANCE SHEETS — (Continued)
                             
        June 30,
    December 31,    
    2005   2005   2004
             
    (In thousands, except share amounts)
 
LIABILITIES
Current liabilities:
                       
 
Accounts payable
  $ 57,708     $ 30,832     $ 13,912  
 
Short-term contract obligation
    27,407       27,407       17,891  
 
Income taxes payable
    31,521       10,236       712  
 
Other current liabilities
    24,195       30,379       34,605  
                   
   
Total current liabilities
    140,831       98,854       67,120  
Long-term liabilities:
                       
 
Contingent convertible senior notes
    453,065       453,065       453,067  
 
Deferred tax liability, net
    8,572       4,986       2,894  
Commitments and Contingencies
                       
STOCKHOLDERS’ EQUITY
Preferred stock, $0.01 par value; shares authorized: 5,000,000; no shares issued
                 
Class A common stock, $0.014 par value; shares authorized:
150,000,000; issued and outstanding: 67,052,326, 67,007,330, 65,419,460 at December 31, 2005, June 30, 2005 and 2004, respectively
    938       938       916  
Class B common stock, $0.014 par value; shares authorized:
1,000,000; issued and outstanding: 0, 0 and 758,032 at December 31, 2005, June 30, 2005 and 2004, respectively
                10  
Additional paid-in capital
    550,006       539,443       517,468  
Accumulated other comprehensive income
    379       (606 )     (1,020 )
Deferred compensation
          (697 )     (1,212 )
Accumulated earnings
    334,894       288,474       230,049  
Less: Treasury stock, 12,647,554, 12,620,554 and 8,681,468 shares at cost at December 31, 2005, June 30, 2005 and 2004, respectively
    (342,730 )     (341,206 )     (190,908 )
                   
   
Total stockholders’ equity
    543,487       486,346       555,303  
                   
    $ 1,145,955     $ 1,043,251     $ 1,078,384  
                   
See accompanying notes to consolidated financial statements.

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MEDICIS PHARMACEUTICAL CORPORATION
CONSOLIDATED STATEMENTS OF INCOME
                                           
    Six Months Ended    
    December 31,   Year Ended June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
    (In thousands, except per share data)
Net product revenues
  $ 155,569     $ 146,999     $ 305,114     $ 291,607     $ 241,909  
Net contract revenues
    8,385       34,168       71,785       12,115       5,630  
                               
 
Net revenues
    163,954       181,167       376,899       303,722       247,539  
                               
Cost of product revenue(1)
    24,111       27,270       55,447       46,606       38,260  
                               
Gross profit
    139,843       153,897       321,452       257,116       209,279  
Operating expenses:
                                       
 
Selling, general and administrative(2)
    89,360       65,736       135,154       118,253       91,648  
 
Research and development(3)
    22,367       45,140       65,676       16,494       29,568  
 
Depreciation and amortization
    12,420       10,222       22,350       16,794       10,125  
                               
Operating income
    15,696       32,799       98,272       105,575       77,938  
Other income, net
    59,801                          
Interest income
    10,059       5,076       11,470       10,050       12,302  
Interest expense
    (5,333 )     (5,324 )     (10,640 )     (10,808 )     (12,580 )
Loss on early extinguishment of debt
                      (58,660 )      
                               
Income before income tax expense
    80,223       32,551       99,102       46,157       77,660  
Income tax expense
    (30,502 )     (11,328 )     (34,112 )     (15,317 )     (26,404 )
                               
Net income
  $ 49,721     $ 21,223     $ 64,990     $ 30,840     $ 51,256  
                               
Basic net income per common share
  $ 0.92     $ 0.38     $ 1.18     $ 0.55     $ 0.94  
                               
Diluted net income per common share
  $ 0.76     $ 0.34     $ 1.01     $ 0.52     $ 0.84  
                               
Cash dividend declared per common share
  $ 0.06     $ 0.06     $ 0.12     $ 0.10     $ 0.025  
                               
Basic common shares outstanding
    54,323       55,972       55,196       55,618       54,376  
                               
Diluted common shares outstanding
    69,772       72,160       70,909       72,481       70,191  
                               
(1) amounts exclude amortization of intangible assets related to acquired products
  $ 10,899     $ 8,933     $ 19,620     $ 14,891     $ 9,166  
(2) amounts include share-based compensation expense
  $ 13,947     $ 258     $ 515     $ 515     $ 365  
(3) amounts include share-based compensation expense
  $ 1,000                          
See accompanying notes to consolidated financial statements.

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MEDICIS PHARMACEUTICAL CORPORATION
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
                                                                                             
                Accumulated                    
    Class A   Class B       Other                
    Common Stock   Common Stock   Additional   Comprehensive           Treasury Stock    
            Paid-In   Income   Deferred   Accumulated        
    Shares   Amount   Shares   Amount   Capital   (Loss)   Compensation   Earnings   Shares   Amount   Total
                                             
    (In thousands)
Balance at June 30, 2002
    61,552     $ 862       758     $ 10     $ 429,515     $ 790     $ (2,094 )   $ 154,923       (6,824 )   $ (154,947 )   $ 429,059  
Comprehensive income:
                                                                                       
 
Net income
                                              51,256                   51,256  
 
Net unrealized gains on available- for-sale securities
                                  1,396                               1,396  
 
Net unrealized losses on foreign currency translation
                                  214                               214  
                                                                   
   
Comprehensive income
                                                                                    52,866  
 
Dividends declared
                                              (1,362 )                 (1,362 )
Restricted shares issued for deferred compensation, net of cancellations
                            (2 )           2                          
Amortization of deferred compensation, net of award reacquisitions
                                        365                         365  
 
Exercise of stock options
    958       14                   12,746                                     12,760  
 
Tax effect of stock options exercised
                            3,394                                     3,394  
 
Purchase of treasury stock
                                                    (1,858 )     (35,961 )     (35,961 )
                                                                   
Balance at June 30, 2003
    62,510       876       758       10       445,653       2,400       (1,727 )     204,817       (8,682 )     (190,908 )     461,121  
Comprehensive income:
                                                                                       
 
Net income
                                              30,840                   30,840  
 
Net unrealized gains on available- for-sale securities
                                  (3,452 )                             (3,452 )
 
Net unrealized gains on foreign currency translation
                                  32                               32  
                                                                   
   
Comprehensive income
                                                                                    27,420  
 
Conversion of contingent convertible senior notes
                            6                                     6  
 
Dividends declared
                                                (5,608 )                 (5,608 )
 
Amortization of deferred compensation, net of award reacquisitions
                                        515                         515  
 
Exercise of stock options
    2,909       40                   51,393                                     51,433  
 
Tax effect of stock options exercised
                            20,416                                     20,416  
                                                                   
Balance at June 30, 2004
    65,419       916       758       10       517,468       (1,020 )     (1,212 )     230,049       (8,682 )     (190,908 )     555,303  
See accompanying notes to consolidated financial statements.

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MEDICIS PHARMACEUTICAL CORPORATION
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
                                                                                             
                Accumulated                    
    Class A   Class B       Other                
    Common Stock   Common Stock   Additional   Comprehensive           Treasury Stock    
            Paid-In   Income   Deferred   Accumulated        
    Shares   Amount   Shares   Amount   Capital   (Loss)   Compensation   Earnings   Shares   Amount   Total
                                             
    (In thousands)
Balance at June 30, 2004
    65,419     $ 916       758     $ 10     $ 517,468     $ (1,020 )   $ (1,212 )   $ 230,049       (8,682 )   $ (190,908 )   $ 555,303  
Comprehensive income:
                                                                                       
 
Net income
                                              64,990                   64,990  
 
Net unrealized losses on available- for-sale securities
                                  (75 )                             (75 )
 
Net unrealized gains on foreign currency translation
                                  489                               489  
                                                                   
   
Comprehensive income
                                                                                    65,404  
Conversion of Class B common stock to Class A common stock
    758       10       (758 )     (10 )                                          
Conversion of contingent convertible senior notes
                            2                                     2  
 
Dividends declared
                                              (6,565 )                 (6,565 )
 
Restricted shares issued for deferred compensation, net of cancellations
    18                         298                         (18 )     (298 )      
Amortization of deferred compensation, net of award reacquisitions
                                        515                         515  
 
Exercise of stock options
    812       12                   16,571                                     16,583  
 
Tax effect of stock options exercised
                            5,104                                     5,104  
 
Purchase of treasury stock
                                                    (3,920 )     (150,000 )     (150,000 )
                                                                   
Balance at June 30, 2005
    67,007       938                   539,443       (606 )     (697 )     288,474       (12,620 )     (341,206 )     486,346  
Comprehensive income:
                                                                                       
 
Net income
                                              49,721                   49,721  
 
Net unrealized gains on available- for-sale securities
                                  636                               636  
 
Net unrealized gains on foreign currency translation
                                  349                               349  
                                                                   
   
Comprehensive income
                                                                                    50,706  
Adjustment for adoption of FAS 123(R)
                            827             697                   (1,524 )      
 
Share-based compensation
                            14,947                                     14,947  
 
Dividends declared
                                              (3,301 )                 (3,301 )
 
Restricted shares issued for deferred compensation
    27                                                 (27 )            
 
Exercise of stock options
    18                         430                                     430  
 
Tax effect of stock options exercised
                            (5,641 )                                   (5,641 )
                                                                   
Balance at December 31, 2005
    67,052     $ 938           $     $ 550,006     $ 379     $     $ 334,894       (12,647 )   $ (342,730 )   $ 543,487  
                                                                   
See accompanying notes to consolidated financial statements.

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
CONSOLIDATED STATEMENTS OF CASH FLOWS
                                               
    Six Months Ended    
    December 31,   Year Ended June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
    (In thousands)
Operating Activities:
                                       
Net income
  $ 49,721     $ 21,223     $ 64,990     $ 30,840     $ 51,256  
Adjustments to reconcile net income to net cash provided by operating activities:
                                       
 
Depreciation and amortization
    12,420       10,222       22,350       16,794       10,125  
 
Amortization of deferred financing fees
    1,072       1,072       2,143       2,144       2,641  
 
Impairment of long-lived assets
    9,171                          
 
Loss (gain) on sale of property and equipment
    34       39       52       (4 )      
 
Loss on sale of product rights
                      32        
 
Loss (gain) on sale of available-for-sale investments
    599       103       882       (599 )     (380 )
 
Write-off of Inamed transaction costs
    14,042                          
 
Share-based compensation expense
    14,947       258       515       515       365  
 
Deferred income tax expense (benefit)
    1,849       (3,060 )     5,369       (3,634 )     8,879  
 
Tax benefit from exercise of stock options
          5,058       5,104       20,416       3,394  
 
Excess tax benefits from share-based payment arrangements
    (73 )                        
 
Provision for doubtful accounts and returns
    (913 )     3,100       3,118       1,050       5,321  
 
Accretion of (discount) premium on investments
    (418 )     5,010       6,528       7,284       3,657  
 
Loss on early extinguishment of debt
                      58,660        
Changes in operating assets and liabilities:
                                       
   
Accounts receivable
    1,436       (957 )     (2,480 )     2,753       (11,318 )
   
Inventories
    1,625       2,621       (1,160 )     (5,535 )     (2,050 )
   
Other current assets
    4,194       (1,942 )     1,886       (1,472 )     (378 )
   
Accounts payable
    27,220       4,557       15,580       (4,655 )     4,553  
   
Income taxes payable
    17,255       5,974       9,524       232       (979 )
   
Other current liabilities
    (6,191 )     (7,813 )     (4,420 )     3,143       9,581  
                               
     
Net cash provided by operating activities
    147,990       45,465       129,981       127,964       84,667  
Investing Activities:
                                       
Purchase of property and equipment
    (748 )     (1,829 )     (2,913 )     (4,594 )     (1,367 )
Proceeds from sale of property and equipment
                      131        
Payment of direct merger costs
    (5,811 )     (129 )     (7,454 )     (633 )     (1,511 )
Payment for purchase of product rights
    (481 )     (3,085 )     (3,296 )     (84,116 )     (81,727 )
Proceeds from sale of product rights
                      12,100        
Purchase of available-for-sale investments
    (203,247 )     (440,602 )     (762,561 )     (888,152 )     (712,040 )
Sale of available-for-sale investments
    159,597       489,352       846,143       622,006       566,080  
Maturity of available-for-sale investments
    174,355       32,451       70,568       123,072       138,975  
Decrease (increase) in restricted cash
                      53,837       (22,153 )
Change in other assets
                      8       34  
                               
     
Net cash provided by (used in) investing activities
    123,665       76,158       140,487       (166,341 )     (113,709 )
Financing Activities:
                                       
Payment of financing costs
          (6 )     (6 )     (5,276 )     (142 )
Payment of dividends
    (3,295 )     (3,115 )     (6,370 )     (5,536 )      
Purchase of treasury stock
          (150,000 )     (150,000 )           (35,961 )
Excess tax benefits from share-based payment arrangements
    73                          
Proceeds from the exercise of stock options
    430       15,674       16,583       51,433       12,760  
                               
     
Net cash (used in) provided by financing activities
    (2,792 )     (137,447 )     (139,793 )     40,621       (23,343 )
Effect of exchange rate on cash and cash equivalents
    349       724       489       31       214  
                               
Net increase (decrease) in cash and cash equivalents
    269,212       (15,100 )     131,164       2,275       (52,171 )
Cash and cash equivalents at beginning of period
    177,785       46,621       46,621       44,346       96,517  
                               
Cash and cash equivalents at end of period
  $ 446,997     $ 31,521     $ 177,785     $ 46,621     $ 44,346  
                               
See accompanying notes to consolidated financial statements.

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
NOTE 1. THE COMPANY AND BASIS OF PRESENTATION
The Company
      Medicis Pharmaceutical Corporation (“Medicis” or the “Company”) is a leading independent specialty pharmaceutical company focusing primarily on the development and marketing of products in the United States (“U.S.”) for the treatment of dermatological, aesthetic and podiatric conditions. Medicis also markets products in Canada for the treatment of dermatological and aesthetic conditions. Medicis has built its business by executing a four-part growth strategy. This strategy consists of promoting existing core brands, developing new products and important product line extensions, entering into strategic collaborations, and acquiring complementary products, technologies and businesses.
      The Company offers a broad range of products addressing various conditions including acne, fungal infections, rosacea, hyperpigmentation, photoaging, psoriasis, eczema, skin and skin-structure infections, seborrheic dermatitis and cosmesis (improvement in the texture and appearance of skin). Medicis currently offers 15 branded products. Its core brands are DYNACIN® (minocycline HCI), LOPROX® (ciclopirox), OMNICEF® (cefdinir), PLEXION® (sodium sulfacetamide/sulfur), RESTYLANE® (hyaluronic acid), TRIAZ® (benzoyl peroxide), and VANOStm (fluocinonide) Cream, 0.1%.
      In March 2003, Medicis expanded into the dermal aesthetic market through its acquisition of the exclusive U.S. and Canadian rights to market, distribute and commercialize the dermal restorative product lines known as RESTYLANE®, PERLANEtm and RESTYLANE FINE LINEStm from Q-Med AB, a Swedish biotechnology/medical device company and its affiliates, collectively Q-Med. RESTYLANE® has been approved by the Food and Drug Administration (the “FDA”) for use in the U.S. as a medical device for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. RESTYLANE®, PERLANEtm and RESTYLANE FINE LINEStm have been approved for use in Canada.
      The consolidated financial statements include the accounts of Medicis Pharmaceutical Corporation and its wholly owned subsidiaries. The Company does not have any subsidiaries in which it does not own 100% of the outstanding stock. All of the Company’s subsidiaries are included in the consolidated financial statements. All significant intercompany accounts and transactions have been eliminated in consolidation.
Basis of Presentation
      Effective December 31, 2005, the Company changed its fiscal year end from June 30 to December 31. This change is being made in order to align the Company’s fiscal year end with other companies within the industry. The resulting six-month period ended December 31, 2005 may be referred to herein as the “Transition Period.” The six-month period ended December 31, 2004 is unaudited. The Company refers to the period beginning July 1, 2004 and ending June 30, 2005 as “fiscal 2005”, the period beginning July 1, 2003 and ending June 30, 2004 as “fiscal 2004” and the period beginning July 1, 2002 and ending June 30, 2003 as “fiscal 2003”.
NOTE 2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Cash and Cash Equivalents
      At December 31, 2005, cash and cash equivalents included highly liquid investments invested in money market accounts consisting of government securities and high-grade commercial paper. These investments are stated at cost, which approximates fair value. The Company considers all highly liquid investments purchased with a remaining maturity of three months or less to be cash equivalents.

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
Short-Term Investments
      The Company’s debt securities are classified as available-for-sale. Available-for-sale securities are carried at fair value with the unrealized gains and losses reported in stockholders’ equity. On an ongoing basis, the Company evaluates its debt securities to determine if a decline in fair value is other-than-temporary. When a decline in fair value is determined to be other-than-temporary, an impairment charge would be recorded and a new cost basis in the investment is established. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization is included in interest income. Realized gains and losses and interest and dividends on securities are included in interest income. The cost of securities sold is based upon the specific identification method.
Inventories
      The Company utilizes third parties to manufacture and package inventories held for sale, takes title to certain inventories once manufactured, and warehouses such goods until packaged for final distribution and sale. Inventories consist of salable products held at the Company’s warehouses, as well as raw materials and components at the manufacturers’ facilities, and are valued at the lower of cost or market using the first-in, first-out method. The Company provides valuation reserves for estimated obsolescence or unmarketable inventory in an amount equal to the difference between the cost of inventory and the estimated market value based upon assumptions about future demand and market conditions.
      Inventories are as follows (amounts in thousands):
                           
        June 30,
    December 31,    
    2005   2005   2004
             
Raw materials
  $ 6,436     $ 5,283     $ 8,785  
Finished goods
    13,925       16,518       11,105  
Valuation reserve
    (1,285 )     (1,100 )     (350 )
                   
 
Total inventories
  $ 19,076     $ 20,701     $ 19,540  
                   
Property and Equipment
      Property and equipment are stated at cost. Depreciation is calculated on a straight-line basis over the estimated useful lives of property and equipment (three to five years). Leasehold improvements are amortized over the shorter of their estimated useful lives or the remaining lease term. Property and equipment consist of the following (amounts in thousands):
                         
        June 30,
    December 31,    
    2005   2005   2004
             
Furniture, fixtures and equipment
  $ 10,064     $ 9,377     $ 7,268  
Leasehold improvements
    1,994       1,989       2,018  
                   
      12,058       11,366       9,286  
Less: accumulated depreciation
    (6,642 )     (5,223 )     (3,444 )
                   
    $ 5,416     $ 6,143     $ 5,842  
                   
      Total depreciation expense for property and equipment was approximately $1.4 million, $1.2 million (unaudited) , $2.6 million, $1.7 million and $0.9 million for the Transition Period, the comparable 2004 six months, and the fiscal years ended June 30, 2005, June 30, 2004 and June 30, 2003, respectively.

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
Goodwill
      Goodwill is recorded when the purchase price paid for an acquisition exceeds the estimated fair value of the net identified tangible and intangible assets acquired. The Company is required to perform an annual impairment review, and more frequently under certain circumstances. The goodwill is subjected to this test during the last quarter of the Company’s fiscal year. The impairment review process compares the fair value of the reporting unit to its carrying value. If the Company determines through the impairment process that goodwill has been impaired, the Company will record the impairment charge in the statement of income. As of December 31, 2005, there was no impairment charge related to goodwill. There can be no assurance that future goodwill impairment tests will not result in a charge to earnings.
      Goodwill was approximately $63.1 million as of December 31, 2005, $64.7 million as of June 30, 2005 and approximately $55.1 million as of June 30, 2004. The decrease during the Transition Period reflects a realized income tax benefit resulting from imputed interest on the contingent purchase price payments to the former shareholders of Ascent Pediatrics, Inc. (“Ascent”), related to the Company’s merger with Ascent completed in 2001. The increase during fiscal 2005 reflects the recording of the third year contingent purchase price payment related to the Company’s merger with Ascent. See Note 10 for further discussion.
Intangible Assets
      The Company has in the past made acquisitions of license agreements, product rights, and other identifiable intangible assets. Intangible assets subject to amortization were approximately $239.8 million, $259.5 million and $276.0 million as of December 31, 2005, June 30, 2005 and 2004, respectively. The Company amortizes intangible assets over their expected useful lives, which range between five and 40 years. Total intangible assets as of December 31, 2005, June 30, 2005 and June 30, 2004 were as follows (dollars in thousands):
                                                                                 
        December 31, 2005   June 30, 2005   June 30, 2004
                 
    Weighted       Accumulated           Accumulated           Accumulated    
    Average Life   Gross   Amortization   Net   Gross   Amortization   Net   Gross   Amortization   Net
                                         
Related to product line acquisitions
    22.4     $ 306,324     $ (73,879 )   $ 232,445     $ 321,698     $ (69,727 )   $ 251,971     $ 319,263     $ (50,724 )   $ 268,539  
Related to business combinations
    7.5       5,082       (1,824 )     3,258       5,082       (1,346 )     3,736       5,082       (730 )     4,352  
Patents and trademarks
    17.8       4,888       (755 )     4,133       4,507       (676 )     3,831       3,647       (507 )     3,140  
                                                             
Total intangible assets
          $ 316,294     $ (76,458 )   $ 239,836     $ 331,287     $ (71,749 )   $ 259,538     $ 327,992     $ (51,961 )   $ 276,031  
                                                             
      Total amortization expense was approximately $11.0 million, $9.0 million (unaudited), $19.8 million, $15.1 million and $9.2 million for the Transition Period, the comparable 2004 six months, fiscal 2005, fiscal 2004 and fiscal 2003, respectively. Based on the intangible assets recorded at December 31, 2005, and assuming no subsequent impairment of the underlying assets, the annual amortization expense for each period, is expected to be as follows: $20.5 million for the years ended December 31, 2006, 2007, and 2008, approximately $17.9 million for the year ended December 31, 2009, and approximately $15.3 million for the year ended December 31, 2010.
Impairment of Long-Lived Assets
      The Company assesses whether indicators of impairment of long-lived assets are present. If such indicators are present, the Company determines whether the sum of the estimated undiscounted cash flows attributable to the assets in question is less than their carrying value. If less, the Company recognizes an

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
impairment loss based on the excess of the carrying amount of the assets over their respective fair values. Fair value is determined by discounted future cash flows, appraisals or other methods. If the assets determined to be impaired are to be held and used, the Company recognizes an impairment loss through a charge to operating results to the extent the present value of anticipated net cash flows attributable to the asset are less than the asset’s carrying value. When it is determined that the useful lives of assets are shorter than originally estimated, and there are sufficient cash flows to support the carrying value of the assets, the Company will accelerate the rate of amortization charges in order to fully amortize the assets over their new shorter useful lives (See Note 3).
      This process requires the use of estimates and assumptions, which are subject to a high degree of judgment. If these assumptions change in the future, the Company may be required to record impairment charges for these assets.
      During the quarter ended December 31, 2005, a long-lived asset related to the Company’s DYNACIN® capsule products was determined to be impaired based on the Company’s analysis of the long-lived asset’s carrying value and projected future cash flows. Factors affecting the long-lived asset’s future cash flows included the Company’s promotional focus on its DYNACIN® tablet products, and competitive pressures in the marketplace. As a result of the impairment analysis, the Company recorded a write-down of approximately $9.2 million related to this long-lived asset, which is included in selling, general and administrative expenses.
Deferred Financing Costs
      Deferred financing costs represent fees and other costs incurred in connection with the June 2002 issuance of the 2.5% Contingent Convertible Senior Notes Due 2032 and the August 2003 issuance of the 1.5% Contingent Convertible Senior Notes Due 2033. These costs are being amortized on a basis that approximates the effective interest method over the five-year period that ends on the initial Put date of the Notes. Accumulated amortization amounted to approximately $6.3 million as of December 31, 2005.
Managed Care and Medicaid Reserves
      The Company establishes and maintains reserves for amounts payable to Managed Care Organizations and state Medicaid programs for the reimbursement of a portion of the retail price of prescriptions filled that are covered by the respective plans. The amounts estimated to be paid relating to products sold are recognized as revenue reductions and as additions to accrued expenses at the time of sale based on the Company’s best estimate of the expected prescription fill rate to these Managed Care and state Medicaid patients using historical experience adjusted to reflect known changes in the factors that impact such reserves.
Other Current Liabilities
      Other current liabilities are as follows (amounts in thousands):
                         
        June 30,
    December 31,    
    2005   2005   2004
             
Accrued incentives
  $ 6,506     $ 9,505     $ 8,069  
Deferred revenue
    1,237       1,862       3,545  
Managed care and Medicaid reserves
    6,081       5,365       11,671  
Other accrued expenses
    10,371       13,647       11,320  
                   
    $ 24,195     $ 30,379     $ 34,605  
                   

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
Revenue Recognition
      Revenue from product sales is recognized pursuant to Staff Accounting Bulletin No. 104 (SAB 104), “Revenue Recognition in Financial Statements.” Accordingly, revenue is recognized when all four of the following criteria are met: (i) persuasive evidence that an arrangement exists; (ii) delivery of the products has occurred; (iii) the selling price is both fixed and determinable; and (iv) collectibility is reasonably assured. The Company’s customers consist primarily of large pharmaceutical wholesalers who sell directly into the retail channel. Provisions for early payment discounts, and estimates for chargebacks, managed care and Medicaid rebates, damaged product returns, and exchanges for expired product are established as a reduction of product sales revenues at the time such revenues are recognized. These revenue reductions are established by the Company’s management as its best estimate at the time of sale based on historical experience adjusted to reflect known changes in the factors that impact such reserves. These revenue reductions are generally reflected either as a direct reduction to accounts receivable through an allowance, or as an addition to accrued expenses if the payment is due to a party other than the wholesale or retail customer.
      The Company enters into licensing arrangements with other parties whereby the Company receives contract revenue based on the terms of the agreement. The timing of revenue recognition is dependent on the level of the Company’s continuing involvement in the manufacture and delivery of licensed products. If the Company has continuing involvement, the revenue is deferred and recognized on a straight-line basis over the period of continuing involvement. In addition, if the licensing arrangements require no continuing involvement and payments are merely based on the passage of time, the Company assesses such payments for revenue recognition under the collectibility criteria of SAB 104. Direct costs related to contract acquisition and origination of licensing agreements are expensed as incurred.
      The Company does not provide any forms of price protection to its wholesale customers and permits product returns if the product is damaged, or if it is returned within six months prior to expiration or up to 12 months after expiration. The Company’s customers consist principally of financially viable wholesalers, and depending on the customer, revenue is based upon shipment (“FOB shipping point”) or receipt (“FOB destination”), net of estimated provisions.
Advertising
      The Company expenses advertising as incurred. Advertising expenses for the Transition Period and the comparable 2004 six months were approximately $12.9 million and $13.3 million (unaudited), respectively, and for fiscal 2005, 2004 and 2003 were approximately $24.2 million, $22.5 million and $20.1 million, respectively. Advertising expenses include samples of the Company’s products given to physicians for marketing to their patients.
Share-Based Compensation
      At December 31, 2005, the Company had six active share-based employee compensation plans. Stock option awards granted from these plans are granted at the fair market value on the date of grant. The option awards vest over a period determined at the time the options are granted, ranging from one to five years, and generally have a maximum term of ten years. Certain options provide for accelerated vesting if there is a change in control (as defined in the plans). When options are exercised, new shares of the Company’s Class A common stock are issued. Prior to July 1, 2005, the Company accounted for share-based employee compensation, including stock options, using the method prescribed in Accounting Principles Board Opinion No. 25, “Accounting for Stock Issued to Employees” and related Interpretations (“APB Opinion No. 25”). Under APB Opinion No. 25, stock options are granted at market price and no compensation cost is recognized, and a disclosure is made regarding the pro forma effect on net earnings assuming compensation cost had been recognized in accordance with Statement of Financial Accounting Standards No. 123, “Accounting for Stock-Based Compensation” (“SFAS No. 123”). On December 16, 2004, the FASB issued

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
SFAS No. 123R, which requires companies to measure and recognize compensation expense for all share-based payments at fair value. SFAS No. 123R eliminates the ability to account for share-based compensation transactions using APB Opinion No. 25, and generally requires that such transactions be accounted for using prescribed fair-value-based methods. SFAS No. 123R permits public companies to adopt its requirements using one of two methods: (a) a “modified prospective” method in which compensation costs are recognized beginning with the effective date based on the requirements of SFAS No. 123R for all share-based payments granted or modified after the effective date, and based on the requirements of SFAS No. 123 for all awards granted to employees prior to the effective date of SFAS No. 123R that remain unvested on the effective date or (b) a “modified retrospective” method which includes the requirements of the modified prospective method described above, but also permits companies to restate based on the amounts previously recognized under SFAS No. 123 for purposes of pro forma disclosures either for all periods presented or prior interim periods of the year of adoption. Effective July 1, 2005, the Company adopted SFAS No. 123R using the modified prospective method. Other than restricted stock, no share-based employee compensation cost has been reflected in net income prior to the adoption of SFAS No. 123R. Results for prior periods have not been restated.
      The adoption of SFAS No. 123R reduced income before income tax expense for the Transition Period by approximately $14.9 million and reduced net income for the Transition Period by approximately $11.0 million. As a result, basic and diluted earnings per share were reduced $0.20 and $0.16, respectively.
      The total value of the stock options awards is expensed ratably over the service period of the employees receiving the awards. As of December 31, 2005, total unrecognized compensation cost related to stock option awards was approximately $64.4 million and the related weighted-average period over which it is expected to be recognized is approximately 2.9 years.
      Prior to the adoption of SFAS No. 123R, the Company presented all tax benefits of deductions resulting from the exercise of stock options as operating cash flows in the condensed consolidated statements of cash flows. SFAS No. 123R requires the cash flows resulting from the tax benefits resulting from tax deductions in excess of the compensation cost recognized for those options (excess tax benefits) to be classified as financing cash flows. The $0.1 million excess tax benefit classified as a financing cash inflow in the Company’s accompanying condensed consolidated statements of cash flows for the Transition Period would have been classified as an operating cash inflow if the Company had not adopted SFAS No. 123R.
      A summary of stock option activity within the Company’s stock-based compensation plans and changes for the Transition Period is as follows:
                                 
            Weighted    
        Weighted   Average    
        Average   Remaining   Aggregate
    Number of   Exercise   Contractual   Intrinsic
    Shares   Price   Term   Value
                 
Balance at June 30, 2005
    13,648,378     $ 26.89                  
Granted
    843,550     $ 32.43                  
Exercised
    (17,996 )   $ 23.87                  
Terminated/expired
    (94,596 )   $ 28.85                  
                         
Balance at December 31, 2005
    14,379,336     $ 27.21       6.5     $ 87,396,722  
                         
      The intrinsic value of options exercised during the Transition Period was $118,047. Options exercisable under the Company’s share-based compensation plans at December 31, 2005 were 7,302,745, with an average exercise price of $24.24, an average remaining contractual term of 5.4 years, and an aggregate intrinsic value of $60,152,809.

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      A summary of fully vested stock options and stock options expected to vest, as of December 31, 2005, is as follows:
                                 
            Weighted    
        Weighted   Average    
        Average   Remaining   Aggregate
    Number of   Exercise   Contractual   Intrinsic
    Shares   Price   Term   Value
                 
Outstanding
    13,816,174     $ 27.19       6.5     $ 84,119,298  
Exercisable
    7,067,028     $ 24.24       5.4     $ 58,262,667  
      The fair value of each stock option award is estimated on the date of the grant using the Black-Scholes option pricing model with the following assumptions:
                 
    Six Months   Six Months
    Ended   Ended
    December 31,   December 31,
    2005   2004
         
        (Unaudited)
Expected dividend yield
    0.4 %     0.3 %
Expected stock price volatility
    0.36       0.44  
Risk-free interest rate
    4.1% to 4.2%       3.6 %
Expected life of options
    6 to 8 Years       5 Years  
                         
    Twelve Months   Twelve Months   Twelve Months
    Ended   Ended   Ended
    June 30,   June 30,   June 30,
    2005   2004   2003
             
Expected dividend yield
    0.3 %     0.3 %     0.3 %
Expected stock price volatility
    0.44       0.49       0.49  
Risk-free interest rate
    3.6 %     3.3 %     2.5 %
Expected life of options
    5 Years       5 Years       5 Years  
      The expected dividend yield is based on expected annual dividend to be paid by the Company as a percentage of the market value of the Company’s stock as of the date of grant. The Company determined that a blend of implied volatility and historical volatility is more reflective of market conditions and a better indicator of expected volatility than using purely historical volatility. The risk-free interest rate is based on the U.S. treasury security rate in effect as of the date of grant. The expected lives of options are based on historical data of the Company.
      The weighted average fair value of stock options granted during the Transition Period, the comparable 2004 six months, fiscal 2005, 2004 and 2003 was $14.15, $16.08 (unaudited), $11.66, $10.17 and $9.10, respectively.

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Table of Contents

MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      The following table illustrates the effect on net income and net income per common share as if the Company had applied the fair value recognition provisions of SFAS No. 123 to all outstanding stock option awards for periods presented prior to the Company’s adoption of SFAS No. 123R (amounts in thousands, except per share amounts):
                                   
    Six Months   Twelve Months   Twelve Months   Twelve Months
    Ended   Ended   Ended   Ended
    December 31,   June 30,   June 30,   June 30,
    2004   2005   2004   2003
                 
    (Unaudited)            
Net income, as reported
  $ 21,223     $ 64,990     $ 30,840     $ 51,256  
Deduct: Total stock-based employee compensation expense determined under fair value based method for all awards, net of related tax effects
    10,195       21,813       17,078       18,056  
                         
Pro-forma net income
  $ 11,028     $ 43,177     $ 13,762     $ 33,200  
                         
Net income per common share:
                               
 
Basic, as reported
  $ 0.38     $ 1.18     $ 0.55     $ 0.94  
 
Basic, pro forma
  $ 0.20     $ 0.78     $ 0.25     $ 0.61  
 
Diluted, as reported
  $ 0.34     $ 1.01     $ 0.52     $ 0.84  
 
Diluted, pro forma
  $ 0.20     $ 0.70     $ 0.23     $ 0.59  
      The Company also grants restricted stock awards to certain employees. Restricted stock awards are valued at the closing market value of the Company’s Class A common stock on the date of grant, and the total value of the award is expensed ratably over the service period of the employees receiving the grants. During the Transition Period, 147,710 shares of restricted stock were granted to certain employees. Share-based compensation expense related to all restricted stock awards outstanding during the Transition Period, the comparable 2004 six months, fiscal 2005, 2004, and 2003 was approximately $0.7 million, $0.3 million (unaudited), $0.5 million, $0.5 million, and $0.4 million, respectively. As of December 31, 2005, the total amount of unrecognized compensation cost related to nonvested restricted stock awards was approximately $4.7 million, and the related weighted-average period over which it is expected to be recognized is approximately 4.3 years.
      A summary of restricted stock activity within the Company’s share-based compensation plans and changes for the Transition Period is as follows:
                 
        Weighted-
        Average
        Grant-Date
Nonvested Shares   Shares   Fair Value
         
Nonvested at June 30, 2005
    92,000     $ 23.41  
Granted
    147,710     $ 32.41  
Vested
    (27,000 )   $ 23.44  
Forfeited
    (450 )   $ 32.41  
             
Nonvested at December 31, 2005
    212,260     $ 29.65  
             
      The total fair value of restricted shares vested during the Transition Period, the comparable 2004 six months and fiscal 2005 was $0.6 million, $0.4 million (unaudited) and $0.4 million, respectively. No restricted shares vested during fiscal 2004 or 2003.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      See Note 18 for further discussion of the Company’s share-based employee compensation plans.
Shipping and Handling Costs
      Substantially all costs of shipping and handling of products to customers are included in selling, general and administrative expense. Shipping and handling costs for the Transition Period, the comparable 2004 six months, fiscal 2005, 2004 and 2003 were approximately $1.4 million, $1.6 million (unaudited), $3.1 million, $3.1 million and $3.5 million, respectively.
Research and Development Costs and Accounting for Strategic Collaborations
      All research and development costs, including payments related to products under development and research consulting agreements, are expensed as incurred. The Company may continue to make non-refundable payments to third parties for new technologies and for research and development work that has been completed. These payments may be expensed at the time of payment depending on the nature of the payment made.
      The Company’s policy on accounting for costs of strategic collaborations determines the timing of the recognition of certain development costs. In addition, this policy determines whether the cost is classified as development expense or capitalized as an asset. Management is required to form judgments with respect to the commercial status of such products in determining whether development costs meet the criteria for immediate expense or capitalization. For example, when the Company acquires certain products for which there is already an Abbreviated New Drug Application (“ANDA”) or a New Drug Application (“NDA”) available, and there is net realizable value based on projected sales for these products, the Company capitalizes the amount paid as an intangible asset. In addition, if the Company acquires product rights that are in the development phase and as to which the Company has no assurance that the third party is required to perform additional research efforts, the Company expenses such payments.
Income Taxes
      Income taxes are determined using an annual effective tax rate, which is generally less than the U.S. Federal statutory rate, primarily because of tax-exempt interest, charitable contribution deductions and research and experimentation tax credits available in the United States. The Company’s effective tax rate may be subject to fluctuations during the fiscal year as new information is obtained which may affect the assumptions it uses to estimate its annual effective tax rate, including factors such as its mix of pre-tax earnings in the various tax jurisdictions in which it operates, valuation allowances against deferred tax assets, reserves for tax audit issues and settlements, utilization of research and experimentation tax credits and changes in tax laws in jurisdictions where the Company conducts operations. The Company recognizes deferred tax assets and liabilities for temporary differences between the financial reporting basis and the tax basis of its assets and liabilities. The Company records valuation allowances against its deferred tax assets to reduce the net carrying value to an amount that management believes is more likely than not to be realized.
Legal Contingencies
      In the ordinary course of business, the Company is involved in legal proceedings involving contractual and employment relationships, product liability claims, patent rights, and a variety of other matters. The Company records contingent liabilities resulting from asserted and unasserted claims against it, when it is probable that a liability has been incurred and the amount of the loss is reasonably estimable. The Company discloses contingent liabilities when there is a reasonable possibility that the ultimate loss will exceed the recorded liability. Estimating probable losses requires analysis of multiple factors, in some cases including judgments about the potential actions of third-party claimants and courts. Therefore, actual losses in any future period

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
are inherently uncertain. Currently, the Company does not believe any of its pending legal proceedings or claims will have a material impact on its financial position or results of operations.
Foreign Currency Translations
      The financial statements of foreign subsidiaries have been translated into U.S. Dollars in accordance with SFAS No. 52, Foreign Currency Translation. All balance sheet accounts have been translated using the exchange rates in effect at the balance sheet date. Income statement amounts have been translated using the average exchange rate for the year. The gains and losses resulting from the changes in exchange rates from year to year have been reported in other comprehensive income. The effect on the consolidated statements of operations of transaction gains and losses is not material for all years presented.
Earnings Per Common Share
      Basic and diluted earnings per common share are calculated in accordance with the requirements of Statement of Financial Accounting Standards No. 128, “Earnings Per Share.” Because the Company has Contingently Convertible Debt (see Note 13), diluted net income per common share must be calculated using the “if-converted” method in accordance with EITF 04-8, “Effect of Contingently Convertible Debt on Diluted Earnings per Share.” Diluted net income per common share is calculated by adjusting net income for tax-effected net interest and issue costs on the Contingent Convertible Debt, divided by the weighted average number of common shares outstanding assuming conversion. The Company adopted EITF 04-8 during fiscal 2005, all earnings per share amounts reflect the adoption of EITF 04-8.
Use of Estimates and Risks and Uncertainties
      The preparation of the consolidated financial statements in conformity with U.S. generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. The accounting estimates that require management’s most significant, difficult and subjective judgments include the assessment of recoverability of long-lived assets; the recognition and measurement of current and deferred income tax assets and liabilities; and the reductions to revenue recorded at the time of sale for sales returns. The actual results experienced by the company may differ from management’s estimates.
      The Company purchases its inventory from third party manufacturers, many of whom are the sole source of products for the Company. The failure of such manufacturers to provide an uninterrupted supply of products could adversely impact the Company’s ability to sell such products.
Fair Value of Financial Instruments
      The carrying amount of cash and cash equivalents, short-term investments, accounts receivable, accounts payable and accrued liabilities reported in the consolidated balance sheets approximates fair value because of the immediate or short-term maturity of these financial instruments. The fair market value of the Company’s long-term debt is estimated based on market quotations at year-end. The fair market value approximates $472.2 million at December 31, 2005.
Supplemental Disclosure of Cash Flow Information
      During the Transition Period, the comparable 2004 six months, fiscal 2005, fiscal 2004 and fiscal 2003, the Company made interest payments of $4.2 million, $4.2 million (unaudited), $8.5 million, $8.8 million and $10.0 million, respectively.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
Reclassifications
      Certain prior year amounts have been reclassified to conform with the current year presentation.
Recent Accounting Pronouncements
      In October 2005, the FASB issued FASB Staff Position (“FSP”) No. 123R-2, Practical Accommodation to the Application of Grant Date as Defined in FASB Statement No. 123R, to provide guidance on determining the grant date for an award as defined in SFAS No. 123R. This FSP stipulates that assuming all other criteria in the grant date definition are met, a mutual understanding of the key terms and conditions of an award to an individual employee is presumed to exist upon the award’s approval in accordance with the relevant corporate governance requirements, provided that the key terms and conditions of an award (a) cannot be negotiated by the recipient with the employer because the award is a unilateral grant, and (b) are expected to be communicated to an individual recipient within a relatively short time period from the date of approval. The Company has applied the principles set forth in this FSP upon its adoption of SFAS No. 123R.
      In November 2005, the FASB issued FSP No. 123R-3, Transition Election to Accounting for the Tax Effects of Share-Based Payment Awards. This FSP requires an entity to follow either the transition guidance for the additional-paid-in-capital pool as prescribed in SFAS No. 123R, or the alternative transition method as described in the FSP. An entity that adopts SFAS No. 123R using the modified prospective application may make a one-time election to adopt the transition method described in this FSP. This FSP became effective in November 2005. The Company will continue to evaluate the impact that the adoption of this FSP could have on its financial statements as it has until one year from the later of its initial adoption of SFAS No. 123R or the effective date of this FSP to evaluate its available transition alternatives and make its one-time election.
      In December 2004, the FASB issued SFAS No. 153, Exchanges of Nonmonetary Assets (“SFAS No. 153”), an amendment of APB Opinion No. 29 Accounting for Nonmonetary Transactions (“APB No. 29”). SFAS No. 153 eliminates the exception from fair value measurement for nonmonetary exchanges of similar productive assets in paragraph 21 (b) of APB No. 29, and replaces it with an exception for exchanges that do not have commercial substance. SFAS No. 153 specifies that a nonmonetary exchange has commercial substance if the future cash flows of the entity are expected to change significantly as a result of the exchange. SFAS No. 153 is effective for the fiscal periods beginning after June 15, 2005 and we will adopt this Statement in the first quarter of fiscal 2006. The Company currently does not anticipate that the effects of the statement will materially affect its consolidated financial position or consolidated results of operations upon adoption.
      In May 2005, the FASB issued SFAS No. 154, Accounting Changes and Error Corrections — A Replacement of APB Opinion No. 20 and FASB Statement No. 3 (“SFAS No. 154”). SFAS No. 154 requires the retrospective application to prior periods’ financial statements of changes in accounting principle, unless it is impractical to determine either the period-specific effects or cumulative effect of the accounting change. SFAS No. 154 also requires that a change in depreciation, amortization, or depletion method for long-lived non-financial assets be accounted for as a change in accounting estimate affected by a change in accounting principle. SFAS No. 154 is affective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005 and the Company will adopt this provision, as applicable, during fiscal year 2006.
      In November 2005, the FASB issued FSP FAS 115-1 and FAS 124-1, The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments (“FSP 115-1”), which provides guidance on determining when investments in certain debt and equity securities are considered impaired, whether that impairment is other-than-temporary, and on measuring such impairment loss. FSP 115-1 also includes accounting considerations subsequent to the recognition of other-than temporary impairment and requires certain disclosures about unrealized losses that have not been recognized as other-than-temporary impair-

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
ments. FSP 115-1 is required to be applied to reporting periods beginning after December 15, 2005 and is required to be adopted by us in the first quarter of fiscal 2006. The Company is currently evaluating the effect that the adoption of FSP 115-1 will have on its consolidated results of operations and financial condition but does not expect it to have a material impact.
NOTE 3. CHANGE IN ESTIMATE
      Effective January 1, 2005, the Company changed the estimated useful life for certain intangible assets related to its merger with Ascent, based on management’s determination that these intangible assets appear to have shorter useful lives than originally estimated. There is no cumulative effect for this change. The effect of this change on net income for fiscal 2005 was to decrease net income by approximately $1.1 million or $0.02 per diluted common share.
NOTE 4. SEGMENT AND PRODUCT INFORMATION
      The Company operates in one significant business segment: Pharmaceuticals. The Company’s current pharmaceutical franchises are divided between the dermatological and non-dermatological fields. The dermatological field represents products for the treatment of acne and acne-related dermatological conditions and non-acne dermatological conditions. The non-dermatological field represents products for the treatment of asthma (until May 2004), urea cycle disorder and contract revenue. The acne and acne-related dermatological product lines include core brands DYNACIN®, PLEXION® and TRIAZ®. The non-acne dermatological product lines include core brands LOPROX®, OMNICEF®, RESTYLANE® and VANOStm. The non-dermatological product lines include AMMONUL®, BUPHENYL® and ORAPRED®. ORAPRED® was one of the Company’s core brands until it was licensed to BioMarin Pharmaceutical Inc. (“BioMarin”) in May 2004 (see Note 7). The non-dermatological field also includes contract revenues associated with licensing agreements and authorized generics.
      The Company’s pharmaceutical products, with the exception of AMMONUL® and BUPHENYL®, are promoted to dermatologists, podiatrists and plastic surgeons. Such products are often prescribed by physicians outside these three specialties; including family practitioners, general practitioners, primary-care physicians and OB/ GYNs, as well as hospitals, government agencies and others. All products, with the exception of BUPHENYL®, are sold primarily to wholesalers and retail chain drug stores. BUPHENYL® is primarily sold directly to hospitals and pharmacies. Prior to the Company’s licensing of ORAPRED® to BioMarin in May 2004, the Company also promoted its pharmaceutical products to pediatricians. During the Transition Period, the comparable 2004 six months, and the last three fiscal years, four wholesalers accounted for the following portions of the Company’s net revenues:
                                         
    Six Months Ended            
    December 31,            
        Fiscal   Fiscal   Fiscal
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
McKesson
    54.9 %     50.8 %     51.2 %     36.9 %     20.2 %
Cardinal
    18.9 %     19.7 %     21.8 %     23.8 %     25.4 %
Quality King
    *       *       *       *       17.0 %
AmerisourceBergen
    *       *       *       *       15.5 %
 
* less than 10%
      McKesson is the sole distributor for the Company’s RESTYLANE® products in the United States and Canada. RESTYLANE®, the Company’s highest-selling product during the Transition Period and fiscal 2005, was launched in the United States in January 2004.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      The percentage of net revenues for each of the product categories is as follows:
                                           
    Six Months Ended   Fiscal Year Ended
    December 31,   June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
Acne and acne-related dermatological products
    28 %     33 %     30 %     30 %     33 %
Non-acne dermatological products
    59       44       47       51       37  
Non-dermatological products
    13       23       23       19       30  
                               
 
Total net revenues
    100 %     100 %     100 %     100 %     100 %
                               
NOTE 5. STRATEGIC COLLABORATIONS
      On September 26, 2002, Medicis entered into an exclusive license and development agreement with Dow Pharmaceutical Sciences, Inc. (“Dow”) for the development and commercialization of a patented dermatologic product. Under terms of the agreement, as amended, Medicis made an initial payment of $5.4 million and a development milestone payment of $8.8 million to Dow during fiscal 2003, a development milestone payment of $2.4 million to Dow during fiscal 2004, and development milestone payments totaling $11.9 million during the Transition Period. In accordance with the agreement between the parties, Medicis is required to make a potential additional payment of $1.0 million upon the certification that a certain development milestone has occurred. All payments were recorded as charges to research and development expense in the periods in which the milestones were achieved.
      On June 26, 2002, Medicis entered into an exclusive strategic alliance with aaiPharma, Inc. (“aaiPharma”) for the development, commercialization and license of a key dermatologic product. Medicis made an initial payment of $7.7 million to aaiPharma during fiscal 2002, a development milestone payment of $6.0 million during fiscal 2003, and had potential additional payments to be made to aaiPharma upon the successful completion of various development milestones. The $7.7 million initial payment and the $6.0 million development milestone payment were recorded as charges to research and development expense during fiscal 2002 and fiscal 2003, respectively. On January 28, 2005, the Company amended its strategic alliance with aaiPharma. The consummation of the amendment has not affected the timing of the development project. The amendment allowed for the immediate transfer of the work product as defined under the agreement, as well as the product’s management and development, to Medicis, and provides that aaiPharma will continue to assist Medicis with the development of the product on a fee for services basis. Medicis will have no future financial obligations to pay aaiPharma on the attainment of clinical milestones, but incurred approximately $8.3 million as a charge to research and development expense during the third quarter of fiscal 2005, as part of the amendment and the assumption of all liabilities associated with the project.
      In addition to the amendment, Medicis entered into a supply agreement with aaiPharma for the eventual manufacture of the product by aaiPharma under certain conditions. Medicis has the right to qualify an alternate manufacturing facility, and aaiPharma agreed to assist Medicis in obtaining these qualifications. Upon the approval of the alternate facility and approval of the product, Medicis will pay aaiPharma approximately $1 million.
      On December 13, 2004, the Company entered into an exclusive development and license agreement and other ancillary agreements with Ansata Therapeutics, Inc. (“Ansata”). The development and license agreement grants Medicis the exclusive, worldwide rights to Ansata’s early stage, proprietary antimicrobial peptide technology. In accordance with the development and license agreement, Medicis paid $5 million upon signing of the contract and will pay approximately $9 million upon the successful completion of certain developmental milestones. Should Medicis continue with the development of this technology, the Company will incur additional milestone payments beyond the development and license agreement. The initial

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
$5 million payment was recorded as a charge to research and development expense during the second quarter of fiscal 2005. The Company also incurred approximately $0.5 million of professional fees related to the completion of the agreements, which was included in selling, general and administrative expenses during the second quarter of fiscal 2005. In addition, the Company entered into an Option Agreement with Ansata where Medicis has the option to acquire Ansata or certain assets of Ansata if certain financial conditions are present.
      On April 19, 1999, the Company acquired 100% of the common stock of Ucyclyd Pharma, Inc. (“Ucyclyd”), a privately held pharmaceutical company based in Baltimore, Maryland, for net cash of approximately $14.3 million. Ucyclyd’s primary products, BUPHENYL® and AMMONUL®, are indicated in the treatment of Urea Cycle Disorder. Under terms of the agreement, the Company paid $15.1 million on April 19, 1999, and paid an additional $5.7 million in contingent payments in April 2000. In November 2004, the Company paid $2.7 million to the former shareholders of Ucyclyd as the final contractual purchase price payment. This $2.7 million payment was recorded as an addition to the original Ucyclyd intangible asset in the Company’s consolidated balance sheets.
      On July 15, 2004, the Company entered into an exclusive license agreement and other ancillary documents with Q-Med to market, distribute, sell and commercialize in the United States and Canada Q-Med’s product currently known as SubQtm. Q-Med has the exclusive right to manufacture SubQtm for Medicis. SubQtm is currently not approved for use in the United States or Canada. Under terms of the license agreement, Medicis Aesthetics Holdings Inc., a wholly owned subsidiary of Medicis, licenses SubQtm for approximately $80 million, due as follows: approximately $30 million on July 15, 2004, which was recorded as a charge to research and development expense during the first quarter of fiscal 2005; approximately $10 million upon completion of certain clinical milestones; approximately $20 million upon satisfaction of certain defined regulatory milestones; and approximately $20 million upon U.S. launch of SubQtm. In addition, the Company incurred approximately $0.7 million of professional fees related to the completion of the agreements during the first quarter of fiscal 2005, which was included in selling, general and administrative expenses. The Company also will make additional milestone payments to Q-Med upon the achievement of certain commercial milestones.
NOTE 6. TERMINATION OF DEFINITIVE MERGER AGREEMENT WITH INAMED CORPORATION
      On March 20, 2005, Medicis and Inamed Corporation (“Inamed”) entered into an Agreement and Plan of Merger (the “Agreement”). Inamed is a global healthcare company that develops, manufactures, and markets breast implants for aesthetic augmentation and reconstructive surgery following a mastectomy, a range of dermal products to correct facial wrinkles, the BioEnterics® LAP-BAND® System designed to treat severe and morbid obesity, and the BioEnterics® Intragastric Balloon (BIB®) system for the treatment of obesity. Under the terms of the Agreement, Inamed was to merge with and into a subsidiary of Medicis and each share of Inamed common stock would have been converted into the right to receive 1.4205 shares of Medicis common stock and $30.00 in cash. The completion of the transaction was subject to several customary conditions, including the receipt of applicable approvals from Medicis’ and Inamed’s stockholders, the absence of any material adverse effect on either party’s business and the receipt of regulatory approvals.
      On December 13, 2005, the Company entered into a merger termination agreement with Inamed following Allergan Inc.’s exchange offer for all outstanding shares of Inamed, which was commenced on November 21, 2005, pursuant to which Medicis and Inamed agreed to terminate the Agreement. In accordance with the terms of the Agreement and the merger termination agreement, Inamed paid Medicis a termination fee of $90.0 million, plus $0.5 million in expense reimbursement fees on December 13, 2005.
      From the inception of the proposed transaction with Inamed through the termination of the Agreement, the Company had incurred approximately $14.0 million of professional and other costs related to the transaction. These costs, which were maintained in other long-term assets in our consolidated balance sheet

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
during the transaction approval process, were expensed upon termination of the Agreement. As a result of the termination, the Company was required to pay Deutsche Bank Trust Company Americas (“Deutsche Bank”) a fee pursuant to a provision in Deutsche Bank’s merger engagement letter whereby Deutsche Bank was entitled to a portion of the termination fee. This fee is included in accounts payable in the Company’s consolidated balance sheets as of December 31, 2005. The Company also incurred business integration costs related to the transaction, including the planning for and implementation of integration activities. These costs were expensed as incurred. During the Transition Period, the Company incurred approximately $4.4 million of business integration planning costs. These costs were primarily consulting and other professional fees.
      During the Transition Period, the Company recognized a net benefit related to the above items of approximately $59.1 million. This is summarized as follows (in millions):
         
Termination fee received from Inamed, including expense reimbursement fees
  $ 90.5  
Less:
       
Transaction costs expensed, including legal and advisory fees
    27.0  
Integration planning costs
    4.4  
       
    $ 59.1  
       
      Approximately $0.7 million of the integration planning costs, incurred during the three months ended September 30, 2005, were classified as selling, general and administrative expenses during the Transition Period. Approximately $59.8 million of the net benefit related to the above items, including $3.7 million of integration planning costs incurred during the three months ended December 31, 2005, was classified as other income, net, during the Transition Period.
      The total net benefit recognized by the Company from the inception of the proposed transaction through the termination of the Agreement was approximately $53.8 million. This includes the $59.1 million benefit recognized during the Transition Period, partially offset by approximately $5.3 million of integration planning costs incurred during the three months ended June 30, 2005.
NOTE 7. LICENSE OF ORAPRED® TO BIOMARIN
      On May 18, 2004, the Company closed an asset purchase agreement and license agreement and executed a securities purchase agreement with BioMarin. The asset purchase agreement involves BioMarin’s purchase of assets related to ORAPRED®, including assets concerning the Ascent field sales force. ORAPRED® and related pediatric intellectual property is owned by Ascent, a wholly owned subsidiary of Medicis. The license agreement granted BioMarin, among other things, the exclusive worldwide rights to ORAPRED®. The securities purchase agreement granted BioMarin the option to purchase all outstanding shares of common stock of Ascent, based on certain conditions. As part of the transaction, the name of Ascent Pediatrics, Inc. was changed to Medicis Pediatrics, Inc.
      Under terms of the original agreements, BioMarin was to make license payments to Ascent of approximately $93 million payable over a five-year period as follows: approximately $10 million as of the date of the transaction; approximately $12.5 million per quarter for four quarters beginning in July 2004; approximately $2.5 million per quarter for the subsequent four quarters beginning in July 2005; approximately $2 million per quarter for the subsequent eight quarters beginning in July 2006; and approximately $1.75 million per quarter for the last four quarters of the five-year period beginning in July 2008. BioMarin was also to make payments of $2.5 million per quarter for six quarters beginning in July 2004 for reimbursement of certain contingent payments as discussed in Note 10. The license agreement will terminate in July 2009. At that time, based on certain conditions, BioMarin would have the option to purchase all outstanding shares of Ascent for approximately $82 million. The payment was to consist of $62 million in cash and $20 million in BioMarin common stock, based on the fair value of the stock at that time. The Company

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
was responsible for the manufacture and delivery of finished goods inventory to BioMarin, and BioMarin was responsible for paying the Company for finished goods inventory delivered through June 30, 2005. As a result, the Company was required to recognize the first $60 million of license payments ratably through June 30, 2005. The license payments received after June 30, 2005 and the reimbursement of contingent payments will be recognized as revenue when all four criteria of SAB 104 have been met.
      As of the closing date of the transaction, BioMarin is responsible for all marketing and promotional efforts regarding the sale of ORAPRED®. As a result, Medicis no longer advertises and promotes any oral liquid prednisolone sodium phosphate solution product or any related line extension. During the term of the license agreement, Medicis will maintain ownership of the intellectual property and, consequently, will continue to amortize the related intangible assets. Payments received from BioMarin under the license agreement will be treated as contract revenue, which is included in net revenues in the consolidated statements of income.
      On January 12, 2005, BioMarin and the Company entered into amendments to the Securities Purchase Agreement and License Agreement entered into on May 18, 2004, a Convertible Promissory Note (the “Convertible Note”) and a Settlement and Mutual Release Agreement (collectively the “Agreements”). Under the terms of the Agreements, transaction payments from BioMarin to Medicis previously totaling $175 million were reduced to $159 million. Beginning with license payments relating to ORAPRED® to be made by BioMarin after July 2005, license payments totaling $93 million were reduced pro rata to $88.4 million. Consideration to be received by Medicis from BioMarin in 2009 for the option relating to the purchase of all outstanding shares of Ascent Pediatrics were reduced from $82 million to $70.6 million. Medicis will take full financial responsibility for contingent payments due to former Ascent Pediatric shareholders without the $5 million in offset payments that would have been paid by BioMarin to Medicis after July 1, 2005. Contingent payments are due to former Ascent Pediatric shareholders from Medicis only if revenue from Ascent Pediatric products exceeds certain thresholds. In addition, Medicis reimbursed BioMarin for actual returns, up to certain agreed-upon limits, of ORAPRED® finished goods received by BioMarin during the quarters ended December 31, 2004, March 31, 2005 and June 30, 2005.
      Additionally, per the terms of the Agreements, Medicis has made available to BioMarin the ability to draw down on a Convertible Note up to $25 million beginning July 1, 2005. The Convertible Note is convertible based on certain terms and conditions including a change of control provision. Money advanced under the Convertible Note is convertible into BioMarin shares at a strike price equal to the BioMarin average closing price for the 20 trading days prior to such advance. The Convertible Note matures on the option purchase date in 2009 as defined in the Securities Purchase Agreement but may be repaid by BioMarin at any time prior to the option purchase date. No monies have been advanced to-date. In conjunction with the Agreements, BioMarin and Medicis have entered into a settlement and Mutual Release Agreement to forever discharge each other from any and all claims, demands, damages, debts, liabilities, actions and causes of action relating to the transaction consummated by the parties other than certain continuing obligations in accordance with the terms of the parties’ agreements. As of December 31, 2005, BioMarin had paid $74.2 million to Medicis under the license agreement, which represents all scheduled payments due through that date under the license agreement.
NOTE 8. ACQUISITION OF DERMAL AESTHETIC ENHANCEMENT PRODUCTS FROM THE Q-MED GROUP
      On March 10, 2003, Medicis acquired all outstanding shares of HA North American Sales AB from Q-Med, a Swedish biotechnology/medical device company. HA North American Sales AB holds a license for the exclusive U.S. and Canadian rights to market, distribute and commercialize the dermal restorative product lines known as RESTYLANE®, PERLANEtm and RESTYLANE FINE LINEStm. RESTYLANE® has been approved by the FDA for use in the U.S. RESTYLANE®, PERLANEtm and RESTYLANE FINE

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
LINEStm have been approved for use in Canada. Under terms of the agreements, a wholly owned subsidiary of Medicis acquired all outstanding shares of HA North American Sales AB for total consideration of approximately $160.0 million, payable upon the successful completion of certain milestones or events. Medicis paid $58.2 million upon closing of the transaction, $53.3 million in December 2003 upon FDA approval of RESTYLANE®, $19.4 million in May 2004 upon certain cumulative commercial milestones being achieved and will pay approximately $29.1 million upon FDA approval of PERLANEtm. Payments and costs related to this acquisition are capitalized as an intangible asset and are amortized over 15 years beginning in March 2003.
NOTE 9. LICENSE AND SALE OF PRODUCTS TO TARO PHARMACEUTICAL INDUSTRIES, LTD.
      On July 27, 2004, the Company entered into an exclusive license and optional purchase agreement with Taro Pharmaceutical Industries, Inc. (“Taro”) pursuant to which Taro will market, distribute and sell the LUSTRA® family of products and two development stage products in the U.S., Canada and Puerto Rico. The LUSTRA® family of products are topical therapies prescribed for the treatment of ultraviolet-induced skin discolorations and hyperpigmentation usually associated with the use of oral contraceptives, pregnancy, hormone replacement therapy, sun damage and superficial trauma. The license agreement extends through July 1, 2007, after which Taro may purchase the product lines.
      On January 14, 2003, Taro licensed with an option to purchase from Medicis four branded prescription product lines for sale in the U.S. and Puerto Rico. The license agreement was effective on January 14, 2003 and extended through June 1, 2004, after which Taro had the option to purchase the product lines. Medicis received quarterly license payments from Taro during the term of the agreement. Under terms of the agreement, Taro licensed from Medicis the following four brands: TOPICORT® (desoximetasone), a topical corticosteroid used for inflammatory skin diseases; A/ T/ S® (erythromycin), a topical antibiotic used in the treatment of acne; OVIDE® (malathion), a pediculicide used in the treatment of head lice; and PRIMSOL® (trimethoprim HCI), an antibiotic oral solution for children with acute otitis media, or middle ear infections. Taro purchased the product lines at the end of the term of the agreement for $12.1 million. The carrying value of the intangible assets related to these products was written off as of the sale date, and a loss of approximately $32,000 was recognized during fiscal 2004 and is included in selling, general and administrative expenses in the accompanying consolidated statements of income. The Company additionally incurred approximately $350,000 of professional fees related to the transaction.
NOTE 10. MERGER OF ASCENT PEDIATRICS, INC.
      As part of its merger with Ascent completed in November 2001, the Company may be required to make contingent purchase price payments (“Contingent Payments”) for each of the first five years following closing based upon reaching certain sales threshold milestones on the Ascent products for each twelve month period through November 15, 2006, subject to certain deductions and set-offs. From time to time the Company assesses the probability and likelihood of payment in the coming respective November period based on current sales trends. There can be no assurance that such payment will ultimately be made nor is the accrual of a liability an indication of current sales levels. A total of approximately $27.4 million is included in short-term contract obligation in the Company’s consolidated balance sheets as of December 31, 2005, representing the first four years’ Contingent Payments. Pursuant to the merger agreement, payment of the contingent portion of the purchase price was withheld pending the final outcome of certain pending litigation. The Company is in the process of distributing the accumulated Contingent Payments to the former shareholders of Ascent as the pending litigation matter has concluded.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
NOTE 11. SHORT-TERM INVESTMENTS
      The Company’s short-term investments are intended to establish a high-quality portfolio that preserves principal, meets liquidity needs, avoids inappropriate concentrations and delivers an appropriate yield in relationship to the Company’s investment guidelines and market conditions. Short-term investments consist of corporate and various government agency and municipal debt securities. Management classifies the Company’s short-term investments as available-for-sale. Available-for-sale securities are carried at fair value with unrealized gains and losses reported in stockholders’ equity. Realized gains and losses and declines in value judged to be other than temporary, if any, are included in operations. A decline in the market value of any available-for-sale security below cost that is deemed to be other than temporary, results in an impairment in the fair value of the investment. The impairment is charged to earnings and a new cost basis for the security is established. Premiums and discounts are amortized or accreted over the life of the related available-for-sale security. Dividend and interest income are recognized when earned. The cost of security sold is calculated using the specific identification method. The following is a summary of available-for-sale securities (amounts in thousands):
                                   
    December 31, 2005
     
        Gross   Gross   Gross
        Unrealized   Unrealized   Fair
    Cost   Gains   Losses   Value
                 
U.S. corporate securities
  $ 73,398     $ 92     $ 274     $ 73,216  
Other debt securities
    222,736       2       419       222,319  
                         
 
Total securities
  $ 296,134     $ 94     $ 693     $ 295,535  
                         
                                   
    June 30, 2005
     
        Gross   Gross   Gross
        Unrealized   Unrealized   Fair
    Cost   Gains   Losses   Value
                 
U.S. corporate securities
  $ 144,017     $ 20     $ 476     $ 143,561  
Other debt securities
    283,372       7       1,157       282,222  
                         
 
Total securities
  $ 427,389     $ 27     $ 1,633     $ 425,783  
                         
                                   
    June 30, 2004
     
        Gross   Gross   Gross
        Unrealized   Unrealized   Fair
    Cost   Gains   Losses   Value
                 
U.S. corporate securities
  $ 123,848     $ 224     $ 360     $ 123,712  
Other debt securities
    465,070       164       1,527       463,707  
                         
 
Total securities
  $ 588,918     $ 388     $ 1,887     $ 587,419  
                         
      The Company’s unrealized losses were due to fluctuations in interest rates. The Company does not believe any of the unrealized losses represented an other-than-temporary impairment based on its evaluation of available evidence as of December 31, 2005.
      During the Transition Period, the comparable six month period in 2004, fiscal 2005 and fiscal 2004, the gross realized gains on sales of available-for-sale securities totaled $658, $217,361 (unaudited), $231,766 and $1,360,154, respectively, and the gross realized losses totaled $599,200, $320,382 (unaudited), $1,117,366 and $236,427, respectively. Such amounts of gains and losses are determined based on the specific identification method. The net adjustment to unrealized gains during the Transition Period, the comparable six month period in 2004, fiscal 2005 and fiscal 2004 on available-for-sale securities included in stockholders’ equity

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
totaled $636,777, $(107,204) (unaudited), $(75,721) and $(3,451,343), respectively. The amortized cost and estimated fair value of the available-for-sale securities at December 31, 2005, by maturity, are shown below (amounts in thousands). Expected maturities will differ from contractual maturities because the issuers of the securities may have the right to prepay obligations without prepayment penalties, and the Company views its available-for-sale securities as available for current operations.
                   
    December 31, 2005
     
        Estimated
    Cost   Fair Value
         
Available-for-sale
               
 
Due in one year or less
  $ 99,662     $ 99,192  
 
Due after one year through five years
    29,123       28,993  
 
Due after five years through 10 years
    4,000       4,000  
 
Due after 10 years
    163,348       163,350  
             
    $ 296,133     $ 295,535  
             
NOTE 12. LINE OF CREDIT
      The Company has a revolving line of credit facility of up to $25.0 million from Wells Fargo Bank, N.A. The facility may be drawn upon by the Company, at its discretion, and is collateralized by certain short-term investments. The outstanding balance of the credit facility bears interest at a floating rate of 150 basis points in excess of the 30-day London Interbank Offered Rate and expires in November 2006. The agreement requires the Company to comply with certain covenants, including covenants relating to the Company’s financial condition and results of operation; we are in compliance with such covenants. The Company has never drawn on this credit facility.
NOTE 13. CONTINGENT CONVERTIBLE SENIOR NOTES
      In June 2002, the Company sold $400.0 million aggregate principal amount of its 2.5% Contingent Convertible Notes Due 2032 (the “Old Notes”) in private transactions. As discussed below, approximately $230.8 million in principal amount of the Old Notes was exchanged for New Notes on August 14, 2003. The Old Notes bear interest at a rate of 2.5% per annum, which is payable on June 4 and December 4 of each year, beginning on December 4, 2002. The Company also agreed to pay contingent interest at a rate equal to 0.5% per annum during any six-month period, with the initial six-month period commencing June 4, 2007, if the average trading price of the Old Notes reaches certain thresholds. The Old Notes will mature on June 4, 2032.
      The Company may redeem some or all of the Old Notes at any time on or after June 11, 2007, at a redemption price, payable in cash, of 100% of the principal amount of the Old Notes, plus accrued and unpaid interest, including contingent interest, if any. Holders of the Old Notes may require the Company to repurchase all or a portion of their Old Notes on June 4, 2007, 2012 and 2017, or upon a change in control, as defined in the indenture governing the Old Notes, at 100% of the principal amount of the Old Notes, plus accrued and unpaid interest to the date of the repurchase, payable in cash.
      The Old Notes are convertible, at the holders’ option, prior to the maturity date into shares of the Company’s Class A common stock in the following circumstances:
  •  during any quarter commencing after June 30, 2002, if the closing price of the Company’s Class A common stock over a specified number of trading days during the previous quarter, including the last trading day of such quarter, is more than 110% of the conversion price of the Old Notes, or $31.96. The Old Notes are initially convertible at a conversion price of $29.05 per share, which is equal to a

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
  conversion rate of approximately 34.4234 shares per $1,000 principal amount of Old Notes, subject to adjustment;
 
  •  if the Company has called the Old Notes for redemption;
 
  •  during the five trading day period immediately following any nine consecutive day trading period in which the trading price of the Old Notes per $1,000 principal amount for each day of such period was less than 95% of the product of the closing sale price of the Company’s Class A common stock on that day multiplied by the number of shares of the Company’s Class A common stock issuable upon conversion of $1,000 principal amount of the Old Notes; or
 
  •  upon the occurrence of specified corporate transactions.
      The Old Notes, which are unsecured, do not contain any restrictions on the payment of dividends, the incurrence of additional indebtedness or the repurchase of the Company’s securities and do not contain any financial covenants.
      The Company incurred $12.6 million of fees and other origination costs related to the issuance of the Old Notes. The Company is amortizing these costs over the five-year Put period, which runs through May 2007. The Put period runs from the date the Old Notes were issued to the date the Company may redeem some or all of the Old Notes.
      On August 14, 2003, the Company exchanged approximately $230.8 million in principal amount of its Old Notes for approximately $283.9 million in principal amount of its 1.5% Contingent Convertible Senior Notes Due 2033 (the “New Notes”). Holders of Old Notes that accepted the Company’s exchange offer received $1,230 in principal amount of New Notes for each $1,000 in principal amount of Old Notes. The terms of the New Notes are similar to the terms of the Old Notes, but have a different interest rate, conversion rate and maturity date. Holders of Old Notes that chose not to exchange continue to be subject to the terms of the Old Notes.
      The New Notes bear interest at a rate of 1.5% per annum, which is payable on June 4 and December 4 of each year, beginning December 4, 2003. The Company will also pay contingent interest at a rate of 0.5% per annum during any six-month period, with the initial six-month period commencing June 4, 2008, if the average trading price of the New Notes reaches certain thresholds. The New Notes mature on June 4, 2033.
      The Company may redeem some or all of the New Notes at any time on or after June 11, 2008, at a redemption price, payable in cash, of 100% of the principal amount of the New Notes, plus accrued and unpaid interest, including contingent interest, if any. Holders of the New Notes may require the Company to repurchase all or a portion of their New Notes on June 4, 2008, 2013 and 2018, or upon a change in control, as defined in the indenture governing the New Notes, at 100% of the principal amount of the New Notes, plus accrued and unpaid interest to the date of the repurchase, payable in cash.
      The New Notes are convertible, at the holders’ option, prior to the maturity date into shares of the Company’s Class A common stock in the following circumstances:
  •  during any quarter commencing after September 30, 2003, if the closing price of the Company’s Class A common stock over a specified number of trading days during the previous quarter, including the last trading day of such quarter, is more than 120% of the conversion price of the New Notes, or $46.51. The Notes are initially convertible at a conversion price of $38.76 per share, which is equal to a conversion rate of approximately 25.7998 shares per $1,000 principal amount of New Notes, subject to adjustment;
 
  •  if the Company has called the New Notes for redemption;

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
  •  during the five trading day period immediately following any nine consecutive day trading period in which the trading price of the New Notes per $1,000 principal amount for each day of such period was less than 95% of the product of the closing sale price of the Company’s Class A common stock on that day multiplied by the number of shares of the Company’s Class A common stock issuable upon conversion of $1,000 principal amount of the New Notes; or
 
  •  upon the occurrence of specified corporate transactions.
      The New Notes, which are unsecured, do not contain any restrictions on the incurrence of additional indebtedness or the repurchase of the Company’s securities and do not contain any financial covenants. The New Notes require an adjustment to the conversion price if the cumulative aggregate of all current and prior dividend increases above $0.025 per share would result in at least a one percent (1%) increase in the conversion price. This threshold has not been reached and no adjustment to the conversion price has been made.
      As a result of the exchange, the outstanding principal amounts of the Old Notes and the New Notes were $169.2 million and $283.9 million, respectively. Both the New Notes and Old Notes are reported in aggregate on the Company’s consolidated balance sheets. The Company incurred approximately $5.1 million of fees and other origination costs related to the issuance of the New Notes. The Company is amortizing these costs over the five-year Put period, which runs through August 2008. The Put period runs from the date the New Notes were issued to the date the Company may redeem some or all of the New Notes.
      During the quarters ended December 31, 2005, September 30, 2005, December 31, 2004, September 30, 2004, June 30, 2004, March 31, 2004 and December 31, 2003, the Old Notes met the criteria for the right of conversion into shares of the Company’s Class A common stock. This right of conversion of the holders of Old Notes was triggered by the stock closing above $31.96 on 20 of the last 30 trading days and the last trading day of the quarters ended December 31, 2005, September 30, 2005, December 31, 2004, September 30, 2004, June 30, 2004, March 31, 2004 and December 31, 2003. The holders of Old Notes have this conversion right only until March 31, 2006. During the quarters ended June 30, 2005 and March 31, 2005, the Old Notes did not meet the criteria for the right of conversion. At the end of all future quarters, the conversion rights will be reassessed in accordance with the bond indenture agreement to determine if the conversion trigger rights have been achieved. During the three months ended September 30, 2004 and March 31, 2004, outstanding principal amounts of $2,000 and $6,000 of Old Notes, respectively, were converted into shares of the Company’s Class A common stock. As of March 10, 2006, no other Old Notes have been converted.
NOTE 14. COMMITMENTS AND CONTINGENCIES
Occupancy Arrangements
      The Company presently occupies approximately 75,000 square feet of office space in Scottsdale, Arizona, at an average annual expense of approximately $2.1 million, under an amended lease agreement that expires in December 2010. The lease contains certain rent escalation clauses and, upon expiration, can be renewed for two additional periods of five years each. Rent expense was approximately $1.2 million, $1.1 million (unaudited), $2.3 million, $2.1 million and $1.5 million for the Transition Period, the comparable 2004 six months, fiscal 2005, 2004 and 2003, respectively. Medicis Aesthetics Canada Ltd., a wholly owned subsidiary, presently leases approximately 3,600 square feet of office space in Toronto, Ontario, Canada, under a lease agreement that expires in February 2008.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      At December 31, 2005, approximate future lease payments under the operating lease are as follows (amounts in thousands):
         
Year Ending December 31,    
     
2006
  $ 2,112  
2007
    2,079  
2008
    2,138  
2009
    2,138  
2010
    2,138  
       
    $ 10,605  
       
Research and Development and Consulting Contracts
      The Company has various consulting agreements with certain scientists in exchange for the assignment of certain rights and consulting services. At December 31, 2005, the Company had approximately $867,300 of commitments (solely attributable to the Chairman of the Central Research Committee of the Company) payable over the remaining five years under an agreement that is cancelable by either party under certain conditions.
Litigation
      In the ordinary course of business, the Company is involved in a number of other legal actions, both as plaintiff and defendant, and could incur uninsured liability in any one or more of them. Although the outcome of these actions is not presently determinable, it is the opinion of the Company’s management, based upon the information available at this time, that the expected outcome of these matters, individually or in the aggregate, will not have a material adverse effect on the results of operations or financial condition of the Company.
NOTE 15. INCOME TAXES
      The provision for income taxes consists of the following (amounts in thousands):
                                             
    Six Months Ended    
    December 31,   Year Ended June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
Current
                                       
 
Federal
  $ 26,780     $ 13,392     $ 27,516     $ 15,831     $ 17,123  
 
State
    1,543       822       1,215       861       1,305  
 
Foreign
    750       110       156       109       14  
                               
      29,073       14,324       28,887       16,801       18,442  
                               
Deferred
                                       
 
Federal
    1,366       (2,854 )     4,456       (1,404 )     7,532  
 
State
    45       (142 )     787       (80 )     430  
 
Foreign
    18             (18 )            
                               
      1,429       (2,996 )     5,225       (1,484 )     7,962  
                               
   
Total
  $ 30,502     $ 11,328     $ 34,112     $ 15,317     $ 26,404  
                               

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      Current income tax expense does not reflect benefit of $0.1 million, $5.1 million (unaudited), $5.1 million, $20.4 million and $3.4 million for the Transition Period, the comparable 2004 six months, fiscal 2005, fiscal 2004, and fiscal 2003, respectively, related to the vesting of restricted stock and exercise of employee stock options recorded directly to “Additional paid-in-capital” in the Company’s consolidated statements of stockholders’ equity. During the Transition Period, the Company reduced “Additional paid-in-capital” by $5.7 million to properly record the amount of excess tax benefits attributable to the prior fiscal years.
      Additionally, current income tax expense does not reflect benefits of $1.6 million resulting from interest imputed on the contingent consideration to be paid to the former shareholders of Ascent in connection with the merger of Ascent during fiscal 2002. The imputed interest deducted for tax purposes reduces the fair value of the recorded contingent consideration. As such, the Company made a corresponding reduction to Ascent goodwill of $1.6 million.
      The reconciliations of the U.S. federal statutory rate to the combined effective tax rate are as follows:
                                         
    Six Months Ended   Year Ended
    December 31,   June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
Statutory federal income tax rate
    35.0 %     35.0 %     35.0 %     35.0 %     35.0 %
State tax rate, net of federal benefit
    1.3       1.4       1.4       1.1       1.5  
Share-based payments
    1.6                          
Tax-exempt interest
          (2.4 )     (1.0 )     (4.2 )     (2.1 )
Other
    0.1       0.8       (1.0 )     1.3       (0.4 )
                               
      38.0 %     34.8 %     34.4 %     33.2 %     34.0 %
                               

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of the Company’s deferred tax assets and liabilities are as follows (amounts in thousands):
                                                   
            June 30,
             
    December 31, 2005   2005   2004
             
    Current   Long-term   Current   Long-term   Current   Long-term
                         
Deferred tax assets:
                                               
 
Net operating loss carryforwards
  $     $ 22,584     $     $ 23,161     $     $ 25,691  
 
Reserves and liabilities
    11,810             10,415             10,390        
 
Unrealized losses on securities
    215             586             555        
 
Research and development credits
          1,246             1,246             1,920  
 
Excess of net book value over tax basis of intangible assets
          8,885             6,613              
 
Share-based payment awards
          4,200                          
 
Foreign tax credit
    713                                
 
Capital loss carryover
          892                          
 
Charitable contributions, other
          824             4,455       3,159       834  
 
Valuation allowance
          (17,515 )           (17,473 )           (17,492 )
                                     
      12,738       21,116       11,001       18,002       14,104       10,953  
Deferred tax liabilities:
                                               
 
Depreciation on property and equipment
          (455 )           (611 )           (175 )
 
Bond interest
          (29,233 )           (22,377 )           (9,068 )
 
Excess of net book value over tax basis of intangible assets
                                  (4,604 )
                                     
Net deferred tax assets (liabilities)
  $ 12,738     $ (8,572 )   $ 11,001     $ (4,986 )   $ 14,104     $ (2,894 )
                                     
      At December 31, 2005, the Company has a federal net operating loss carryforward of approximately $64.5 million that begins expiring in varying amounts in the years 2008 through 2020 if not previously utilized. The net operating loss carryforward was acquired in connection with the Company’s merger with Ascent during fiscal 2002. As a result of the merger and related ownership change for Ascent, the annual utilization of the net operating loss carryforward is limited under Internal Revenue Code Section 382. Based upon this limitation, the Company estimates that approximately $18.0 million of the $64.5 million net operating loss carryforward will be realized. Accordingly, a valuation reserve has been recorded for the remaining net operating loss carryforward that is not expected to be realized.
      At December 31, 2005, the Company had a research and experimentation credit carryforward of approximately $1.3 million that begins expiring in varying amounts in the years 2008 through 2020 if not previously utilized. All of the research and experimentation credit carryforward was acquired in connection with the Company’s merger with Ascent during fiscal 2002 and is subject to the limitation under Internal Revenue Code Section 383. As a result of this limitation, the Company does not expect to realize any of the research and experimentation credits acquired from Ascent. Accordingly, a valuation reserve of $1.3 million has been established for the acquired research and experimentation credits.
      At December 31, 2005, the Company had a foreign tax credit carryover of approximately $0.7 million. The foreign tax credit will expire in 2016 if not previously utilized.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      As a result of the limitations described above, the Company has recorded a deferred tax asset valuation allowance of $17.5 million related to the net operating loss and research and experimentation credit carryforwards acquired in the merger with Ascent. Subsequent realization of loss and credit carryforwards in excess of the amounts estimated to be realized as of December 31, 2005 will be applied to reduce the valuation allowance and goodwill recorded in connection with the merger with Ascent.
      During fiscal 2004, the Internal Revenue Service issued Notice 2003-65 providing taxpayers additional guidance regarding the computations under Internal Revenue Code Section 382. The application of Notice 2003-65
to Ascent’s net operating losses resulted in an increase of $11.9 million in the Company’s estimate of the initial recognition of Ascent’s net operating losses it will utilize. As a result, the Company reclassified approximately $4.1 million from goodwill to deferred tax assets and the related valuation allowance to reflect the increased estimate of the income tax benefit it will realize from utilization of Ascent’s net operating loss carryforwards.
      The Company recorded a deferred tax asset of approximately $215,000, $617,000 (unaudited), $586,000 and $555,000 for the Transition Period, the comparable 2004 six months, fiscal 2005 and fiscal 2004, respectively, relating to unrealized losses on available-for-sale securities presented in other comprehensive income in stockholders’ equity.
      During the Transition Period, the comparable 2004 six months and fiscal 2005, the Company made net tax payments of $11.8 million, $3.1 million (unaudited) and $13.9 million, respectively. The Company received net refunds of $3.7 million during fiscal 2004 and made tax payments of $16.7 million during fiscal 2003.
      The Company operates in multiple tax jurisdictions and is periodically subject to audit in these jurisdictions. These audits can involve complex issues that may require an extended period of time to resolve and may cover multiple years. The Company and its domestic subsidiaries file a consolidated U.S. federal income tax return. Such returns have either been audited or settled through statute expiration through fiscal 2000. The Company and its consolidated subsidiaries are currently under examination for fiscal year ended 2003 and 2004. The Company does not believe that the examination will have a material effect on the financial position of the Company. The Company continually assesses its tax filing positions and believes that an adequate provision for taxes has been made for all open years that may be subject to audit.
NOTE 16. STOCK TRANSACTIONS
      Class A common stock has one vote per share. During September 2004, all 758,032 outstanding shares of the Company’s Class B common stock were exchanged for 758,032 shares of the Company’s Class A common stock. As of December 31, 2005, there were no shares of Class B common stock outstanding.
      During the three months ended December 31, 2004 and September 30, 2004, Medicis purchased 2,177,286 and 1,743,800 shares of its Class A common stock in the open market at an average price of $38.65 and $37.76 per share, respectively. These stock purchases were made in accordance with a stock repurchase program that was approved by the Company’s Board of Directors in August 2004. This program provided for the repurchase of up to $150.0 million of Class A common stock at such times as management determined. As of December 31, 2005, the Company had repurchased a total of approximately $150.0 million of Class A common stock pursuant to this program, all during the six months ended December 31, 2004. As the purchase limit had been reached, the plan was terminated. During the Transition Period, Medicis did not purchase any of its shares of Class A common stock. The timing and amount of any future payments will depend on market conditions and corporate considerations.
      On January 2, 2004, the Company announced a 2 for 1 stock split in the form of a stock dividend payable on January 23, 2004 to stockholders of record at the close of business on January 12, 2004. All share and per share data have been restated to reflect the stock split effected in the form of a stock dividend.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      During fiscal 2003, Medicis purchased 1,856,600 shares of its Class A common stock in the open market at an average price of $19.37 per share. These stock purchases were made in accordance with a stock repurchase program that was approved by the Company’s Board of Directors in May 1999. This program provided for the repurchase of up to $75 million of Class A common stock at such times as management determined. The Company had repurchased a total of approximately $50.2 million toward the $75 million before it was replaced by another plan in May 2003, when the Company’s Board of Directors approved a new program that authorized the repurchase of up to $75 million of its common stock. This plan was subsequently replaced by the August 2004 stock repurchase program.
NOTE 17. DIVIDENDS DECLARED ON COMMON STOCK
      During the Transition Period and the comparable 2004 six months, fiscal 2005 and fiscal 2004, the Company paid quarterly cash dividends aggregating $3.3 million, $3.1 million (unaudited), $6.4 million, $5.5 million, respectively, on its common stock. In addition, on December 14, 2005, the Company declared a cash dividend of $0.03 per issued and outstanding share of common stock payable on January 31, 2006 to stockholders of record at the close of business on January 3, 2006. The $1.6 million dividend was recorded as a reduction of accumulated earnings and is included in other current liabilities in the accompanying consolidated balance sheets as of December 31, 2005. Prior to these dividends, the Company had not paid a cash dividend on our common stock. The Company has not adopted a dividend policy.
NOTE 18. STOCK OPTION PLANS
      As of December 31, 2005, the Company has six active Stock Option Plans (the 2004, 2002, 1998, 1996, 1995 and 1992 Plans or, collectively, the “Plans”). As of December 31, 2005, the 2004, 2002, 1998, 1996, 1995 and 1992 Plans had the following options outstanding: 353,050, 5,635,315, 5,320,428, 1,249,477, 1,281,968, and 539,098, respectively. Except for the 2002 Stock Option Plan, which only includes non-qualified incentive options, the Plans allow the Company to designate options as qualified incentive or non-qualified on an as-needed basis. Qualified and non-qualified stock options vest over a period determined at the time the options are granted, ranging from one to five years, and generally have a maximum term of ten years. Options are granted at the fair market value on the grant date. Options outstanding at December 31, 2005 vary in price from $6.06 to $39.04, with a weighted average exercise price of $27.21 as is set forth in the following chart:
                                         
        Weighted   Weighted       Weighted
        Average   Average       Average
    Number   Contractual   Exercise   Number   Exercise
Range of Exercise Prices   Outstanding   Life   Price   Exercisable   Price
                     
$ 6.06 - $14.42
    1,191,709       3.20     $ 11.27       1,191,709     $ 11.27  
$14.50 - $18.33
    2,284,364       6.35     $ 18.22       1,035,222     $ 18.08  
$18.57 - $23.53
    288,138       6.36     $ 21.69       174,008     $ 21.11  
$23.65 - $26.95
    2,108,662       5.62     $ 26.75       1,474,284     $ 26.75  
$26.98 - $27.63
    1,985,128       4.60     $ 27.63       1,966,808     $ 27.63  
$27.70 - $29.13
    138,410       7.01     $ 28.34       44,110     $ 28.20  
$29.20 - $29.20
    2,361,070       7.58     $ 29.20       588,621     $ 29.20  
$29.25 - $36.06
    1,330,505       7.76     $ 31.76       360,945     $ 30.34  
$38.45 - $38.45
    2,544,350       8.54     $ 38.45       320,038     $ 38.45  
$39.04 - $39.04
    147,000       8.75     $ 39.04       147,000     $ 39.04  
                               
      14,379,336       6.49     $ 27.21       7,302,745     $ 24.24  
                               

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
      A summary of stock options granted within the Plans and related information for the Transition Period and fiscal 2005, fiscal 2004 and fiscal 2003 is as follows:
                                 
                Weighted
                Average
    Qualified   Non-Qualified   Total   Price
                 
Balance at June 30, 2002
    3,956,382       7,179,224       11,135,606     $ 21.08  
 
Granted
    12,340       3,476,376       3,488,716     $ 19.11  
Exercised
    (451,596 )     (505,234 )     (956,830 )   $ 13.33  
Terminated/expired
    (310,664 )     (575,236 )     (885,900 )   $ 22.32  
                         
Balance at June 30, 2003
    3,206,462       9,575,130       12,781,592     $ 21.11  
 
Granted
    10,272       3,403,248       3,413,520     $ 29.32  
Exercised
    (1,383,395 )     (1,526,179 )     (2,909,574 )   $ 17.68  
Terminated/expired
    (275,772 )     (985,822 )     (1,261,594 )   $ 25.41  
                         
Balance at June 30, 2004
    1,557,567       10,466,377       12,023,944     $ 23.82  
 
Granted
          2,795,890       2,795,890     $ 38.48  
Exercised
    (269,554 )     (542,216 )     (811,770 )   $ 20.43  
Terminated/expired
    (62,896 )     (296,790 )     (359,686 )   $ 28.82  
                         
Balance at June 30, 2005
    1,225,117       12,423,261       13,648,378     $ 26.89  
                         
 
Granted
          843,550       843,550     $ 32.43  
Exercised
    (9,552 )     (8,444 )     (17,996 )   $ 23.87  
Terminated/expired
    (10,626 )     (83,970 )     (94,596 )   $ 28.85  
                         
Balance at December 31, 2005
    1,204,939       13,174,397       14,379,336     $ 27.21  
                         
NOTE 19. NET INCOME PER COMMON SHARE
      The following table sets forth the computation of basic and diluted net income per common share (in thousands, except per share amounts):
                                         
    Six Months Ended    
    December 31,   Fiscal Year Ended June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
BASIC
                                       
Net income
  $ 49,721     $ 21,223     $ 64,990     $ 30,840     $ 51,256  
Weighted average number of common shares outstanding
    54,323       55,972       55,196       55,618       54,376  
                               
Basic net income per common share
  $ 0.92     $ 0.38     $ 1.18     $ 0.55     $ 0.94  
                               

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
                                           
    Six Months Ended    
    December 31,   Fiscal Year Ended June 30,
         
    2005   2004   2005   2004   2003
                     
        (Unaudited)            
DILUTED
                                       
Net income
  $ 49,721     $ 21,223     $ 64,990     $ 30,840     $ 51,256  
Add:
                                       
 
Tax-effected interest expense and issue costs related to Old Notes
    1,677       1,675       3,347       3,884       7,901  
 
Tax-effected interest expense and issue costs related to New Notes
    1,677       1,677       3,353       2,925        
                               
Net income assuming dilution
  $ 53,075     $ 24,575     $ 71,690     $ 37,649     $ 59,157  
Weighted average number of common shares
    54,323       55,972       55,196       55,618       54,376  
Effect of dilutive securities:
                                       
 
Old Notes
    5,823       5,823       5,823       6,777       13,770  
 
New Notes
    7,325       7,325       7,325       6,446        
 
Stock options and restricted stock
    2,301       3,040       2,565       3,640       2,045  
                               
Weighted average number of common shares assuming dilution
    69,772       72,160       70,909       72,481       70,191  
                               
Diluted net income per common share
  $ 0.76     $ 0.34     $ 1.01     $ 0.52     $ 0.84  
                               
      Diluted net income per common share must be calculated using the “if-converted” method in accordance with EITF 04-8, “Effect of Contingently Convertible Debt on Diluted Earnings per Share.” Diluted net income per share is calculated by adjusting net income for tax-effected net interest and issue costs on the Old Notes and New Notes, divided by the weighted average number of common shares outstanding assuming conversion. All earnings per share amounts presented reflect the adoption of EITF 04-8.
      The diluted net income per common share computation for the Transition Period excludes 6,120,755 shares of stock that represented outstanding stock options that were anti-dilutive.
      The diluted net income per common share computation for the six months ended December 31, 2004 excludes 2,459,862 (unaudited) shares of stock that represented outstanding stock options whose exercise price were greater than the average market price of the common shares during the period and were anti-dilutive.
      The dilutive net income per common share computation for fiscal 2005, fiscal 2004 and fiscal 2003 excludes 2,734,600, 5,393 and 3,098163 shares of stock, respectively, which represented outstanding stock options whose exercise prices were greater than the average market price of the common shares during the respective fiscal years and were anti-dilutive.
NOTE 20. FINANCIAL INSTRUMENTS — CONCENTRATIONS OF CREDIT AND OTHER RISKS
      Financial instruments that potentially subject the Company to significant concentrations of credit risk consist principally of cash, cash equivalents, short-term investments and accounts receivable.
      The Company maintains cash, cash equivalents and short-term investments primarily with two financial institutions that invest funds in short-term, interest-bearing, investment-grade, marketable securities. Financial instruments that potentially subject the Company to concentrations of credit risk consist primarily of investments in debt securities and trade receivables. The Company generally places its investments with high-

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
credit quality counterparties. Investments in debt securities with original maturities of greater than six months consist primarily of AAA rated financial instruments and counterparties. The Company’s investments are primarily in direct obligations of the United States government or its agencies and municipal auction-rate securities.
      At December 31, 2005, and at the end of fiscal 2005 and fiscal 2004, three customers comprised approximately 83.2%, 86.3% and 88.8%, respectively, of accounts receivable. The Company does not require collateral from its customers, but performs periodic credit evaluations of its customers’ financial condition. Management does not believe a significant credit risk exists at December 31, 2005.
      The Company’s inventory is contract manufactured. The Company and the manufacturers of its products rely on suppliers of raw materials used in the production of its products. Some of these materials are available from only one source and others may become available from only one source. Any disruption in the supply of raw materials or an increase in the cost of raw materials to these manufacturers could have a significant effect on their ability to supply the Company with its products. The failure of any such suppliers to meet its commitment on schedule could have a material adverse effect on the Company’s business, operating results and financial condition. If a sole-source supplier were to go out of business or otherwise become unable to meet its supply commitments, the process of locating and qualifying alternate sources could require up to several months, during which time the Company’s production could be delayed. Such delays could have a material adverse effect on the Company’s business, operating results and financial condition.
NOTE 21. FAIR VALUE OF FINANCIAL INSTRUMENTS
      The carrying amount of cash equivalents approximates fair value because their maturity is less than three months. The carrying amount of short-term investments approximates fair value because the longer-term instruments have interest rate reset features that regularly adjust to current market rates. The carrying amount of accounts receivable, accounts payable and accrued liabilities approximates fair value due to the short-term maturity of the amounts. The fair value of capital lease obligations, long-term debt and lines of credit approximate their carrying value as they are estimated by discounting the future cash flows at rates currently offered to the Company for similar debt instruments.
NOTE 22. DEFINED CONTRIBUTION PLAN
      The Company has a defined contribution plan (the “Contribution Plan”) that is intended to qualify under Section 401(k) of the Internal Revenue Code. All employees, except those who have not attained the age of 21, are eligible to participate in the Contribution Plan. Participants may contribute, through payroll deductions, up to 20.0% of their basic compensation, not to exceed Internal Revenue Code limitations. Although the Contribution Plan provides for profit sharing contributions by the Company, the Company had not made any such contributions since its inception until April 2002. Beginning in April 2002, the Company began matching employee contributions at 50% of the first 3% of basic compensation contributed by the participants, and during the Transition Period and during fiscal 2005 made a discretionary contribution to the plan. During the Transition Period, the comparable 2004 six months, fiscal 2005, fiscal 2004 and fiscal 2003, the Company recognized expense related to matching and discretionary contributions under the Contribution Plan of $442,000, $162,000 (unaudited), $803,000, $340,000 and $307,000, respectively.

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
NOTE 23. QUARTERLY FINANCIAL INFORMATION (UNAUDITED)
      The tables below list the quarterly financial information for the Transition Period, fiscal 2005 and 2004. All figures are in thousands, except per share amounts, and certain amounts do not total the annual amounts due to rounding.
Six Months Ended December 31, 2005
                 
    (For the Quarters Ended)
     
    September 30,   December 31,
    2005(a)   2005(b)
         
Net revenues
  $ 83,264     $ 80,690  
Gross profit(1)
    71,240       68,603  
Net income
    12,460       37,261  
Basic net income per common share
  $ 0.23     $ 0.69  
Diluted net income per common share
  $ 0.20     $ 0.56  
Year Ended June 30, 2005
                                 
    (For the Quarters Ended)
     
    September 30,   December 31,   March 31,   June 30,
    2004(c)   2004(d)   2005(e)   2005(f)
                 
Net revenues
  $ 88,818     $ 92,349     $ 95,188     $ 100,544  
Gross profit(1)
    74,985       78,911       81,274       86,282  
Net income
    1,023       20,201       19,371       24,395  
Basic net income per common share
  $ 0.02     $ 0.37     $ 0.36     $ 0.45  
Diluted net income per common share
  $ 0.02     $ 0.31     $ 0.30     $ 0.38  
Year Ended June 30, 2004
                                 
    (For the Quarters Ended)
     
    September 30,   December 31,   March 31,   June 30,
    2003   2003(g)   2004   2004
                 
Net revenues
  $ 63,295     $ 70,633     $ 81,839     $ 87,954  
Gross profit(1)
    53,114       59,396       68,721       75,885  
Loss on early extinguishment of debt
    (58,660 )                  
Net (loss) income
    (27,164 )     13,627       20,671       23,705  
Basic net (loss) income per common share
  $ (0.50 )   $ 0.25     $ 0.37     $ 0.42  
Diluted net (loss) income per common share
  $ (0.50 )   $ 0.21     $ 0.31     $ 0.34  
 
(1)  Gross profit does not include amortization of the related intangibles.
      Quarterly results were impacted by the following items:
  (a)  Operating expenses included approximately $7.7 million of compensation expense related to stock options and restricted stock, and approximately $0.7 million of business integration planning costs related to the proposed merger with Inamed.
  (b)  Operating expenses included approximately $11.9 million paid to Dow related to a research and development collaboration, a charge of approximately $9.2 million for the write-down of a long-lived asset and approximately $7.3 million of compensation expense related to stock options and restricted stock. Other income included approximately $60.0 million related to a termination fee received from

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MEDICIS PHARMACEUTICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)
  Inamed related to the termination of the proposed merger with Inamed, net of the expensing of accumulated transaction costs and business integration planning costs incurred.
  (c)  Operating expenses included approximately $30.0 million paid to Q-Med related to an exclusive license agreement for the development of SubQtm, and approximately $0.7 million of professional fees related to the agreement.
  (d)  Operating expense included approximately $5.0 million paid to Ansata related to an exclusive development and license agreement, and approximately $0.5 million of professional fees related to the agreement.
  (e)  Operating expenses included approximately $8.3 million paid to aaiPharma related to a research and development collaboration. Effective January 1, 2005, the Company changed the estimated useful life for certain intangible assets related to its merger with Ascent. This change increased amortization expense by approximately $0.8 million during the quarter ended March 31, 2005.
  (f)  Operating expenses included approximately $5.3 million of business integration planning costs related to the proposed merger with Inamed. Effective January 1, 2005, the Company accelerated the estimated useful life for certain intangible assets related to its merger with Ascent. This change increased amortization expense by approximately $0.8 million during the quarter ended June 30, 2005.
  (g)  Operating expenses included approximately $2.4 million paid to Dow for a research and development collaboration.

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SCHEDULE II — VALUATION AND QUALIFYING ACCOUNTS
                                             
    Balance at   Charged to   Charged to        
    Beginning   Costs and   Other       Balance at End
Description   of Year   Expenses   Accounts   Deductions   of Year
                     
    (In thousands)
Six Months Ended December 31, 2005
                                       
 
Deducted from Asset Accounts:
                                       
 
Accounts Receivable:
                                       
   
Allowances
  $ 19,073     $ 42,755           $ (43,668 )   $ 18,160  
Year Ended June 30, 2005
                                       
 
Deducted from Asset Accounts:
                                       
 
Accounts Receivable:
                                       
   
Allowances
  $ 15,955     $ 95,979           $ (92,861 )   $ 19,073  
Year Ended June 30, 2004
                                       
 
Deducted from Asset Accounts:
                                       
 
Accounts Receivable:
                                       
   
Allowances
  $ 15,079     $ 96,263           $ (95,387 )   $ 15,955  
Year Ended June 30, 2003
                                       
 
Deducted from Asset Accounts:
                                       
 
Accounts Receivable:
                                       
   
Allowances
  $ 10,628     $ 78,044           $ (73,593 )   $ 15,079  

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Index to Exhibits
         
Exhibit No.   Description
     
   12+     Computation of Ratios of Earnings to Fixed Charges
  21 .1+   Subsidiaries
  23 .1+   Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm
  24 .1   Power of Attorney See signature page
  31 .1+   Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a) of the Securities Exchange Act, as amended
  31 .2+   Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a) of the Securities Exchange Act, as amended
  32 .1+   Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
  32 .2+   Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 
Filed herewith