The markets closed mixed with the Dow adding 5 points to 23,163 while Nasdaq lost 19 points to 6,605 as investors continued to monitor earnings.

On the upside

uniQure (Nasdaq: QURE) will advance AMT-061 into a pivotal study in 2018 for patients with severe and moderately severe hemophilia B.

Shares MongoDB (Nasdaq: MDB) surged in its market debut.

Qudian (NYSE: QD) stock continued to soar.

On the downside

Earthstone Energy (NYSE: ESTE) priced its public offering of 4.5 million shares of common stock at the discounted price of $9.25 per share.

United Continental (NYSE: UAL) reported lower third quarter earnings and warned of lower unit revenue in the fourth quarter.

Benchmark Electronics (NYSE: BHE) reported lower third quarter earnings.

In the broad market, advancing issues barely edged out decliners by a slim margin on the NYSE while decliners outpaced advancers by more than 4 to 3 on Nasdaq. The broader S&P 500 edged up a fraction to 2,562. Bitcoin eased $1 to $5,721.