UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                           (Amendment No. [_______])*


                            MARKETAXESS HOLDINGS INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    COMMON STOCK, PAR VALUE $0.003 PER SHARE
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   57060D 10 8
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                DECEMBER 31, 2004
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]  Rule 13d-1(b)

[ ]  Rule 13d-1(c)

[x]  Rule 13d-1(d)

     *The  remainder  of this cover  page  shall be filled  out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which could
alter the disclosures provided in a prior cover page.

     The  information  required in the remainder of this cover page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes).

                               Page 1 of 16 Pages


                                    13G
CUSIP No.
57060D 10 8                                          Page 2 of 16 Pages

--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           J.P. Morgan Partners (23A SBIC), L.P. (f/k/a J.P. Morgan Partners
           (23A SBIC), LLC)

           13-3986302
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                                (b)  [ ]
--------------------------------------------------------------------------------
     3     SEC USE ONLY
--------------------------------------------------------------------------------
     4     CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------------------------------------------------------------------
                          5    SOLE VOTING POWER

  NUMBER OF                    800,000 shares of Common Stock
   SHARES    -------------------------------------------------------------------
BENEFICIALLY              6    SHARED VOTING POWER
  OWNED BY
    EACH                       754,692 shares of Common Stock (See Item 4(c))
 REPORTING   -------------------------------------------------------------------
   PERSON                 7    SOLE DISPOSITIVE POWER
    WITH
                               800,000 shares of Common Stock
            --------------------------------------------------------------------
                          8    SHARED DISPOSITIVE POWER

                               754,692 shares of Common Stock (See Item 4(c))
--------------------------------------------------------------------------------
     9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,554,692 shares of Common Stock (See Item 4(a))
--------------------------------------------------------------------------------
    10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
--------------------------------------------------------------------------------
           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

    11     Approximately 9.99% as of the date of this Statement (based on
           22,815,806 shares of Common Stock issued and outstanding as of
           November 10, 2004). (See Item 4(b))
--------------------------------------------------------------------------------
           TYPE OF REPORTING PERSON*
    12
           PN - Partnership
--------------------------------------------------------------------------------

                               Page 2 of 16 Pages


                                    13G
CUSIP No.
57060D 10 8                                          Page 3 of 16 Pages

--------------------------------------------------------------------------------
     1     NAME OF REPORTING PERSON
           S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           LabMorgan Corporation

           13-4184941
--------------------------------------------------------------------------------
     2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*    (a)  [ ]
                                                                (b)  [ ]
--------------------------------------------------------------------------------
     3     SEC USE ONLY
--------------------------------------------------------------------------------
     4     CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------------------------------------------------------------------
                          5    SOLE VOTING POWER

  NUMBER OF                    800,000 shares of Common Stock
   SHARES    -------------------------------------------------------------------
BENEFICIALLY              6    SHARED VOTING POWER
  OWNED BY
    EACH                       754,692 shares of Common Stock (See Item 4(c))
 REPORTING   -------------------------------------------------------------------
   PERSON                 7    SOLE DISPOSITIVE POWER
    WITH
                               800,000 shares of Common Stock
            --------------------------------------------------------------------
                          8    SHARED DISPOSITIVE POWER

                               754,692 shares of Common Stock (See Item 4(c))
--------------------------------------------------------------------------------
     9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,554,692 shares of Common Stock (See Item 4(a))
--------------------------------------------------------------------------------
    10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
--------------------------------------------------------------------------------
           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

    11     Approximately 9.99% as of the date of this Statement (based on
           22,815,806 shares of Common Stock issued and outstanding as of
           November 10, 2004). (See Item 4(b))
--------------------------------------------------------------------------------
           TYPE OF REPORTING PERSON*
    12
           CO - Corporation
--------------------------------------------------------------------------------

                               Page 3 of 16 Pages


ITEM 1.

      (a)   Name of Issuer

                 MarketAxess Holdings Inc.

      (b)   Address of Issuer's Principal Executive Offices:

                 140 Broadway, 42nd Floor
                 New York, NY 10005

ITEM 2.

      (a)   Name of Persons Filing:

                 J.P. Morgan Partners (23A SBIC), L.P. ("JPMP (23A SBIC)") 
                 LabMorgan Corporation ("LabMorgan")

                 Supplemental information relating to the ownership and control
                 of the persons filing this Statement is included in Exhibit
                 2(a) attached hereto.

      (b)   Address of Principal Business Office:

                 1221 Avenue of the Americas
                 New York, NY 10020


      (c)   Citizenship:

                 Delaware

      (d)   Title of Class of Securities:

                 Common Stock, par value $0.003 per share

      (e)   CUSIP Number:

                 57060D 10 8

ITEM 3.     IF THIS STATEMENT IS FILED PURSUANT TO RULE 13D-1(B), OR 13D-2(B),
            CHECK WHETHER THE PERSON FILING IS A:

      (a)   |_| Broker or dealer registered under section 15 of the Act (15
                U.S.C. 78o).

      (b)   |_| Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

      (c)   |_| Insurance company as defined in section 3(a)(19) of the Act (15
                U.S.C. 78c).

                               Page 4 of 16 Pages


      (d)   |_| Investment company registered under section 8 of the Investment
                Company Act of 1940 (15 U.S.C 80a-8).

      (e)   |_| An investment adviser in accordance with
                ss.240.13d-1(b)(1)(ii)(E);

      (f)   |_| An employee benefit plan or endowment fund in accordance with
                ss.240.13d-1(b)(1)(ii)(F);

      (g)   |_| A parent holding company or control person in accordance with
                ss. 240.13d-1(b)(1)(ii)(G);

      (h)   |_| A savings associations as defined in Section 3(b) of the Federal
                Deposit Insurance Act (12 U.S.C. 1813);

      (i)   |_| A church plan that is excluded from the definition of an
                investmentcompany under section 3(c)(14) of the Investment
                Company Act of 1940 (15 U.S.C. 80a-3);

      (j)   |_| Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

      If this statement is filed pursuant to Rule 13d-1(c), check this box |_|

ITEM 4.     OWNERSHIP


      (a)   Amount Beneficially Owned

                  JPMP (23A SBIC): 1,554,692 shares of Common Stock (includes
                  754,692 shares of Common Stock issuable to JPMP (23A SBIC)
                  upon conversion of shares of nonvoting common stock, par value
                  $0.003 per share, of the Issuer ("Nonvoting Common Stock")
                  held by JPMP (23A SBIC)). This amount excludes (i) 800,000
                  shares of Common Stock held by LabMorgan and included below,
                  and (ii) the remaining 470,625 shares of Nonvoting Common
                  Stock held by JPMP (23A SBIC) because the terms of the
                  Nonvoting Common Stock contain a limitation on acquiring
                  shares of Common Stock if the conversion would result in the
                  holder beneficially owning more than 9.99% of the outstanding
                  shares of Common Stock. In total, 800,000 shares of Common
                  Stock and 1,225,317 shares of Nonvoting Common Stock are owned
                  by JPMP (23A SBIC).

                  LabMorgan: 1,554,692 shares of Common Stock (includes 754,692
                  shares of Common Stock issuable to LabMorgan pursuant to any
                  combination of the exercise of a warrant (the "Warrant") or
                  the conversion of shares of Nonvoting Common Stock held by
                  LabMorgan). This amount excludes (i) 800,000 shares of Common
                  Stock held by JPMP and included above, and (ii) an aggregate
                  of 1,839,278 shares from any combination of the remaining
                  portion of the Nonvoting Common Stock

                               Page 5 of 16 Pages

            and the remaining portion of the Warrant, because the terms of the
            Nonvoting Common Stock and the Warrant contain a limitation on
            acquiring shares of Common Stock if the conversion or exercise would
            result in the holder beneficially owning more than 9.99% of the
            outstanding shares of Common Stock. In total, 800,000 shares of
            Common Stock, 1,360,337 shares of Nonvoting Common Stock and a
            Warrant to purchase 1,233,633 shares of Common Stock are owned by
            LabMorgan.

      (b)   Percent of Class

                 Approximately 9.99% as of the date of this Statement (based on
                 22,815,806 shares of Common Stock issued and outstanding as of
                 November 10, 2004).

      (c)   Number of shares as to which the person has:

            (i)   Sole power to vote or direct the vote:

                        JPMP (23A SBIC):          800,000 shares of Common Stock
                        LabMorgan:                800,000 shares of Common Stock

            (ii)  Shared power to vote or direct the vote:

                       JPMP (23A SBIC):          754,692 shares of Common Stock
                       LabMorgan:                754,692 shares of Common Stock
     
                       JPMP (23A SBIC) and LabMorgan share the power to vote or
                       direct the vote of these shares of Common Stock because
                       they each have the right to acquire a maximum of 754,692
                       shares of Common Stock pursuant to any combination of
                       the conversion of shares of Nonvoting Common Stock held
                       by each of them or the exercise of the Warrant held by
                       LabMorgan. To the extent that one of JPMP (23A SBIC) or
                       LabMorgan so acquires such shares of Common Stock, the
                       other is precluded from acquiring such shares of Common
                       Stock because the terms of the Nonvoting Common Stock
                       and the Warrant contain a limitation on acquiring shares
                       of Common Stock if the conversion or exercise would
                       result in the holder beneficially owning more than 9.99%
                       of the outstanding shares of Common Stock

            (iii) Sole power to dispose or to direct the disposition of:

                       JPMP (23A SBIC):          800,000 shares of Common Stock
                       LabMorgan:                800,000 shares of Common Stock

            (iv)  Shared power to dispose or to direct the disposition of:

                       JPMP (23A SBIC):          754,692 shares of Common Stock

                               Page 6 of 16 Pages


                       LabMorgan:                754,692 shares of Common Stock

                       JPMP (23A SBIC) and LabMorgan share the power to dispose
                       or to direct the disposition of these shares of Common
                       Stock because they each have the right to acquire a
                       maximum of 754,692 shares of Common Stock pursuant to
                       any combination of the conversion of shares of Nonvoting
                       Common Stock held by each of them or the exercise of the
                       Warrant held by LabMorgan. To the extent that one of
                       JPMP (23A SBIC) or LabMorgan so acquires such shares of
                       Common Stock, the other is precluded from acquiring such
                       shares of Common Stock because the terms of the
                       Nonvoting Common Stock and the Warrant contain a
                       limitation on acquiring shares of Common Stock if the
                       conversion or exercise would result in the holder
                       beneficially owning more than 9.99% of the outstanding
                       shares of Common Stock

ITEM 5.     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                 Inapplicable

ITEM 6.     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON


                 Inapplicable

Item 7.     Identification and Classification of the Subsidiary Which Acquired
            the Security Being Reported on By the Parent Holding Company

                 Inapplicable

ITEM 8.     IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

                 See the Joint Filing Agreement Attached hereto as Exhibit 8.

ITEM 9.     NOTICE OF DISSOLUTION OF THE GROUP

                 Inapplicable

ITEM 10.    CERTIFICATION

                 Inapplicable

                                  Page 7 of 16


                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated this 14th day of February, 2005

                            J.P. MORGAN PARTNERS (23A SBIC), L.P.

                            By:  J.P. Morgan Partners (23A SBIC Manager), Inc.,
                                 its General Partner

                            By:  /s/Jeffrey C. Walker
                                 ----------------------------------------
                                   Name:  Jeffrey C. Walker
                                   Title: President

                            LABMORGAN CORPORATION

                            By:  /s/Jeffrey C. Walker
                                 ----------------------------------------
                                   Name:  Jeffrey C. Walker
                                   Title: President

                               Page 8 of 16 Pages

                                  EXHIBIT 2(a)


      This statement is being filed by J.P. Morgan Partners (23A SBIC), L.P., a
Delaware limited partnership (hereinafter referred to as "JPMP (23A SBIC)"), and
LabMorgan Corporation, a Delaware corporation (hereinafter referred to as
"LabMorgan"). The principal business address of JPMP (23A SBIC) and LabMorgan is
1221 Avenue of the Americas, New York, NY 10020.

      JPMP (23A SBIC) is engaged in the venture capital and leveraged buyout
business. The general partner of JPMP (23A SBIC) is J.P. Morgan Partners (23A
SBIC Manager), Inc., a Delaware corporation (hereinafter referred to as "JPMP
(23A Manager)"), whose principal business office is located at the same address
as JPMP (23A SBIC) and is also indirectly (through JPMP (23A SBIC)) engaged in
the venture capital and leveraged buyout business. Set forth in Schedule A
hereto and incorporated herein by reference are the names, business addresses,
principal occupations and employment of each executive officer and director of
JPMP (23A Manager). As general partner of JPMP (23A SBIC), JPMP 23A Manager may
be deemed to beneficially own the shares held by JPMP (23A SBIC).

      JPMP (23A Manager) is a wholly owned subsidiary of JPMorgan Chase Bank,
National Association, a National Banking Association (hereinafter referred to as
"JPM Chase Bank") which is engaged in the commercial banking business with its
principal office located at 270 Park Avenue, New York, New York 10017. Set forth
in Schedule B hereto and incorporated herein by reference are the names,
business addresses, principal occupations and employments of each executive
officer and director of JPM Chase Bank.

      JPM Chase Bank is a wholly owned subsidiary of JPMorgan Chase & Co., a
Delaware corporation (hereinafter referred to as "JPMorgan Chase") which is
engaged (primarily through subsidiaries) in the commercial banking business with
its principal office located at 270 Park Avenue, New York, New York 10017. Set
forth in Schedule C hereto and incorporated herein by reference are the names,
business addresses, principal occupations and employments of each executive
officer and director of JPMorgan Chase.

      LabMorgan is engaged in the venture capital and leveraged buyout business.
Set forth in Schedule D hereto and incorporated herein by reference are the
names, business addresses, principal occupations and employment of each
executive officer and director of LabMorgan. LabMorgan is a wholly owned
subsidiary of JPMorgan Chase, which is described above.

                               Page 9 of 16 Pages

                                                                      SCHEDULE A

                  J.P. MORGAN PARTNERS (SBIC 23A MANAGER), INC.

                              EXECUTIVE OFFICERS(1)

President                          Jeffrey C. Walker*
Chief Investment Officer           Arnold L. Chavkin*
Managing Director                  Srinivas Akkaraju*
Managing Director                  Christopher Albinson*
Managing Director                  Dr. Dana Beth Ardi*
Managing Director                  Richard Aube*
Managing Director                  Christopher C. Behrens*
Managing Director                  John Breckenridge*
Managing Director                  Julie Casella-Esposito*
Managing Director                  Rodney A. Ferguson*
Managing Director                  Cornell P. French*
Managing Director                  Michael R. Hannon*
Managing Director                  Matthew Lori*
Managing Director                  Jonathan R. Lynch*
Managing Director                  Bryan Martin*
Managing Director                  Sunil Mishra*
Managing Director                  Stephen P. Murray*
Managing Director                  Timothy Purcell*
Managing Director                  John Reardon*
Managing Director                  Faith Rosenfeld*
Managing Director                  Shahan D. Soghikian*
Managing Director                  William Stuck*
Managing Director                  Patrick J. Sullivan*
Managing Director                  Timothy J. Walsh*
Managing Director                  Richard D. Waters, Jr. *
Managing Director                  Damion E. Wicker, M.D.*


                                 SOLE DIRECTOR (1)

                               Jeffrey C. Walker*

----------------
(1)   Each of whom is a United States citizen.

*     Principal occupation is employee and/or officer of J.P. Morgan Partners,
      LLC. Business address is c/o J.P. Morgan Partners, LLC, 1221 Avenue of the
      Americas, New York, New York 10020.

                              Page 10 of 16 Pages

                                                                      SCHEDULE B


                    JPMORGAN CHASE BANK, NATIONAL ASSOCIATION


                              EXECUTIVE OFFICERS(1)


William B. Harrison, Jr.       Chairman and Chief Executive Officer.

James Dimon                    President and Chief Operating Officer.

Austin A. Adams                Chief Information Officer.

Steven D. Black                Co-Chief Executive Officer, Investment Bank.

William I. Campbell            Chief Executive Officer, Card Services.

Michael J. Cavanagh            Chief Financial Officer.

David A. Coulter               Chairman, West Coast Region.

John J. Farrell                Director Human Resources, Head of Real
                               Estate/Facilities, General Services, Security.

Joan Guggenheimer              Co-General Counsel.

Frederick W. Hill              Director of Corporate Marketing and
                               Communications.

Samuel Todd Maclin             Head, Commercial Banking.

Jay Mandelbaum                 Head, Strategy and Business Development.

William H. McDavid             Co-General Counsel.

Heidi Miller                   Chief Executive Officer, Treasury & Securities
                               Services.

Charles W. Scharf              Head, Retail Financial Services.

Richard J. Srednicki           Executive Vice President, Card Services.

James E. Staley                Head, Asset & Wealth Management.

Don M. Wilson III              Chief Risk Officer.

William T. Winters             Co-Chief Executive Officer, Investment Bank.


(1)   Each of whom is a United States citizen whose principal occupation is
      employee or officer of J.P. Morgan Chase & Co. Business address is c/o
      J.P. Morgan Chase & Co., 270 Park Avenue, New York, New York 10017.

                              Page 11 of 16 Pages


                                  DIRECTORS(1)

NAME                                PRINCIPAL OCCUPATION OR EMPLOYMENT
----                                ----------------------------------

William B. Harrison, Jr.            Chairman and Chief Executive Officer.

James Dimon                         President and Chief Operating Officer.

Michael J. Cavanagh                 Chief Financial Officer.

David A. Coulter                    Chairman, West Coast Region.

Charles W. Scharf                   Head, Retail Financial Services.

Don M. Wilson III                   Chief Risk Officer.

-----------------
(1)   Each of whom is a United States citizen and has a business address of c/o
      J.P. Morgan Chase & Co., 270 Park Avenue, New York, New York 10017.


                              Page 12 of 16 Pages

                                                                      SCHEDULE C

                              JPMORGAN CHASE & CO.

                              EXECUTIVE OFFICERS(1)

William B. Harrison, Jr.     Chairman and Chief Executive Officer.

James Dimon                  President and Chief Operating Officer.

Austin A. Adams              Chief Information Officer.

Steven D. Black              Co-Chief Executive Officer, Investment Bank.

William I. Campbell          Chief Executive Officer, Card Services.

Michael J. Cavanagh          Chief Financial Officer.

David A. Coulter             Chairman, West Coast Region.

John J. Farrell              Director Human Resources, Head of Real
                             Estate/Facilities, General Services, Security.

Joan Guggenheimer            Co-General Counsel.

Frederick W. Hill            Director of Corporate Marketing and Communications.

Samuel Todd Maclin           Head, Commercial Banking.

Jay Mandelbaum               Head, Strategy and Business Development.

William H. McDavid           Co-General Counsel.

Heidi Miller                 Chief Executive Officer, Treasury & Securities
                             Services.

Charles W. Scharf            Head, Retail Financial Services.

Richard J. Srednicki         Executive Vice President, Card Services.

James E. Staley              Head, Asset & Wealth Management.

Don M. Wilson III            Chief Risk Officer.

William T. Winters           Co-Chief Executive Officer, Investment Bank.



(1)   Each of whom is a United States citizen whose principal occupation is
      employee or officer of J.P. Morgan Chase & Co. Business address is c/o
      J.P. Morgan Chase & Co., 270 Park Avenue, New York, New York 10017.

                              Page 13 of 16 Pages


                                  DIRECTORS(1)

NAME                       PRINCIPAL OCCUPATION OR EMPLOYMENT
--------------------------------------------------------------------------------
Hans W. Becherer           Retired Chairman of the Board and
                           Chief Executive Officer
                           Deere & Company
--------------------------------------------------------------------------------
John H. Biggs              Former Chairman and CEO
                           TIAA - CREF
--------------------------------------------------------------------------------
Lawrence A. Bossidy        Retired Chairman of the Board
                           Honeywell International Inc.
--------------------------------------------------------------------------------
Stephen B. Burke           President
                           Comcast Cable Communications, Inc.
--------------------------------------------------------------------------------
James S. Crown             President
                           Henry Crown and Company
--------------------------------------------------------------------------------
James Dimon                President and Chief Operating Officer
                           JPMorgan Chase & Co.
--------------------------------------------------------------------------------
Ellen V. Futter            President and Trustee
                           American Museum of Natural History
--------------------------------------------------------------------------------
William H. Gray, III       Retired President and Chief Executive Officer
                           The College Fund/UNCF
--------------------------------------------------------------------------------
William B. Harrison, Jr.   Chairman of the Board and Chief Executive Officer
                           JPMorgan Chase & Co.
--------------------------------------------------------------------------------
Laban P. Jackson, Jr.      Chairman and Chief Executive Officer
                           Clear Creek Properties, Inc.
--------------------------------------------------------------------------------
John W. Kessler            Owner
                           John W. Kessler Company
--------------------------------------------------------------------------------
Robert I. Lipp             Chairman
                           The St. Paul Travelers Companies, Inc.
--------------------------------------------------------------------------------
Richard A. Monoogian       Chairman and Chief Executive Officer
                           Masco Corporation
--------------------------------------------------------------------------------
David C. Novak             Chairman and Chief Executive Officer
                           Yum! Brands, Inc.
--------------------------------------------------------------------------------
Lee R. Raymond             Chairman of the Board and Chief Executive Officer
                           Exxon Mobil Corporation
--------------------------------------------------------------------------------
John R. Stafford           Retired Chairman of the Board
                           Wyeth
--------------------------------------------------------------------------------

(1)   Each of whom is a United States citizen and has a business address of c/o
      JPMorgan Chase & Co, 270 Park Avenue, New York, New York 10017.

                              Page 14 of 16 Pages

                                                                      SCHEDULE D


                              LABMORGAN CORPORATION

                               EXECUTIVE OFFICERS(1)


President                       Jeffrey C. Walker*
Chief Investment Officer        Arnold L. Chavkin*
Managing Director               Srinivas Akkaraju*
Managing Director               Christopher Albinson*
Managing Director               Dr. Dana Beth Ardi*
Managing Director               Richard Aube*
Managing Director               Christopher C. Behrens*
Managing Director               John Breckenridge*
Managing Director               Julie Casella-Esposito*
Managing Director               Carty Chock*
Managing Director               Rodney A. Ferguson*
Managing Director               Cornell P. French*
Managing Director               Michael R. Hannon*
Managing Director               Matthew Lori*
Managing Director               Jonathan R. Lynch*
Managing Director               Bryan Martin*
Managing Director               Sunil Mishra*
Managing Director               Stephen P. Murray*
Managing Director               Timothy Purcell*
Managing Director               John Reardon*
Managing Director               Faith Rosenfeld*
Managing Director               Shahan D. Soghikian*
Managing Director               William Stuck*
Managing Director               Patrick J. Sullivan*
Managing Director               Timothy J. Walsh*
Managing Director               Richard D. Waters, Jr. *
Managing Director               Damion E. Wicker, M.D.*


                                 SOLE DIRECTOR(1)

                               Jeffrey C. Walker*

-----------------
(1)   Each of whom is a United States citizen.

*     Principal occupation is employee and/or officer of J.P. Morgan Partners,
      LLC. Business address is c/o J.P. Morgan Partners, LLC, 1221 Avenue of the
      Americas, New York, New York 10020.

                              Page 15 of 16 Pages




                                    EXHIBIT 8


                             JOINT FILING AGREEMENT



      The undersigned hereby agree that they are filing this statement jointly
pursuant to Rule 13d-1(k)(1). Each of them is responsible for the timely filing
of such Schedule 13G and any amendments thereto, and for the completeness and
accuracy of the information concerning such person contained therein; but none
of them is responsible for the completeness or accuracy of the information
concerning the other persons making the filing, unless such person knows or has
reason to believe that such information is inaccurate.

      In accordance with Rule 13d-1(k)(1) promulgated under the Securities and
Exchange Act of 1934, as amended, the undersigned hereby agree to the joint
filing with each other on behalf of each of them of to such a statement on
Schedule 13G with respect to the common stock of MarketAxess Holdings Inc.
beneficially owned by each of them. This Joint Filing Agreement shall be
included as an exhibit to such Schedule 13G.



      IN WITNESS WHEREOF, the undersigned hereby executed this agreement on
February 14, 2005.



                                 J.P. MORGAN PARTNERS (23A SBIC), L.P.

                                 By:  J.P. Morgan Partners (23A SBIC Manager), 
                                      Inc., its General Partner

                                 By:  /s/Jeffrey C. Walker
                                      --------------------
                                        Name:  Jeffrey C. Walker
                                        Title: President


                                 LABMORGAN CORPORATION

                                 By:  /s/Jeffrey C. Walker
                                      --------------------
                                        Name:  Jeffrey C. Walker
                                        Title: President


                              Page 16 of 16 Pages