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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

 

SCHEDULE 13G/A

 

Under the Securities Exchange Act of 1934

(Amendment No. 2)*

 

Mirati Therapeutics, Inc.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

60468T105

(CUSIP Number)

December 31, 2015

(Date of Event Which Requires Filing of this Statement)

 

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

o Rule 13d-1(b)

o Rule 13d-1(c)

x Rule 13d-1(d)

 

 

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

 

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

CUSIP No. 60468T105

SCHEDULE 13G/A

Page 2 of 9 Pages

1	NAME OF REPORTING PERSONS   OrbiMed Advisors LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) o (b) o
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER   0
		6	SHARED VOTING POWER   376,999
		7	SOLE DISPOSITIVE POWER   0
		8	SHARED DISPOSITIVE POWER   376,999
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   376,999
10	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES			o
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)   1.92%*
12	TYPE OF REPORTING PERSON   IA

* This percentage is based upon 19,265,922 shares outstanding as of October 30, 2015, as set forth in the Issuer’s Form 10-Q filed with the Securities and Exchange Commission on November 6, 2015 and includes 344,799 shares issuable upon the exercise of warrants.

CUSIP No. 60468T105

SCHEDULE 13G/A

Page 3 of 9 Pages

1	NAME OF REPORTING PERSONS   OrbiMed Capital GP IV LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) o (b) o
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER   0
		6	SHARED VOTING POWER   376,999
		7	SOLE DISPOSITIVE POWER   0
		8	SHARED DISPOSITIVE POWER   376,999
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   376,999
10	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES			o
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)   1.92%*
12	TYPE OF REPORTING PERSON   OO

* This percentage is based upon 19,265,922 shares outstanding as of October 30, 2015, as set forth in the Issuer’s Form 10-Q filed with the Securities and Exchange Commission on November 6, 2015 and includes 344,799 shares issuable upon the exercise of warrants.

 

CUSIP No. 60468T105

SCHEDULE 13G/A

Page 4 of 9 Pages

1	NAME OF REPORTING PERSONS   Samuel D. Isaly
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) o (b) o
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION   United States
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER   0
		6	SHARED VOTING POWER   376,999
		7	SOLE DISPOSITIVE POWER   0
		8	SHARED DISPOSITIVE POWER   376,999
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   376,999
10	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES			o
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)   1.92%*
12	TYPE OF REPORTING PERSON   IN

* This percentage is based upon 19,265,922 shares outstanding as of October 30, 2015, as set forth in the Issuer’s Form 10-Q filed with the Securities and Exchange Commission on November 6, 2015 and includes 344,799 shares issuable upon the exercise of warrants.

 

CUSIP No.  60468T105

SCHEDULE 13G/A

Page 5 of 9 Pages

 

Mirati Therapeutics, Inc.

(b) Address of Issuer’s Principal Executive Offices:

9393 Towne Centre Drive, Suite 200

San Diego, CA 92121

Item 2.

(a) Name of Person Filing:

This Schedule 13G is being filed by each of the following persons (each, a “Reporting Person” and together, the “Reporting Persons”):

(i)  OrbiMed Capital GP IV LLC ("GP IV")

(ii)  OrbiMed Advisors LLC ("Advisors")

(iii) Samuel D. Isaly ("Isaly")

See Exhibit A for the Reporting Persons’ agreement for a joint filing of a single statement on their behalf.

(b) Address of Principal Business Office:

The address of the principal business office of each of GP IV, Advisors and Isaly is 601 Lexington Avenue, 54th Floor, New York, NY 10022.

(c) Citizenship:

Please refer to Item 4 on each cover sheet for each filing person.

(d) Title of Class of Securities:

Common Stock, par value $0.001 per share (the “Common Stock”)

(e) CUSIP No.:

60468T105

 

CUSIP No. 60468T105

SCHEDULE 13G/A

Page 6 of 9 Pages

 

 

 

 

CUSIP No. 60468T105

SCHEDULE 13G/A

Page 7 of 9 Pages

 

 

Item 4. Ownership:

GP IV is the General Partner of OrbiMed Private Investments IV, LP (“OPI IV”), which holds 32,200 shares of Common Stock (“Shares”) and warrants to purchase 344,799 Shares. Advisors is an investment advisor in accordance with § 240.13d-1(b)(1)(ii)(E) and the Managing Member of GP IV. Isaly is the Managing Member of Advisors and a control person in accordance with § 240.13d-1(b)(1)(ii)(G). On the basis of these relationships, GP IV, Advisors and Isaly may be deemed to share beneficial ownership of the Shares and warrants to purchase Shares directly held by OPI IV.

(a) Amount beneficially owned: See the response(s) to Item 9 on the attached cover page(s).

(b) Percent of class: See the response(s) to Item 11 on the attached cover page(s).

(c) Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote: See the response(s) to Item 5 on the attached cover page(s).

(ii) Shared power to vote or to direct the vote: See the response(s) to Item 6 on the attached cover page(s).

(iii) Sole power to dispose or to direct the disposition of: See the response(s) to Item 7 on the attached cover page(s).

(iv) Shared power to dispose or to direct the disposition of: See the response(s) to Item 8 on the attached cover page(s).

Item 5. Ownership of Five Percent or Less of a Class.

X

Item 6. Ownership of More Than Five Percent on Behalf of Another Person.

Not Applicable.

Item 7. Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

 

Not Applicable.

Item 8. Identification and Classification of Members of the Group.

 

Not Applicable.

Item 9. Notice of Dissolution of Group.

 

Not Applicable.

Item 10. Certification.