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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                          ----------------------------

                                   SCHEDULE TO

   TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES
                              EXCHANGE ACT OF 1934
                                (AMENDMENT NO. 2)

                          IR BIOSCIENCES HOLDINGS, INC.
         (Name of Subject Company (Issuer) and Filing Person (Offeror))

                        WARRANTS TO PURCHASE COMMON STOCK
                         (Title of Class of Securities)

                                   382685 10 5
                      (CUSIP Number of Class of Securities)
                            (Underlying Common Stock)

                    MICHAEL WILHELM, CHIEF EXECUTIVE OFFICER
                          IR BIOSCIENCES HOLDINGS, INC.
                        4021 NORTH 75TH STREET, SUITE 201
                            SCOTTSDALE, ARIZONA 85251
                                 (480) 922-3926
            (Name, Address and Telephone Number of Person Authorized
       to Receive Notices and Communications on Behalf of Filing Persons)

                                  WITH COPY TO:
                             Thomas J. Poletti, Esq.
                            Katherine J. Blair, Esq.
                   Kirkpatrick & Lockhart Nicholson Graham LLP
                       10100 Santa Monica Blvd., 7th Floor
                          Los Angeles, California 90067
               Telephone: (310) 552-5000 Facsimile: (310) 552-5001

                                January 24, 2005
     (Date Tender Offer First Published, Sent or Given to Security Holders)

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                           CALCULATION OF FILING FEE:

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         Transaction Valuation(1)               Amount of Filing Fee(1)(2)
--------------------------------------------------------------------------------
              $7,992,660.42                              $940.74*
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*Previously paid.

(1) Estimated for purposes of calculating the amount of the filing fee only. An
offer is made to holders of 13,780,449 Warrants to temporarily reduce the
exercise price of such Warrants from $0.50 to $0.20 per share. The transaction
value is calculated pursuant to Rule 0-11(b)(2) and 0-11(a)(4) using the average
of the high and low sales price of the issuer's Common Stock underlying the
Warrants on January 21, 2005.

(2)  Calculated by multiplying the Transaction Valuation by 0.0001177.

         [ ] Check the box if any part of the fee is offset as provided by Rule
0-11(a)(2) and identify the filing with which the offsetting fee was previously
paid. Identify the previous filing by registration statement number, or the Form
or Schedule and the date of its filing.

         Amount Previously Paid:            Not applicable.
         Form or Registration No.:          Not applicable.
         Filing Party:                      Not applicable.
         Date Filed:                        Not applicable.

         [ ] Check the box if the filing relates solely to preliminary
communications made before the commencement of a tender offer.

         Check the appropriate box(es) below to designate any transactions to
which the statement relates:

         [ ]  third-party tender offer subject to Rule 14d-1.
         [X]  issuer tender offer subject to Rule 13e-4.
         [ ]  going-private transaction subject to Rule 13e-3.
         [ ]  amendment to Schedule 13D under Rule 13d-2.

         Check the following box if the filing is a final amendment reporting
the results of the tender offer: [ ]

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INTRODUCTORY STATEMENT

This Amendment No. 2 amends and supplements the Tender Offer Statement on
Schedule TO initially filed with the Securities and Exchange Commission on
January 24, 2005, relating to an offer (the "Offer") by IR Biosciences Holdings,
Inc., a Delaware corporation (the "Issuer" or the "Company), to temporarily
reduce the exercise price of certain warrants issued in October 2004 (the
"Warrants") from $0.50 to $0.20 per share.

The Issuer has elected to extend the Offer until 9:00 am, Pacific Standard Time,
on March 4, 2005. The Issuer is sending to each Warrant holder (i) a letter
notifying the holder of the extension of the Offer, filed herewith as Exhibit
12(a)(1)(ii), and (ii) the revised Offer Letter to Warrant Holders, filed
herewith as Exhibit 12(a)(1)(i), which (1) amends and restates the expiration
date of the Offer as March 4, 2005 at 9:00 am, Pacific Standard Time and (2)
clarifies that Warrant holders will receive any written notice of an extension
of the Offer no later than 5:00 pm on the expiration date.





ITEM 12.    EXHIBITS.

            The following are attached as exhibits to this Schedule TO:

            (a)    (1)(i) Offer Letter to Warrant Holders and Letter of
                   Transmittal, dated January 24, 2005 and as amended February
                   18, 2005 (filed herewith).

                   (1)(ii) Notice Letter to Warrant Holders, dated February 18,
                   2005, informing holders of the extension of the Offer (filed
                   herewith).

            (b)    Not applicable.
            (c)    Not applicable.

            (d)    (1) Employment Agreement dated December 16, 2002 between
                   ImmuneRegen BioSciences, Inc., a subsidiary of the Issuer,
                   and Michael Wilhelm (incorporated by reference to exhibit
                   10.1 of the Issuer's registration statement on Form SB-2
                   (file no. 333-120784) filed with the Securities and Exchange
                   Commission on November 24, 2004).

                   (2) 2003 Stock Option, Deferred Stock and Restricted Stock
                   Plan (incorporated by reference to exhibit 4.1 of the
                   Issuer's registration statement on Form S-8 (file no.
                   333-113511) filed with the Securities and Exchange Commission
                   on March 11, 2004).

                   (3) Form of Stock Option Agreement (Employee) (incorporated
                   by reference to exhibit 4.2 of the Issuer's registration
                   statement on Form S-8 (file no. 333-113511) filed with the
                   Securities and Exchange Commission on March 11, 2004).

                                       2



                   (4) Form of Stock Option Agreement (Executive) (incorporated
                   by reference to exhibit 4.3 of the Issuer's registration
                   statement on Form S-8 (file no. 333-113511) filed with the
                   Securities and Exchange Commission on March 11, 2004).

                   (5) Form of Stock Option Agreement (Super Executive)
                   (incorporated by reference to exhibit 4.4 of the Issuer's
                   registration statement on Form S-8 (file no. 333-113511)
                   filed with the Securities and Exchange Commission on March
                   11, 2004).

                   (6) Form of Stock Option Agreement (Other) (incorporated by
                   reference to exhibit 4.5 of the Issuer's registration
                   statement on Form S-8 (file no. 333-113511) filed with the
                   Securities and Exchange Commission on March 11, 2004).

                   (7) Form of Restricted Stock Award Agreement (Employee)
                   (incorporated by reference to exhibit 4.6 of the Issuer's
                   registration statement on Form S-8 (file no. 333-113511)
                   filed with the Securities and Exchange Commission on March
                   11, 2004).

                   (8) Form of Restricted Stock Award Agreement (Executive)
                   (incorporated by reference to exhibit 4.7 of the Issuer's
                   registration statement on Form S-8 (file no. 333-113511)
                   filed with the Securities and Exchange Commission on March
                   11, 2004).

                   (9) Form of Restricted Stock Award Agreement (Super
                   Executive) (incorporated by reference to exhibit 4.8 of the
                   Issuer's registration statement on Form S-8 (file no.
                   333-113511) filed with the Securities and Exchange Commission
                   on March 11, 2004).

                   (10) Form of Restricted Stock Award Agreement (Other)
                   (incorporated by reference to exhibit 4.9 of the Issuer's
                   registration statement on Form S-8 (file no. 333-113511)
                   filed with the Securities and Exchange Commission on March
                   11, 2004).

                   (11) Form of Warrant (incorporated by reference to exhibit
                   4.1 of the Issuer's current report on Form 8-K filed with the
                   Securities and Exchange Commission on October 19, 2004).

                   (12) Form of Registration Rights (incorporated by reference
                   to exhibit 4.2 of the Issuer's current report on Form 8-K
                   filed with the Securities and Exchange Commission on October
                   19, 2004).

                   (13) Form of Anti-Dilution Rights (incorporated by reference
                   to exhibit 4.3 of the Issuer's current report on Form 8-K
                   filed with the Securities and Exchange Commission on October
                   19, 2004).

                                       3



                   (14) Form of Subscription Agreement (incorporated by
                   reference to exhibit 10.1 of the Issuer's current report on
                   Form 8-K filed with the Securities and Exchange Commission on
                   October 19, 2004).

            (e)    Not applicable.
            (f)    Not applicable.
            (g)    Not applicable.
            (h)    Not applicable.

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                                   SIGNATURES

         After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

                                            IR Biosciences Holdings, Inc.

                                            By: /S/ MICHAEL WILHELM
                                                --------------------------------
                                            Name:   Michael Wilhelm
                                            Title:  Chief Executive Officer

Dated:  February 18, 2005

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