SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

SCHEDULE 13G
(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b) (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)

Insmed Incorporated

(Name of Issuer)

 

Common Stock

(Title of Class of Securities)


 

457669208

(CUSIP Number)


 

December 31, 2007

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

 

o Rule 13d-1(b)
ý Rule 13d-1(c)
o Rule 13d-1(d)



*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).







 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 2 of 10 Pages

 

 

 

 

 

 


1

 

 NAME OF REPORTING PERSON:
Biotechnology Value Fund, L.P.
 I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):

 

 

 

2

 

 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

 

(a)  ý

 

 

 

 

(b)  o

 

 

 

 

 

 

3

 

 SEC USE ONLY

 

 


 


 


 


 


 

 

4

 

 CITIZENSHIP OR PLACE OF ORGANIZATION


 


 


 Delaware


 


 

 


 

 

5

 

 SOLE VOTING POWER

NUMBER OF

 

 

 

 0

SHARES

 

 

BENEFICIALLY

 

6

 

 SHARED VOTING POWER

OWNED

 

 

 

 0

BY

 

 

EACH

 

7

 

 SOLE DISPOSITIVE POWER

REPORTING

 

 

 

 0

PERSON

 

 

WITH:

 

8

 

 SHARED DISPOSITIVE POWER

 

 

 

 

 0

 

9

 

 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

 


 


 


 0


 


 

 

10

 

 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

 

o


 


 


 


 


 

 

11

 

 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

 


 


 


  0%


 


 

 

12

 

 TYPE OF REPORTING PERSON*

 

 

 


 

 PN

 

 





 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 3 of 10 Pages

 

 

 

 

 

 


1

 

 NAME OF REPORTING PERSON:
Biotechnology Value Fund II, L.P.
 I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):

 

 

 

2

 

 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

 

(a)  ý

 

 

 

 

(b)  o

 

 

 

 

 

 

3

 

 SEC USE ONLY

 

 


 


 


 


 


 

 

4

 

 CITIZENSHIP OR PLACE OF ORGANIZATION

 

 


 


 


 Delaware


 


 

 


 

 

5

 

 SOLE VOTING POWER

NUMBER OF

 

 

 

 0

SHARES

 

 

BENEFICIALLY

 

6

 

 SHARED VOTING POWER

OWNED

 

 

 

 0

BY

 

 

EACH

 

7

 

 SOLE DISPOSITIVE POWER

REPORTING

 

 

 

 0

PERSON

 

 

WITH:

 

8

 

 SHARED DISPOSITIVE POWER

 

 

 

 

 0

 

9

 

 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

 


 


 


 0


 


 

 

10

 

 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

 

o


 


 


 


 


 


11

 

 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

 


 


 


 0%


 


 

 

12

 

 TYPE OF REPORTING PERSON*

 

 

 


 

PN

 

 

 

 

 

 

 




 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 4 of 10 Pages

 

 

 

 

 

 


1

 

 NAME OF REPORTING PERSON:
BVF Investments, L.L.C.
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):

 

 

 

2

 

 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

 

(a)  ý

 

 

 

 

(b)  o

 

 

 

 

 

 

3

 

 SEC USE ONLY

 

 


 


 


 


 


 

 

4

 

 CITIZENSHIP OR PLACE OF ORGANIZATION

 

 


 


 


 Delaware


 


 

 

 

 

5

 

 SOLE VOTING POWER

NUMBER OF

 

 

 

 0

SHARES

 

 

BENEFICIALLY

 

6

 

 SHARED VOTING POWER

OWNED

 

 

 

 0

BY

 

 

EACH

 

7

 

 SOLE DISPOSITIVE POWER

REPORTING

 

 

 

 0

PERSON

 

 

WITH:

 

8

 

 SHARED DISPOSITIVE POWER

 

 

 

 

 0


 

9

 

 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

 


 


 


 0


 


 

 

10

 

 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

 

o


 


 


 


 


 

 

11

 

 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

 


 


 


 0%


 


 

 

12

 

 TYPE OF REPORTING PERSON*

 

 


 


 


 OO


 


 

 





 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 5 of 10 Pages

 

 

 

 

 

 


1

 

 NAME OF REPORTING PERSON:
Investment 10, L.L.C.
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):

 

 

 

2

 

 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

 

(a)  ý

 

 

 

 

(b)  o

 

 

 

 

 

 

3

 

 SEC USE ONLY

 

 


 


 


 


 


 

 

4

 

 CITIZENSHIP OR PLACE OF ORGANIZATION

 

 


 


 


 Illinois


 


 

 


 

 

5

 

 SOLE VOTING POWER

NUMBER OF

 

 

 

 0

SHARES

 

 

BENEFICIALLY

 

6

 

 SHARED VOTING POWER

OWNED

 

 

 

 0

BY

 

 

EACH

 

7

 

 SOLE DISPOSITIVE POWER

REPORTING

 

 

 

 0

PERSON

 

 

WITH:

 

8

 

 SHARED DISPOSITIVE POWER

 

 

 

 

 0

 

9

 

 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

 


 


 


 0


 


 

 

10

 

 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

 

o


 


 


 


 


 

 

11

 

 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

 


 


 


 0%


 


 

 

12

 

 TYPE OF REPORTING PERSON*

 

 


 


 


 OO


 


 

 





 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 6 of 10 Pages

 

 

 

 

 

 


1

 

 NAME OF REPORTING PERSON:
BVF Partners L.P.
 I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):

 

 

 

2

 

 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

 

(a)  ý

 

 

 

 

(b)  o

 

 

 

 

 

 

3

 

 SEC USE ONLY

 

 


 


 


 


 


 

 

4

 

 CITIZENSHIP OR PLACE OF ORGANIZATION

 

 


 


 


 Delaware


 


 

 


 

 

5

 

 SOLE VOTING POWER

NUMBER OF

 

 

 

 0

SHARES

 

 

BENEFICIALLY

 

6

 

 SHARED VOTING POWER

OWNED

 

 

 

 0

BY

 

 

EACH

 

7

 

 SOLE DISPOSITIVE POWER

REPORTING

 

 

 

 0

PERSON

 

 

WITH:

 

8

 

 SHARED DISPOSITIVE POWER

 

 

 

 

 0

 

9

 

 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

 


 


 


 0


 


 

 

10

 

 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

 

o


 


 


 


 


 

 

11

 

 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

 


 


 


 0%


 


 

 

12

 

 TYPE OF REPORTING PERSON*

 

 


 


 


 PN


 


 

 





 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 7 of 10 Pages

 

 

 

 

 

 


1

 

 NAME OF REPORTING PERSON:
BVF Inc.
 S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY):

 

 

 

2

 

 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

 

(a)  ý

 

 

 

 

(b)  o

 

 

 

 

 

 

3

 

 SEC USE ONLY

 

 


 


 


 


 


 

 

4

 

 CITIZENSHIP OR PLACE OF ORGANIZATION

 

 


 


 


 Delaware


 


 

 

 

 

5

 

 SOLE VOTING POWER

NUMBER OF

 

 

 

 0

SHARES

 

 

BENEFICIALLY

 

6

 

 SHARED VOTING POWER

OWNED

 

 

 

 0

BY

 

 

EACH

 

7

 

 SOLE DISPOSITIVE POWER

REPORTING

 

 

 

 0

PERSON

 

 

WITH:

 

8

 

 SHARED DISPOSITIVE POWER

 

 

 

 

 0

 

9

 

 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

 


 


 


 0


 


 

 

10

 

 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

 

o


 


 


 


 


 

 

11

 

 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

 


 


 


 0%


 


 

 

12

 

 TYPE OF REPORTING PERSON*

 

 


 


 


 IA, CO


 


 

 





 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 8 of 10 Pages

 

 

 

 

 

 



ITEM 1(a).      NAME OF ISSUER:

                         Insmed Incorporated (“Insmed”)

ITEM 1(b).      ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

4851 Lake Brook Drive

Glen Allen, VA 23060


ITEM 2(a).      NAME OF PERSON FILING:

                         This Schedule 13G is being filed on behalf of the following persons (the "Reporting Persons"):

 

(i)

 

 Biotechnology Value Fund, L.P. ("BVF")

 

(ii)

 

 Biotechnology Value Fund II, L.P. ("BVF2")

 

(iii)

 

 BVF Investments, L.L.C. ("Investments")

 

(iv)

 

 Investment 10, L.L.C. ("ILL10")

 

(v)

 

 BVF Partners L.P. ("Partners")

 

(vi)

 

 BVF Inc. ("BVF Inc.")

ITEM 2(b).      ADDRESS OF PRINCIPAL BUSINESS OFFICE:

                         The principal business office of the Reporting Persons comprising the group filing this Schedule 13G is located at 900 North Michigan Avenue, Suite 1100, Chicago, Illinois, 60611.

ITEM 2(c).      CITIZENSHIP:

 

 

 BVF:

 a Delaware limited partnership

 

 

 BVF2:

 a Delaware limited partnership

 

 

 Investments:

 a Delaware limited liability company

 

 

 ILL10:

 an Illinois limited liability company

 

 

 Partners:

 a Delaware limited partnership

 

 

 BVF Inc.:

 a Delaware corporation

ITEM 2(d).      TITLE OF CLASS OF SECURITIES:

                         This Schedule 13G is being filed with respect to the common stock, par value $0.01 per share ("Common Stock"), of Insmed. The Reporting Persons' percentage ownership of Common Stock is based on 121,824,889 shares of Common Stock being outstanding.

                 

    As of December 31, 2007, BVF, BVF2, Investments, ILL10, Partners and BVF do not beneficially own any shares of Common Stock of Insmed.

ITEM 2(e).      CUSIP Number:

457669208






 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 9 of 10 Pages

 

 

 

 

 

 



ITEM 3.        IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), or 13d-2(b) or (c) CHECK WHETHER THE PERSON FILING IS:    One of the following

                        Not applicable as this Schedule 13G is filed pursuant to Rule 13d-1(c).

ITEM 4.        OWNERSHIP:

                        The information in items 1 and 5 through 11 on the cover pages (pp. 2 - 7) on this Schedule 13G is hereby incorporated by reference.

ITEM 5.        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

                        If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following.  ý

ITEM 6.        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

                        Not applicable.

ITEM 7.        IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:

                        Not applicable.

ITEM 8.        IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:

                        Not applicable.

ITEM 9.        NOTICE OF DISSOLUTION OF GROUP:

                        Not applicable.





 

 

 

 

 

CUSIP No. 457669208

 

13G

 

Page 10 of 10 Pages

 

 

 

 

 

 



ITEM 10.        CERTIFICATION

                        By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

                        After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.


Dated:

 

January 28, 2008



 


 


BIOTECHNOLOGY VALUE FUND, L.P.


 


 


By:


 


BVF Partners L.P., its general partner


 


 


 


 


By:


 


BVF Inc., its general partner


 


 


 


 


 


 


By:


 


 /s/ Mark N. Lampert

 

 

 

 

 

 

 

 


 Mark N. Lampert
 President


 


 


BIOTECHNOLOGY VALUE FUND II, L.P.


 


 


By:


 


BVF Partners L.P., its general partner


 


 


 


 


By:


 


BVF Inc., its general partner


 


 


 


 


 


 


By:


 


 /s/ Mark N. Lampert

 

 

 

 

 

 

 

 


 Mark N. Lampert
 President


 


 


BVF INVESTMENTS, L.L.C.


 


 


By:


 


BVF Partners L.P., its manager


 


 


 


 


By:


 


BVF Inc., its general partner


 


 


 


 


 


 


By:


 


 /s/ Mark N. Lampert

 

 

 

 

 

 

 

 


 Mark N. Lampert
 President



 


 


INVESTMENT 10, L.L.C.


 


 


By:


 


BVF Partners L.P., its attorney-in-fact


 


 


 


 


By:


 


BVF Inc., its general partner


 


 


 


 


 


 


By:


 


 /s/ Mark N. Lampert

 

 

 

 

 

 

 

 


 Mark N. Lampert
 President


 


 


BVF PARTNERS L.P.


 


 


By:


 


BVF Inc., its general partner


 


 


 


 


 


 


By:


 


 /s/ Mark N. Lampert

 

 

 

 

 

 

 

 


 Mark N. Lampert
 President


 


 



BVF INC.


 


 


 


 


 


 


By:


 


 /s/ Mark N. Lampert

 

 

 

 

 

 

 

 


 Mark N. Lampert
 President