UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G

                   Under the Securities Exchange Act of 1934*

                                  Depomed, Inc.
                                  -------------
                                (Name of Issuer)

                           Common Stock, no par value
                           --------------------------
                         (Title of Class of Securities)

                                    249908104
                                    ---------
                                 (CUSIP Number)

                                   May 1, 2007
                                   -----------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 (the "Act") or otherwise subject to the liabilities of that
  section of the Act but shall be subject to all other provisions of the Act
  (however, see the Notes).







-------------------------------------                       --------------------
CUSIP No.  249908104                        13G             Page 2 of 10 Pages
-------------------------------------                       --------------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Third Point LLC
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a) [ ]
                                                                     (b) [X]

---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             3,900,000
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            3,900,000
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           3,900,000
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           8.2%
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON

           OO
---------- ---------------------------------------------------------------------





-------------------------------------                       --------------------
CUSIP No.  249908104                        13G             Page 3 of 10 Pages
-------------------------------------                       --------------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Daniel S. Loeb
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a) [ ]
                                                                     (b) [X]

---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             3,900,000
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            3,900,000
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           3,900,000
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           8.2%
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON

           IN
---------- ---------------------------------------------------------------------






-------------------------------------                       --------------------
CUSIP No.  249908104                        13G             Page 4 of 10 Pages
-------------------------------------                       --------------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Third Point Offshore Fund, Ltd.
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                     (a) [ ]
                                                                     (b) [X]

---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Cayman Islands
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             2,498,700
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            2,498,700
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,498,700
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           5.3%
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON

           OO
---------- ---------------------------------------------------------------------





Item 1(a):          Name of Issuer:
---------           --------------

     The name of the issuer is Depomed, Inc., a corporation organized under the
laws of the State of California (the "Company").

Item 1(b):         Address of Issuer's Principal Executive Offices:
---------          -----------------------------------------------

     The Company's principal executive office is located at 1360 O'Brien Drive,
Menlo Park, California 94025.

Item 2(a):         Name of Person Filing:
----------         ----------------------

     This Schedule 13G is filed by:

     (i)  Third Point LLC, a Delaware limited liability company (the "Management
          Company"), which serves as investment manager or adviser to a variety
          of hedge funds and managed accounts (such funds and accounts,
          collectively, the "Funds"), with respect to shares of Common Stock (as
          defined in Item 2(d)) directly owned by the Funds; and

     (ii) Mr. Daniel S. Loeb ("Mr. Loeb"), who is the Chief Executive Officer of
          the Management Company and controls its business activities, with
          respect to shares of Common Stock indirectly beneficially owned by Mr.
          Loeb by virtue of such position.

     (iii) Third Point Offshore Fund, Ltd., a Cayman Islands limited liability
           exempted company (the "Offshore Fund") which invests and trades in
           securities, with respect to shares of Common Stock directly held by
           it.

     The Management Company, Mr. Loeb and the Offshore Fund are hereinafter
sometimes collectively referred to as the "Reporting Persons." Any disclosures
herein with respect to persons other than the Reporting Persons are made on
information and belief after making inquiry to the appropriate party.

Item 2(b):          Address of Principal Business Office or, if None,
---------           -------------------------------------------------
                    Residence:
                    ---------

     The address of the principal business office of the Management Company and
Mr. Loeb is 390 Park Avenue, New York, New York 10022. The address of the
principal business office of the Offshore Fund is c/o Walkers SPV Limited,
Walker House, 87 Mary Street, George Town, Grand Cayman KY1-9002, Cayman
Islands, British West Indies.

Item 2(c):          Citizenship:
---------           -----------

     The Management Company is organized as a limited liability company under
the laws of the State of Delaware. Mr. Loeb is a United States citizen. The
Offshore Fund is organized as a limited liability exempted company under the
laws of the Cayman Islands.

                                       5




Item 2(d):         Title of Class of Securities:
---------          ----------------------------

         Common Stock, no par value ("Common Stock").

Item 2(e):          CUSIP Number:
---------           ------------

         249908104.

Item 3:             If this statement is filed pursuant to Rules 13d-1(b)
------              -----------------------------------------------------
                    or 13d-2(b) or (c), check whether the person filing is a:
                    --------------------------------------------------------

               A.   [ ] Broker or dealer registered under Section 15 of the Act,
               B.   [ ] Bank as defined in Section 3(a)(6) of the Act,
               C.   [ ] Insurance Company as defined in Section 3(a)(19) of the
                        Act,
               D.   [ ] Investment Company registered under Section 8 of the
                        Investment Company Act of 1940,
               E.   [ ] Investment Adviser in accordance with Rule
                        13d-1(b)(1)(ii)(E),
               F.   [ ] Employee Benefit Plan or Endowment Fund in accordance
                        with 13d-1 (b)(1)(ii)(F),
               G.   [ ] Parent Holding Company or control person in accordance
                        with Rule 13d-1(b)(1)(ii)(G),
               H.   [ ] Savings Association as defined in Section 3(b) of the
                        Federal Deposit Insurance Act,
               I.   [ ] Church Plan that is excluded from the definition of an
                        investment company under Section 3(c)(14) of the
                        Investment Company Act of 1940,
               J.   [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

Item 4:             Ownership:
------              ---------

     The beneficial ownership of Common Stock by the Reporting Persons, as of
the date of this Schedule 13G, is as follows:

   A.   Third Point LLC
        ---------------
        (a) Amount beneficially owned: 3,900,000
        (b) Percent of class: 8.2%. The percentages used herein and in the rest
of this Schedule 13G are calculated based upon the 47,470,067 shares of Common
Stock issued and outstanding as of May 3, 2007, as reported in the Company's
Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2007.
        (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 3,900,000
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 3,900,000

                                       6




   B.   Daniel S. Loeb
        ---------------
        (a) Amount beneficially owned: 3,900,000
        (b) Percent of class: 8.2%.
        (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 3,900,000
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 3,900,000


   C.   Third Point Offshore Fund, Ltd.
        -------------------------------
        (a) Amount beneficially owned: 2,498,700
        (b) Percent of class: 5.3%.
        (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 2,498,700
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 2,498,700

Item 5:      Ownership of Five Percent or Less of a Class:
------       --------------------------------------------

If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following: [ ]

Item 6:      Ownership of More than Five Percent on Behalf of Another Person:
------       ---------------------------------------------------------------

Other than as set forth herein, no other person has the right to receive or the
power to direct the receipt of dividends from, or proceeds from the sale of, in
excess of 5% of the total outstanding Common Stock.

Item 7:      Identification and Classification of the Subsidiary Which
------       ---------------------------------------------------------
             Acquired the Security Being Reported on by the Parent Holding
             -------------------------------------------------------------
             Company:
             -------

Not applicable.

Item 8:      Identification and Classification of Members of the Group:
------       ---------------------------------------------------------

Not applicable.

Item 9:      Notice of Dissolution of Group:
------       ------------------------------

Not applicable.

                                       7


Item 10:     Certification:
-------      -------------

Each of the Reporting Persons hereby makes the following certification:

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.



                         [Signatures on following page]


                                       8











                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


Dated: May 11, 2007


                                THIRD POINT LLC

                                By: Daniel S. Loeb, Chief Executive Officer


                                By: /s/ Justin Nadler
                                    --------------------------------------------
                                    Name:  Justin Nadler
                                    Title: Attorney-in-Fact



                                THIRD POINT OFFSHORE FUND, LTD.

                                By: Daniel S. Loeb, Director


                                By: /s/ Justin Nadler
                                    --------------------------------------------
                                    Name:  Justin Nadler
                                    Title: Attorney-in-Fact



                                DANIEL S. LOEB


                                By: /s/ Justin Nadler
                                    --------------------------------------------
                                    Name:  Justin Nadler
                                    Title: Attorney-in-Fact





                 [SIGNATURE PAGE TO SCHEDULE 13G WITH RESPECT TO
                                 DEPOMED, INC.]







                                  EXHIBIT INDEX
                                  -------------

Exhibit 99.1:   Joint Filing Agreement, dated May 11, 2007, by and between the
                Reporting Persons.

Exhibit 99.2:   Power of Attorney  granted by Mr. Daniel S. Loeb in favor of
                James Kelly,  Justin Nadler,  Zachary Snow and Keith Waller,
                dated December 1, 2006.