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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 2)*



                          PANACOS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)



                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                   69811Q 10 6
--------------------------------------------------------------------------------
                                 (CUSIP Number)



                                DECEMBER 31, 2006
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[_]  Rule 13d-1(b)

[X]  Rule 13d-1(c)

[_]  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).




PERSONS WHO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS FORM ARE
NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB CONTROL
NUMBER.





-------------------------                              -------------------------
CUSIP No.                              13G             Page 2 of 11 Pages
-------------------------                              -------------------------


 1.      NAMES OF REPORTING PERSONS

         Great Point Partners, LLC

         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
         37-1475292

 2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

         (a)    [_]

         (b)    [_]


--------------------------------------------------------------------------------
 3.      SEC USE ONLY



--------------------------------------------------------------------------------
 4.      CITIZENSHIP OR PLACE OF ORGANIZATION

         USA

NUMBER OF SHARES          5.    SOLE VOTING POWER

  BENEFICIALLY                  0

 OWNED BY EACH            6.    SHARED VOTING POWER
                                                             2,180,015
REPORTING PERSON
                          7.    SOLE DISPOSITIVE POWER
     WITH
                                0

                          8.    SHARED DISPOSITIVE POWER

                                                             2,180,015

 9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               2,180,015

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES (See Instructions)                                           [_]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

               4.31%

12.      TYPE OF REPORTING PERSON (See Instructions)

               OO





                                       2




-------------------------                              -------------------------
CUSIP No.                              13G             Page 3 of 11 Pages
-------------------------                              -------------------------


 1.      NAMES OF REPORTING PERSONS

         Biomedical Value Fund, L.P.

         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
         37-1475295

 2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

         (a)    [_]

         (b)    [_]


--------------------------------------------------------------------------------
 3.      SEC USE ONLY



--------------------------------------------------------------------------------
 4.      CITIZENSHIP OR PLACE OF ORGANIZATION

         USA

NUMBER OF SHARES          5.    SOLE VOTING POWER

  BENEFICIALLY                                               0

 OWNED BY EACH            6.    SHARED VOTING POWER
                                                             1,082,916
REPORTING PERSON
                          7.    SOLE DISPOSITIVE POWER
     WITH
                                                             0
                          8.    SHARED DISPOSITIVE POWER

                                                             1,082,916

 9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

               1,082,916

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES (See Instructions)                                           [_]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

               2.14%

12.      TYPE OF REPORTING PERSON (See Instructions)

                PN



                                       3



-------------------------                              -------------------------
CUSIP No.                              13G             Page 4 of 11 Pages
-------------------------                              -------------------------


 1.      NAMES OF REPORTING PERSONS

         Biomedical Offshore Value Fund, Ltd.

         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):
         N/A

 2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

         (a)    [_]

         (b)    [_]


--------------------------------------------------------------------------------
 3.      SEC USE ONLY



--------------------------------------------------------------------------------
 4.      CITIZENSHIP OR PLACE OF ORGANIZATION

         Cayman Islands

NUMBER OF SHARES          5.    SOLE VOTING POWER

  BENEFICIALLY                                               0

 OWNED BY EACH            6.    SHARED VOTING POWER
                                                             1,097,099
REPORTING PERSON
                          7.    SOLE DISPOSITIVE POWER
     WITH                                                    0

                          8.    SHARED DISPOSITIVE POWER

                                                             1,097,099

 9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                1,097,099

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES (See Instructions)                                           [_]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

               2.18%

12.      TYPE OF REPORTING PERSON (See Instructions)

               CO



                                       4



-------------------------                              -------------------------
CUSIP No.                              13G             Page 5 of 11 Pages
-------------------------                              -------------------------


 1.      NAMES OF REPORTING PERSONS

         Dr. Jeffrey R. Jay, M.D.

         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):


 2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

         (a)    [_]

         (b)    [_]


--------------------------------------------------------------------------------
 3.      SEC USE ONLY



--------------------------------------------------------------------------------
 4.      CITIZENSHIP OR PLACE OF ORGANIZATION

         USA

NUMBER OF SHARES          5.    SOLE VOTING POWER

  BENEFICIALLY                                               0

 OWNED BY EACH            6.    SHARED VOTING POWER
                                                             2,180,015
REPORTING PERSON
                          7.    SOLE DISPOSITIVE POWER
     WITH                                                    0

                          8.    SHARED DISPOSITIVE POWER

                                                             2,180,015

 9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                2,180,015

10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
         SHARES (See Instructions)                                           [_]

11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

               4.31%

12.      TYPE OF REPORTING PERSON (See Instructions)

               IN



                                       5




-------------------------                              -------------------------
CUSIP No.                              13G             Page 6 of 11 Pages
-------------------------                              -------------------------


     ITEM 1.

                    (a)       Name of Issuer

                              Panacos Pharmaceuticals, Inc.

                    (b)       Address of Issuer's Principal Executive Offices

                              134 Coolidge Avenue
                              Watertown, MA  02472

     ITEM 2.

                      (a)     Name of Person Filing

                              Great Point Partners, LLC
                              Biomedical Value Fund, L.P.
                              Biomedical Offshore Value Fund, Ltd.
                              Dr. Jeffrey R. Jay, M.D.

                    The Reporting Persons have entered into a Joint Filing
                    Statement, dated February 14, 2007, a copy of which is filed
                    with this Schedule 13G as Exhibit A, pursuant to which the
                    Reporting Persons have agreed to file this statement jointly
                    in accordance with the provisions of Rule 13d-1(k)(1) under
                    the Act.

                    (b)  Address of Principal Business Office, or if none,
                         Residence

                         The address of the principal business office of each of
                         the Reporting Persons is

                                  165 Mason Street, 3rd Floor
                                  Greenwich, CT 06830

                    (c)  Citizenship

                    Great Point Partners, LLC is a limited liability company
                    organized under the laws of the State of Delaware.
                    Biomedical Value Fund, L.P. is a limited partnership
                    organized under the laws of the State of Delaware.
                    Biomedical Offshore Value Fund, Ltd. is an exempted company
                    incorporated under the provisions of the Companies Law of
                    the Cayman Islands. Dr. Jeffrey R. Jay, M.D. is a citizen of
                    the United States.

                    (d)  Title of Class of Securities

                         Common Stock

                    (e)  CUSIP Number

                         69811Q 10 6

     ITEM 3.        IF THIS STATEMENT IS FILED PURSUANT TO SS.240.13D-1(b) OR
                    240.13D.2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

                             Not Applicable.

                    (a)  [_]  Broker or dealer registered under Section 15 of
                              the Act (15 U.S.C. 78o)


                                       6



-------------------------                              -------------------------
CUSIP No.                              13G             Page 7 of 11 Pages
-------------------------                              -------------------------

                 (b)  [_]  Bank as defined in Section 3(a)(6) of the Act (15
                           U.S.C. 78c).

                 (c)  [_]  Insurance company as defined in Section 3(a)(19)
                           of the Act (15. U.S.C. 78c).

                 (d)  [_]  Investment Company registered under Section 8 of
                           the Investment Company Act of 1940 (15 U.S.C.
                           80a-8).

                 (e)  [_]  An investment adviser in accordance with
                           ss.240.13d-1(b)(1)(ii)(E).

                 (f)  [_]  An employee benefit plan or endowment fund in
                           accordance with ss.240.13d-1(b)(1)(ii)(F).

                 (g)  [_]  A parent holding company or control person in
                           accordance with ss.240.13d-1(b)(1)(ii)(G).

                 (h)  [_]  A savings associations as defined in Section 3(b)
                           of the Federal Deposit Insurance Act (12 U.S.C.
                           1813).

                 (i)  [_]  A church plan that is excluded from the definition
                           of an investment company under Section 3(c)(14) of
                           the Investment Company Act of 1940 (15 U.S.C.
                           80a-3).

                 (j)  [_]  Group, in accordance with  ss.240.13d-1(b)(1)(ii)(J).

     ITEM 4.     OWNERSHIP

                 Biomedical Value Fund, L.P. ("BVF") is the direct beneficial
                 owner of 1,082,916 shares of Common Stock of the Issuer (the
                 "BVF Shares"). Great Point GP, LLC, is the general partner of
                 BVF, and by virtue of such status may be deemed to be the
                 beneficial owner of the BVF Shares. Great Point Partners, LLC
                 is the investment manager of BVF, and by virtue of such status
                 may be deemed to be the beneficial owner of the BVF Shares. Dr.
                 Jeffrey R. Jay, M.D. has voting and investment power with
                 respect to the BVF Shares, and therefore may be deemed to be
                 the beneficial owner of the BVF Shares.

                 Biomedical Offshore Value Fund, Ltd. ("BOVF") is the direct
                 beneficial owner of 1,097,099 shares of Common Stock of the
                 Issuer (the "BOVF Shares"). Great Point Partners, LLC is the
                 investment manager of BOVF, and by virtue of such status may be
                 deemed to be the beneficial owner of the BOVF Shares. Dr.
                 Jeffrey R. Jay, M.D. has voting and investment power with
                 respect to the BOVF Shares, and therefore may be deemed to be
                 the beneficial owner of the BOVF Shares.

                 Notwithstanding the above, Great Point Partners, LLC and Dr.
                 Jay disclaim beneficial ownership of the BVF Shares and the
                 BOVF Shares and Great Point GP, LLC disclaims beneficial
                 ownership of the BVF Shares, except to the extent of their
                 respective pecuniary interests.

                 The Information in Items 1 and 5 through 11 on the cover pages
                 of this Amendment No. 3 to Schedule 13G is hereby incorporated
                 by reference.

                 Provide the following information regarding the aggregate
                 number and percentage of the class of securities of the issuer
                 identified in Item 1.

                 1. GREAT POINT PARTNERS, LLC

                 (a) Amount beneficially owned: 2,180,015


                                     7



-------------------------                              -------------------------
CUSIP No.                              13G             Page 8 of 11 Pages
-------------------------                              -------------------------

             b)    Percent of class: 4.31%.

             c)    Number of shares as to which the person has:

                   (i)    Sole power to vote or to direct the vote:  - 0 -

                   (ii)   Shared power to vote or to direct the vote:
                          2,180,015

                   (iii)  Sole power to dispose or to direct the disposition of:
                           - 0 -.

                   (iv)   Shared power to dispose or to direct the disposition
                          of: 2,180,015

             2.    BIOMEDICAL VALUE FUND, L.P.

             (a)   Amount beneficially owned: 1,082,916

             (b)   Percent of class: 2.14%.

             (c)   Number of shares as to which the person has:

                   (i)    Sole power to vote or to direct the vote: 1,082,916

                   (ii)   Shared power to vote or to direct the vote: 0.

                   (iii)  Sole power to dispose or to direct the disposition of:
                          1,082,916

                   (iv)   Shared power to dispose or to direct the disposition
                          of: 0.

             2.    BIOMEDICAL OFFSHORE VALUE FUND, LTD.

             (a)   Amount beneficially owned: 1,097,099

             (b)   Percent of class: 2.18%.

             (c)   Number of shares as to which the person has:

                   (i)    Sole power to vote or to direct the vote: 1,097,099

                   (ii)   Shared power to vote or to direct the vote: 0.

                   (iii)  Sole power to dispose or to direct the disposition of:
                          1,097,099

                   (iv)   Shared power to dispose or to direct the disposition
                          of: 0.

             2.    DR. JEFFREY R. JAY, M.D.

             (a)   Amount beneficially owned: 2,180,015

             (b)   Percent of class: 4.31%.

             (c)   Number of shares as to which the person has:

                   (i)    Sole power to vote or to direct the vote: 0

                   (ii)   Shared power to vote or to direct the vote: 2,180,015

                   (iii)  Sole power to dispose or to direct the disposition of:
                          0

                   (iv)   Shared power to dispose or to direct the disposition
                          of: 2,180,015

                                       8



-------------------------                              -------------------------
CUSIP No.                              13G             Page 9 of 11 Pages
-------------------------                              -------------------------


ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                If this statement is being filed to report the fact that as of
the date hereof each of the Reporting Persons has ceased to be the beneficial
owner of more than five percent of the class of securities, check the following
[X].

ITEM 6.         OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

                See item 4.

ITEM 7.         IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
                COMPANY

                Not Applicable.

ITEM 8.         IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

                Not Applicable.

ITEM 9.         NOTICE OF DISSOLUTION OF GROUP

                Not Applicable.

ITEM 10.        CERTIFICATION

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as
participant in any transaction having that purpose or effect.




                                       9



-------------------------                              -------------------------
CUSIP No.                              13G             Page 10 of 11 Pages
-------------------------                              -------------------------


                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date:  February 14, 2007

                                  GREAT POINT PARTNERS, LLC

                                  By:  /S/ DR. JEFFREY R. JAY, M.D.
                                       -----------------------------------------
                                       Dr. Jeffrey R. Jay, M.D.,
                                         as senior managing member


                                  BIOMEDICAL VALUE FUND, L.P.

                                  By: Great Point GP, LLC,
                                          as general partner

                                  By:  /S/ DR. JEFFREY R. JAY, M.D.
                                       -----------------------------------------
                                       Dr. Jeffrey R. Jay, M.D.,
                                         as senior managing member

                                  BIOMEDICAL OFFSHORE VALUE FUND, LTD.

                                  By: Great Point Partners, LLC,
                                          as investment manager

                                  By:  /S/ DR. JEFFREY R. JAY, M.D.
                                       -----------------------------------------
                                       Dr. Jeffrey R. Jay, M.D.,
                                         as senior managing member



                                  /S/ DR. JEFFREY R. JAY, M.D.
                                  ----------------------------------------------
                                  DR. JEFFREY R. JAY, M.D.




                                       10




                                                                       EXHIBIT A

                             JOINT FILING STATEMENT

         Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange
Act of 1934, as amended, the undersigned agree that the Statement on Schedule
13G and any amendments thereto to which this exhibit is attached is filed on
behalf of each of them.

Date:  February 14, 2007

                                    GREAT POINT PARTNERS, LLC

                                    By:  /S/ DR. JEFFREY R. JAY, M.D.
                                         ---------------------------------------
                                         Dr. Jeffrey R. Jay, M.D.,
                                           as senior managing member


                                    BIOMEDICAL VALUE FUND, L.P.

                                    By: Great Point GP, LLC,
                                            as general partner

                                    By:  /S/ DR. JEFFREY R. JAY, M.D.
                                         ---------------------------------------
                                         Dr. Jeffrey R. Jay, M.D.,
                                           as senior managing member

                                    BIOMEDICAL OFFSHORE VALUE FUND, LTD.

                                    By: Great Point Partners, LLC,
                                            as investment manager

                                    By:  /S/ DR. JEFFREY R. JAY, M.D.
                                         ---------------------------------------
                                         Dr. Jeffrey R. Jay, M.D.,
                                           as senior managing member



                                    /S/ DR. JEFFREY R. JAY, M.D.
                                    --------------------------------------------
                                    DR. JEFFREY R. JAY, M.D.