UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                Date of report (Date of earliest event reported):

                                December 4, 2008

                           HEMISPHERX BIOPHARMA, INC.
               (Exact Name of Registrant as Specified in Charter)

                           Delaware 0-27072 52-0845822
             (State or Other Jurisdiction (Commission (IRS Employer
               of Incorporation) File Number) Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania, 19103
          (Address of Principal Executive Offices, including Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080

                                 Not Applicable
          (Former Name or Former Address, if Changed Since Last Report)

     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
           following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities
    Act (17 CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange
    Act (17 CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the
    Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the
    Exchange Act (17 CFR 240.13e-4(c))

===============================================================================






Section 5 - Corporate Governance and Management

Hemispherx  Biopharma,  Inc.  announced the appointment of a new Chief Financial
Officer (interim),  Charles T. Bernhardt, C.P.A, M.B.A., to be effective January
1, 2009.


For more  information,  please see the December 4, 2008 press  release  attached
hereto as exhibit 99.1.


The following Exhibit is filed as part of this report:

Exhibit No.                Description

   99.1         Press Release dated December 4, 2008









                                   Signatures

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the registrant has caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Date: December 8, 2008

                                           HEMISPHERX BIOPHARMA, INC.

                                           /s/ William A. Carter
                                           -----------------------------------
                                           William A. Carter, M.D.,
                                           Chief Executive Officer






                                                   Exhibit 99.1
Company/Investor Contact:
Dianne Will                                       Sean Collins, Sr. Partner
Hemispherx Biopharma, Inc.                        CCG Investor Relations
518-398-6222                                      310-477-9800
ir@hemispherx.net


           Hemispherx Biopharma Announces New Chief Financial Officer

Philadelphia, PA., December 4, 2008 - Hemispherx Biopharma, Inc. (NYSE Alternext
US: HEB) announced the appointment of a new Chief Financial  Officer  (interim),
Charles T.  Bernhardt,  C.P.A,  M.B.A.,  effective  January  1, 2009.  Robert E.
Peterson,  Hemispherx's  Chief Financial  Officer for approximately 20 years, is
retiring at that time;  he will retain a position of  Consultant  and  Financial
Advisor to the Company.

Under Mr.  Peterso's  tenure,  he was instrumental in a number of private stock
placements  prior  to the  company's  "going  public"  in  1995.  Those  private
placements which were significant in the Company's growth and clinical  progress
included   investments  made  by  diverse   sophisticated   investors  including
principals  at  Clayton,  Dubilier  and Rice,  a  preeminent  M&A  Firm;  Canaan
Partners;  Dr. Lee  Pierce;  the  Lawrence  Tisch  family and Mr.  Gerald  Tsai,
formerly of Smith-Barney.

Mr. Bernhardt,  age 47, is a Certified Public Accountant,  graduate of Villanova
University  and most  recently was the  Director of  Accounting  for  Healthcare
Division of Thomson Reuters  (NYSE-TRI),  an overall company with $12 billion in
annual revenues and 50,000 total  world-wide  employees.  He was responsible for
their  Healthcare  Division's  accounting  operations  as  well  as  the  shared
financial services for the Healthcare and Scientific  Divisions.  Earlier in his
career, he was a Regional Controller for Comcast Cable,  Director of Finance for
TelAmerica Media and is an alumni of public accounting's Big Four in KPMG.

Hemispherx's CEO/Chairman,  Dr. William Carter commented: "Over the last several
months, under Mr. Peterson's tutelage,  we have seen a smooth gradual transition
to Mr. Bernhardt's leadership. By their continuing to work together, the Company
is  guaranteed  to  continue  to have  outstanding  financial  leadership  going
forward."

                          About Hemispherx Biopharma

Hemispherx  Biopharma,  Inc.  is a  specialty  pharma  company  engaged  in  the
manufacture  and clinical  development  of new drug  entities  for  treatment of
seriously debilitating disorders. Hemispherx's flagship products include Alferon
N Injection(R)  (FDA approved for a category of sexually  transmitted  diseases)
and the  experimental  therapeutics,  Ampligen(R)  and Oragens.  Ampligen(R) and
Oragens  represent  experimental  RNA nucleic acids being developed for globally
important debilitating diseases and disorders of the immune system. Hemispherx's
platform  technology  includes  large and small agent  components  for potential
treatment  of  various  severely  debilitating  and life  threatening  diseases.
Hemispherx has in excess of 50 issued patents  comprising its core  intellectual
property estate and a fully commercialized product (Alferon N Injection(R)). The
Company  wholly  owns and  exclusively  operates a GMP  certified  manufacturing
facility in the United  States for  commercial  products.  For more  information
please visit www.hemispherx.net.

Information  contained in this news release other than  historical  information,
should be considered  forward-looking and is subject to various risk factors and
uncertainties. For instance, the strategies and operations of Hemispherx involve
risk of competition,  changing market conditions, change in laws and regulations
affecting these industries and numerous other factors  discussed in this release
and in the Company's  filings with the Securities and Exchange  Commission.  Any
specifically referenced investigational drugs and associated technologies of the
Company  (including  Ampligen(R),  Alferon LDO and Oragens) are  experimental in
nature  and as such  are not  designated  safe  and  effective  by a  regulatory
authority for general use and are legally available only through clinical trials
with the referenced  disorders.  The  forward-looking  statements  represent the
Company's  judgment  as of the  date of this  release.  The  Company  disclaims,
however,  any intent or obligation to update these  forward-looking  statements.
Clinical trials for other potential indications of the approved biologic Alferon
N Injection(R) do not imply that the product will ever be specifically  approved
commercially for these other treatment indications; similarly, the completion of
the NDA filing  process  with  Ampligen(R)  does not imply that the product will
ever be approved commercially.

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