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MAIA Biotechnology (MAIA) is one of the earliest pioneers of telomere targeting as a therapeutic strategy

MAIA Biotechnology (MAIA) is one of the earliest pioneers of telomere targeting as a therapeutic strategy
Biotech Stocks
MAIA is one of the earliest pioneers of telomere targeting as a therapeutic strategy, and we share in the enthusiasm for the FDA approval of imetelstat for rare blood cancers originating in bone marrow. We have found that telomere targeting as a mechanism of action plays a key role in treating certain cancers, and we are studying this science in our Phase 2 trial of THIO in high-risk non-small cell lung cancer (NSCLC)," said Vlad Vitoc, M.D., Chairman and CEO of MAIA

MAIA Biotechnology, Inc (NYSEAMERICAN: MAIA)., a trailblazer in the field of telomere-targeting therapies, is ushering in a new era of cancer treatment, leveraging the profound potential of telomeric functions. This novel approach received a significant endorsement with the recent FDA approval of imetelstat for hematologic malignancies, setting a precedent that MAIA aims to follow with its leading candidate, THIO, in the fight against non-small cell lung cancer (NSCLC).

Innovative Approaches to Targeting Cancer

Telomere targeting, a strategy that MAIA has been pioneering, plays a critical role in treating certain cancers. This method involves disrupting the protective ends of chromosomes in cancer cells, known as telomeres, which are crucial for their survival and proliferation. MAIA’s leading investigational drug, THIO (6-thio-2’-deoxyguanosine), exploits this vulnerability in cancer cells by integrating into their telomeres, leading to rapid cell death.

Dr. Vlad Vitoc, Chairman and CEO of MAIA, highlighted the recent promising outcomes from their Phase 2 trial of THIO in high-risk NSCLC patients who are resistant to checkpoint inhibitors and chemotherapy. “Our most recent clinical data shows THIO’s exceptional efficacy in these patients. We salute Geron for validating the pathway,” Dr. Vitoc stated.

THIO: A Catalyst for Change in NSCLC Treatment

THIO is not just another cancer drug; it's a telomere-targeting agent that induces profound biological responses in cancer cells. It damages telomeric DNA, which not only causes direct cancer cell death but also sparks both innate and adaptive immune responses. This dual-action makes THIO a powerful candidate for sequential treatment with PD-(L)1 inhibitors, showing potential for significant and persistent tumor regression by creating a cancer-specific immune memory.

Phase 2 Clinical Trial: THIO-101

The ongoing THIO-101 trial is a pioneering study designed to test THIO’s efficacy as an anticancer compound and a priming immune activator. Administered in low doses prior to cemiplimab (Libtayo®), the hypothesis is that THIO enhances and prolongs the immune response in advanced NSCLC patients who have progressed after first-line treatment with other checkpoint inhibitors. “The trial aims to evaluate the safety and tolerability of THIO, and assess its clinical efficacy using the Overall Response Rate as the primary endpoint,” explained Dr. Vitoc.

Recent Company highlights and key achievements 

  • New science for cancer therapy drives powerful value proposition

  • Exceptional measures of efficacy by lead drug THIO in Phase 2 clinical trial

  • Funding of more than $12M year-to-date, including $7.4 million in Q2’24 so far

  • Secured continued insider investment through independent board members’ participation in private placement equity financings

  • Newest data shows THIO’s strong outperformance against standard-of-care treatments in non-small cell lung cancer (NSCLC)

  • 38% overall response rate (ORR) in third-line (3L) setting (THIO 180mg) vs. ~6% for currently available treatments in a similar population

  • 5.5 months median progression-free survival (PFS) (3L, THIO 180mg) more than double PFS of current chemotherapy treatments

Looking Forward

As MAIA Biotechnology continues to develop THIO and explore its full potential, the oncology community watches with anticipation, hopeful for a new, effective weapon against hard-to-treat cancers. With ongoing trials and a commitment to innovative cancer solutions, MAIA is not just participating in the evolution of cancer treatment; it’s aiming to lead it. This blog post leverages information directly related to the advancements in telomere-targeting therapies by MAIA Biotechnology and outlines their clinical and regulatory journey, providing a hopeful outlook for the future of cancer treatment.

Other notable biotech stocks to look forard to include MIRA Pharmaceuticals (NASDAQ: MIRA), Cassava Sciences Inc (NASDAQ: SAVA), Incyte Corp (NASDAQ: INCY) and Jazz Pharmaceuticals (NASDAQ: JAZZ).

Disclaimer: This blog post is for informational purposes only and does not constitute financial advice or an endorsement of MAIA or its strategies. FOR EDUCATIONAL AND INFORMATION PURPOSES ONLY; NOT INVESTMENT ADVICE. Please ensure to fully read and comprehend our disclaimer found at https://digitalcoinstandard.com//disclaimer/. https://digitalcoinstandard.com/ has been compensated five hundred dollars by a 3rd party Momentum Media LLC  for content distribution services on MAIA for July 22th, 2024. https://digitalcoinstandard.com/ is neither an investment advisor nor a registered broker. No current owner, employee, or independent contractor of https://digitalcoinstandard.com/ is registered as a securities broker-dealer, broker, investment advisor, or IA representative with the U.S. Securities and Exchange Commission, any state securities regulatory authority, or any self-regulatory organization. This article may contain forward-looking statements as defined under Section 27A of the Securities Act of 1933 and 21E of the Exchange Act of 1934. These statements, often incorporating terms like “believes,” “anticipates,” “estimates,” “expects,” “projects,” “intends,” or similar expressions about future performance or conduct, are based on present expectations, estimates, and projections, and are not historical facts. They carry various risks and uncertainties that may result in significant deviation from the anticipated results or events. Past performance does not guarantee future results.https://digitalcoinstandard.com/ does not commit to updating forward-looking statements based on new information or future events. Readers are encouraged to review all public SEC filings made by the profiled companies at https://www.sec.gov/edgar/searchedgar/companysearch. It is always important to conduct thorough due diligence and exercise caution in trading.https://digitalcoinstandard.com/ is not managed by a licensed broker, a dealer, or a registered investment adviser. The content here is purely informational and should not be taken as investment advice. The Private Securities Litigation Reform Act of 1995 provides investors a safe harbor regarding forward-looking statements. Any statement that projects, foresees, expects, anticipates, estimates, believes, or understands certain actions to possibly occur are not historical facts and may be forward-looking statements. These statements are based on expectations, estimates, and projections that could cause actual results to differ greatly from those anticipated. Investing in micro-cap and growth securities is speculative and entails a high degree of risk, potentially leading to a total or substantial loss of investment. Please note that no content published here constitutes a recommendation to buy or sell a security. It is solely informational, and you should not construe it as legal, tax, investment, financial, or other advice. No content in this article constitutes an offer or solicitation by https://digitalcoinstandard.com/ or any third-party service provider to buy or sell securities or other financial instruments. The content in this article does not address the circumstances of any specific individual or entity and does not constitute professional and/or financial advice. https://digitalcoinstandard.com/ is not a fiduciary by virtue of any person’s use of or access to this content. 

Source: https://finance.yahoo.com/news/maia-biotechnology-announces-date-achievements-140700794.html

https://finance.yahoo.com/news/maia-biotechnologys-telomere-targeting-functionality-163100746.html

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Country: United States
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