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InvestorNewsBreaks — VistaGen Therapeutics Inc. (NASDAQ: VTGN) Releases Data on New Preclinical Mechanism of Action Regarding Potential Anti-Anxiety Activity

VistaGen Therapeutics (NASDAQ: VTGN), a biopharmaceutical company developing a new generation of medicines with potential to go beyond the current standard of care for anxiety, depression and other central nervous system (“CNS”) disorders, has released data regarding a new mechanism of action. The data was gathered from a preclinical tissue distribution study studying laboratory rats and evaluating a single intranasal administration of radiolabeled carbon-14 PH94B. According to the announcement, activity was largely confined to the nasal passages with minimal activity detected in other tissues, including the CNS. The reported also noted that no appreciable activity was observed in the brain. VistaGen reported that this data supports the proposed mechanism of action of PH94B involving binding to receptors of peripheral neurons in the nasal passages rather than neuronal receptors in the CNS. This binding limits transport of molecules to the circulatory system and minimizes potential systemic exposure. “We are very excited about these new study results, which further highlight how the mechanism of action of PH94B is fundamentally differentiated from all current anti-anxiety therapies,” said VistaGen CEO Shawn K. Singh in the press release. “When combined with previously announced preclinical electrophysiology data demonstrating that the mechanism of action of PH94B does not involve direct activation of GABA-A receptors, which is in distinct contrast to the mechanism of action of benzodiazepines, we see a growing body of evidence suggesting that PH94B has potential to achieve anti-anxiety effects without requiring systemic uptake or causing benzodiazepine-like side effects and safety concerns. At a time when the current drug treatment paradigm for Social Anxiety Disorder, or SAD, is falling far short of delivering necessary relief without worrisome potential consequences, an innovative treatment alternative is imperative. If successfully developed in our ongoing PALISADE Phase 3 Program, PH94B has the potential to fill that void as the first fast-acting, on-demand acute treatment of anxiety for more than 23 million Americans who suffer from SAD.”

To view the full press release, visit https://ibn.fm/f0l6G

About VistaGen Therapeutics Inc.

VistaGen Therapeutics is a biopharmaceutical company committed to developing and commercializing innovative medicines with the potential to go beyond the current standard of care for anxiety, depression and other CNS disorders. Each of VistaGen’s drug candidates has a differentiated potential mechanism of action, has been well-tolerated in all clinical studies to date and has therapeutic potential in multiple CNS markets. For more information about the company, please visit www.VistaGen.com.

NOTE TO INVESTORS: The latest news and updates relating to VTGN are available in the company’s newsroom at https://ibn.fm/VTGN

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